SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2w58'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUI_B_AB1B100_1
(PROTEASE)		 2w58 PRIMOSOME COMPONENT
(HELICASE LOADER)
(Geobacillus
kaustophilus) 		5 / 10 GLY A 232
ASP A 230
ASP A 229
GLY A 168
PRO A 300
 None
None
MG  A1311 ( 3.9A)
None
None
 0.89A 1muiA-2w58A:
undetectable		 1muiA-2w58A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_2
(LIVER
CARBOXYLESTERASE I)		 2w58 PRIMOSOME COMPONENT
(HELICASE LOADER)
(Geobacillus
kaustophilus) 		3 / 3 PHE A 245
LEU A 231
MET A 267
 None
 0.77A 1mx1D-2w58A:
undetectable		 1mx1D-2w58A:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_B_BEZB12_0
(CES1 PROTEIN)		 2w58 PRIMOSOME COMPONENT
(HELICASE LOADER)
(Geobacillus
kaustophilus) 		4 / 4 GLY A 232
SER A 263
VAL A 197
LEU A 274
 None
 1.07A 1yajB-2w58A:
undetectable		 1yajB-2w58A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2w58 PRIMOSOME COMPONENT
(HELICASE LOADER)
(Geobacillus
kaustophilus) 		3 / 3 GLY A 171
GLY A 173
THR A 175
 ADP  A1310 (-3.4A)
ADP  A1310 (-3.4A)
MG  A1311 ( 3.6A)
 0.44A 3si7B-2w58A:
4.9		 3si7B-2w58A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2w58 PRIMOSOME COMPONENT
(HELICASE LOADER)
(Geobacillus
kaustophilus) 		5 / 12 LEU A 257
SER A 191
ALA A 182
LEU A 200
VAL A 197
 None
 1.27A 4ib4A-2w58A:
undetectable		 4ib4A-2w58A:
17.73