SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2w5o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DBB_H_STRH229_1
(IGG1-KAPPA DB3 FAB
(HEAVY CHAIN)
IGG1-KAPPA DB3 FAB
(LIGHT CHAIN))		 2w5o ALPHA-L-ARABINOFURAN
OSIDASE
(Fusarium
graminearum) 		4 / 8 GLY A 246
TRP A 256
GLY A 244
TYR A 260
 None
 0.89A 1dbbH-2w5oA:
undetectable
1dbbL-2w5oA:
undetectable		 1dbbH-2w5oA:
20.37
1dbbL-2w5oA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_D_AG2D7015_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 2w5o ALPHA-L-ARABINOFURAN
OSIDASE
(Fusarium
graminearum) 		4 / 7 LEU A  48
LEU A 173
LEU A 107
GLY A 117
 None
 0.88A 1n13D-2w5oA:
undetectable
1n13E-2w5oA:
undetectable		 1n13D-2w5oA:
14.44
1n13E-2w5oA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_A_ACTA1107_0
(C5A PEPTIDASE)		 2w5o ALPHA-L-ARABINOFURAN
OSIDASE
(Fusarium
graminearum) 		4 / 5 LEU A 104
GLY A  57
ILE A  73
PHE A  71
 None
 0.88A 1xf1A-2w5oA:
undetectable		 1xf1A-2w5oA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_B_ACTB1108_0
(C5A PEPTIDASE)		 2w5o ALPHA-L-ARABINOFURAN
OSIDASE
(Fusarium
graminearum) 		4 / 6 LEU A 104
GLY A  57
ILE A  73
PHE A  71
 None
 0.87A 1xf1B-2w5oA:
undetectable		 1xf1B-2w5oA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XL6_B_SPMB3001_1
(INWARD RECTIFIER
POTASSIUM CHANNEL)		 2w5o ALPHA-L-ARABINOFURAN
OSIDASE
(Fusarium
graminearum) 		4 / 5 ALA A 356
TYR A  44
ALA A 336
TYR A 337
 None
AHR  A 501 ( 4.8A)
None
None
 1.06A 1xl6A-2w5oA:
undetectable
1xl6B-2w5oA:
undetectable		 1xl6A-2w5oA:
19.78
1xl6B-2w5oA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 2w5o ALPHA-L-ARABINOFURAN
OSIDASE
(Fusarium
graminearum) 		3 / 3 ALA A 287
GLY A 246
SER A 253
 None
 0.55A 2ivuA-2w5oA:
2.5		 2ivuA-2w5oA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLK_B_SPMB1302_1
(ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 10)		 2w5o ALPHA-L-ARABINOFURAN
OSIDASE
(Fusarium
graminearum) 		4 / 4 ALA A 356
TYR A  44
ALA A 336
TYR A 337
 None
AHR  A 501 ( 4.8A)
None
None
 1.02A 2wlkA-2w5oA:
undetectable
2wlkB-2w5oA:
undetectable		 2wlkA-2w5oA:
19.78
2wlkB-2w5oA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2w5o ALPHA-L-ARABINOFURAN
OSIDASE
(Fusarium
graminearum) 		3 / 3 TYR A 184
ASP A 214
ASP A 266
 None
 0.67A 3ou6B-2w5oA:
undetectable		 3ou6B-2w5oA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2w5o ALPHA-L-ARABINOFURAN
OSIDASE
(Fusarium
graminearum) 		3 / 3 LEU A 359
PRO A 360
ARG A 223
 None
None
AHR  A 500 (-3.9A)
 0.62A 4klrB-2w5oA:
undetectable		 4klrB-2w5oA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_A_QDNA602_1
(CYTOCHROME P450 2D6)		 2w5o ALPHA-L-ARABINOFURAN
OSIDASE
(Fusarium
graminearum) 		5 / 11 LEU A 130
GLY A  97
LEU A  98
SER A 124
PHE A  71
 None
 1.06A 4wnuA-2w5oA:
undetectable		 4wnuA-2w5oA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_C_QDNC602_1
(CYTOCHROME P450 2D6)		 2w5o ALPHA-L-ARABINOFURAN
OSIDASE
(Fusarium
graminearum) 		5 / 11 LEU A 130
GLY A  97
LEU A  98
SER A 124
PHE A  71
 None
 1.19A 4wnuC-2w5oA:
undetectable		 4wnuC-2w5oA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		 2w5o ALPHA-L-ARABINOFURAN
OSIDASE
(Fusarium
graminearum) 		4 / 6 THR A 133
LEU A 130
ASP A 129
LEU A 160
 None
 1.04A 4wozA-2w5oA:
undetectable
4wozB-2w5oA:
undetectable		 4wozA-2w5oA:
21.90
4wozB-2w5oA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		 2w5o ALPHA-L-ARABINOFURAN
OSIDASE
(Fusarium
graminearum) 		4 / 5 LEU A 130
ASP A 129
LEU A 160
THR A 133
 None
 1.03A 4wozF-2w5oA:
undetectable
4wozH-2w5oA:
undetectable		 4wozF-2w5oA:
21.90
4wozH-2w5oA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_G_SAMG601_0
(NS5
METHYLTRANSFERASE)		 2w5o ALPHA-L-ARABINOFURAN
OSIDASE
(Fusarium
graminearum) 		5 / 12 GLY A 246
GLY A 244
TRP A 256
VAL A 306
ILE A 278
 None
 1.04A 5wz1G-2w5oA:
undetectable		 5wz1G-2w5oA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_H_SAMH601_0
(NS5
METHYLTRANSFERASE)		 2w5o ALPHA-L-ARABINOFURAN
OSIDASE
(Fusarium
graminearum) 		5 / 12 GLY A 246
GLY A 244
TRP A 256
VAL A 306
ILE A 278
 None
 1.01A 5wz1H-2w5oA:
undetectable		 5wz1H-2w5oA:
22.04