SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2w59'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB6_0
(GRAMICIDIN A)		 2w59 IGY FCU3-4
(Gallus
gallus) 		3 / 3 TRP A 491
ALA A 500
VAL A 498
 None
 0.96A 1bdwA-2w59A:
undetectable
1bdwB-2w59A:
undetectable		 1bdwA-2w59A:
5.94
1bdwB-2w59A:
5.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K17_B_OHBB701_0
(LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A)		 2w59 IGY FCU3-4
(Gallus
gallus) 		4 / 5 GLU A 437
SER A 381
PRO A 378
SER A 379
 None
 1.35A 4k17B-2w59A:
undetectable		 4k17B-2w59A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MGH_A_ACTA1320_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 2w59 IGY FCU3-4
(Gallus
gallus) 		4 / 5 VAL A 374
LEU A 377
ILE A 350
LEU A 442
 None
 0.82A 4mghA-2w59A:
undetectable		 4mghA-2w59A:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z7F_C_FOLC201_0
(FOLATE ECF
TRANSPORTER)		 2w59 IGY FCU3-4
(Gallus
gallus) 		5 / 12 SER A 358
ALA A 497
PHE A 503
THR A 501
THR A 505
 None
 1.42A 4z7fC-2w59A:
undetectable		 4z7fC-2w59A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_A_ACTA403_0
(D-ALANINE--D-ALANINE
LIGASE)		 2w59 IGY FCU3-4
(Gallus
gallus) 		4 / 6 ARG A 448
GLY A 426
SER A 425
LEU A 424
 None
 1.28A 5bphA-2w59A:
undetectable		 5bphA-2w59A:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_2
(TUBULIN BETA-2B
CHAIN)		 2w59 IGY FCU3-4
(Gallus
gallus) 		3 / 3 THR A 420
PRO A 484
ARG A 485
 None
 0.87A 5nd7B-2w59A:
undetectable		 5nd7B-2w59A:
18.85