SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2w5f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSS_G_CCSG149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 2w5f ENDO-1,4-BETA-XYLANA
SE Y
(Ruminiclostridiu
m
thermocellum) 		4 / 7 SER A 118
THR A 159
ASN A 157
TYR A 119
 None
 0.98A 1dssG-2w5fA:
undetectable		 1dssG-2w5fA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSS_R_CCSR149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 2w5f ENDO-1,4-BETA-XYLANA
SE Y
(Ruminiclostridiu
m
thermocellum) 		4 / 8 SER A 118
THR A 159
ASN A 157
TYR A 119
 None
 1.00A 1dssR-2w5fA:
undetectable		 1dssR-2w5fA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q97_B_ADNB486_1
(SR PROTEIN KINASE)		 2w5f ENDO-1,4-BETA-XYLANA
SE Y
(Ruminiclostridiu
m
thermocellum) 		4 / 4 VAL A 279
ALA A 377
LEU A 414
PHE A 378
 None
 1.18A 1q97B-2w5fA:
undetectable		 1q97B-2w5fA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_1
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 2w5f ENDO-1,4-BETA-XYLANA
SE Y
(Ruminiclostridiu
m
thermocellum) 		3 / 3 GLY A  64
ASP A 173
ASN A  62
 None
CD  A1559 (-2.1A)
None
 0.53A 1vq1A-2w5fA:
undetectable		 1vq1A-2w5fA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_1
(RETINOIC ACID
RECEPTOR, BETA)		 2w5f ENDO-1,4-BETA-XYLANA
SE Y
(Ruminiclostridiu
m
thermocellum) 		5 / 12 PHE A 203
ALA A 486
ILE A 538
LEU A 195
LEU A 461
 None
 1.11A 1xdkB-2w5fA:
undetectable		 1xdkB-2w5fA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_A_ADNA901_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 2w5f ENDO-1,4-BETA-XYLANA
SE Y
(Ruminiclostridiu
m
thermocellum) 		5 / 10 PHE A 483
ILE A 538
ALA A 476
VAL A 205
TYR A 199
 None
 1.44A 2gl0A-2w5fA:
undetectable
2gl0B-2w5fA:
undetectable		 2gl0A-2w5fA:
14.88
2gl0B-2w5fA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_B_ADNB902_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 2w5f ENDO-1,4-BETA-XYLANA
SE Y
(Ruminiclostridiu
m
thermocellum) 		5 / 11 PHE A 483
ILE A 538
ALA A 476
VAL A 205
TYR A 199
 None
 1.47A 2gl0B-2w5fA:
undetectable
2gl0C-2w5fA:
undetectable		 2gl0B-2w5fA:
14.88
2gl0C-2w5fA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_C_ADNC903_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 2w5f ENDO-1,4-BETA-XYLANA
SE Y
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ILE A 538
ALA A 476
VAL A 205
TYR A 199
PHE A 483
 None
 1.47A 2gl0A-2w5fA:
undetectable
2gl0C-2w5fA:
undetectable		 2gl0A-2w5fA:
14.88
2gl0C-2w5fA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_E_ADNE905_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 2w5f ENDO-1,4-BETA-XYLANA
SE Y
(Ruminiclostridiu
m
thermocellum) 		5 / 11 PHE A 483
ILE A 538
ALA A 476
VAL A 205
TYR A 199
 None
 1.50A 2gl0E-2w5fA:
undetectable
2gl0F-2w5fA:
undetectable		 2gl0E-2w5fA:
14.88
2gl0F-2w5fA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_F_ADNF906_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 2w5f ENDO-1,4-BETA-XYLANA
SE Y
(Ruminiclostridiu
m
thermocellum) 		5 / 11 ILE A 538
ALA A 476
VAL A 205
TYR A 199
PHE A 483
 None
 1.44A 2gl0D-2w5fA:
undetectable
2gl0F-2w5fA:
undetectable		 2gl0D-2w5fA:
14.88
2gl0F-2w5fA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HKK_A_ALEA300_1
(CARBONIC ANHYDRASE 2)		 2w5f ENDO-1,4-BETA-XYLANA
SE Y
(Ruminiclostridiu
m
thermocellum) 		4 / 6 ASN A 394
HIS A 276
GLN A 457
THR A 231
 None
XYP  A1001 (-3.9A)
None
None
 1.20A 2hkkA-2w5fA:
undetectable		 2hkkA-2w5fA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_1
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 2w5f ENDO-1,4-BETA-XYLANA
SE Y
(Ruminiclostridiu
m
thermocellum) 		3 / 3 SER A 471
ASP A 432
ASP A 477
 None
 0.70A 2plwA-2w5fA:
undetectable		 2plwA-2w5fA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 2w5f ENDO-1,4-BETA-XYLANA
SE Y
(Ruminiclostridiu
m
thermocellum) 		3 / 3 ASP A 333
ASN A 336
THR A 284
 None
XYP  A1001 (-2.9A)
None
 0.80A 2q63B-2w5fA:
undetectable		 2q63B-2w5fA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMT_C_CCSC166_0
(GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL)		 2w5f ENDO-1,4-BETA-XYLANA
SE Y
(Ruminiclostridiu
m
thermocellum) 		4 / 8 SER A 118
THR A 159
ASN A 157
TYR A 119
 None
 0.99A 3dmtC-2w5fA:
undetectable		 3dmtC-2w5fA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_0
(REPRESSOR PROTEIN
MPHR(A))		 2w5f ENDO-1,4-BETA-XYLANA
SE Y
(Ruminiclostridiu
m
thermocellum) 		5 / 12 LEU A 209
GLY A  88
SER A 122
ILE A 219
SER A 218
 None
 1.06A 3frqB-2w5fA:
undetectable		 3frqB-2w5fA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEO_B_LLTB261_1
(DEOXYCYTIDINE KINASE)		 2w5f ENDO-1,4-BETA-XYLANA
SE Y
(Ruminiclostridiu
m
thermocellum) 		4 / 7 VAL A 498
LEU A 446
TYR A 442
PHE A 483
 None
 1.06A 3qeoB-2w5fA:
undetectable		 3qeoB-2w5fA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_D_ACTD502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2w5f ENDO-1,4-BETA-XYLANA
SE Y
(Ruminiclostridiu
m
thermocellum) 		3 / 3 GLY A  64
THR A  68
ASN A  65
 None
CD  A1559 (-3.5A)
None
 0.62A 3v4tD-2w5fA:
1.1		 3v4tD-2w5fA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_D_DVAD8_0
(VAL-GRAMICIDIN A)		 2w5f ENDO-1,4-BETA-XYLANA
SE Y
(Ruminiclostridiu
m
thermocellum) 		3 / 3 TRP A 512
VAL A 503
TRP A 504
 XYP  A1001 (-4.0A)
None
XYP  A1002 (-4.2A)
 0.92A 3zq8C-2w5fA:
undetectable
3zq8D-2w5fA:
undetectable		 3zq8C-2w5fA:
3.81
3zq8D-2w5fA:
3.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUB_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2w5f ENDO-1,4-BETA-XYLANA
SE Y
(Ruminiclostridiu
m
thermocellum) 		3 / 3 TYR A 332
ARG A 274
HIS A 276
 None
None
XYP  A1001 (-3.9A)
 1.19A 4fubA-2w5fA:
undetectable		 4fubA-2w5fA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0O_A_URFA303_1
(RRNA N-GLYCOSIDASE)		 2w5f ENDO-1,4-BETA-XYLANA
SE Y
(Ruminiclostridiu
m
thermocellum) 		4 / 5 TYR A 396
ASN A 394
TYR A 393
ILE A 407
 XYP  A1001 ( 4.8A)
None
None
None
 1.30A 4o0oA-2w5fA:
undetectable		 4o0oA-2w5fA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_B_SAMB601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 2w5f ENDO-1,4-BETA-XYLANA
SE Y
(Ruminiclostridiu
m
thermocellum) 		5 / 12 GLY A  82
ASP A  81
SER A  77
SER A 166
VAL A  73
 None
 1.13A 5dpdB-2w5fA:
undetectable		 5dpdB-2w5fA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 2w5f ENDO-1,4-BETA-XYLANA
SE Y
(Ruminiclostridiu
m
thermocellum) 		5 / 12 LEU A 446
ALA A 485
LEU A 195
ILE A 458
LEU A 521
 None
 1.07A 5ljeA-2w5fA:
undetectable		 5ljeA-2w5fA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LOG_A_LDPA1004_1
(PUTATIVE
O-METHYLTRANSFERASE)		 2w5f ENDO-1,4-BETA-XYLANA
SE Y
(Ruminiclostridiu
m
thermocellum) 		4 / 6 ASP A  39
LYS A  87
ASP A  46
ASN A 264
 None
 1.39A 5logA-2w5fA:
2.2		 5logA-2w5fA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_A_EPAA502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 2w5f ENDO-1,4-BETA-XYLANA
SE Y
(Ruminiclostridiu
m
thermocellum) 		5 / 10 PRO A 363
LEU A 309
ILE A 313
ALA A 381
VAL A 335
 None
 1.27A 5m0oA-2w5fA:
undetectable		 5m0oA-2w5fA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2w5f ENDO-1,4-BETA-XYLANA
SE Y
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ILE A 158
GLY A  88
TYR A 149
ALA A 151
VAL A  95
 None
 1.28A 5n0xB-2w5fA:
undetectable		 5n0xB-2w5fA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		 2w5f ENDO-1,4-BETA-XYLANA
SE Y
(Ruminiclostridiu
m
thermocellum) 		5 / 12 LEU A 446
VAL A 423
GLY A 422
ASP A 455
GLY A 453
 None
 1.22A 5nnaA-2w5fA:
2.1		 5nnaA-2w5fA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		 2w5f ENDO-1,4-BETA-XYLANA
SE Y
(Ruminiclostridiu
m
thermocellum) 		5 / 12 LEU A 446
VAL A 423
GLY A 422
ASP A 455
GLY A 453
 None
 1.23A 5nnaB-2w5fA:
undetectable		 5nnaB-2w5fA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)		 2w5f ENDO-1,4-BETA-XYLANA
SE Y
(Ruminiclostridiu
m
thermocellum) 		5 / 12 LEU A 446
VAL A 423
GLY A 422
ASP A 455
GLY A 453
 None
 1.21A 5nnaC-2w5fA:
undetectable		 5nnaC-2w5fA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)		 2w5f ENDO-1,4-BETA-XYLANA
SE Y
(Ruminiclostridiu
m
thermocellum) 		5 / 12 LEU A 446
VAL A 423
GLY A 422
ASP A 455
GLY A 453
 None
 1.20A 5nnaD-2w5fA:
undetectable		 5nnaD-2w5fA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V1S_A_SAMA604_0
(RADICAL SAM)		 2w5f ENDO-1,4-BETA-XYLANA
SE Y
(Ruminiclostridiu
m
thermocellum) 		5 / 9 LEU A 209
GLU A 233
THR A 213
TYR A  84
SER A  85
 None
XYP  A1002 (-3.5A)
None
None
None
 1.49A 5v1sA-2w5fA:
0.0		 5v1sA-2w5fA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7B_B_PA1B204_1
(ACYLOXYACYL
HYDROLASE SMALL
SUBUNIT
ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT)		 2w5f ENDO-1,4-BETA-XYLANA
SE Y
(Ruminiclostridiu
m
thermocellum) 		3 / 3 GLY A 297
ASN A 292
ARG A 308
 None
 0.70A 5w7bD-2w5fA:
3.9		 5w7bD-2w5fA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 2w5f ENDO-1,4-BETA-XYLANA
SE Y
(Ruminiclostridiu
m
thermocellum) 		3 / 3 THR A  68
GLU A  42
HIS A  38
 CD  A1559 (-3.5A)
CD  A1559 (-3.0A)
CD  A1560 ( 3.5A)
 0.89A 5xiqD-2w5fA:
undetectable		 5xiqD-2w5fA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 2w5f ENDO-1,4-BETA-XYLANA
SE Y
(Ruminiclostridiu
m
thermocellum) 		5 / 12 SER A 118
VAL A  37
GLY A  93
ALA A 155
ASN A 264
 None
 1.10A 6bqgA-2w5fA:
undetectable		 6bqgA-2w5fA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_A_BEZA701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 2w5f ENDO-1,4-BETA-XYLANA
SE Y
(Ruminiclostridiu
m
thermocellum) 		5 / 11 GLY A 275
LEU A 278
ALA A 381
ALA A 385
PHE A 317
 None
 1.29A 6qgbA-2w5fA:
undetectable		 6qgbA-2w5fA:
22.54