SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2w4o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K2R_A_H4BA1760_1
(NITRIC-OXIDE
SYNTHASE)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.40A 1k2rA-2w4oA:
undetectable
1k2rB-2w4oA:
1.2		 1k2rA-2w4oA:
20.91
1k2rB-2w4oA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K2R_B_H4BB2760_1
(NITRIC-OXIDE
SYNTHASE)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.41A 1k2rA-2w4oA:
undetectable
1k2rB-2w4oA:
1.2		 1k2rA-2w4oA:
20.91
1k2rB-2w4oA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K2S_A_H4BA1760_1
(NITRIC-OXIDE
SYNTHASE)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.37A 1k2sA-2w4oA:
undetectable
1k2sB-2w4oA:
undetectable		 1k2sA-2w4oA:
20.91
1k2sB-2w4oA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K2S_B_H4BB2760_1
(NITRIC-OXIDE
SYNTHASE)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.36A 1k2sA-2w4oA:
undetectable
1k2sB-2w4oA:
undetectable		 1k2sA-2w4oA:
20.91
1k2sB-2w4oA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K2T_A_H4BA1760_1
(NITRIC-OXIDE
SYNTHASE)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.41A 1k2tA-2w4oA:
undetectable
1k2tB-2w4oA:
undetectable		 1k2tA-2w4oA:
20.91
1k2tB-2w4oA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K2T_B_H4BB2760_1
(NITRIC-OXIDE
SYNTHASE)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.42A 1k2tA-2w4oA:
undetectable
1k2tB-2w4oA:
undetectable		 1k2tA-2w4oA:
20.91
1k2tB-2w4oA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K2U_A_H4BA1760_1
(NITRIC-OXIDE
SYNTHASE)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.40A 1k2uA-2w4oA:
undetectable
1k2uB-2w4oA:
undetectable		 1k2uA-2w4oA:
20.91
1k2uB-2w4oA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K2U_B_H4BB2760_1
(NITRIC-OXIDE
SYNTHASE)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.41A 1k2uA-2w4oA:
undetectable
1k2uB-2w4oA:
undetectable		 1k2uA-2w4oA:
20.91
1k2uB-2w4oA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LZX_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.43A 1lzxA-2w4oA:
1.1
1lzxB-2w4oA:
undetectable		 1lzxA-2w4oA:
20.91
1lzxB-2w4oA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LZX_B_H4BB1760_1
(NITRIC-OXIDE
SYNTHASE)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.42A 1lzxA-2w4oA:
1.1
1lzxB-2w4oA:
undetectable		 1lzxA-2w4oA:
20.91
1lzxB-2w4oA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LZZ_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.44A 1lzzA-2w4oA:
undetectable
1lzzB-2w4oA:
undetectable		 1lzzA-2w4oA:
20.91
1lzzB-2w4oA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LZZ_B_H4BB1760_1
(NITRIC-OXIDE
SYNTHASE)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.42A 1lzzA-2w4oA:
undetectable
1lzzB-2w4oA:
undetectable		 1lzzA-2w4oA:
20.91
1lzzB-2w4oA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M00_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.43A 1m00A-2w4oA:
undetectable
1m00B-2w4oA:
undetectable		 1m00A-2w4oA:
20.91
1m00B-2w4oA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M00_B_H4BB1760_1
(NITRIC-OXIDE
SYNTHASE)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.44A 1m00A-2w4oA:
undetectable
1m00B-2w4oA:
undetectable		 1m00A-2w4oA:
20.91
1m00B-2w4oA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMV_A_H4BA1760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.43A 1mmvA-2w4oA:
undetectable
1mmvB-2w4oA:
undetectable		 1mmvA-2w4oA:
20.91
1mmvB-2w4oA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMV_B_H4BB2760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.42A 1mmvA-2w4oA:
undetectable
1mmvB-2w4oA:
undetectable		 1mmvA-2w4oA:
20.91
1mmvB-2w4oA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMW_A_H4BA1760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.42A 1mmwA-2w4oA:
undetectable
1mmwB-2w4oA:
undetectable		 1mmwA-2w4oA:
20.91
1mmwB-2w4oA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMW_B_H4BB2760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.43A 1mmwA-2w4oA:
undetectable
1mmwB-2w4oA:
undetectable		 1mmwA-2w4oA:
20.91
1mmwB-2w4oA:
20.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		5 / 9 LEU A  52
GLY A  53
VAL A  60
ALA A  73
LEU A 171
 DKI  A1338 (-3.8A)
DKI  A1338 (-3.3A)
DKI  A1338 (-4.2A)
DKI  A1338 ( 3.7A)
DKI  A1338 (-4.9A)
 0.50A 1muoA-2w4oA:
24.4		 1muoA-2w4oA:
31.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OM4_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.43A 1om4A-2w4oA:
1.1
1om4B-2w4oA:
undetectable		 1om4A-2w4oA:
20.26
1om4B-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OM4_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.43A 1om4A-2w4oA:
1.1
1om4B-2w4oA:
undetectable		 1om4A-2w4oA:
20.26
1om4B-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OM5_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 8 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.39A 1om5A-2w4oA:
undetectable
1om5B-2w4oA:
undetectable		 1om5A-2w4oA:
20.81
1om5B-2w4oA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OM5_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.35A 1om5A-2w4oA:
undetectable
1om5B-2w4oA:
undetectable		 1om5A-2w4oA:
20.81
1om5B-2w4oA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6H_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.41A 1p6hA-2w4oA:
1.1
1p6hB-2w4oA:
1.5		 1p6hA-2w4oA:
20.81
1p6hB-2w4oA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6H_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.40A 1p6hA-2w4oA:
1.1
1p6hB-2w4oA:
1.4		 1p6hA-2w4oA:
20.81
1p6hB-2w4oA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6I_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.42A 1p6iA-2w4oA:
1.1
1p6iB-2w4oA:
1.4		 1p6iA-2w4oA:
20.81
1p6iB-2w4oA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6I_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.43A 1p6iA-2w4oA:
1.1
1p6iB-2w4oA:
1.4		 1p6iA-2w4oA:
20.81
1p6iB-2w4oA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6J_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.43A 1p6jA-2w4oA:
1.1
1p6jB-2w4oA:
undetectable		 1p6jA-2w4oA:
20.81
1p6jB-2w4oA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6J_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.42A 1p6jA-2w4oA:
1.1
1p6jB-2w4oA:
undetectable		 1p6jA-2w4oA:
20.81
1p6jB-2w4oA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.43A 1p6kA-2w4oA:
1.2
1p6kB-2w4oA:
1.2		 1p6kA-2w4oA:
20.81
1p6kB-2w4oA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.42A 1p6kA-2w4oA:
1.2
1p6kB-2w4oA:
1.2		 1p6kA-2w4oA:
20.81
1p6kB-2w4oA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.43A 1rs6A-2w4oA:
1.4
1rs6B-2w4oA:
0.9		 1rs6A-2w4oA:
20.81
1rs6B-2w4oA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 8 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.42A 1rs6A-2w4oA:
1.4
1rs6B-2w4oA:
undetectable		 1rs6A-2w4oA:
20.81
1rs6B-2w4oA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.44A 1rs7A-2w4oA:
1.2
1rs7B-2w4oA:
1.2		 1rs7A-2w4oA:
20.81
1rs7B-2w4oA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.43A 1rs7A-2w4oA:
1.2
1rs7B-2w4oA:
1.3		 1rs7A-2w4oA:
20.81
1rs7B-2w4oA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		5 / 9 LEU A  52
VAL A  60
LEU A 104
LEU A 116
LEU A 120
 DKI  A1338 (-3.8A)
DKI  A1338 (-4.2A)
None
None
DKI  A1338 (-4.2A)
 0.44A 1xkkA-2w4oA:
22.1		 1xkkA-2w4oA:
27.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		5 / 9 VAL A  60
LYS A  75
LEU A 104
LEU A 116
LEU A 120
 DKI  A1338 (-4.2A)
None
None
None
DKI  A1338 (-4.2A)
 0.63A 1xkkA-2w4oA:
22.1		 1xkkA-2w4oA:
27.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YI4_A_ADNA306_1
(PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		5 / 10 LEU A  52
ALA A  73
ILE A 102
LEU A 118
LEU A 171
 DKI  A1338 (-3.8A)
DKI  A1338 ( 3.7A)
DKI  A1338 ( 4.4A)
DKI  A1338 ( 4.7A)
DKI  A1338 (-4.9A)
 0.44A 1yi4A-2w4oA:
22.7		 1yi4A-2w4oA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZVL_A_H4BA900_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.39A 1zvlA-2w4oA:
undetectable
1zvlB-2w4oA:
0.8		 1zvlA-2w4oA:
20.81
1zvlB-2w4oA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZVL_B_H4BB920_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.39A 1zvlA-2w4oA:
undetectable
1zvlB-2w4oA:
0.8		 1zvlA-2w4oA:
20.81
1zvlB-2w4oA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.44A 1zzqA-2w4oA:
1.2
1zzqB-2w4oA:
1.2		 1zzqA-2w4oA:
20.35
1zzqB-2w4oA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.41A 1zzqA-2w4oA:
1.1
1zzqB-2w4oA:
1.3		 1zzqA-2w4oA:
20.35
1zzqB-2w4oA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		7 / 12 LEU A  52
GLY A  53
VAL A  60
ALA A  73
VAL A 121
ASP A 164
ASP A 185
 DKI  A1338 (-3.8A)
DKI  A1338 (-3.3A)
DKI  A1338 (-4.2A)
DKI  A1338 ( 3.7A)
DKI  A1338 (-3.9A)
None
DKI  A1338 (-3.8A)
 0.86A 2fumA-2w4oA:
18.7		 2fumA-2w4oA:
29.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		7 / 12 LEU A  52
GLY A  53
VAL A  60
VAL A 121
ASP A 164
ASN A 169
ASP A 185
 DKI  A1338 (-3.8A)
DKI  A1338 (-3.3A)
DKI  A1338 (-4.2A)
DKI  A1338 (-3.9A)
None
None
DKI  A1338 (-3.8A)
 1.04A 2fumA-2w4oA:
18.7		 2fumA-2w4oA:
29.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		7 / 12 LEU A  52
GLY A  53
VAL A  60
ALA A  73
VAL A 121
ASN A 169
ASP A 185
 DKI  A1338 (-3.8A)
DKI  A1338 (-3.3A)
DKI  A1338 (-4.2A)
DKI  A1338 ( 3.7A)
DKI  A1338 (-3.9A)
None
DKI  A1338 (-3.8A)
 0.86A 2fumC-2w4oA:
23.8		 2fumC-2w4oA:
29.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G6H_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 8 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.41A 2g6hA-2w4oA:
1.1
2g6hB-2w4oA:
1.4		 2g6hA-2w4oA:
20.35
2g6hB-2w4oA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G6H_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.41A 2g6hA-2w4oA:
1.1
2g6hB-2w4oA:
1.5		 2g6hA-2w4oA:
20.35
2g6hB-2w4oA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G6K_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.43A 2g6kA-2w4oA:
1.5
2g6kB-2w4oA:
1.3		 2g6kA-2w4oA:
20.35
2g6kB-2w4oA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G6K_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.43A 2g6kA-2w4oA:
1.4
2g6kB-2w4oA:
1.3		 2g6kA-2w4oA:
20.35
2g6kB-2w4oA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G6M_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.42A 2g6mA-2w4oA:
1.4
2g6mB-2w4oA:
undetectable		 2g6mA-2w4oA:
20.35
2g6mB-2w4oA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G6M_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.43A 2g6mA-2w4oA:
1.4
2g6mB-2w4oA:
undetectable		 2g6mA-2w4oA:
20.35
2g6mB-2w4oA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HX3_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.42A 2hx3A-2w4oA:
1.3
2hx3B-2w4oA:
undetectable		 2hx3A-2w4oA:
20.26
2hx3B-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HX3_B_H4BB760_1
(NITRIC-OXIDE
SYNTHASE)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.42A 2hx3A-2w4oA:
1.4
2hx3B-2w4oA:
undetectable		 2hx3A-2w4oA:
20.26
2hx3B-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HX4_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.42A 2hx4A-2w4oA:
1.4
2hx4B-2w4oA:
1.2		 2hx4A-2w4oA:
20.26
2hx4B-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HX4_B_H4BB760_1
(NITRIC-OXIDE
SYNTHASE)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.41A 2hx4A-2w4oA:
1.4
2hx4B-2w4oA:
1.2		 2hx4A-2w4oA:
20.26
2hx4B-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B3M_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.43A 3b3mA-2w4oA:
undetectable
3b3mB-2w4oA:
undetectable		 3b3mA-2w4oA:
20.26
3b3mB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B3M_B_H4BB760_1
(NITRIC-OXIDE
SYNTHASE)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.42A 3b3mA-2w4oA:
undetectable
3b3mB-2w4oA:
undetectable		 3b3mA-2w4oA:
20.26
3b3mB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B3N_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.42A 3b3nA-2w4oA:
1.4
3b3nB-2w4oA:
1.3		 3b3nA-2w4oA:
20.26
3b3nB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B3N_B_H4BB760_1
(NITRIC-OXIDE
SYNTHASE)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.42A 3b3nA-2w4oA:
1.4
3b3nB-2w4oA:
1.3		 3b3nA-2w4oA:
20.26
3b3nB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B3O_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.43A 3b3oA-2w4oA:
undetectable
3b3oB-2w4oA:
undetectable		 3b3oA-2w4oA:
20.26
3b3oB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B3O_B_H4BB760_1
(NITRIC-OXIDE
SYNTHASE)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.44A 3b3oA-2w4oA:
undetectable
3b3oB-2w4oA:
undetectable		 3b3oA-2w4oA:
20.26
3b3oB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B3P_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.38A 3b3pA-2w4oA:
undetectable
3b3pB-2w4oA:
undetectable		 3b3pA-2w4oA:
20.26
3b3pB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B3P_B_H4BB760_1
(NITRIC-OXIDE
SYNTHASE)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 8 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.38A 3b3pA-2w4oA:
undetectable
3b3pB-2w4oA:
undetectable		 3b3pA-2w4oA:
20.26
3b3pB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 5 GLN A 147
THR A 291
HIS A 156
LEU A 155
 None
 1.33A 3ce6A-2w4oA:
undetectable		 3ce6A-2w4oA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 5 GLN A 147
THR A 291
HIS A 156
LEU A 155
 None
 1.32A 3ce6C-2w4oA:
undetectable		 3ce6C-2w4oA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 5 LEU A 170
GLN A 147
HIS A 162
LEU A 155
 None
 1.23A 3ce6D-2w4oA:
undetectable		 3ce6D-2w4oA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 LEU A  52
VAL A  60
LYS A  75
LEU A 171
 DKI  A1338 (-3.8A)
DKI  A1338 (-4.2A)
None
DKI  A1338 (-4.9A)
 0.65A 3cs9D-2w4oA:
19.6		 3cs9D-2w4oA:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC5_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.42A 3fc5A-2w4oA:
undetectable
3fc5B-2w4oA:
1.2		 3fc5A-2w4oA:
20.26
3fc5B-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC5_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.41A 3fc5A-2w4oA:
undetectable
3fc5B-2w4oA:
1.2		 3fc5A-2w4oA:
20.26
3fc5B-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		7 / 12 LEU A  52
GLY A  53
GLY A  55
VAL A  60
ALA A  73
LYS A  75
LEU A 171
 DKI  A1338 (-3.8A)
DKI  A1338 (-3.3A)
None
DKI  A1338 (-4.2A)
DKI  A1338 ( 3.7A)
None
DKI  A1338 (-4.9A)
 0.53A 3fupB-2w4oA:
21.3		 3fupB-2w4oA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_A_LEIA16_0
(COIL SER L16D-PEN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 GLN A 147
LEU A 149
GLU A 150
LEU A 295
 None
 0.93A 3h5gA-2w4oA:
undetectable
3h5gC-2w4oA:
undetectable		 3h5gA-2w4oA:
7.37
3h5gC-2w4oA:
7.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_B_NIOB5661_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 8 ALA A 142
THR A 231
LEU A 234
ALA A 273
 None
 0.96A 3hrdA-2w4oA:
undetectable
3hrdB-2w4oA:
undetectable		 3hrdA-2w4oA:
21.57
3hrdB-2w4oA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HSN_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.45A 3hsnA-2w4oA:
undetectable
3hsnB-2w4oA:
undetectable		 3hsnA-2w4oA:
20.26
3hsnB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HSN_B_H4BB1760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.43A 3hsnA-2w4oA:
undetectable
3hsnB-2w4oA:
undetectable		 3hsnA-2w4oA:
20.26
3hsnB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HSO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.41A 3hsoA-2w4oA:
undetectable
3hsoB-2w4oA:
undetectable		 3hsoA-2w4oA:
20.26
3hsoB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HSO_B_H4BB1760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.44A 3hsoA-2w4oA:
undetectable
3hsoB-2w4oA:
undetectable		 3hsoA-2w4oA:
20.26
3hsoB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HSP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.41A 3hspA-2w4oA:
undetectable
3hspB-2w4oA:
undetectable		 3hspA-2w4oA:
20.26
3hspB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HSP_B_H4BB1760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.41A 3hspA-2w4oA:
undetectable
3hspB-2w4oA:
undetectable		 3hspA-2w4oA:
20.26
3hspB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT3_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.45A 3jt3A-2w4oA:
undetectable
3jt3B-2w4oA:
undetectable		 3jt3A-2w4oA:
20.26
3jt3B-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.44A 3jt3A-2w4oA:
undetectable
3jt3B-2w4oA:
undetectable		 3jt3A-2w4oA:
20.26
3jt3B-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.46A 3jt4A-2w4oA:
undetectable
3jt4B-2w4oA:
undetectable		 3jt4A-2w4oA:
20.26
3jt4B-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.43A 3jt4A-2w4oA:
undetectable
3jt4B-2w4oA:
undetectable		 3jt4A-2w4oA:
20.26
3jt4B-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT5_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.46A 3jt5A-2w4oA:
undetectable
3jt5B-2w4oA:
undetectable		 3jt5A-2w4oA:
20.26
3jt5B-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT5_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.43A 3jt5A-2w4oA:
undetectable
3jt5B-2w4oA:
undetectable		 3jt5A-2w4oA:
20.26
3jt5B-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT6_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.44A 3jt6A-2w4oA:
undetectable
3jt6B-2w4oA:
undetectable		 3jt6A-2w4oA:
20.26
3jt6B-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT6_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.42A 3jt6A-2w4oA:
undetectable
3jt6B-2w4oA:
undetectable		 3jt6A-2w4oA:
20.26
3jt6B-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT7_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.45A 3jt7A-2w4oA:
undetectable
3jt7B-2w4oA:
undetectable		 3jt7A-2w4oA:
20.26
3jt7B-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT7_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.43A 3jt7A-2w4oA:
undetectable
3jt7B-2w4oA:
undetectable		 3jt7A-2w4oA:
20.26
3jt7B-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT8_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.44A 3jt8A-2w4oA:
undetectable
3jt8B-2w4oA:
undetectable		 3jt8A-2w4oA:
20.26
3jt8B-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT8_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.44A 3jt8A-2w4oA:
undetectable
3jt8B-2w4oA:
undetectable		 3jt8A-2w4oA:
20.26
3jt8B-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT9_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.45A 3jt9A-2w4oA:
undetectable
3jt9B-2w4oA:
undetectable		 3jt9A-2w4oA:
20.26
3jt9B-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT9_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.43A 3jt9A-2w4oA:
undetectable
3jt9B-2w4oA:
undetectable		 3jt9A-2w4oA:
20.26
3jt9B-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JTA_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.45A 3jtaA-2w4oA:
undetectable
3jtaB-2w4oA:
undetectable		 3jtaA-2w4oA:
20.26
3jtaB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JTA_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.45A 3jtaA-2w4oA:
undetectable
3jtaB-2w4oA:
undetectable		 3jtaA-2w4oA:
20.26
3jtaB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWS_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.44A 3jwsA-2w4oA:
undetectable
3jwsB-2w4oA:
undetectable		 3jwsA-2w4oA:
20.52
3jwsB-2w4oA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWS_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.43A 3jwsA-2w4oA:
undetectable
3jwsB-2w4oA:
undetectable		 3jwsA-2w4oA:
20.52
3jwsB-2w4oA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWT_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.44A 3jwtA-2w4oA:
1.4
3jwtB-2w4oA:
1.6		 3jwtA-2w4oA:
20.52
3jwtB-2w4oA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.44A 3jwtA-2w4oA:
1.4
3jwtB-2w4oA:
1.6		 3jwtA-2w4oA:
20.52
3jwtB-2w4oA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWU_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.46A 3jwuA-2w4oA:
undetectable
3jwuB-2w4oA:
undetectable		 3jwuA-2w4oA:
20.52
3jwuB-2w4oA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWU_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.43A 3jwuA-2w4oA:
undetectable
3jwuB-2w4oA:
undetectable		 3jwuA-2w4oA:
20.52
3jwuB-2w4oA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWV_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.47A 3jwvA-2w4oA:
undetectable
3jwvB-2w4oA:
undetectable		 3jwvA-2w4oA:
20.52
3jwvB-2w4oA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWV_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.43A 3jwvA-2w4oA:
undetectable
3jwvB-2w4oA:
undetectable		 3jwvA-2w4oA:
20.52
3jwvB-2w4oA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX0_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.45A 3jx0A-2w4oA:
undetectable
3jx0B-2w4oA:
undetectable		 3jx0A-2w4oA:
20.26
3jx0B-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX0_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.43A 3jx0A-2w4oA:
undetectable
3jx0B-2w4oA:
undetectable		 3jx0A-2w4oA:
20.26
3jx0B-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX1_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.45A 3jx1A-2w4oA:
1.2
3jx1B-2w4oA:
undetectable		 3jx1A-2w4oA:
20.26
3jx1B-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.45A 3jx4A-2w4oA:
undetectable
3jx4B-2w4oA:
undetectable		 3jx4A-2w4oA:
20.26
3jx4B-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		8 / 12 LEU A  52
GLY A  53
VAL A  60
ALA A  73
LYS A  75
ILE A 102
LEU A 171
ASP A 185
 DKI  A1338 (-3.8A)
DKI  A1338 (-3.3A)
DKI  A1338 (-4.2A)
DKI  A1338 ( 3.7A)
None
DKI  A1338 ( 4.4A)
DKI  A1338 (-4.9A)
DKI  A1338 (-3.8A)
 0.67A 3lxnA-2w4oA:
21.3		 3lxnA-2w4oA:
28.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		8 / 12 LEU A  52
GLY A  53
VAL A  60
ALA A  73
LYS A  75
VAL A 121
LEU A 171
ASP A 185
 DKI  A1338 (-3.8A)
DKI  A1338 (-3.3A)
DKI  A1338 (-4.2A)
DKI  A1338 ( 3.7A)
None
DKI  A1338 (-3.9A)
DKI  A1338 (-4.9A)
DKI  A1338 (-3.8A)
 0.78A 3lxnA-2w4oA:
21.3		 3lxnA-2w4oA:
28.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2R_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.46A 3n2rA-2w4oA:
undetectable
3n2rB-2w4oA:
undetectable		 3n2rA-2w4oA:
20.26
3n2rB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2R_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.45A 3n2rA-2w4oA:
undetectable
3n2rB-2w4oA:
undetectable		 3n2rA-2w4oA:
20.26
3n2rB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5Y_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.49A 3n5yA-2w4oA:
undetectable
3n5yB-2w4oA:
undetectable		 3n5yA-2w4oA:
20.26
3n5yB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5Y_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.44A 3n5yA-2w4oA:
undetectable
3n5yB-2w4oA:
undetectable		 3n5yA-2w4oA:
20.26
3n5yB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5Z_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.48A 3n5zA-2w4oA:
undetectable
3n5zB-2w4oA:
undetectable		 3n5zA-2w4oA:
20.26
3n5zB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5Z_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.45A 3n5zA-2w4oA:
undetectable
3n5zB-2w4oA:
undetectable		 3n5zA-2w4oA:
20.26
3n5zB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLK_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.44A 3nlkA-2w4oA:
undetectable
3nlkB-2w4oA:
undetectable		 3nlkA-2w4oA:
20.52
3nlkB-2w4oA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLK_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.44A 3nlkA-2w4oA:
undetectable
3nlkB-2w4oA:
undetectable		 3nlkA-2w4oA:
20.52
3nlkB-2w4oA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLM_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.43A 3nlmA-2w4oA:
undetectable
3nlmB-2w4oA:
1.3		 3nlmA-2w4oA:
20.26
3nlmB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLM_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.44A 3nlmA-2w4oA:
undetectable
3nlmB-2w4oA:
1.3		 3nlmA-2w4oA:
20.26
3nlmB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLN_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.44A 3nlnA-2w4oA:
undetectable
3nlnB-2w4oA:
undetectable		 3nlnA-2w4oA:
20.52
3nlnB-2w4oA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLN_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.42A 3nlnA-2w4oA:
undetectable
3nlnB-2w4oA:
undetectable		 3nlnA-2w4oA:
20.52
3nlnB-2w4oA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.42A 3nloA-2w4oA:
undetectable
3nloB-2w4oA:
undetectable		 3nloA-2w4oA:
20.52
3nloB-2w4oA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLO_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.45A 3nloA-2w4oA:
undetectable
3nloB-2w4oA:
undetectable		 3nloA-2w4oA:
20.52
3nloB-2w4oA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLV_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.45A 3nlvA-2w4oA:
undetectable
3nlvB-2w4oA:
undetectable		 3nlvA-2w4oA:
20.26
3nlvB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLV_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.43A 3nlvA-2w4oA:
undetectable
3nlvB-2w4oA:
undetectable		 3nlvA-2w4oA:
20.26
3nlvB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLW_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.44A 3nlwA-2w4oA:
undetectable
3nlwB-2w4oA:
undetectable		 3nlwA-2w4oA:
20.26
3nlwB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLW_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.43A 3nlwA-2w4oA:
undetectable
3nlwB-2w4oA:
undetectable		 3nlwA-2w4oA:
20.26
3nlwB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLX_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.44A 3nlxA-2w4oA:
1.4
3nlxB-2w4oA:
undetectable		 3nlxA-2w4oA:
20.26
3nlxB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLX_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.45A 3nlxA-2w4oA:
1.4
3nlxB-2w4oA:
undetectable		 3nlxA-2w4oA:
20.26
3nlxB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLY_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.46A 3nlyA-2w4oA:
1.4
3nlyB-2w4oA:
undetectable		 3nlyA-2w4oA:
20.26
3nlyB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLZ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.46A 3nlzA-2w4oA:
undetectable
3nlzB-2w4oA:
undetectable		 3nlzA-2w4oA:
20.26
3nlzB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLZ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.44A 3nlzA-2w4oA:
undetectable
3nlzB-2w4oA:
undetectable		 3nlzA-2w4oA:
20.26
3nlzB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NM0_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.44A 3nm0A-2w4oA:
undetectable
3nm0B-2w4oA:
undetectable		 3nm0A-2w4oA:
20.26
3nm0B-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NM0_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.43A 3nm0A-2w4oA:
undetectable
3nm0B-2w4oA:
undetectable		 3nm0A-2w4oA:
20.26
3nm0B-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNY_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.45A 3nnyA-2w4oA:
undetectable
3nnyB-2w4oA:
undetectable		 3nnyA-2w4oA:
20.26
3nnyB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNY_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.43A 3nnyA-2w4oA:
undetectable
3nnyB-2w4oA:
undetectable		 3nnyA-2w4oA:
20.26
3nnyB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNZ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.43A 3nnzA-2w4oA:
undetectable
3nnzB-2w4oA:
undetectable		 3nnzA-2w4oA:
20.26
3nnzB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNZ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.44A 3nnzA-2w4oA:
undetectable
3nnzB-2w4oA:
undetectable		 3nnzA-2w4oA:
20.26
3nnzB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PNE_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.46A 3pneA-2w4oA:
undetectable
3pneB-2w4oA:
undetectable		 3pneA-2w4oA:
20.26
3pneB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PNE_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.44A 3pneA-2w4oA:
undetectable
3pneB-2w4oA:
undetectable		 3pneA-2w4oA:
20.26
3pneB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PNF_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.45A 3pnfA-2w4oA:
undetectable
3pnfB-2w4oA:
undetectable		 3pnfA-2w4oA:
20.26
3pnfB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PNF_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.43A 3pnfA-2w4oA:
undetectable
3pnfB-2w4oA:
undetectable		 3pnfA-2w4oA:
20.26
3pnfB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PNG_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.43A 3pngA-2w4oA:
undetectable
3pngB-2w4oA:
undetectable		 3pngA-2w4oA:
20.26
3pngB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PNG_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.43A 3pngA-2w4oA:
undetectable
3pngB-2w4oA:
undetectable		 3pngA-2w4oA:
20.26
3pngB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q99_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.45A 3q99A-2w4oA:
undetectable
3q99B-2w4oA:
undetectable		 3q99A-2w4oA:
20.26
3q99B-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q99_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.45A 3q99A-2w4oA:
undetectable
3q99B-2w4oA:
undetectable		 3q99A-2w4oA:
20.26
3q99B-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q9A_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.45A 3q9aA-2w4oA:
undetectable
3q9aB-2w4oA:
undetectable		 3q9aA-2w4oA:
20.26
3q9aB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q9A_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.43A 3q9aA-2w4oA:
undetectable
3q9aB-2w4oA:
undetectable		 3q9aA-2w4oA:
20.26
3q9aB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQJ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.43A 3rqjA-2w4oA:
1.4
3rqjB-2w4oA:
undetectable		 3rqjA-2w4oA:
20.26
3rqjB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQJ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.43A 3rqjA-2w4oA:
1.4
3rqjB-2w4oA:
undetectable		 3rqjA-2w4oA:
20.26
3rqjB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQK_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.46A 3rqkA-2w4oA:
1.2
3rqkB-2w4oA:
undetectable		 3rqkA-2w4oA:
20.26
3rqkB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQK_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.44A 3rqkA-2w4oA:
1.2
3rqkB-2w4oA:
undetectable		 3rqkA-2w4oA:
20.26
3rqkB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQL_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.42A 3rqlA-2w4oA:
undetectable
3rqlB-2w4oA:
undetectable		 3rqlA-2w4oA:
20.26
3rqlB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQM_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.43A 3rqmA-2w4oA:
1.4
3rqmB-2w4oA:
undetectable		 3rqmA-2w4oA:
20.26
3rqmB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQM_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.44A 3rqmA-2w4oA:
1.4
3rqmB-2w4oA:
undetectable		 3rqmA-2w4oA:
20.26
3rqmB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQN_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.44A 3rqnA-2w4oA:
1.1
3rqnB-2w4oA:
undetectable		 3rqnA-2w4oA:
20.26
3rqnB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQN_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.43A 3rqnA-2w4oA:
1.1
3rqnB-2w4oA:
undetectable		 3rqnA-2w4oA:
20.26
3rqnB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SVP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.44A 3svpA-2w4oA:
1.4
3svpB-2w4oA:
undetectable		 3svpA-2w4oA:
20.26
3svpB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SVP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.42A 3svpA-2w4oA:
1.4
3svpB-2w4oA:
undetectable		 3svpA-2w4oA:
20.26
3svpB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SVQ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.44A 3svqA-2w4oA:
undetectable
3svqB-2w4oA:
undetectable		 3svqA-2w4oA:
20.26
3svqB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SVQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.43A 3svqA-2w4oA:
undetectable
3svqB-2w4oA:
undetectable		 3svqA-2w4oA:
20.26
3svqB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYL_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.43A 3tylA-2w4oA:
undetectable
3tylB-2w4oA:
undetectable		 3tylA-2w4oA:
20.26
3tylB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYL_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.43A 3tylA-2w4oA:
undetectable
3tylB-2w4oA:
undetectable		 3tylA-2w4oA:
20.26
3tylB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYM_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.42A 3tymA-2w4oA:
undetectable
3tymB-2w4oA:
undetectable		 3tymA-2w4oA:
20.26
3tymB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYM_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.42A 3tymA-2w4oA:
undetectable
3tymB-2w4oA:
undetectable		 3tymA-2w4oA:
20.26
3tymB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYN_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.43A 3tynA-2w4oA:
undetectable
3tynB-2w4oA:
undetectable		 3tynA-2w4oA:
20.26
3tynB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYN_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.43A 3tynA-2w4oA:
undetectable
3tynB-2w4oA:
undetectable		 3tynA-2w4oA:
20.26
3tynB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.43A 3tyoA-2w4oA:
undetectable
3tyoB-2w4oA:
undetectable		 3tyoA-2w4oA:
20.26
3tyoB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYO_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.44A 3tyoA-2w4oA:
undetectable
3tyoB-2w4oA:
undetectable		 3tyoA-2w4oA:
20.26
3tyoB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.47A 3ufoA-2w4oA:
undetectable
3ufoB-2w4oA:
undetectable		 3ufoA-2w4oA:
20.26
3ufoB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFO_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.44A 3ufoA-2w4oA:
undetectable
3ufoB-2w4oA:
undetectable		 3ufoA-2w4oA:
20.26
3ufoB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.39A 3ufpA-2w4oA:
undetectable
3ufpB-2w4oA:
undetectable		 3ufpA-2w4oA:
20.26
3ufpB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.40A 3ufpA-2w4oA:
undetectable
3ufpB-2w4oA:
undetectable		 3ufpA-2w4oA:
20.26
3ufpB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFQ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.41A 3ufqA-2w4oA:
undetectable
3ufqB-2w4oA:
undetectable		 3ufqA-2w4oA:
20.26
3ufqB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.42A 3ufqA-2w4oA:
undetectable
3ufqB-2w4oA:
undetectable		 3ufqA-2w4oA:
20.26
3ufqB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.34A 3ufrA-2w4oA:
undetectable
3ufrB-2w4oA:
undetectable		 3ufrA-2w4oA:
20.26
3ufrB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.44A 3ufrA-2w4oA:
undetectable
3ufrB-2w4oA:
undetectable		 3ufrA-2w4oA:
20.26
3ufrB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFS_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.45A 3ufsA-2w4oA:
undetectable
3ufsB-2w4oA:
undetectable		 3ufsA-2w4oA:
20.26
3ufsB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFS_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.41A 3ufsA-2w4oA:
undetectable
3ufsB-2w4oA:
undetectable		 3ufsA-2w4oA:
20.26
3ufsB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFT_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.43A 3uftA-2w4oA:
undetectable
3uftB-2w4oA:
undetectable		 3uftA-2w4oA:
20.26
3uftB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.40A 3uftA-2w4oA:
undetectable
3uftB-2w4oA:
undetectable		 3uftA-2w4oA:
20.26
3uftB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFU_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.45A 3ufuA-2w4oA:
undetectable
3ufuB-2w4oA:
undetectable		 3ufuA-2w4oA:
20.26
3ufuB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFU_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.44A 3ufuA-2w4oA:
undetectable
3ufuB-2w4oA:
undetectable		 3ufuA-2w4oA:
20.26
3ufuB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFV_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.45A 3ufvA-2w4oA:
undetectable
3ufvB-2w4oA:
undetectable		 3ufvA-2w4oA:
20.26
3ufvB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFV_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.42A 3ufvA-2w4oA:
undetectable
3ufvB-2w4oA:
undetectable		 3ufvA-2w4oA:
20.26
3ufvB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFW_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.44A 3ufwA-2w4oA:
undetectable
3ufwB-2w4oA:
undetectable		 3ufwA-2w4oA:
20.26
3ufwB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFW_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.42A 3ufwA-2w4oA:
undetectable
3ufwB-2w4oA:
undetectable		 3ufwA-2w4oA:
20.26
3ufwB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		7 / 12 LEU A  52
VAL A  60
ALA A  73
LYS A  75
LEU A 116
LEU A 120
LEU A 171
 DKI  A1338 (-3.8A)
DKI  A1338 (-4.2A)
DKI  A1338 ( 3.7A)
None
None
DKI  A1338 (-4.2A)
DKI  A1338 (-4.9A)
 0.88A 3ug2A-2w4oA:
19.7		 3ug2A-2w4oA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C39_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.44A 4c39A-2w4oA:
undetectable
4c39B-2w4oA:
undetectable		 4c39A-2w4oA:
20.26
4c39B-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C39_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.42A 4c39A-2w4oA:
undetectable
4c39B-2w4oA:
undetectable		 4c39A-2w4oA:
20.26
4c39B-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAM_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.44A 4camA-2w4oA:
undetectable
4camB-2w4oA:
undetectable		 4camA-2w4oA:
20.26
4camB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAM_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.43A 4camA-2w4oA:
undetectable
4camB-2w4oA:
undetectable		 4camA-2w4oA:
20.26
4camB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAN_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.44A 4canA-2w4oA:
undetectable
4canB-2w4oA:
undetectable		 4canA-2w4oA:
20.26
4canB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAN_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.43A 4canA-2w4oA:
undetectable
4canB-2w4oA:
undetectable		 4canA-2w4oA:
20.26
4canB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.43A 4caoA-2w4oA:
undetectable
4caoB-2w4oA:
undetectable		 4caoA-2w4oA:
20.26
4caoB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAO_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.46A 4caoA-2w4oA:
undetectable
4caoB-2w4oA:
undetectable		 4caoA-2w4oA:
20.26
4caoB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.44A 4capA-2w4oA:
undetectable
4capB-2w4oA:
undetectable		 4capA-2w4oA:
20.26
4capB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAQ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.45A 4caqA-2w4oA:
undetectable
4caqB-2w4oA:
undetectable		 4caqA-2w4oA:
20.26
4caqB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.43A 4caqA-2w4oA:
undetectable
4caqB-2w4oA:
undetectable		 4caqA-2w4oA:
20.26
4caqB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CDT_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.44A 4cdtA-2w4oA:
undetectable
4cdtB-2w4oA:
0.7		 4cdtA-2w4oA:
20.26
4cdtB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CDT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.43A 4cdtA-2w4oA:
undetectable
4cdtB-2w4oA:
0.7		 4cdtA-2w4oA:
20.26
4cdtB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		6 / 10 LEU A  52
GLY A  53
GLY A  55
VAL A  60
ALA A  73
LEU A 171
 DKI  A1338 (-3.8A)
DKI  A1338 (-3.3A)
None
DKI  A1338 (-4.2A)
DKI  A1338 ( 3.7A)
DKI  A1338 (-4.9A)
 0.61A 4ckjA-2w4oA:
21.3		 4ckjA-2w4oA:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.44A 4ctpA-2w4oA:
undetectable
4ctpB-2w4oA:
undetectable		 4ctpA-2w4oA:
20.26
4ctpB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.44A 4ctpA-2w4oA:
undetectable
4ctpB-2w4oA:
undetectable		 4ctpA-2w4oA:
20.26
4ctpB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTQ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.45A 4ctqA-2w4oA:
undetectable
4ctqB-2w4oA:
undetectable		 4ctqA-2w4oA:
20.26
4ctqB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.45A 4ctqA-2w4oA:
undetectable
4ctqB-2w4oA:
undetectable		 4ctqA-2w4oA:
20.26
4ctqB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.47A 4ctrA-2w4oA:
undetectable
4ctrB-2w4oA:
undetectable		 4ctrA-2w4oA:
20.26
4ctrB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.43A 4ctrA-2w4oA:
undetectable
4ctrB-2w4oA:
undetectable		 4ctrA-2w4oA:
20.26
4ctrB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTT_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.47A 4cttA-2w4oA:
undetectable
4cttB-2w4oA:
undetectable		 4cttA-2w4oA:
20.26
4cttB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.41A 4cttA-2w4oA:
undetectable
4cttB-2w4oA:
undetectable		 4cttA-2w4oA:
20.26
4cttB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTU_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.42A 4ctuA-2w4oA:
undetectable
4ctuB-2w4oA:
undetectable		 4ctuA-2w4oA:
20.26
4ctuB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTU_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.40A 4ctuA-2w4oA:
undetectable
4ctuB-2w4oA:
undetectable		 4ctuA-2w4oA:
20.26
4ctuB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTV_A_H4BA1718_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.43A 4ctvA-2w4oA:
undetectable
4ctvB-2w4oA:
undetectable		 4ctvA-2w4oA:
20.26
4ctvB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTV_B_H4BB1720_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.45A 4ctvA-2w4oA:
undetectable
4ctvB-2w4oA:
undetectable		 4ctvA-2w4oA:
20.26
4ctvB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTW_A_H4BA1718_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.42A 4ctwA-2w4oA:
undetectable
4ctwB-2w4oA:
undetectable		 4ctwA-2w4oA:
20.26
4ctwB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTW_B_H4BB1720_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.43A 4ctwA-2w4oA:
undetectable
4ctwB-2w4oA:
undetectable		 4ctwA-2w4oA:
20.26
4ctwB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTX_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.45A 4ctxA-2w4oA:
undetectable
4ctxB-2w4oA:
undetectable		 4ctxA-2w4oA:
20.26
4ctxB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTX_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.44A 4ctxA-2w4oA:
undetectable
4ctxB-2w4oA:
undetectable		 4ctxA-2w4oA:
20.26
4ctxB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX5_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.44A 4cx5A-2w4oA:
1.4
4cx5B-2w4oA:
undetectable		 4cx5A-2w4oA:
20.26
4cx5B-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX5_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.44A 4cx5A-2w4oA:
1.4
4cx5B-2w4oA:
undetectable		 4cx5A-2w4oA:
20.26
4cx5B-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX6_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.44A 4cx6A-2w4oA:
undetectable
4cx6B-2w4oA:
undetectable		 4cx6A-2w4oA:
20.26
4cx6B-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX6_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.42A 4cx6A-2w4oA:
undetectable
4cx6B-2w4oA:
undetectable		 4cx6A-2w4oA:
20.26
4cx6B-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1N_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.44A 4d1nA-2w4oA:
undetectable
4d1nB-2w4oA:
undetectable		 4d1nA-2w4oA:
21.36
4d1nB-2w4oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1N_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.44A 4d1nA-2w4oA:
undetectable
4d1nB-2w4oA:
undetectable		 4d1nA-2w4oA:
21.36
4d1nB-2w4oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1N_C_H4BC760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.43A 4d1nC-2w4oA:
undetectable
4d1nD-2w4oA:
undetectable		 4d1nC-2w4oA:
21.36
4d1nD-2w4oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1N_D_H4BD760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.44A 4d1nC-2w4oA:
undetectable
4d1nD-2w4oA:
undetectable		 4d1nC-2w4oA:
21.36
4d1nD-2w4oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D2Y_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.44A 4d2yA-2w4oA:
undetectable
4d2yB-2w4oA:
undetectable		 4d2yA-2w4oA:
20.26
4d2yB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D2Y_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.42A 4d2yA-2w4oA:
undetectable
4d2yB-2w4oA:
undetectable		 4d2yA-2w4oA:
20.26
4d2yB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D2Z_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.46A 4d2zA-2w4oA:
undetectable
4d2zB-2w4oA:
undetectable		 4d2zA-2w4oA:
20.26
4d2zB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D2Z_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.42A 4d2zA-2w4oA:
undetectable
4d2zB-2w4oA:
undetectable		 4d2zA-2w4oA:
20.26
4d2zB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D30_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.43A 4d30A-2w4oA:
undetectable
4d30B-2w4oA:
undetectable		 4d30A-2w4oA:
20.26
4d30B-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D30_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.43A 4d30A-2w4oA:
undetectable
4d30B-2w4oA:
undetectable		 4d30A-2w4oA:
20.26
4d30B-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D31_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.44A 4d31A-2w4oA:
undetectable
4d31B-2w4oA:
undetectable		 4d31A-2w4oA:
20.26
4d31B-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D31_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.41A 4d31A-2w4oA:
undetectable
4d31B-2w4oA:
undetectable		 4d31A-2w4oA:
20.26
4d31B-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D32_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.45A 4d32A-2w4oA:
undetectable
4d32B-2w4oA:
undetectable		 4d32A-2w4oA:
20.26
4d32B-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D3B_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.44A 4d3bA-2w4oA:
undetectable
4d3bB-2w4oA:
undetectable		 4d3bA-2w4oA:
20.26
4d3bB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D3B_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.42A 4d3bA-2w4oA:
undetectable
4d3bB-2w4oA:
undetectable		 4d3bA-2w4oA:
20.26
4d3bB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7O_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.44A 4d7oA-2w4oA:
undetectable
4d7oB-2w4oA:
undetectable		 4d7oA-2w4oA:
20.26
4d7oB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7O_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.43A 4d7oA-2w4oA:
undetectable
4d7oB-2w4oA:
undetectable		 4d7oA-2w4oA:
20.26
4d7oB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EUX_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.43A 4euxA-2w4oA:
undetectable
4euxB-2w4oA:
undetectable		 4euxA-2w4oA:
20.26
4euxB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EUX_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.42A 4euxA-2w4oA:
undetectable
4euxB-2w4oA:
undetectable		 4euxA-2w4oA:
20.26
4euxB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVW_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.45A 4fvwA-2w4oA:
undetectable
4fvwB-2w4oA:
undetectable		 4fvwA-2w4oA:
20.26
4fvwB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVW_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.43A 4fvwA-2w4oA:
undetectable
4fvwB-2w4oA:
undetectable		 4fvwA-2w4oA:
20.26
4fvwB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVX_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.42A 4fvxA-2w4oA:
undetectable
4fvxB-2w4oA:
undetectable		 4fvxA-2w4oA:
20.26
4fvxB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVX_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.41A 4fvxA-2w4oA:
undetectable
4fvxB-2w4oA:
undetectable		 4fvxA-2w4oA:
20.26
4fvxB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVY_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.43A 4fvyA-2w4oA:
undetectable
4fvyB-2w4oA:
undetectable		 4fvyA-2w4oA:
20.26
4fvyB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVY_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.43A 4fvyA-2w4oA:
undetectable
4fvyB-2w4oA:
undetectable		 4fvyA-2w4oA:
20.26
4fvyB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVZ_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.43A 4fvzA-2w4oA:
undetectable
4fvzB-2w4oA:
undetectable		 4fvzA-2w4oA:
20.26
4fvzB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVZ_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.44A 4fvzA-2w4oA:
undetectable
4fvzB-2w4oA:
undetectable		 4fvzA-2w4oA:
20.26
4fvzB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FW0_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.46A 4fw0A-2w4oA:
undetectable
4fw0B-2w4oA:
undetectable		 4fw0A-2w4oA:
20.26
4fw0B-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FW0_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.44A 4fw0A-2w4oA:
undetectable
4fw0B-2w4oA:
undetectable		 4fw0A-2w4oA:
20.26
4fw0B-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GQE_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.44A 4gqeA-2w4oA:
undetectable
4gqeB-2w4oA:
undetectable		 4gqeA-2w4oA:
20.26
4gqeB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GQE_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.43A 4gqeA-2w4oA:
undetectable
4gqeB-2w4oA:
undetectable		 4gqeA-2w4oA:
20.26
4gqeB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		5 / 11 VAL A  60
ALA A  73
LYS A  75
LEU A 118
LEU A 171
 DKI  A1338 (-4.2A)
DKI  A1338 ( 3.7A)
None
DKI  A1338 ( 4.7A)
DKI  A1338 (-4.9A)
 0.47A 4iaaA-2w4oA:
22.5		 4iaaA-2w4oA:
29.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		8 / 12 GLY A  53
VAL A  60
ALA A  73
LEU A 104
LEU A 116
GLY A 124
GLU A 125
LEU A 171
 DKI  A1338 (-3.3A)
DKI  A1338 (-4.2A)
DKI  A1338 ( 3.7A)
None
None
None
None
DKI  A1338 (-4.9A)
 0.79A 4ifgA-2w4oA:
34.1		 4ifgA-2w4oA:
31.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMT_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.44A 4imtA-2w4oA:
undetectable
4imtB-2w4oA:
undetectable		 4imtA-2w4oA:
20.26
4imtB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMT_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.39A 4imtA-2w4oA:
undetectable
4imtB-2w4oA:
undetectable		 4imtA-2w4oA:
20.26
4imtB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMW_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.44A 4imwA-2w4oA:
undetectable
4imwB-2w4oA:
undetectable		 4imwA-2w4oA:
20.26
4imwB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMW_A_H4BA805_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.40A 4imwA-2w4oA:
undetectable
4imwB-2w4oA:
undetectable		 4imwA-2w4oA:
20.26
4imwB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSF_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.50A 4jsfA-2w4oA:
0.6
4jsfB-2w4oA:
undetectable		 4jsfA-2w4oA:
20.26
4jsfB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSF_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.44A 4jsfA-2w4oA:
0.6
4jsfB-2w4oA:
undetectable		 4jsfA-2w4oA:
20.26
4jsfB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSG_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.43A 4jsgA-2w4oA:
undetectable
4jsgB-2w4oA:
undetectable		 4jsgA-2w4oA:
20.26
4jsgB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSG_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.43A 4jsgA-2w4oA:
undetectable
4jsgB-2w4oA:
undetectable		 4jsgA-2w4oA:
20.26
4jsgB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSH_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.45A 4jshA-2w4oA:
undetectable
4jshB-2w4oA:
undetectable		 4jshA-2w4oA:
20.26
4jshB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSH_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.42A 4jshA-2w4oA:
undetectable
4jshB-2w4oA:
undetectable		 4jshA-2w4oA:
20.26
4jshB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSI_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.46A 4jsiA-2w4oA:
undetectable
4jsiB-2w4oA:
undetectable		 4jsiA-2w4oA:
20.26
4jsiB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSI_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.42A 4jsiA-2w4oA:
undetectable
4jsiB-2w4oA:
undetectable		 4jsiA-2w4oA:
20.26
4jsiB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSJ_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.45A 4jsjA-2w4oA:
undetectable
4jsjB-2w4oA:
undetectable		 4jsjA-2w4oA:
20.26
4jsjB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSJ_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.45A 4jsjA-2w4oA:
undetectable
4jsjB-2w4oA:
undetectable		 4jsjA-2w4oA:
20.26
4jsjB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5D_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.45A 4k5dA-2w4oA:
0.7
4k5dB-2w4oA:
undetectable		 4k5dA-2w4oA:
20.26
4k5dB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5D_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.42A 4k5dA-2w4oA:
0.7
4k5dB-2w4oA:
undetectable		 4k5dA-2w4oA:
20.26
4k5dB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5E_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.43A 4k5eA-2w4oA:
undetectable
4k5eB-2w4oA:
undetectable		 4k5eA-2w4oA:
20.26
4k5eB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5E_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.44A 4k5eA-2w4oA:
undetectable
4k5eB-2w4oA:
undetectable		 4k5eA-2w4oA:
20.26
4k5eB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5F_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.42A 4k5fA-2w4oA:
undetectable
4k5fB-2w4oA:
undetectable		 4k5fA-2w4oA:
20.26
4k5fB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5F_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.43A 4k5fA-2w4oA:
undetectable
4k5fB-2w4oA:
undetectable		 4k5fA-2w4oA:
20.26
4k5fB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5G_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.44A 4k5gA-2w4oA:
undetectable
4k5gB-2w4oA:
undetectable		 4k5gA-2w4oA:
20.26
4k5gB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5G_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.42A 4k5gA-2w4oA:
undetectable
4k5gB-2w4oA:
undetectable		 4k5gA-2w4oA:
20.26
4k5gB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCH_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.45A 4kchA-2w4oA:
undetectable
4kchB-2w4oA:
undetectable		 4kchA-2w4oA:
20.26
4kchB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCH_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.42A 4kchA-2w4oA:
undetectable
4kchB-2w4oA:
undetectable		 4kchA-2w4oA:
20.26
4kchB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCI_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.45A 4kciA-2w4oA:
undetectable
4kciB-2w4oA:
undetectable		 4kciA-2w4oA:
20.26
4kciB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCI_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.39A 4kciA-2w4oA:
undetectable
4kciB-2w4oA:
undetectable		 4kciA-2w4oA:
20.26
4kciB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCJ_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.44A 4kcjA-2w4oA:
undetectable
4kcjB-2w4oA:
undetectable		 4kcjA-2w4oA:
20.26
4kcjB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCJ_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.42A 4kcjA-2w4oA:
undetectable
4kcjB-2w4oA:
undetectable		 4kcjA-2w4oA:
20.26
4kcjB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCK_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.42A 4kckA-2w4oA:
undetectable
4kckB-2w4oA:
undetectable		 4kckA-2w4oA:
20.26
4kckB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCK_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.43A 4kckA-2w4oA:
undetectable
4kckB-2w4oA:
undetectable		 4kckA-2w4oA:
20.26
4kckB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCL_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.44A 4kclA-2w4oA:
undetectable
4kclB-2w4oA:
1.0		 4kclA-2w4oA:
20.26
4kclB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCL_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.43A 4kclA-2w4oA:
undetectable
4kclB-2w4oA:
1.0		 4kclA-2w4oA:
20.26
4kclB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCM_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.45A 4kcmA-2w4oA:
undetectable
4kcmB-2w4oA:
undetectable		 4kcmA-2w4oA:
20.26
4kcmB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCM_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.44A 4kcmA-2w4oA:
undetectable
4kcmB-2w4oA:
undetectable		 4kcmA-2w4oA:
20.26
4kcmB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.45A 4kcnA-2w4oA:
undetectable
4kcnB-2w4oA:
undetectable		 4kcnA-2w4oA:
20.26
4kcnB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.44A 4kcnA-2w4oA:
undetectable
4kcnB-2w4oA:
undetectable		 4kcnA-2w4oA:
20.26
4kcnB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCO_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.44A 4kcoA-2w4oA:
undetectable
4kcoB-2w4oA:
undetectable		 4kcoA-2w4oA:
20.26
4kcoB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCO_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.44A 4kcoA-2w4oA:
undetectable
4kcoB-2w4oA:
undetectable		 4kcoA-2w4oA:
20.26
4kcoB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_B_8PRB601_1
(RHODOPSIN KINASE)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 8 GLY A  55
VAL A  60
ALA A  73
LYS A  75
 None
DKI  A1338 (-4.2A)
DKI  A1338 ( 3.7A)
None
 0.25A 4l9iB-2w4oA:
20.5		 4l9iB-2w4oA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUX_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.44A 4luxA-2w4oA:
undetectable
4luxB-2w4oA:
undetectable		 4luxA-2w4oA:
20.26
4luxB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUX_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.44A 4luxA-2w4oA:
undetectable
4luxB-2w4oA:
undetectable		 4luxA-2w4oA:
20.26
4luxB-2w4oA:
20.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		5 / 6 LEU A  52
GLY A  53
VAL A  60
ALA A  73
LEU A 171
 DKI  A1338 (-3.8A)
DKI  A1338 (-3.3A)
DKI  A1338 (-4.2A)
DKI  A1338 ( 3.7A)
DKI  A1338 (-4.9A)
 0.44A 4o0wA-2w4oA:
25.6		 4o0wA-2w4oA:
31.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_B_ASCB304_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 ILE A 230
TYR A 207
PHE A 320
ASN A 321
 None
 1.46A 4o7gB-2w4oA:
undetectable		 4o7gB-2w4oA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		9 / 12 LEU A  52
GLY A  53
GLY A  55
VAL A  60
ALA A  73
LYS A  75
LEU A 171
ALA A 184
ASP A 185
 DKI  A1338 (-3.8A)
DKI  A1338 (-3.3A)
None
DKI  A1338 (-4.2A)
DKI  A1338 ( 3.7A)
None
DKI  A1338 (-4.9A)
DKI  A1338 (-3.1A)
DKI  A1338 (-3.8A)
 0.78A 4otiA-2w4oA:
17.4		 4otiA-2w4oA:
29.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		5 / 8 LEU A  52
VAL A  60
ILE A 102
HIS A 162
LEU A 171
 DKI  A1338 (-3.8A)
DKI  A1338 (-4.2A)
DKI  A1338 ( 4.4A)
None
DKI  A1338 (-4.9A)
 0.86A 4qrcA-2w4oA:
21.3		 4qrcA-2w4oA:
28.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		5 / 8 LEU A  52
VAL A  60
LYS A  75
ILE A 102
LEU A 171
 DKI  A1338 (-3.8A)
DKI  A1338 (-4.2A)
None
DKI  A1338 ( 4.4A)
DKI  A1338 (-4.9A)
 0.76A 4qrcA-2w4oA:
21.3		 4qrcA-2w4oA:
28.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		6 / 10 ALA A  73
LYS A  75
ILE A 102
LEU A 120
VAL A 121
LEU A 171
 DKI  A1338 ( 3.7A)
None
DKI  A1338 ( 4.4A)
DKI  A1338 (-4.2A)
DKI  A1338 (-3.9A)
DKI  A1338 (-4.9A)
 0.63A 4rz7A-2w4oA:
9.4		 4rz7A-2w4oA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCH_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.42A 4uchA-2w4oA:
undetectable
4uchB-2w4oA:
undetectable		 4uchA-2w4oA:
20.79
4uchB-2w4oA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCH_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 8 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.41A 4uchA-2w4oA:
undetectable
4uchB-2w4oA:
undetectable		 4uchA-2w4oA:
20.79
4uchB-2w4oA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGZ_A_H4BA760_1
(NEURONAL NITRIC
OXIDE SYNTHASE)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.45A 4ugzA-2w4oA:
undetectable
4ugzB-2w4oA:
undetectable		 4ugzA-2w4oA:
20.26
4ugzB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGZ_B_H4BB760_1
(NEURONAL NITRIC
OXIDE SYNTHASE)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.42A 4ugzA-2w4oA:
undetectable
4ugzB-2w4oA:
undetectable		 4ugzA-2w4oA:
20.26
4ugzB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH0_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.44A 4uh0A-2w4oA:
undetectable
4uh0B-2w4oA:
undetectable		 4uh0A-2w4oA:
20.26
4uh0B-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH0_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.42A 4uh0A-2w4oA:
undetectable
4uh0B-2w4oA:
undetectable		 4uh0A-2w4oA:
20.26
4uh0B-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH1_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.42A 4uh1A-2w4oA:
undetectable
4uh1B-2w4oA:
undetectable		 4uh1A-2w4oA:
20.26
4uh1B-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH1_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.42A 4uh1A-2w4oA:
undetectable
4uh1B-2w4oA:
undetectable		 4uh1A-2w4oA:
20.26
4uh1B-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH2_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.45A 4uh2A-2w4oA:
undetectable
4uh2B-2w4oA:
undetectable		 4uh2A-2w4oA:
20.26
4uh2B-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH2_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.40A 4uh2A-2w4oA:
undetectable
4uh2B-2w4oA:
undetectable		 4uh2A-2w4oA:
20.26
4uh2B-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH3_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.46A 4uh3A-2w4oA:
undetectable
4uh3B-2w4oA:
undetectable		 4uh3A-2w4oA:
20.26
4uh3B-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.42A 4uh3A-2w4oA:
undetectable
4uh3B-2w4oA:
undetectable		 4uh3A-2w4oA:
20.26
4uh3B-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.43A 4uh4A-2w4oA:
undetectable
4uh4B-2w4oA:
undetectable		 4uh4A-2w4oA:
20.26
4uh4B-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.44A 4uh4A-2w4oA:
undetectable
4uh4B-2w4oA:
undetectable		 4uh4A-2w4oA:
20.26
4uh4B-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH5_A_H4BA760_1
(NEURONAL NITRIC
OXIDE SYNTHASE)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.43A 4uh5A-2w4oA:
undetectable
4uh5B-2w4oA:
undetectable		 4uh5A-2w4oA:
21.36
4uh5B-2w4oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH5_B_H4BB760_1
(NEURONAL NITRIC
OXIDE SYNTHASE)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.42A 4uh5A-2w4oA:
undetectable
4uh5B-2w4oA:
undetectable		 4uh5A-2w4oA:
21.36
4uh5B-2w4oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH6_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.41A 4uh6A-2w4oA:
undetectable
4uh6B-2w4oA:
undetectable		 4uh6A-2w4oA:
21.36
4uh6B-2w4oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH6_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.43A 4uh6A-2w4oA:
undetectable
4uh6B-2w4oA:
undetectable		 4uh6A-2w4oA:
21.36
4uh6B-2w4oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPM_A_H4BA760_1
(NEURONAL NITRIC
OXIDE SYNTHASE)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.44A 4upmA-2w4oA:
undetectable
4upmB-2w4oA:
undetectable		 4upmA-2w4oA:
20.26
4upmB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPM_B_H4BB760_1
(NEURONAL NITRIC
OXIDE SYNTHASE)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.43A 4upmA-2w4oA:
undetectable
4upmB-2w4oA:
undetectable		 4upmA-2w4oA:
20.26
4upmB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPN_A_H4BA760_1
(NEURONAL NITRIC
OXIDE SYNTHASE)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.42A 4upnA-2w4oA:
undetectable
4upnB-2w4oA:
undetectable		 4upnA-2w4oA:
20.26
4upnB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPN_B_H4BB760_1
(NEURONAL NITRIC
OXIDE SYNTHASE)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.43A 4upnA-2w4oA:
undetectable
4upnB-2w4oA:
1.2		 4upnA-2w4oA:
20.26
4upnB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.45A 4upoA-2w4oA:
undetectable
4upoB-2w4oA:
undetectable		 4upoA-2w4oA:
20.26
4upoB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPO_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.44A 4upoA-2w4oA:
undetectable
4upoB-2w4oA:
undetectable		 4upoA-2w4oA:
20.26
4upoB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.44A 4uppA-2w4oA:
undetectable
4uppB-2w4oA:
undetectable		 4uppA-2w4oA:
20.26
4uppB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.45A 4uppA-2w4oA:
undetectable
4uppB-2w4oA:
undetectable		 4uppA-2w4oA:
20.26
4uppB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		6 / 9 LEU A  52
VAL A  60
LYS A  75
ILE A 102
LEU A 171
ILE A 183
 DKI  A1338 (-3.8A)
DKI  A1338 (-4.2A)
None
DKI  A1338 ( 4.4A)
DKI  A1338 (-4.9A)
None
 0.90A 4v01B-2w4oA:
21.3		 4v01B-2w4oA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3U_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.41A 4v3uA-2w4oA:
undetectable
4v3uB-2w4oA:
undetectable		 4v3uA-2w4oA:
21.36
4v3uB-2w4oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3U_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.45A 4v3uA-2w4oA:
undetectable
4v3uB-2w4oA:
undetectable		 4v3uA-2w4oA:
21.36
4v3uB-2w4oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3U_C_H4BC760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.42A 4v3uC-2w4oA:
undetectable
4v3uD-2w4oA:
1.5		 4v3uC-2w4oA:
21.36
4v3uD-2w4oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3U_D_H4BD760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.42A 4v3uC-2w4oA:
undetectable
4v3uD-2w4oA:
1.5		 4v3uC-2w4oA:
21.36
4v3uD-2w4oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3V_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.44A 4v3vA-2w4oA:
0.4
4v3vB-2w4oA:
undetectable		 4v3vA-2w4oA:
20.26
4v3vB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3V_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.43A 4v3vA-2w4oA:
undetectable
4v3vB-2w4oA:
undetectable		 4v3vA-2w4oA:
20.26
4v3vB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3W_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.46A 4v3wA-2w4oA:
undetectable
4v3wB-2w4oA:
1.4		 4v3wA-2w4oA:
20.26
4v3wB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3X_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.43A 4v3xA-2w4oA:
undetectable
4v3xB-2w4oA:
undetectable		 4v3xA-2w4oA:
20.26
4v3xB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3X_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.42A 4v3xA-2w4oA:
undetectable
4v3xB-2w4oA:
undetectable		 4v3xA-2w4oA:
20.26
4v3xB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3Y_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.45A 4v3yA-2w4oA:
undetectable
4v3yB-2w4oA:
undetectable		 4v3yA-2w4oA:
20.26
4v3yB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3Z_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.43A 4v3zA-2w4oA:
undetectable
4v3zB-2w4oA:
undetectable		 4v3zA-2w4oA:
20.26
4v3zB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3Z_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.41A 4v3zA-2w4oA:
undetectable
4v3zB-2w4oA:
undetectable		 4v3zA-2w4oA:
20.26
4v3zB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.49A 5ad4A-2w4oA:
undetectable
5ad4B-2w4oA:
undetectable		 5ad4A-2w4oA:
20.26
5ad4B-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.41A 5ad4A-2w4oA:
undetectable
5ad4B-2w4oA:
undetectable		 5ad4A-2w4oA:
20.26
5ad4B-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD5_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.40A 5ad5A-2w4oA:
undetectable
5ad5B-2w4oA:
undetectable		 5ad5A-2w4oA:
20.26
5ad5B-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD5_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.40A 5ad5A-2w4oA:
undetectable
5ad5B-2w4oA:
undetectable		 5ad5A-2w4oA:
20.26
5ad5B-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD6_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.46A 5ad6A-2w4oA:
undetectable
5ad6B-2w4oA:
undetectable		 5ad6A-2w4oA:
20.26
5ad6B-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD6_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.41A 5ad6A-2w4oA:
undetectable
5ad6B-2w4oA:
undetectable		 5ad6A-2w4oA:
20.26
5ad6B-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD7_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.43A 5ad7A-2w4oA:
0.0
5ad7B-2w4oA:
0.0		 5ad7A-2w4oA:
20.26
5ad7B-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD7_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.41A 5ad7A-2w4oA:
undetectable
5ad7B-2w4oA:
undetectable		 5ad7A-2w4oA:
20.26
5ad7B-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD8_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.45A 5ad8A-2w4oA:
0.0
5ad8B-2w4oA:
0.0		 5ad8A-2w4oA:
20.26
5ad8B-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD8_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.40A 5ad8A-2w4oA:
undetectable
5ad8B-2w4oA:
undetectable		 5ad8A-2w4oA:
20.26
5ad8B-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD9_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.40A 5ad9A-2w4oA:
undetectable
5ad9B-2w4oA:
undetectable		 5ad9A-2w4oA:
20.26
5ad9B-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD9_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.37A 5ad9A-2w4oA:
undetectable
5ad9B-2w4oA:
undetectable		 5ad9A-2w4oA:
20.26
5ad9B-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADA_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.43A 5adaA-2w4oA:
undetectable
5adaB-2w4oA:
undetectable		 5adaA-2w4oA:
20.26
5adaB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADA_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.42A 5adaA-2w4oA:
undetectable
5adaB-2w4oA:
undetectable		 5adaA-2w4oA:
20.26
5adaB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADB_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.45A 5adbA-2w4oA:
0.0
5adbB-2w4oA:
0.0		 5adbA-2w4oA:
20.26
5adbB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADB_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.37A 5adbA-2w4oA:
undetectable
5adbB-2w4oA:
undetectable		 5adbA-2w4oA:
20.26
5adbB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADC_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.43A 5adcA-2w4oA:
undetectable
5adcB-2w4oA:
undetectable		 5adcA-2w4oA:
20.26
5adcB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADC_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.42A 5adcA-2w4oA:
undetectable
5adcB-2w4oA:
undetectable		 5adcA-2w4oA:
20.26
5adcB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADD_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.45A 5addA-2w4oA:
undetectable
5addB-2w4oA:
undetectable		 5addA-2w4oA:
20.26
5addB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADE_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.47A 5adeA-2w4oA:
undetectable
5adeB-2w4oA:
undetectable		 5adeA-2w4oA:
20.26
5adeB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADF_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.44A 5adfA-2w4oA:
undetectable
5adfB-2w4oA:
undetectable		 5adfA-2w4oA:
21.36
5adfB-2w4oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADF_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.42A 5adfA-2w4oA:
0.0
5adfB-2w4oA:
1.0		 5adfA-2w4oA:
21.36
5adfB-2w4oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADG_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.40A 5adgA-2w4oA:
undetectable
5adgB-2w4oA:
undetectable		 5adgA-2w4oA:
21.36
5adgB-2w4oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADG_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.42A 5adgA-2w4oA:
undetectable
5adgB-2w4oA:
undetectable		 5adgA-2w4oA:
21.36
5adgB-2w4oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADI_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.41A 5adiA-2w4oA:
undetectable
5adiB-2w4oA:
undetectable		 5adiA-2w4oA:
21.36
5adiB-2w4oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADI_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.42A 5adiA-2w4oA:
0.0
5adiB-2w4oA:
1.0		 5adiA-2w4oA:
21.36
5adiB-2w4oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGK_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.43A 5agkA-2w4oA:
undetectable
5agkB-2w4oA:
undetectable		 5agkA-2w4oA:
20.26
5agkB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGK_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.40A 5agkA-2w4oA:
undetectable
5agkB-2w4oA:
undetectable		 5agkA-2w4oA:
20.26
5agkB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGL_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.45A 5aglA-2w4oA:
undetectable
5aglB-2w4oA:
undetectable		 5aglA-2w4oA:
20.26
5aglB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGL_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.42A 5aglA-2w4oA:
undetectable
5aglB-2w4oA:
undetectable		 5aglA-2w4oA:
20.26
5aglB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGM_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.43A 5agmA-2w4oA:
undetectable
5agmB-2w4oA:
undetectable		 5agmA-2w4oA:
20.26
5agmB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGM_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.45A 5agmA-2w4oA:
undetectable
5agmB-2w4oA:
undetectable		 5agmA-2w4oA:
20.26
5agmB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGN_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.44A 5agnA-2w4oA:
undetectable
5agnB-2w4oA:
undetectable		 5agnA-2w4oA:
20.26
5agnB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGN_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.42A 5agnA-2w4oA:
undetectable
5agnB-2w4oA:
undetectable		 5agnA-2w4oA:
20.26
5agnB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.43A 5agoA-2w4oA:
undetectable
5agoB-2w4oA:
1.3		 5agoA-2w4oA:
20.26
5agoB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGO_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.40A 5agoA-2w4oA:
undetectable
5agoB-2w4oA:
1.3		 5agoA-2w4oA:
20.26
5agoB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.45A 5agpA-2w4oA:
undetectable
5agpB-2w4oA:
undetectable		 5agpA-2w4oA:
20.26
5agpB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.41A 5agpA-2w4oA:
undetectable
5agpB-2w4oA:
undetectable		 5agpA-2w4oA:
20.26
5agpB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CU6_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 TYR A 218
VAL A 222
PRO A 285
ALA A 209
 None
 0.83A 5cu6A-2w4oA:
21.4		 5cu6A-2w4oA:
26.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.47A 5fvpA-2w4oA:
1.1
5fvpB-2w4oA:
undetectable		 5fvpA-2w4oA:
20.26
5fvpB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.40A 5fvpA-2w4oA:
undetectable
5fvpB-2w4oA:
undetectable		 5fvpA-2w4oA:
20.26
5fvpB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVQ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.45A 5fvqA-2w4oA:
undetectable
5fvqB-2w4oA:
undetectable		 5fvqA-2w4oA:
20.26
5fvqB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.41A 5fvqA-2w4oA:
undetectable
5fvqB-2w4oA:
undetectable		 5fvqA-2w4oA:
20.26
5fvqB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.44A 5fvrA-2w4oA:
undetectable
5fvrB-2w4oA:
undetectable		 5fvrA-2w4oA:
20.26
5fvrB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.41A 5fvrA-2w4oA:
undetectable
5fvrB-2w4oA:
undetectable		 5fvrA-2w4oA:
20.26
5fvrB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVS_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.45A 5fvsA-2w4oA:
undetectable
5fvsB-2w4oA:
undetectable		 5fvsA-2w4oA:
20.26
5fvsB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVS_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.43A 5fvsA-2w4oA:
undetectable
5fvsB-2w4oA:
undetectable		 5fvsA-2w4oA:
20.26
5fvsB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVT_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.44A 5fvtA-2w4oA:
undetectable
5fvtB-2w4oA:
undetectable		 5fvtA-2w4oA:
20.26
5fvtB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.41A 5fvtA-2w4oA:
undetectable
5fvtB-2w4oA:
undetectable		 5fvtA-2w4oA:
20.26
5fvtB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVU_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.42A 5fvuA-2w4oA:
undetectable
5fvuB-2w4oA:
undetectable		 5fvuA-2w4oA:
21.36
5fvuB-2w4oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVU_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.41A 5fvuA-2w4oA:
undetectable
5fvuB-2w4oA:
undetectable		 5fvuA-2w4oA:
21.36
5fvuB-2w4oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVV_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.44A 5fvvA-2w4oA:
undetectable
5fvvB-2w4oA:
undetectable		 5fvvA-2w4oA:
21.36
5fvvB-2w4oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVV_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.43A 5fvvA-2w4oA:
undetectable
5fvvB-2w4oA:
undetectable		 5fvvA-2w4oA:
21.36
5fvvB-2w4oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVW_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.44A 5fvwA-2w4oA:
undetectable
5fvwB-2w4oA:
undetectable		 5fvwA-2w4oA:
21.36
5fvwB-2w4oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVW_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.42A 5fvwA-2w4oA:
undetectable
5fvwB-2w4oA:
undetectable		 5fvwA-2w4oA:
21.36
5fvwB-2w4oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVX_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.44A 5fvxA-2w4oA:
undetectable
5fvxB-2w4oA:
undetectable		 5fvxA-2w4oA:
21.36
5fvxB-2w4oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVX_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.43A 5fvxA-2w4oA:
0.0
5fvxB-2w4oA:
0.9		 5fvxA-2w4oA:
21.36
5fvxB-2w4oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FW0_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.45A 5fw0A-2w4oA:
undetectable
5fw0B-2w4oA:
undetectable		 5fw0A-2w4oA:
20.26
5fw0B-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FW0_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.43A 5fw0A-2w4oA:
undetectable
5fw0B-2w4oA:
undetectable		 5fw0A-2w4oA:
20.26
5fw0B-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0N_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.43A 5g0nA-2w4oA:
undetectable
5g0nB-2w4oA:
undetectable		 5g0nA-2w4oA:
20.26
5g0nB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0N_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.41A 5g0nA-2w4oA:
undetectable
5g0nB-2w4oA:
undetectable		 5g0nA-2w4oA:
20.26
5g0nB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0O_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.44A 5g0oA-2w4oA:
undetectable
5g0oB-2w4oA:
undetectable		 5g0oA-2w4oA:
20.26
5g0oB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0O_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.39A 5g0oA-2w4oA:
undetectable
5g0oB-2w4oA:
undetectable		 5g0oA-2w4oA:
20.26
5g0oB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		6 / 12 LEU A  52
VAL A  60
ALA A  73
LEU A 120
LEU A 171
ASP A 185
 DKI  A1338 (-3.8A)
DKI  A1338 (-4.2A)
DKI  A1338 ( 3.7A)
DKI  A1338 (-4.2A)
DKI  A1338 (-4.9A)
DKI  A1338 (-3.8A)
 0.82A 5h2uB-2w4oA:
22.5		 5h2uB-2w4oA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 GLY A  53
GLY A  55
VAL A  60
LYS A  75
 DKI  A1338 (-3.3A)
None
DKI  A1338 (-4.2A)
None
 0.31A 5izjA-2w4oA:
22.0		 5izjA-2w4oA:
29.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 GLY A  53
GLY A  55
VAL A  60
LYS A  75
 DKI  A1338 (-3.3A)
None
DKI  A1338 (-4.2A)
None
 0.35A 5j5xA-2w4oA:
22.5		 5j5xA-2w4oA:
29.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		6 / 12 GLY A  53
VAL A  60
ALA A  73
LEU A 171
ALA A 184
ASP A 185
 DKI  A1338 (-3.3A)
DKI  A1338 (-4.2A)
DKI  A1338 ( 3.7A)
DKI  A1338 (-4.9A)
DKI  A1338 (-3.1A)
DKI  A1338 (-3.8A)
 0.68A 5l2iA-2w4oA:
7.2		 5l2iA-2w4oA:
27.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		7 / 11 LEU A  52
GLY A  53
VAL A  60
ALA A  73
LEU A 118
GLU A 125
LEU A 171
 DKI  A1338 (-3.8A)
DKI  A1338 (-3.3A)
DKI  A1338 (-4.2A)
DKI  A1338 ( 3.7A)
DKI  A1338 ( 4.7A)
None
DKI  A1338 (-4.9A)
 0.51A 5lvnA-2w4oA:
13.2		 5lvnA-2w4oA:
29.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_E_ADNE401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		5 / 10 GLY A  53
VAL A  60
ALA A  73
ILE A 102
LEU A 120
 DKI  A1338 (-3.3A)
DKI  A1338 (-4.2A)
DKI  A1338 ( 3.7A)
DKI  A1338 ( 4.4A)
DKI  A1338 (-4.2A)
 0.56A 5lw1E-2w4oA:
20.1		 5lw1E-2w4oA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OTR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 5 TYR A 218
VAL A 222
PRO A 285
ALA A 209
 None
 0.80A 5otrA-2w4oA:
21.0		 5otrA-2w4oA:
26.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNR_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.42A 5unrA-2w4oA:
0.0
5unrB-2w4oA:
0.0		 5unrA-2w4oA:
20.26
5unrB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNR_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.41A 5unrA-2w4oA:
undetectable
5unrB-2w4oA:
undetectable		 5unrA-2w4oA:
20.26
5unrB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNS_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.44A 5unsA-2w4oA:
undetectable
5unsB-2w4oA:
undetectable		 5unsA-2w4oA:
20.26
5unsB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNS_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.42A 5unsA-2w4oA:
undetectable
5unsB-2w4oA:
undetectable		 5unsA-2w4oA:
20.26
5unsB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNT_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.48A 5untA-2w4oA:
undetectable
5untB-2w4oA:
undetectable		 5untA-2w4oA:
20.26
5untB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNT_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.40A 5untA-2w4oA:
undetectable
5untB-2w4oA:
undetectable		 5untA-2w4oA:
20.26
5untB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNU_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.45A 5unuA-2w4oA:
undetectable
5unuB-2w4oA:
undetectable		 5unuA-2w4oA:
20.26
5unuB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNU_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.40A 5unuA-2w4oA:
undetectable
5unuB-2w4oA:
undetectable		 5unuA-2w4oA:
20.26
5unuB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNV_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.48A 5unvA-2w4oA:
undetectable
5unvB-2w4oA:
undetectable		 5unvA-2w4oA:
20.26
5unvB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNW_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.45A 5unwA-2w4oA:
undetectable
5unwB-2w4oA:
undetectable		 5unwA-2w4oA:
20.26
5unwB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNW_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.38A 5unwA-2w4oA:
undetectable
5unwB-2w4oA:
undetectable		 5unwA-2w4oA:
20.26
5unwB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNX_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.43A 5unxA-2w4oA:
undetectable
5unxB-2w4oA:
undetectable		 5unxA-2w4oA:
20.26
5unxB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNX_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.38A 5unxA-2w4oA:
undetectable
5unxB-2w4oA:
undetectable		 5unxA-2w4oA:
20.26
5unxB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNY_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.44A 5unyA-2w4oA:
undetectable
5unyB-2w4oA:
undetectable		 5unyA-2w4oA:
20.26
5unyB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNY_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.42A 5unyA-2w4oA:
undetectable
5unyB-2w4oA:
undetectable		 5unyA-2w4oA:
20.26
5unyB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNZ_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 5 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.45A 5unzA-2w4oA:
0.0
5unzB-2w4oA:
0.0		 5unzA-2w4oA:
20.26
5unzB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNZ_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.45A 5unzA-2w4oA:
undetectable
5unzB-2w4oA:
undetectable		 5unzA-2w4oA:
20.26
5unzB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO0_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.41A 5uo0A-2w4oA:
1.2
5uo0B-2w4oA:
0.0		 5uo0A-2w4oA:
20.26
5uo0B-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO0_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.44A 5uo0A-2w4oA:
undetectable
5uo0B-2w4oA:
undetectable		 5uo0A-2w4oA:
20.26
5uo0B-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO1_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.42A 5uo1A-2w4oA:
undetectable
5uo1B-2w4oA:
undetectable		 5uo1A-2w4oA:
21.36
5uo1B-2w4oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO1_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.40A 5uo1A-2w4oA:
undetectable
5uo1B-2w4oA:
undetectable		 5uo1A-2w4oA:
21.36
5uo1B-2w4oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO2_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.42A 5uo2A-2w4oA:
undetectable
5uo2B-2w4oA:
undetectable		 5uo2A-2w4oA:
21.36
5uo2B-2w4oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO2_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.43A 5uo2A-2w4oA:
undetectable
5uo2B-2w4oA:
undetectable		 5uo2A-2w4oA:
21.36
5uo2B-2w4oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO3_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.43A 5uo3A-2w4oA:
undetectable
5uo3B-2w4oA:
undetectable		 5uo3A-2w4oA:
21.36
5uo3B-2w4oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO3_B_H4BB803_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.46A 5uo3A-2w4oA:
undetectable
5uo3B-2w4oA:
undetectable		 5uo3A-2w4oA:
21.36
5uo3B-2w4oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO4_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.41A 5uo4A-2w4oA:
undetectable
5uo4B-2w4oA:
undetectable		 5uo4A-2w4oA:
21.36
5uo4B-2w4oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO4_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.40A 5uo4A-2w4oA:
undetectable
5uo4B-2w4oA:
undetectable		 5uo4A-2w4oA:
21.36
5uo4B-2w4oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO5_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.41A 5uo5A-2w4oA:
undetectable
5uo5B-2w4oA:
undetectable		 5uo5A-2w4oA:
21.36
5uo5B-2w4oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO5_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.41A 5uo5A-2w4oA:
undetectable
5uo5B-2w4oA:
undetectable		 5uo5A-2w4oA:
21.36
5uo5B-2w4oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO6_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.41A 5uo6A-2w4oA:
0.0
5uo6B-2w4oA:
0.0		 5uo6A-2w4oA:
21.36
5uo6B-2w4oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO6_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.40A 5uo6A-2w4oA:
undetectable
5uo6B-2w4oA:
undetectable		 5uo6A-2w4oA:
21.36
5uo6B-2w4oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO7_B_H4BB803_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.40A 5uo7A-2w4oA:
undetectable
5uo7B-2w4oA:
undetectable		 5uo7A-2w4oA:
21.36
5uo7B-2w4oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA307_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 5 ASP A  40
PRO A 111
GLU A 113
THR A 110
 None
 1.48A 5uxcA-2w4oA:
3.7		 5uxcA-2w4oA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUI_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.46A 5vuiA-2w4oA:
undetectable
5vuiB-2w4oA:
undetectable		 5vuiA-2w4oA:
20.26
5vuiB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUI_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.41A 5vuiA-2w4oA:
undetectable
5vuiB-2w4oA:
undetectable		 5vuiA-2w4oA:
20.26
5vuiB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUJ_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.49A 5vujA-2w4oA:
undetectable
5vujB-2w4oA:
undetectable		 5vujA-2w4oA:
20.26
5vujB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUK_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.47A 5vukA-2w4oA:
undetectable
5vukB-2w4oA:
undetectable		 5vukA-2w4oA:
20.26
5vukB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUK_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.42A 5vukA-2w4oA:
undetectable
5vukB-2w4oA:
undetectable		 5vukA-2w4oA:
20.26
5vukB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUL_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.44A 5vulA-2w4oA:
undetectable
5vulB-2w4oA:
undetectable		 5vulA-2w4oA:
20.26
5vulB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUL_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.42A 5vulA-2w4oA:
undetectable
5vulB-2w4oA:
undetectable		 5vulA-2w4oA:
20.26
5vulB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUM_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.47A 5vumA-2w4oA:
undetectable
5vumB-2w4oA:
undetectable		 5vumA-2w4oA:
20.26
5vumB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUM_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.42A 5vumA-2w4oA:
undetectable
5vumB-2w4oA:
undetectable		 5vumA-2w4oA:
20.26
5vumB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.43A 5vunA-2w4oA:
undetectable
5vunB-2w4oA:
undetectable		 5vunA-2w4oA:
20.26
5vunB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.41A 5vunA-2w4oA:
undetectable
5vunB-2w4oA:
undetectable		 5vunA-2w4oA:
20.26
5vunB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.44A 5vuoA-2w4oA:
undetectable
5vuoB-2w4oA:
undetectable		 5vuoA-2w4oA:
20.26
5vuoB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.42A 5vuoA-2w4oA:
undetectable
5vuoB-2w4oA:
undetectable		 5vuoA-2w4oA:
20.26
5vuoB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUP_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.44A 5vupA-2w4oA:
undetectable
5vupB-2w4oA:
undetectable		 5vupA-2w4oA:
20.26
5vupB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUP_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.42A 5vupA-2w4oA:
undetectable
5vupB-2w4oA:
undetectable		 5vupA-2w4oA:
20.26
5vupB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUQ_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.43A 5vuqA-2w4oA:
undetectable
5vuqB-2w4oA:
undetectable		 5vuqA-2w4oA:
20.26
5vuqB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUQ_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.42A 5vuqA-2w4oA:
undetectable
5vuqB-2w4oA:
undetectable		 5vuqA-2w4oA:
20.26
5vuqB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUR_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.46A 5vurA-2w4oA:
0.0
5vurB-2w4oA:
1.2		 5vurA-2w4oA:
20.26
5vurB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUR_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.40A 5vurA-2w4oA:
undetectable
5vurB-2w4oA:
undetectable		 5vurA-2w4oA:
20.26
5vurB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUS_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.44A 5vusA-2w4oA:
undetectable
5vusB-2w4oA:
undetectable		 5vusA-2w4oA:
20.26
5vusB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUS_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.42A 5vusA-2w4oA:
undetectable
5vusB-2w4oA:
undetectable		 5vusA-2w4oA:
20.26
5vusB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUT_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.44A 5vutA-2w4oA:
undetectable
5vutB-2w4oA:
undetectable		 5vutA-2w4oA:
20.26
5vutB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUT_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.42A 5vutA-2w4oA:
undetectable
5vutB-2w4oA:
undetectable		 5vutA-2w4oA:
20.26
5vutB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUU_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.46A 5vuuA-2w4oA:
undetectable
5vuuB-2w4oA:
undetectable		 5vuuA-2w4oA:
20.26
5vuuB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUU_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.40A 5vuuA-2w4oA:
undetectable
5vuuB-2w4oA:
undetectable		 5vuuA-2w4oA:
20.26
5vuuB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUV_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.40A 5vuvA-2w4oA:
1.3
5vuvB-2w4oA:
undetectable		 5vuvA-2w4oA:
21.36
5vuvB-2w4oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUV_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.40A 5vuvA-2w4oA:
1.3
5vuvB-2w4oA:
undetectable		 5vuvA-2w4oA:
21.36
5vuvB-2w4oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUW_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.41A 5vuwA-2w4oA:
1.6
5vuwB-2w4oA:
undetectable		 5vuwA-2w4oA:
21.36
5vuwB-2w4oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUW_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.41A 5vuwA-2w4oA:
1.7
5vuwB-2w4oA:
undetectable		 5vuwA-2w4oA:
21.36
5vuwB-2w4oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUX_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.42A 5vuxA-2w4oA:
1.6
5vuxB-2w4oA:
undetectable		 5vuxA-2w4oA:
21.36
5vuxB-2w4oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUX_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.39A 5vuxA-2w4oA:
1.6
5vuxB-2w4oA:
0.0		 5vuxA-2w4oA:
21.36
5vuxB-2w4oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUY_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.45A 5vuyA-2w4oA:
1.3
5vuyB-2w4oA:
undetectable		 5vuyA-2w4oA:
21.36
5vuyB-2w4oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUY_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.34A 5vuyA-2w4oA:
1.3
5vuyB-2w4oA:
undetectable		 5vuyA-2w4oA:
21.36
5vuyB-2w4oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUZ_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.42A 5vuzA-2w4oA:
undetectable
5vuzB-2w4oA:
undetectable		 5vuzA-2w4oA:
21.36
5vuzB-2w4oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUZ_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.42A 5vuzA-2w4oA:
undetectable
5vuzB-2w4oA:
undetectable		 5vuzA-2w4oA:
21.36
5vuzB-2w4oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV0_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.42A 5vv0A-2w4oA:
1.3
5vv0B-2w4oA:
undetectable		 5vv0A-2w4oA:
21.59
5vv0B-2w4oA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV0_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.42A 5vv0A-2w4oA:
1.3
5vv0B-2w4oA:
undetectable		 5vv0A-2w4oA:
21.59
5vv0B-2w4oA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV1_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.42A 5vv1A-2w4oA:
undetectable
5vv1B-2w4oA:
undetectable		 5vv1A-2w4oA:
21.36
5vv1B-2w4oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV1_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.43A 5vv1A-2w4oA:
undetectable
5vv1B-2w4oA:
undetectable		 5vv1A-2w4oA:
21.36
5vv1B-2w4oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV2_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.42A 5vv2A-2w4oA:
undetectable
5vv2B-2w4oA:
undetectable		 5vv2A-2w4oA:
21.36
5vv2B-2w4oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV2_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.44A 5vv2A-2w4oA:
undetectable
5vv2B-2w4oA:
undetectable		 5vv2A-2w4oA:
21.36
5vv2B-2w4oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV3_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.42A 5vv3A-2w4oA:
1.3
5vv3B-2w4oA:
undetectable		 5vv3A-2w4oA:
21.36
5vv3B-2w4oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV3_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.40A 5vv3A-2w4oA:
1.3
5vv3B-2w4oA:
undetectable		 5vv3A-2w4oA:
21.36
5vv3B-2w4oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV4_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.43A 5vv4A-2w4oA:
0.0
5vv4B-2w4oA:
1.1		 5vv4A-2w4oA:
21.36
5vv4B-2w4oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV4_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.41A 5vv4A-2w4oA:
undetectable
5vv4B-2w4oA:
undetectable		 5vv4A-2w4oA:
21.36
5vv4B-2w4oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV5_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.44A 5vv5A-2w4oA:
undetectable
5vv5B-2w4oA:
undetectable		 5vv5A-2w4oA:
21.36
5vv5B-2w4oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV5_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.42A 5vv5A-2w4oA:
undetectable
5vv5B-2w4oA:
undetectable		 5vv5A-2w4oA:
21.36
5vv5B-2w4oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		5 / 9 LEU A  52
VAL A  60
LYS A  75
ILE A 102
ASP A 185
 DKI  A1338 (-3.8A)
DKI  A1338 (-4.2A)
None
DKI  A1338 ( 4.4A)
DKI  A1338 (-3.8A)
 1.02A 5yf9X-2w4oA:
21.5		 5yf9X-2w4oA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUQ_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 6 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.47A 6auqA-2w4oA:
undetectable
6auqB-2w4oA:
undetectable		 6auqA-2w4oA:
15.73
6auqB-2w4oA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUQ_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.41A 6auqA-2w4oA:
undetectable
6auqB-2w4oA:
undetectable		 6auqA-2w4oA:
15.73
6auqB-2w4oA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUR_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.43A 6aurA-2w4oA:
undetectable
6aurB-2w4oA:
undetectable		 6aurA-2w4oA:
15.73
6aurB-2w4oA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUR_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.42A 6aurA-2w4oA:
undetectable
6aurB-2w4oA:
undetectable		 6aurA-2w4oA:
15.73
6aurB-2w4oA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUS_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.43A 6ausA-2w4oA:
undetectable
6ausB-2w4oA:
undetectable		 6ausA-2w4oA:
15.73
6ausB-2w4oA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUS_B_H4BB803_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.41A 6ausA-2w4oA:
undetectable
6ausB-2w4oA:
undetectable		 6ausA-2w4oA:
15.73
6ausB-2w4oA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUT_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.45A 6autA-2w4oA:
undetectable
6autB-2w4oA:
undetectable		 6autA-2w4oA:
15.73
6autB-2w4oA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUT_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.41A 6autA-2w4oA:
undetectable
6autB-2w4oA:
undetectable		 6autA-2w4oA:
15.73
6autB-2w4oA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.43A 6auuA-2w4oA:
undetectable
6auuB-2w4oA:
undetectable		 6auuA-2w4oA:
15.73
6auuB-2w4oA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.40A 6auuA-2w4oA:
undetectable
6auuB-2w4oA:
undetectable		 6auuA-2w4oA:
15.73
6auuB-2w4oA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUV_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.43A 6auvA-2w4oA:
undetectable
6auvB-2w4oA:
undetectable		 6auvA-2w4oA:
15.73
6auvB-2w4oA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUV_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.41A 6auvA-2w4oA:
undetectable
6auvB-2w4oA:
undetectable		 6auvA-2w4oA:
15.73
6auvB-2w4oA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUW_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.46A 6auwA-2w4oA:
undetectable
6auwB-2w4oA:
undetectable		 6auwA-2w4oA:
15.73
6auwB-2w4oA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUW_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.40A 6auwA-2w4oA:
undetectable
6auwB-2w4oA:
undetectable		 6auwA-2w4oA:
15.73
6auwB-2w4oA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUX_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.43A 6auxA-2w4oA:
undetectable
6auxB-2w4oA:
undetectable		 6auxA-2w4oA:
15.73
6auxB-2w4oA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUX_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.41A 6auxA-2w4oA:
undetectable
6auxB-2w4oA:
undetectable		 6auxA-2w4oA:
15.73
6auxB-2w4oA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUY_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.41A 6auyA-2w4oA:
undetectable
6auyB-2w4oA:
undetectable		 6auyA-2w4oA:
15.36
6auyB-2w4oA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUY_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.40A 6auyA-2w4oA:
undetectable
6auyB-2w4oA:
1.1		 6auyA-2w4oA:
15.36
6auyB-2w4oA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUZ_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.43A 6auzA-2w4oA:
undetectable
6auzB-2w4oA:
undetectable		 6auzA-2w4oA:
15.36
6auzB-2w4oA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUZ_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.42A 6auzA-2w4oA:
undetectable
6auzB-2w4oA:
undetectable		 6auzA-2w4oA:
15.36
6auzB-2w4oA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV0_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.44A 6av0A-2w4oA:
undetectable
6av0B-2w4oA:
undetectable		 6av0A-2w4oA:
15.36
6av0B-2w4oA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV0_B_H4BB803_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.42A 6av0A-2w4oA:
undetectable
6av0B-2w4oA:
undetectable		 6av0A-2w4oA:
15.36
6av0B-2w4oA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV1_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.42A 6av1A-2w4oA:
0.7
6av1B-2w4oA:
undetectable		 6av1A-2w4oA:
15.36
6av1B-2w4oA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV1_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.40A 6av1A-2w4oA:
0.7
6av1B-2w4oA:
undetectable		 6av1A-2w4oA:
15.36
6av1B-2w4oA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV2_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.43A 6av2A-2w4oA:
undetectable
6av2B-2w4oA:
undetectable		 6av2A-2w4oA:
15.36
6av2B-2w4oA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV2_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.42A 6av2A-2w4oA:
undetectable
6av2B-2w4oA:
undetectable		 6av2A-2w4oA:
15.36
6av2B-2w4oA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV3_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.41A 6av3A-2w4oA:
undetectable
6av3B-2w4oA:
undetectable		 6av3A-2w4oA:
15.36
6av3B-2w4oA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV3_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.43A 6av3A-2w4oA:
undetectable
6av3B-2w4oA:
undetectable		 6av3A-2w4oA:
15.36
6av3B-2w4oA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV4_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.42A 6av4A-2w4oA:
undetectable
6av4B-2w4oA:
undetectable		 6av4A-2w4oA:
15.36
6av4B-2w4oA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV4_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.43A 6av4A-2w4oA:
undetectable
6av4B-2w4oA:
undetectable		 6av4A-2w4oA:
15.36
6av4B-2w4oA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV5_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.42A 6av5A-2w4oA:
undetectable
6av5B-2w4oA:
undetectable		 6av5A-2w4oA:
15.36
6av5B-2w4oA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV5_B_H4BB803_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.42A 6av5A-2w4oA:
undetectable
6av5B-2w4oA:
undetectable		 6av5A-2w4oA:
15.36
6av5B-2w4oA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIC_A_H4BA802_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.43A 6cicA-2w4oA:
undetectable
6cicB-2w4oA:
undetectable		 6cicA-2w4oA:
15.36
6cicB-2w4oA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIC_B_H4BB802_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.41A 6cicA-2w4oA:
undetectable
6cicB-2w4oA:
undetectable		 6cicA-2w4oA:
15.36
6cicB-2w4oA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CID_A_H4BA802_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.41A 6cidA-2w4oA:
undetectable
6cidB-2w4oA:
undetectable		 6cidA-2w4oA:
15.36
6cidB-2w4oA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CID_B_H4BB803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		4 / 7 TRP A 266
PHE A 261
ARG A 278
VAL A 269
 None
 1.41A 6cidA-2w4oA:
1.2
6cidB-2w4oA:
undetectable		 6cidA-2w4oA:
15.36
6cidB-2w4oA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens) 		3 / 3 LEU A 289
GLY A 228
PHE A 261
 None
 0.58A 6exiC-2w4oA:
undetectable		 6exiC-2w4oA:
14.08