SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2w5s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7W_A_MTXA301_1
(PTERIDINE REDUCTASE)		 2w5s PROCESSED GLYCEROL
PHOSPHATE
LIPOTEICHOIC ACID
SYNTHASE
(Staphylococcus
aureus) 		5 / 12 ARG A 563
PHE A 547
LEU A 545
LEU A 613
ASP A 610
 None
 1.32A 1e7wA-2w5sA:
undetectable		 1e7wA-2w5sA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA471_1
(CYTOCHROME P450 51)		 2w5s PROCESSED GLYCEROL
PHOSPHATE
LIPOTEICHOIC ACID
SYNTHASE
(Staphylococcus
aureus) 		4 / 8 TYR A 477
PHE A 500
PHE A 260
HIS A 483
 None
 1.04A 1x8vA-2w5sA:
undetectable		 1x8vA-2w5sA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		 2w5s PROCESSED GLYCEROL
PHOSPHATE
LIPOTEICHOIC ACID
SYNTHASE
(Staphylococcus
aureus) 		4 / 6 TYR A 621
GLY A 548
PHE A 547
SER A 310
 None
 1.13A 2a3cA-2w5sA:
undetectable		 2a3cA-2w5sA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 2w5s PROCESSED GLYCEROL
PHOSPHATE
LIPOTEICHOIC ACID
SYNTHASE
(Staphylococcus
aureus) 		5 / 12 SER A 395
GLY A 348
VAL A 381
ALA A 371
TYR A 350
 None
 1.19A 2avdB-2w5sA:
undetectable		 2avdB-2w5sA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		 2w5s PROCESSED GLYCEROL
PHOSPHATE
LIPOTEICHOIC ACID
SYNTHASE
(Staphylococcus
aureus) 		5 / 12 PHE A 285
LEU A 452
LEU A 410
ILE A 252
ILE A 470
 None
 0.89A 2bdmA-2w5sA:
undetectable		 2bdmA-2w5sA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_B_SAMB1500_0
(ASPARTOKINASE)		 2w5s PROCESSED GLYCEROL
PHOSPHATE
LIPOTEICHOIC ACID
SYNTHASE
(Staphylococcus
aureus) 		4 / 7 SER A 408
ASP A 344
ARG A 356
GLU A 304
 None
None
GP9  A1644 (-3.0A)
None
 0.96A 2cdqB-2w5sA:
undetectable		 2cdqB-2w5sA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1357_1
(PROSTAGLANDIN
REDUCTASE 2)		 2w5s PROCESSED GLYCEROL
PHOSPHATE
LIPOTEICHOIC ACID
SYNTHASE
(Staphylococcus
aureus) 		4 / 6 TYR A 417
LEU A 384
ASN A 383
ASP A 422
 None
 1.43A 2w98A-2w5sA:
undetectable
2w98B-2w5sA:
undetectable		 2w98A-2w5sA:
20.22
2w98B-2w5sA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2w5s PROCESSED GLYCEROL
PHOSPHATE
LIPOTEICHOIC ACID
SYNTHASE
(Staphylococcus
aureus) 		4 / 6 ILE A 252
ILE A 365
TYR A 360
LEU A 254
 None
 1.17A 3adsA-2w5sA:
undetectable		 3adsA-2w5sA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_1
(O-METHYLTRANSFERASE)		 2w5s PROCESSED GLYCEROL
PHOSPHATE
LIPOTEICHOIC ACID
SYNTHASE
(Staphylococcus
aureus) 		3 / 3 ASP A 302
PHE A 305
SER A 321
 None
 0.92A 3i5uB-2w5sA:
undetectable		 3i5uB-2w5sA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA278_0
(UNIVERSAL STRESS
PROTEIN)		 2w5s PROCESSED GLYCEROL
PHOSPHATE
LIPOTEICHOIC ACID
SYNTHASE
(Staphylococcus
aureus) 		3 / 3 SER A 301
GLY A 298
SER A 321
 None
 0.62A 3loqA-2w5sA:
undetectable		 3loqA-2w5sA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_1
(CARBONIC ANHYDRASE)		 2w5s PROCESSED GLYCEROL
PHOSPHATE
LIPOTEICHOIC ACID
SYNTHASE
(Staphylococcus
aureus) 		3 / 3 GLN A 258
PHE A 260
TYR A 441
 None
 1.02A 3ucjA-2w5sA:
undetectable		 3ucjA-2w5sA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 2w5s PROCESSED GLYCEROL
PHOSPHATE
LIPOTEICHOIC ACID
SYNTHASE
(Staphylococcus
aureus) 		4 / 6 HIS A 253
HIS A 476
SER A 256
ASP A 425
 None
MN  A1642 ( 3.4A)
MN  A1642 ( 4.6A)
None
 1.15A 4blvA-2w5sA:
3.2		 4blvA-2w5sA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CCQ_A_ACTA1317_0
(THIOREDOXIN
REDUCTASE)		 2w5s PROCESSED GLYCEROL
PHOSPHATE
LIPOTEICHOIC ACID
SYNTHASE
(Staphylococcus
aureus) 		3 / 3 LEU A 606
GLU A 607
SER A 609
 None
 0.71A 4ccqA-2w5sA:
undetectable		 4ccqA-2w5sA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2w5s PROCESSED GLYCEROL
PHOSPHATE
LIPOTEICHOIC ACID
SYNTHASE
(Staphylococcus
aureus) 		4 / 8 TYR A 455
ILE A 252
LEU A 448
TYR A 441
 None
 0.89A 4iqqD-2w5sA:
undetectable		 4iqqD-2w5sA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_A_ASCA303_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 2w5s PROCESSED GLYCEROL
PHOSPHATE
LIPOTEICHOIC ACID
SYNTHASE
(Staphylococcus
aureus) 		4 / 7 HIS A 409
ILE A 411
TYR A 360
ARG A 356
 None
None
None
GP9  A1644 (-3.0A)
 1.31A 4o7gA-2w5sA:
undetectable
4o7gB-2w5sA:
undetectable		 4o7gA-2w5sA:
18.78
4o7gB-2w5sA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ1_B_AB1B201_0
(HIV-1 PROTEASE)		 2w5s PROCESSED GLYCEROL
PHOSPHATE
LIPOTEICHOIC ACID
SYNTHASE
(Staphylococcus
aureus) 		5 / 12 VAL A 469
GLY A 242
GLY A 538
ILE A 539
ILE A 249
 None
ACT  A1643 ( 3.8A)
ACT  A1643 ( 4.4A)
None
None
 0.75A 6dj1A-2w5sA:
undetectable		 6dj1A-2w5sA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 2w5s PROCESSED GLYCEROL
PHOSPHATE
LIPOTEICHOIC ACID
SYNTHASE
(Staphylococcus
aureus) 		5 / 12 LEU A 314
SER A 301
PHE A 363
ASN A 309
VAL A 359
 None
 1.41A 6drxA-2w5sA:
undetectable		 6drxA-2w5sA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_0
(ADENOSYLHOMOCYSTEINA
SE)		 2w5s PROCESSED GLYCEROL
PHOSPHATE
LIPOTEICHOIC ACID
SYNTHASE
(Staphylococcus
aureus) 		5 / 12 HIS A 416
THR A 420
ASP A 388
LEU A 384
GLY A 385
 GP9  A1644 (-4.0A)
None
None
None
None
 1.48A 6exiA-2w5sA:
undetectable		 6exiA-2w5sA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNA_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 2w5s PROCESSED GLYCEROL
PHOSPHATE
LIPOTEICHOIC ACID
SYNTHASE
(Staphylococcus
aureus) 		3 / 3 ARG A 619
LYS A 323
TYR A 328
 None
 0.94A 6gnaA-2w5sA:
undetectable		 6gnaA-2w5sA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNB_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 2w5s PROCESSED GLYCEROL
PHOSPHATE
LIPOTEICHOIC ACID
SYNTHASE
(Staphylococcus
aureus) 		3 / 3 ARG A 619
LYS A 323
TYR A 328
 None
 0.94A 6gnbA-2w5sA:
undetectable		 6gnbA-2w5sA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_2
(-)		 2w5s PROCESSED GLYCEROL
PHOSPHATE
LIPOTEICHOIC ACID
SYNTHASE
(Staphylococcus
aureus) 		4 / 6 TYR A 477
HIS A 416
ASN A 415
TYR A 441
 None
GP9  A1644 (-4.0A)
None
None
 1.37A 6gneA-2w5sA:
2.1		 6gneA-2w5sA:
21.78