SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2w5h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_2
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 2w5h SERINE/THREONINE-PRO
TEIN KINASE NEK2
(Homo
sapiens) 		4 / 4 THR A 121
LEU A 120
VAL A 155
LEU A 149
 None
 0.94A 1fbmD-2w5hA:
undetectable		 1fbmD-2w5hA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_CCSB417_0
(ESTROGEN RECEPTOR)		 2w5h SERINE/THREONINE-PRO
TEIN KINASE NEK2
(Homo
sapiens) 		3 / 3 GLN A 119
LYS A 156
VAL A 147
 None
 0.91A 2jfaB-2w5hA:
undetectable		 2jfaB-2w5hA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1351_1
(PROSTAGLANDIN
REDUCTASE 2)		 2w5h SERINE/THREONINE-PRO
TEIN KINASE NEK2
(Homo
sapiens) 		5 / 10 ILE A  98
PHE A 112
TYR A 182
VAL A 155
LEU A 149
 None
 1.45A 2w98A-2w5hA:
undetectable		 2w98A-2w5hA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECLB600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2w5h SERINE/THREONINE-PRO
TEIN KINASE NEK2
(Homo
sapiens) 		4 / 8 LEU A  39
THR A  81
ALA A   5
ILE A  25
 None
 0.83A 3jusB-2w5hA:
undetectable		 3jusB-2w5hA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A2000_1
(P38A)		 2w5h SERINE/THREONINE-PRO
TEIN KINASE NEK2
(Homo
sapiens) 		5 / 12 ASP A 198
ILE A 199
VAL A 155
ARG A 115
ILE A 265
 None
 1.17A 3ohtA-2w5hA:
19.4
3ohtB-2w5hA:
19.3		 3ohtA-2w5hA:
24.50
3ohtB-2w5hA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2O_B_CLQB1079_0
(SAPOSIN-B)		 2w5h SERINE/THREONINE-PRO
TEIN KINASE NEK2
(Homo
sapiens) 		3 / 3 MET A  44
GLU A  48
LEU A  52
 None
 0.68A 4v2oB-2w5hA:
undetectable		 4v2oB-2w5hA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 2w5h SERINE/THREONINE-PRO
TEIN KINASE NEK2
(Homo
sapiens) 		6 / 12 ILE A  14
GLY A  15
TYR A  88
CYH A  89
GLY A  92
PHE A 148
 None
 0.66A 5vc3A-2w5hA:
24.2		 5vc3A-2w5hA:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_1
(MRNA CAPPING ENZYME
P5)		 2w5h SERINE/THREONINE-PRO
TEIN KINASE NEK2
(Homo
sapiens) 		3 / 3 TYR A  83
ASP A  40
ASP A  76
 None
 0.75A 5x6yA-2w5hA:
undetectable		 5x6yA-2w5hA:
16.50