SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2w5e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_A_RBFA191_1
(LUMAZINE PROTEIN)
2w5e PUTATIVE SERINE
PROTEASE

(Mamastrovirus
1)
5 / 12 VAL A 457
GLN A 567
ALA A 576
THR A 539
ILE A 578
None
1.17A 3a35A-2w5eA:
2.8
3a35A-2w5eA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_B_RBFB191_1
(LUMAZINE PROTEIN)
2w5e PUTATIVE SERINE
PROTEASE

(Mamastrovirus
1)
5 / 12 VAL A 457
GLN A 567
ALA A 576
THR A 539
ILE A 578
None
1.14A 3a35B-2w5eA:
2.7
3a35B-2w5eA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3B_A_RBFA191_1
(LUMAZINE PROTEIN)
2w5e PUTATIVE SERINE
PROTEASE

(Mamastrovirus
1)
5 / 12 VAL A 457
GLN A 567
ALA A 576
THR A 539
ILE A 578
None
1.19A 3a3bA-2w5eA:
3.4
3a3bA-2w5eA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDY_A_RBFA187_1
(LUMAZINE PROTEIN)
2w5e PUTATIVE SERINE
PROTEASE

(Mamastrovirus
1)
5 / 12 VAL A 457
GLN A 567
ALA A 576
THR A 539
ILE A 578
None
1.15A 3ddyA-2w5eA:
3.1
3ddyA-2w5eA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)
2w5e PUTATIVE SERINE
PROTEASE

(Mamastrovirus
1)
5 / 12 ILE A 440
GLY A 447
ALA A 520
ALA A 459
VAL A 462
None
1.06A 3jb3A-2w5eA:
undetectable
3jb3A-2w5eA:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_2
(HIV-1 PROTEASE)
2w5e PUTATIVE SERINE
PROTEASE

(Mamastrovirus
1)
5 / 10 ASP A 489
ILE A 490
ILE A 456
PRO A 554
ALA A 553
None
0.99A 3t3cB-2w5eA:
undetectable
3t3cB-2w5eA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_B_GM4B301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)
2w5e PUTATIVE SERINE
PROTEASE

(Mamastrovirus
1)
6 / 11 ALA A 503
TYR A 521
LEU A 526
TYR A 473
ALA A 436
LEU A 505
None
1.22A 6dk1B-2w5eA:
undetectable
6dk1B-2w5eA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_C_GM4C301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)
2w5e PUTATIVE SERINE
PROTEASE

(Mamastrovirus
1)
5 / 11 ALA A 503
TYR A 521
LEU A 526
TYR A 473
ALA A 436
None
1.37A 6dk1C-2w5eA:
0.0
6dk1C-2w5eA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_1
(TYROSINE-PROTEIN
KINASE ABL1)
2w5e PUTATIVE SERINE
PROTEASE

(Mamastrovirus
1)
4 / 5 LEU A 526
TYR A 521
ILE A 490
GLY A 435
None
1.06A 6hd6A-2w5eA:
undetectable
6hd6A-2w5eA:
19.75