SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2w4k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 12 LEU A  19
VAL A  27
ALA A  40
GLU A  64
ILE A  71
GLY A  99
 ADP  A1303 ( 3.9A)
ADP  A1303 (-4.0A)
ADP  A1303 (-3.5A)
ADP  A1303 ( 4.8A)
None
None
 0.83A 1iepB-2w4kA:
16.3		 1iepB-2w4kA:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 LEU A  19
ALA A  40
LYS A  42
GLU A  64
LEU A  91
LEU A  95
ASP A 161
 ADP  A1303 ( 3.9A)
ADP  A1303 (-3.5A)
ADP  A1303 (-2.7A)
ADP  A1303 ( 4.8A)
None
None
MG  A1304 ( 2.8A)
 0.77A 1m17A-2w4kA:
25.3		 1m17A-2w4kA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDN_A_LEUA487_0
(L-AMINO ACID OXIDASE)		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		4 / 7 ASN A 144
HIS A 137
PHE A 162
ILE A 123
 MG  A1304 ( 4.2A)
None
None
None
 1.36A 1tdnA-2w4kA:
undetectable		 1tdnA-2w4kA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 ALA A  40
GLU A  64
LEU A  68
LEU A 130
HIS A 137
 ADP  A1303 (-3.5A)
ADP  A1303 ( 4.8A)
None
None
None
 0.49A 1uwhA-2w4kA:
24.0		 1uwhA-2w4kA:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 12 ALA A  40
LYS A  42
GLU A  64
LEU A  68
LEU A 130
HIS A 137
 ADP  A1303 (-3.5A)
ADP  A1303 (-2.7A)
ADP  A1303 ( 4.8A)
None
None
None
 0.51A 1uwhB-2w4kA:
23.8		 1uwhB-2w4kA:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 VAL A  27
ALA A  40
GLU A  64
LEU A 130
HIS A 137
 ADP  A1303 (-4.0A)
ADP  A1303 (-3.5A)
ADP  A1303 ( 4.8A)
None
None
 0.51A 1uwjA-2w4kA:
6.8		 1uwjA-2w4kA:
26.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 VAL A  27
ALA A  40
GLU A  64
LEU A 130
HIS A 137
 ADP  A1303 (-4.0A)
ADP  A1303 (-3.5A)
ADP  A1303 ( 4.8A)
None
None
 0.51A 1uwjB-2w4kA:
6.8		 1uwjB-2w4kA:
26.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 9 LEU A  19
VAL A  27
LYS A  42
LEU A  79
LEU A  91
LEU A  95
 ADP  A1303 ( 3.9A)
ADP  A1303 (-4.0A)
ADP  A1303 (-2.7A)
None
None
None
 0.70A 1xkkA-2w4kA:
17.1		 1xkkA-2w4kA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YI4_A_ADNA306_1
(PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 10 LEU A  19
ALA A  40
ILE A  77
LEU A  93
ILE A 160
 ADP  A1303 ( 3.9A)
ADP  A1303 (-3.5A)
ADP  A1303 ( 4.2A)
ADP  A1303 ( 4.1A)
ADP  A1303 ( 4.1A)
 0.70A 1yi4A-2w4kA:
27.3		 1yi4A-2w4kA:
29.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 9 LEU A  68
PHE A 162
LEU A 130
ILE A 135
TYR A 129
 None
 1.15A 2f78A-2w4kA:
undetectable		 2f78A-2w4kA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		9 / 12 LEU A  19
GLY A  20
VAL A  27
ALA A  40
VAL A  96
ASP A 139
LYS A 141
ASN A 144
MET A 146
 ADP  A1303 ( 3.9A)
ADP  A1303 (-3.4A)
ADP  A1303 (-4.0A)
ADP  A1303 (-3.5A)
ADP  A1303 (-3.6A)
None
None
MG  A1304 ( 4.2A)
ADP  A1303 (-4.2A)
 0.81A 2fumA-2w4kA:
27.4		 2fumA-2w4kA:
26.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		9 / 12 LEU A  19
VAL A  27
ALA A  40
VAL A  96
ASP A 139
LYS A 141
ASN A 144
MET A 146
ASP A 161
 ADP  A1303 ( 3.9A)
ADP  A1303 (-4.0A)
ADP  A1303 (-3.5A)
ADP  A1303 (-3.6A)
None
None
MG  A1304 ( 4.2A)
ADP  A1303 (-4.2A)
MG  A1304 ( 2.8A)
 0.82A 2fumA-2w4kA:
27.4		 2fumA-2w4kA:
26.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		8 / 12 LEU A  19
GLY A  20
VAL A  27
ALA A  40
VAL A  96
ASN A 144
MET A 146
ASP A 161
 ADP  A1303 ( 3.9A)
ADP  A1303 (-3.4A)
ADP  A1303 (-4.0A)
ADP  A1303 (-3.5A)
ADP  A1303 (-3.6A)
MG  A1304 ( 4.2A)
ADP  A1303 (-4.2A)
MG  A1304 ( 2.8A)
 0.85A 2fumB-2w4kA:
27.1		 2fumB-2w4kA:
26.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		8 / 12 LEU A  19
GLY A  20
VAL A  27
ALA A  40
VAL A  96
LYS A 141
ASN A 144
ASP A 161
 ADP  A1303 ( 3.9A)
ADP  A1303 (-3.4A)
ADP  A1303 (-4.0A)
ADP  A1303 (-3.5A)
ADP  A1303 (-3.6A)
None
MG  A1304 ( 4.2A)
MG  A1304 ( 2.8A)
 0.81A 2fumB-2w4kA:
27.1		 2fumB-2w4kA:
26.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 LEU A  19
GLY A  20
VAL A  27
ALA A  40
VAL A  96
ASN A 144
MET A 146
 ADP  A1303 ( 3.9A)
ADP  A1303 (-3.4A)
ADP  A1303 (-4.0A)
ADP  A1303 (-3.5A)
ADP  A1303 (-3.6A)
MG  A1304 ( 4.2A)
ADP  A1303 (-4.2A)
 0.90A 2fumC-2w4kA:
25.3		 2fumC-2w4kA:
26.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		8 / 12 LEU A  19
GLY A  20
GLY A  22
VAL A  27
ALA A  40
LYS A 141
ASN A 144
MET A 146
 ADP  A1303 ( 3.9A)
ADP  A1303 (-3.4A)
ADP  A1303 ( 3.8A)
ADP  A1303 (-4.0A)
ADP  A1303 (-3.5A)
None
MG  A1304 ( 4.2A)
ADP  A1303 (-4.2A)
 0.87A 2fumD-2w4kA:
25.3		 2fumD-2w4kA:
26.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 LEU A  19
GLY A  20
VAL A  27
LYS A  42
GLU A  64
LEU A  68
LEU A  91
 ADP  A1303 ( 3.9A)
ADP  A1303 (-3.4A)
ADP  A1303 (-4.0A)
ADP  A1303 (-2.7A)
ADP  A1303 ( 4.8A)
None
None
 0.66A 2ivuA-2w4kA:
26.1		 2ivuA-2w4kA:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_A_ACTA653_0
(ACETYL-COENZYME A
SYNTHETASE)		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		4 / 5 VAL A 232
VAL A 205
GLY A 204
TRP A 201
 None
 1.11A 2p2fA-2w4kA:
undetectable		 2p2fA-2w4kA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 12 ALA A  40
GLU A  64
LEU A  68
ILE A  77
HIS A 137
ASP A 161
 ADP  A1303 (-3.5A)
ADP  A1303 ( 4.8A)
None
ADP  A1303 ( 4.2A)
None
MG  A1304 ( 2.8A)
 1.16A 3gp0A-2w4kA:
22.5		 3gp0A-2w4kA:
29.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 12 VAL A  27
ALA A  40
GLU A  64
LEU A  68
ILE A  77
HIS A 137
 ADP  A1303 (-4.0A)
ADP  A1303 (-3.5A)
ADP  A1303 ( 4.8A)
None
ADP  A1303 ( 4.2A)
None
 0.59A 3gp0A-2w4kA:
22.5		 3gp0A-2w4kA:
29.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 7 LYS A  42
VAL A  76
LEU A  91
LEU A  95
ILE A 159
 ADP  A1303 (-2.7A)
None
None
None
None
 0.80A 3gp0A-2w4kA:
22.5		 3gp0A-2w4kA:
29.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 ALA A  40
LYS A  42
GLU A  64
LEU A  68
ILE A  77
 ADP  A1303 (-3.5A)
ADP  A1303 (-2.7A)
ADP  A1303 ( 4.8A)
None
ADP  A1303 ( 4.2A)
 0.56A 3hecA-2w4kA:
22.4		 3hecA-2w4kA:
30.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 ALA A  40
LYS A  42
GLU A  64
LEU A  68
LEU A  95
 ADP  A1303 (-3.5A)
ADP  A1303 (-2.7A)
ADP  A1303 ( 4.8A)
None
None
 0.56A 3hecA-2w4kA:
22.4		 3hecA-2w4kA:
30.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 VAL A  27
ALA A  40
LYS A  42
LEU A  68
ILE A  77
 ADP  A1303 (-4.0A)
ADP  A1303 (-3.5A)
ADP  A1303 (-2.7A)
None
ADP  A1303 ( 4.2A)
 0.69A 3hegA-2w4kA:
22.2		 3hegA-2w4kA:
30.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEG_A_BAXA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		4 / 6 VAL A  76
ILE A 135
HIS A 137
ILE A 159
 None
 0.36A 3hegA-2w4kA:
22.2		 3hegA-2w4kA:
30.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 8 ALA A  40
LYS A  42
GLU A  64
LEU A  91
LEU A  95
 ADP  A1303 (-3.5A)
ADP  A1303 (-2.7A)
ADP  A1303 ( 4.8A)
None
None
 0.46A 3lfaA-2w4kA:
21.9		 3lfaA-2w4kA:
29.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		4 / 6 VAL A  65
ILE A  71
MET A 146
ARG A   5
 None
None
ADP  A1303 (-4.2A)
None
 1.05A 3mssC-2w4kA:
22.4		 3mssC-2w4kA:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_1
(P38A)		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 12 GLY A  20
VAL A  27
ALA A  40
LYS A  42
LEU A  68
ILE A  77
 ADP  A1303 (-3.4A)
ADP  A1303 (-4.0A)
ADP  A1303 (-3.5A)
ADP  A1303 (-2.7A)
None
ADP  A1303 ( 4.2A)
 0.70A 3ohtA-2w4kA:
5.0		 3ohtA-2w4kA:
27.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_2
(P38A)		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		3 / 3 GLU A  64
LEU A  91
LEU A  95
 ADP  A1303 ( 4.8A)
None
None
 0.49A 3ohtA-2w4kA:
5.0		 3ohtA-2w4kA:
27.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_1
(P38A)		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 GLY A  20
VAL A  27
ALA A  40
LYS A  42
LEU A  68
 ADP  A1303 (-3.4A)
ADP  A1303 (-4.0A)
ADP  A1303 (-3.5A)
ADP  A1303 (-2.7A)
None
 0.50A 3ohtB-2w4kA:
5.0		 3ohtB-2w4kA:
27.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_2
(P38A)		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		3 / 3 GLU A  64
LEU A  91
LEU A  95
 ADP  A1303 ( 4.8A)
None
None
 0.49A 3ohtB-2w4kA:
5.0		 3ohtB-2w4kA:
27.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_1
(CYCLIN-DEPENDENT
KINASE 8)		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 VAL A  27
ALA A  40
GLU A  64
LEU A  68
ILE A  77
LEU A 130
HIS A 137
 ADP  A1303 (-4.0A)
ADP  A1303 (-3.5A)
ADP  A1303 ( 4.8A)
None
ADP  A1303 ( 4.2A)
None
None
 0.69A 3rgfA-2w4kA:
5.0		 3rgfA-2w4kA:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WAR_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA)		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 8 LYS A  42
ILE A  77
MET A 146
ILE A 160
ASP A 161
 ADP  A1303 (-2.7A)
ADP  A1303 ( 4.2A)
ADP  A1303 (-4.2A)
ADP  A1303 ( 4.1A)
MG  A1304 ( 2.8A)
 0.77A 3warA-2w4kA:
27.2		 3warA-2w4kA:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WAR_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA)		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 8 VAL A  27
LYS A  42
MET A 146
ILE A 160
ASP A 161
 ADP  A1303 (-4.0A)
ADP  A1303 (-2.7A)
ADP  A1303 (-4.2A)
ADP  A1303 ( 4.1A)
MG  A1304 ( 2.8A)
 0.74A 3warA-2w4kA:
27.2		 3warA-2w4kA:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		8 / 12 LEU A  19
VAL A  27
ALA A  40
LYS A  42
GLU A  64
LEU A  68
LEU A 130
HIS A 137
 ADP  A1303 ( 3.9A)
ADP  A1303 (-4.0A)
ADP  A1303 (-3.5A)
ADP  A1303 (-2.7A)
ADP  A1303 ( 4.8A)
None
None
None
 0.65A 3wzeA-2w4kA:
22.4		 3wzeA-2w4kA:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		8 / 12 VAL A  27
ALA A  40
LYS A  42
GLU A  64
LEU A  68
ILE A  71
LEU A 130
HIS A 137
 ADP  A1303 (-4.0A)
ADP  A1303 (-3.5A)
ADP  A1303 (-2.7A)
ADP  A1303 ( 4.8A)
None
None
None
None
 0.88A 3wzeA-2w4kA:
22.4		 3wzeA-2w4kA:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		4 / 7 ASP A 199
GLY A 204
THR A 207
ILE A 206
 None
 0.77A 4acaC-2w4kA:
undetectable		 4acaC-2w4kA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 12 LEU A  19
VAL A  27
ALA A  40
LYS A  42
GLU A  64
LEU A  68
 ADP  A1303 ( 3.9A)
ADP  A1303 (-4.0A)
ADP  A1303 (-3.5A)
ADP  A1303 (-2.7A)
ADP  A1303 ( 4.8A)
None
 0.58A 4agcA-2w4kA:
21.9		 4agcA-2w4kA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		9 / 12 LEU A  19
VAL A  27
ALA A  40
LYS A  42
GLU A  64
LEU A  68
GLY A  99
LEU A 130
HIS A 137
 ADP  A1303 ( 3.9A)
ADP  A1303 (-4.0A)
ADP  A1303 (-3.5A)
ADP  A1303 (-2.7A)
ADP  A1303 ( 4.8A)
None
None
None
None
 0.76A 4asdA-2w4kA:
16.4		 4asdA-2w4kA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 ALA A  25
SER A  21
VAL A  27
ILE A 160
ASN A 144
 ADP  A1303 ( 3.7A)
None
ADP  A1303 (-4.0A)
ADP  A1303 ( 4.1A)
MG  A1304 ( 4.2A)
 1.08A 4c49A-2w4kA:
undetectable		 4c49A-2w4kA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		4 / 7 GLY A  99
GLY A  98
ASN A 151
GLU A 100
 None
 1.12A 4fgkB-2w4kA:
undetectable		 4fgkB-2w4kA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 11 VAL A  27
ALA A  40
LYS A  42
LEU A  93
GLU A 143
ILE A 160
ASP A 161
 ADP  A1303 (-4.0A)
ADP  A1303 (-3.5A)
ADP  A1303 (-2.7A)
ADP  A1303 ( 4.1A)
None
ADP  A1303 ( 4.1A)
MG  A1304 ( 2.8A)
 0.69A 4iaaA-2w4kA:
27.1		 4iaaA-2w4kA:
28.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JJK_A_FOLA601_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		4 / 8 ALA A  97
GLU A  17
LEU A  19
LEU A  95
 None
None
ADP  A1303 ( 3.9A)
None
 0.86A 4jjkA-2w4kA:
undetectable		 4jjkA-2w4kA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 LEU A  19
VAL A  27
ALA A  40
LYS A  42
LEU A  93
LEU A  95
ASP A 161
 ADP  A1303 ( 3.9A)
ADP  A1303 (-4.0A)
ADP  A1303 (-3.5A)
ADP  A1303 (-2.7A)
ADP  A1303 ( 4.1A)
None
MG  A1304 ( 2.8A)
 0.61A 4mkcA-2w4kA:
25.1		 4mkcA-2w4kA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 LEU A  19
VAL A  27
LYS A  42
LEU A  93
LEU A  95
GLY A  99
ASP A 161
 ADP  A1303 ( 3.9A)
ADP  A1303 (-4.0A)
ADP  A1303 (-2.7A)
ADP  A1303 ( 4.1A)
None
None
MG  A1304 ( 2.8A)
 0.87A 4mkcA-2w4kA:
25.1		 4mkcA-2w4kA:
25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		4 / 6 LEU A  19
GLY A  20
VAL A  27
ALA A  40
 ADP  A1303 ( 3.9A)
ADP  A1303 (-3.4A)
ADP  A1303 (-4.0A)
ADP  A1303 (-3.5A)
 0.16A 4o0wA-2w4kA:
22.2		 4o0wA-2w4kA:
32.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 10 ALA A  40
LYS A  42
ILE A  77
LEU A  95
VAL A  96
 ADP  A1303 (-3.5A)
ADP  A1303 (-2.7A)
ADP  A1303 ( 4.2A)
None
ADP  A1303 (-3.6A)
 0.67A 4rz7A-2w4kA:
10.8		 4rz7A-2w4kA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 12 LEU A  19
ALA A  40
LYS A  42
GLU A  64
LEU A  91
LEU A  95
 ADP  A1303 ( 3.9A)
ADP  A1303 (-3.5A)
ADP  A1303 (-2.7A)
ADP  A1303 ( 4.8A)
None
None
 0.40A 4wkqA-2w4kA:
25.4		 4wkqA-2w4kA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 ILE A 209
LEU A 105
PHE A 102
ILE A 123
ILE A 206
 None
 1.10A 4x5jA-2w4kA:
undetectable		 4x5jA-2w4kA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 VAL A  27
ALA A  40
LYS A  42
ASP A 161
PHE A 162
 ADP  A1303 (-4.0A)
ADP  A1303 (-3.5A)
ADP  A1303 (-2.7A)
MG  A1304 ( 2.8A)
None
 0.74A 4xv2A-2w4kA:
23.9		 4xv2A-2w4kA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 ALA A  40
LYS A  42
LEU A  68
ASP A 161
PHE A 162
 ADP  A1303 (-3.5A)
ADP  A1303 (-2.7A)
None
MG  A1304 ( 2.8A)
None
 0.85A 4xv2B-2w4kA:
24.0		 4xv2B-2w4kA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 VAL A  27
ALA A  40
LYS A  42
LEU A  68
PHE A 162
 ADP  A1303 (-4.0A)
ADP  A1303 (-3.5A)
ADP  A1303 (-2.7A)
None
None
 0.82A 5cswA-2w4kA:
23.9		 5cswA-2w4kA:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		3 / 3 ASN A 144
LEU A  68
PHE A 138
 MG  A1304 ( 4.2A)
None
None
 0.77A 5dsgA-2w4kA:
undetectable		 5dsgA-2w4kA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 12 ALA A  40
LYS A  42
GLU A  64
LEU A  68
LEU A 130
HIS A 137
 ADP  A1303 (-3.5A)
ADP  A1303 (-2.7A)
ADP  A1303 ( 4.8A)
None
None
None
 0.59A 5hi2A-2w4kA:
24.3		 5hi2A-2w4kA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 11 LEU A  19
GLY A  20
VAL A  27
ALA A  40
LEU A  93
GLU A 143
 ADP  A1303 ( 3.9A)
ADP  A1303 (-3.4A)
ADP  A1303 (-4.0A)
ADP  A1303 (-3.5A)
ADP  A1303 ( 4.1A)
None
 0.29A 5lvnA-2w4kA:
29.8		 5lvnA-2w4kA:
27.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_E_ADNE401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 10 GLY A  20
VAL A  27
ALA A  40
ILE A  77
LEU A  95
 ADP  A1303 (-3.4A)
ADP  A1303 (-4.0A)
ADP  A1303 (-3.5A)
ADP  A1303 ( 4.2A)
None
 0.47A 5lw1E-2w4kA:
22.6		 5lw1E-2w4kA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 GLU A  17
GLY A  20
VAL A  27
ALA A  40
LYS A  42
GLU A  64
LEU A  93
 None
ADP  A1303 (-3.4A)
ADP  A1303 (-4.0A)
ADP  A1303 (-3.5A)
ADP  A1303 (-2.7A)
ADP  A1303 ( 4.8A)
ADP  A1303 ( 4.1A)
 0.56A 5mafA-2w4kA:
29.2		 5mafA-2w4kA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 GLY A  20
VAL A  27
ALA A  40
LYS A  42
LEU A  93
GLY A  99
ILE A 160
 ADP  A1303 (-3.4A)
ADP  A1303 (-4.0A)
ADP  A1303 (-3.5A)
ADP  A1303 (-2.7A)
ADP  A1303 ( 4.1A)
None
ADP  A1303 ( 4.1A)
 0.74A 5mafA-2w4kA:
29.2		 5mafA-2w4kA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 10 LEU A  19
VAL A  27
LYS A  42
GLU A  64
GLY A  99
 ADP  A1303 ( 3.9A)
ADP  A1303 (-4.0A)
ADP  A1303 (-2.7A)
ADP  A1303 ( 4.8A)
None
 0.67A 5mo4A-2w4kA:
20.2		 5mo4A-2w4kA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 12 LEU A  19
VAL A  27
ALA A  40
LYS A  42
GLU A  64
LEU A  91
 ADP  A1303 ( 3.9A)
ADP  A1303 (-4.0A)
ADP  A1303 (-3.5A)
ADP  A1303 (-2.7A)
ADP  A1303 ( 4.8A)
None
 0.50A 5vcyA-2w4kA:
25.4		 5vcyA-2w4kA:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 10 LYS A 158
ILE A 159
ILE A 123
LEU A 124
ILE A  71
 None
 1.28A 5vkqA-2w4kA:
undetectable
5vkqD-2w4kA:
undetectable		 5vkqA-2w4kA:
11.63
5vkqD-2w4kA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 10 ILE A  71
LYS A 158
ILE A 159
ILE A 123
LEU A 124
 None
 1.30A 5vkqA-2w4kA:
undetectable
5vkqB-2w4kA:
undetectable		 5vkqA-2w4kA:
11.63
5vkqB-2w4kA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 10 ILE A  71
LYS A 158
ILE A 159
ILE A 123
LEU A 124
 None
 1.27A 5vkqC-2w4kA:
undetectable
5vkqD-2w4kA:
undetectable		 5vkqC-2w4kA:
11.63
5vkqD-2w4kA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 LEU A  19
VAL A  27
ALA A  40
LYS A  42
GLU A  64
LEU A  95
ASP A 161
 ADP  A1303 ( 3.9A)
ADP  A1303 (-4.0A)
ADP  A1303 (-3.5A)
ADP  A1303 (-2.7A)
ADP  A1303 ( 4.8A)
None
MG  A1304 ( 2.8A)
 0.55A 5y80A-2w4kA:
25.8		 5y80A-2w4kA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 8 LEU A  19
VAL A  27
LYS A  42
ILE A 160
ASP A 161
 ADP  A1303 ( 3.9A)
ADP  A1303 (-4.0A)
ADP  A1303 (-2.7A)
ADP  A1303 ( 4.1A)
MG  A1304 ( 2.8A)
 0.69A 5y9mA-2w4kA:
26.7		 5y9mA-2w4kA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 8 VAL A  27
LYS A  42
MET A 146
ILE A 160
ASP A 161
 ADP  A1303 (-4.0A)
ADP  A1303 (-2.7A)
ADP  A1303 (-4.2A)
ADP  A1303 ( 4.1A)
MG  A1304 ( 2.8A)
 0.83A 5y9mA-2w4kA:
26.7		 5y9mA-2w4kA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		4 / 8 LEU A  19
VAL A  27
LYS A  42
ILE A 160
 ADP  A1303 ( 3.9A)
ADP  A1303 (-4.0A)
ADP  A1303 (-2.7A)
ADP  A1303 ( 4.1A)
 0.63A 5y9mX-2w4kA:
26.8		 5y9mX-2w4kA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 8 VAL A  27
LYS A  42
MET A 146
ILE A 160
ASP A 161
 ADP  A1303 (-4.0A)
ADP  A1303 (-2.7A)
ADP  A1303 (-4.2A)
ADP  A1303 ( 4.1A)
MG  A1304 ( 2.8A)
 0.84A 5y9mX-2w4kA:
26.8		 5y9mX-2w4kA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_B_NIOB401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 7 VAL A  27
LYS A  42
MET A 146
ILE A 160
ASP A 161
 ADP  A1303 (-4.0A)
ADP  A1303 (-2.7A)
ADP  A1303 (-4.2A)
ADP  A1303 ( 4.1A)
MG  A1304 ( 2.8A)
 0.98A 5yf9B-2w4kA:
26.6		 5yf9B-2w4kA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 9 LEU A  19
VAL A  27
LYS A  42
ILE A  77
ILE A 160
ASP A 161
 ADP  A1303 ( 3.9A)
ADP  A1303 (-4.0A)
ADP  A1303 (-2.7A)
ADP  A1303 ( 4.2A)
ADP  A1303 ( 4.1A)
MG  A1304 ( 2.8A)
 0.81A 5yf9X-2w4kA:
27.2		 5yf9X-2w4kA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 9 VAL A  27
LYS A  42
ILE A  77
MET A 146
ILE A 160
ASP A 161
 ADP  A1303 (-4.0A)
ADP  A1303 (-2.7A)
ADP  A1303 ( 4.2A)
ADP  A1303 (-4.2A)
ADP  A1303 ( 4.1A)
MG  A1304 ( 2.8A)
 1.01A 5yf9X-2w4kA:
27.2		 5yf9X-2w4kA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YWM_X_NIOX403_0
(CASEIN KINASE II
SUBUNIT ALPHA')		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 7 VAL A  27
LYS A  42
ILE A  77
ILE A 160
ASP A 161
 ADP  A1303 (-4.0A)
ADP  A1303 (-2.7A)
ADP  A1303 ( 4.2A)
ADP  A1303 ( 4.1A)
MG  A1304 ( 2.8A)
 0.58A 5ywmX-2w4kA:
27.0		 5ywmX-2w4kA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_K_PACK1_0
(SERINE PROTEASE NS3
PEPTIDE
PAC-DLY-DLY-DAR)		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		3 / 3 ALA A  40
VAL A   9
TYR A  13
 ADP  A1303 (-3.5A)
None
None
 0.58A 5zmqH-2w4kA:
1.6		 5zmqH-2w4kA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 12 LEU A  19
VAL A  27
ALA A  40
LYS A  42
GLU A  64
GLY A  99
 ADP  A1303 ( 3.9A)
ADP  A1303 (-4.0A)
ADP  A1303 (-3.5A)
ADP  A1303 (-2.7A)
ADP  A1303 ( 4.8A)
None
 0.50A 5zv2B-2w4kA:
22.7		 5zv2B-2w4kA:
16.00