SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2w5z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTX_A_CVIA200_0
(HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR IN QACA
5'REGION)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 ILE A3863
GLU A3857
ILE A3856
ALA A3902
ASN A3900
 None
 1.28A 1jtxA-2w5zA:
undetectable		 1jtxA-2w5zA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTX_A_CVIA200_0
(HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR IN QACA
5'REGION)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 ILE A3887
GLU A3857
ILE A3856
ALA A3902
ASN A3900
 None
 1.26A 1jtxA-2w5zA:
undetectable		 1jtxA-2w5zA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N6C_A_SAMA402_0
(SET
DOMAIN-CONTAINING
PROTEIN 7)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 11 ILE A3838
GLY A3840
ASN A3906
HIS A3907
TYR A3944
 SAH  A4971 (-4.3A)
SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
 0.48A 1n6cA-2w5zA:
11.3		 1n6cA-2w5zA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R3A_A_SAMA304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		6 / 12 GLY A3840
HIS A3907
TYR A3944
CYH A3957
CYH A3959
LEU A3968
 SAH  A4971 ( 3.7A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 ( 2.3A)
ZN  A4970 (-2.3A)
SAH  A4971 ( 4.9A)
 0.44A 2r3aA-2w5zA:
12.9		 2r3aA-2w5zA:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R3A_A_SAMA304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3840
TYR A3883
HIS A3907
CYH A3957
CYH A3959
 SAH  A4971 ( 3.7A)
None
SAH  A4971 (-4.7A)
ZN  A4970 ( 2.3A)
ZN  A4970 (-2.3A)
 0.70A 2r3aA-2w5zA:
12.9		 2r3aA-2w5zA:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_SALB900_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		4 / 5 LEU A3940
TYR A3942
ILE A3928
ALA A3902
 None
 0.99A 3n8yB-2w5zA:
undetectable		 3n8yB-2w5zA:
17.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OOI_A_SAMA237_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		7 / 12 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3957
CYH A3959
LEU A3968
 SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 ( 2.3A)
ZN  A4970 (-2.3A)
SAH  A4971 ( 4.9A)
 0.51A 3ooiA-2w5zA:
14.2		 3ooiA-2w5zA:
30.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OOI_A_SAMA237_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		6 / 12 GLY A3840
TYR A3883
ASN A3906
HIS A3907
TYR A3944
CYH A3959
 SAH  A4971 ( 3.7A)
None
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 (-2.3A)
 0.63A 3ooiA-2w5zA:
14.2		 3ooiA-2w5zA:
30.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OOI_A_SAMA237_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3840
TYR A3883
HIS A3907
TYR A3944
CYH A3957
 SAH  A4971 ( 3.7A)
None
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 ( 2.3A)
 1.44A 3ooiA-2w5zA:
14.2		 3ooiA-2w5zA:
30.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OOI_A_SAMA237_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3842
TYR A3883
HIS A3907
TYR A3944
CYH A3959
 None
None
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 (-2.3A)
 1.32A 3ooiA-2w5zA:
14.2		 3ooiA-2w5zA:
30.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OPE_A_SAMA7_0
(PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 ( 2.3A)
 0.35A 3opeA-2w5zA:
14.6		 3opeA-2w5zA:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OPE_A_SAMA7_0
(PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3959
 SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 (-2.3A)
 1.20A 3opeA-2w5zA:
14.6		 3opeA-2w5zA:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OPE_A_SAMA7_0
(PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3840
TYR A3883
ASN A3906
HIS A3907
TYR A3944
 SAH  A4971 ( 3.7A)
None
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
 0.68A 3opeA-2w5zA:
14.6		 3opeA-2w5zA:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQ4_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H2)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 ASN A3906
HIS A3907
TYR A3944
CYH A3957
CYH A3959
 SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 ( 2.3A)
ZN  A4970 (-2.3A)
 0.40A 3rq4A-2w5zA:
9.4		 3rq4A-2w5zA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 ASN A3906
HIS A3907
TYR A3944
CYH A3957
CYH A3959
 SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 ( 2.3A)
ZN  A4970 (-2.3A)
 0.44A 3s8pA-2w5zA:
7.9		 3s8pA-2w5zA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQT_C_C5EC301_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		4 / 8 VAL A3927
TYR A3942
CYH A3913
ILE A3856
 None
 1.33A 4bqtC-2w5zA:
undetectable
4bqtD-2w5zA:
undetectable		 4bqtC-2w5zA:
20.17
4bqtD-2w5zA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 ASN A3906
HIS A3907
TYR A3944
CYH A3957
CYH A3959
 SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 ( 2.3A)
ZN  A4970 (-2.3A)
 0.44A 4bupA-2w5zA:
8.4		 4bupA-2w5zA:
25.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 11 ILE A3838
GLY A3840
ASN A3906
HIS A3907
TYR A3944
 SAH  A4971 (-4.3A)
SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
 0.40A 4e47A-2w5zA:
11.8		 4e47A-2w5zA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_B_SAMB800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 11 ILE A3838
GLY A3840
ASN A3906
HIS A3907
TYR A3944
 SAH  A4971 (-4.3A)
SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
 0.39A 4e47B-2w5zA:
10.2		 4e47B-2w5zA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_C_SAMC800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 11 ILE A3838
GLY A3840
ASN A3906
HIS A3907
TYR A3944
 SAH  A4971 (-4.3A)
SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
 0.46A 4e47C-2w5zA:
11.5		 4e47C-2w5zA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 11 ILE A3838
GLY A3840
ASN A3906
HIS A3907
TYR A3944
 SAH  A4971 (-4.3A)
SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
 0.39A 4jdsA-2w5zA:
11.6		 4jdsA-2w5zA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 11 ILE A3838
GLY A3840
ASN A3906
HIS A3907
TYR A3944
 SAH  A4971 (-4.3A)
SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
 0.39A 4jdsB-2w5zA:
11.7		 4jdsB-2w5zA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_C_SAMC401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 11 ILE A3838
GLY A3840
ASN A3906
HIS A3907
TYR A3944
 SAH  A4971 (-4.3A)
SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
 0.44A 4jdsC-2w5zA:
11.6		 4jdsC-2w5zA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 ILE A3838
GLY A3840
ASN A3906
HIS A3907
TYR A3944
 SAH  A4971 (-4.3A)
SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
 0.44A 4jlgA-2w5zA:
11.6		 4jlgA-2w5zA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 ALA A3902
ILE A3887
GLY A3860
ALA A3859
ILE A3928
 None
 0.86A 4nkxB-2w5zA:
undetectable		 4nkxB-2w5zA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKN_B_KANB403_1
(L-LACTATE
DEHYDROGENASE A
CHAIN)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 9 VAL A3831
ALA A3902
ARG A3841
ILE A3905
ILE A3928
 None
 1.23A 4oknB-2w5zA:
undetectable		 4oknB-2w5zA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNM_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 ( 2.3A)
 0.24A 4ynmA-2w5zA:
14.7		 4ynmA-2w5zA:
27.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNM_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 ( 2.3A)
 0.22A 4ynmB-2w5zA:
14.9		 4ynmB-2w5zA:
27.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNM_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3840
TYR A3883
ASN A3906
HIS A3907
TYR A3944
 SAH  A4971 ( 3.7A)
None
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
 0.65A 4ynmB-2w5zA:
14.9		 4ynmB-2w5zA:
27.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3840
TYR A3883
HIS A3907
TYR A3944
CYH A3957
 SAH  A4971 ( 3.7A)
None
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 ( 2.3A)
 1.45A 4ynpA-2w5zA:
14.7		 4ynpA-2w5zA:
27.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		6 / 12 GLY A3840
TYR A3883
HIS A3907
TYR A3944
CYH A3957
CYH A3959
 SAH  A4971 ( 3.7A)
None
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 ( 2.3A)
ZN  A4970 (-2.3A)
 0.55A 4ynpA-2w5zA:
14.7		 4ynpA-2w5zA:
27.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3842
TYR A3883
HIS A3907
TYR A3944
CYH A3959
 None
None
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 (-2.3A)
 1.34A 4ynpA-2w5zA:
14.7		 4ynpA-2w5zA:
27.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 10 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 ( 2.3A)
 0.27A 4ynpB-2w5zA:
14.9		 4ynpB-2w5zA:
27.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 10 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3959
 SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 (-2.3A)
 1.16A 4ynpB-2w5zA:
14.9		 4ynpB-2w5zA:
27.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 10 GLY A3840
TYR A3883
ASN A3906
HIS A3907
TYR A3944
 SAH  A4971 ( 3.7A)
None
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
 0.74A 4ynpB-2w5zA:
14.9		 4ynpB-2w5zA:
27.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_A_SAMA3004_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 ( 2.3A)
 0.28A 4ypaA-2w5zA:
14.6		 4ypaA-2w5zA:
27.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_A_SAMA3004_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3959
 SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 (-2.3A)
 1.18A 4ypaA-2w5zA:
14.6		 4ypaA-2w5zA:
27.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_A_SAMA3004_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3840
TYR A3883
ASN A3906
HIS A3907
TYR A3944
 SAH  A4971 ( 3.7A)
None
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
 0.66A 4ypaA-2w5zA:
14.6		 4ypaA-2w5zA:
27.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 ( 2.3A)
 0.20A 4ypaB-2w5zA:
14.9		 4ypaB-2w5zA:
27.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_C_SAMC2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 ( 2.3A)
 0.26A 4ypaC-2w5zA:
14.3		 4ypaC-2w5zA:
27.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_C_SAMC2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3959
 SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 (-2.3A)
 1.16A 4ypaC-2w5zA:
14.3		 4ypaC-2w5zA:
27.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_D_SAMD2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3959
 SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 (-2.3A)
 1.17A 4ypaD-2w5zA:
14.6		 4ypaD-2w5zA:
27.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_D_SAMD2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		6 / 12 GLY A3840
TYR A3883
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4971 ( 3.7A)
None
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 ( 2.3A)
 0.56A 4ypaD-2w5zA:
14.6		 4ypaD-2w5zA:
27.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 ( 2.3A)
 0.27A 4ypeA-2w5zA:
14.6		 4ypeA-2w5zA:
27.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3959
 SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 (-2.3A)
 1.23A 4ypeA-2w5zA:
14.6		 4ypeA-2w5zA:
27.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPE_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 11 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 ( 2.3A)
 0.21A 4ypeB-2w5zA:
15.2		 4ypeB-2w5zA:
27.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPE_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 11 GLY A3840
TYR A3883
ASN A3906
HIS A3907
TYR A3944
 SAH  A4971 ( 3.7A)
None
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
 0.68A 4ypeB-2w5zA:
15.2		 4ypeB-2w5zA:
27.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPU_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 ( 2.3A)
 0.23A 4ypuA-2w5zA:
14.6		 4ypuA-2w5zA:
27.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPU_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3959
 SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 (-2.3A)
 1.18A 4ypuA-2w5zA:
14.6		 4ypuA-2w5zA:
27.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPU_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3840
TYR A3883
ASN A3906
HIS A3907
TYR A3944
 SAH  A4971 ( 3.7A)
None
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
 0.69A 4ypuA-2w5zA:
14.6		 4ypuA-2w5zA:
27.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPU_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 11 GLY A3840
TYR A3883
ASN A3906
HIS A3907
TYR A3944
 SAH  A4971 ( 3.7A)
None
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
 0.58A 4ypuB-2w5zA:
14.8		 4ypuB-2w5zA:
27.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 11 ILE A3838
GLY A3840
ASN A3906
HIS A3907
TYR A3944
 SAH  A4971 (-4.3A)
SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
 0.44A 5ayfA-2w5zA:
11.6		 5ayfA-2w5zA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 PHE A3904
HIS A3907
TYR A3944
CYH A3957
CYH A3959
 None
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 ( 2.3A)
ZN  A4970 (-2.3A)
 1.38A 5cprB-2w5zA:
7.4		 5cprB-2w5zA:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHN_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 ASN A3906
HIS A3907
TYR A3944
PHE A3946
CYH A3957
 SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
None
ZN  A4970 ( 2.3A)
 0.82A 5jhnA-2w5zA:
12.1		 5jhnA-2w5zA:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHN_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 ( 2.3A)
 0.25A 5jhnA-2w5zA:
12.1		 5jhnA-2w5zA:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHN_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3959
 SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 (-2.3A)
 1.23A 5jhnA-2w5zA:
12.1		 5jhnA-2w5zA:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHN_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3840
TYR A3883
ASN A3906
HIS A3907
TYR A3944
 SAH  A4971 ( 3.7A)
None
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
 0.62A 5jhnA-2w5zA:
12.1		 5jhnA-2w5zA:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHN_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 ASN A3906
HIS A3907
TYR A3944
PHE A3946
CYH A3957
 SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
None
ZN  A4970 ( 2.3A)
 0.78A 5jhnB-2w5zA:
12.1		 5jhnB-2w5zA:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHN_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 ( 2.3A)
 0.27A 5jhnB-2w5zA:
12.1		 5jhnB-2w5zA:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHN_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3959
 SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 (-2.3A)
 1.27A 5jhnB-2w5zA:
12.1		 5jhnB-2w5zA:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHN_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3840
TYR A3883
ASN A3906
HIS A3907
TYR A3944
 SAH  A4971 ( 3.7A)
None
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
 0.63A 5jhnB-2w5zA:
12.1		 5jhnB-2w5zA:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JIN_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 ASN A3906
HIS A3907
TYR A3944
PHE A3946
CYH A3957
 SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
None
ZN  A4970 ( 2.3A)
 0.75A 5jinB-2w5zA:
12.2		 5jinB-2w5zA:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JIY_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 ASN A3906
HIS A3907
TYR A3944
PHE A3946
CYH A3957
 SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
None
ZN  A4970 ( 2.3A)
 0.82A 5jiyA-2w5zA:
12.0		 5jiyA-2w5zA:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JIY_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 ( 2.3A)
 0.27A 5jiyA-2w5zA:
12.0		 5jiyA-2w5zA:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JIY_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3959
 SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 (-2.3A)
 1.25A 5jiyA-2w5zA:
12.0		 5jiyA-2w5zA:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JIY_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3840
TYR A3883
ASN A3906
HIS A3907
TYR A3944
 SAH  A4971 ( 3.7A)
None
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
 0.64A 5jiyA-2w5zA:
12.0		 5jiyA-2w5zA:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JIY_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 ASN A3906
HIS A3907
TYR A3944
PHE A3946
CYH A3957
 SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
None
ZN  A4970 ( 2.3A)
 0.78A 5jiyB-2w5zA:
12.1		 5jiyB-2w5zA:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JIY_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 ( 2.3A)
 0.28A 5jiyB-2w5zA:
12.1		 5jiyB-2w5zA:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JIY_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3959
 SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 (-2.3A)
 1.30A 5jiyB-2w5zA:
12.1		 5jiyB-2w5zA:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JIY_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3840
TYR A3883
ASN A3906
HIS A3907
TYR A3944
 SAH  A4971 ( 3.7A)
None
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
 0.63A 5jiyB-2w5zA:
12.1		 5jiyB-2w5zA:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JJ0_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 ASN A3906
HIS A3907
TYR A3944
PHE A3946
CYH A3957
 SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
None
ZN  A4970 ( 2.3A)
 0.76A 5jj0B-2w5zA:
12.2		 5jj0B-2w5zA:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JJ0_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 ( 2.3A)
 0.29A 5jj0B-2w5zA:
12.2		 5jj0B-2w5zA:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JJ0_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3959
 SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 (-2.3A)
 1.31A 5jj0B-2w5zA:
12.2		 5jj0B-2w5zA:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKL_B_SAMB8009_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN,HISTONE H3.1
PEPTIDE,ZINC FINGER
DOMAIN-CONTAINING
PROTEIN)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		6 / 12 GLY A3840
ASN A3906
HIS A3907
TYR A3944
PHE A3946
LEU A3968
 SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
None
SAH  A4971 ( 4.9A)
 1.28A 5kklB-2w5zA:
5.2		 5kklB-2w5zA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3840
HIS A3907
CYH A3957
CYH A3959
LEU A3968
 SAH  A4971 ( 3.7A)
SAH  A4971 (-4.7A)
ZN  A4970 ( 2.3A)
ZN  A4970 (-2.3A)
SAH  A4971 ( 4.9A)
 0.54A 5lsuA-2w5zA:
14.5		 5lsuA-2w5zA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		3 / 3 ASN A3906
TYR A3944
CYH A3957
 SAH  A4971 (-3.1A)
SAH  A4971 (-4.9A)
ZN  A4970 ( 2.3A)
 0.12A 5lsuB-2w5zA:
14.3		 5lsuB-2w5zA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGL_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		3 / 3 VAL A3893
VAL A3862
GLN A3923
 None
 0.70A 5qglA-2w5zA:
undetectable		 5qglA-2w5zA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0K_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 ASN A3906
HIS A3907
TYR A3944
PHE A3946
CYH A3957
 SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
None
ZN  A4970 ( 2.3A)
 0.81A 5t0kA-2w5zA:
12.2		 5t0kA-2w5zA:
27.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0K_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 ( 2.3A)
 0.23A 5t0kA-2w5zA:
12.2		 5t0kA-2w5zA:
27.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0K_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3840
TYR A3883
ASN A3906
HIS A3907
TYR A3944
 SAH  A4971 ( 3.7A)
None
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
 0.61A 5t0kA-2w5zA:
12.2		 5t0kA-2w5zA:
27.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0K_B_SAMB1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 ASN A3906
HIS A3907
TYR A3944
PHE A3946
CYH A3957
 SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
None
ZN  A4970 ( 2.3A)
 0.82A 5t0kB-2w5zA:
12.4		 5t0kB-2w5zA:
27.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0K_B_SAMB1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 ( 2.3A)
 0.23A 5t0kB-2w5zA:
12.4		 5t0kB-2w5zA:
27.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0M_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 ASN A3906
HIS A3907
TYR A3944
PHE A3946
CYH A3957
 SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
None
ZN  A4970 ( 2.3A)
 0.80A 5t0mA-2w5zA:
12.3		 5t0mA-2w5zA:
27.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0M_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 ASN A3906
HIS A3907
TYR A3944
PHE A3946
CYH A3957
 SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
None
ZN  A4970 ( 2.3A)
 0.81A 5t0mB-2w5zA:
12.0		 5t0mB-2w5zA:
27.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0M_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 ( 2.3A)
 0.28A 5t0mB-2w5zA:
12.0		 5t0mB-2w5zA:
27.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0M_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3959
 SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 (-2.3A)
 1.25A 5t0mB-2w5zA:
12.0		 5t0mB-2w5zA:
27.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TEG_B_SAMB401_0
(HISTONE H4 MUTANT
PEPTIDE WITH
H4K20NORLEUCINE
N-LYSINE
METHYLTRANSFERASE
KMT5A)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 10 GLY A3840
ARG A3841
TYR A3883
ASN A3906
HIS A3907
 SAH  A4971 ( 3.7A)
None
None
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
 0.86A 5tegB-2w5zA:
15.7
5tegE-2w5zA:
undetectable		 5tegB-2w5zA:
30.96
5tegE-2w5zA:
4.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TEG_B_SAMB401_0
(HISTONE H4 MUTANT
PEPTIDE WITH
H4K20NORLEUCINE
N-LYSINE
METHYLTRANSFERASE
KMT5A)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 10 GLY A3840
TYR A3883
ASN A3906
HIS A3907
TYR A3944
 SAH  A4971 ( 3.7A)
None
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
 0.69A 5tegB-2w5zA:
15.7
5tegE-2w5zA:
undetectable		 5tegB-2w5zA:
30.96
5tegE-2w5zA:
4.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TQR_B_SAMB8009_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2, POLYCOMB
PROTEIN SUZ12)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 10 GLY A3840
TYR A3883
ASN A3906
HIS A3907
TYR A3944
 SAH  A4971 ( 3.7A)
None
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
 0.54A 5tqrB-2w5zA:
9.5		 5tqrB-2w5zA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 11 ASN A3906
HIS A3907
TYR A3944
PHE A3946
CYH A3957
 SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
None
ZN  A4970 ( 2.3A)
 0.83A 5ttfA-2w5zA:
12.0		 5ttfA-2w5zA:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 11 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 ( 2.3A)
 0.19A 5ttfA-2w5zA:
12.0		 5ttfA-2w5zA:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 11 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3959
 SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 (-2.3A)
 1.26A 5ttfA-2w5zA:
12.0		 5ttfA-2w5zA:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 ASN A3906
HIS A3907
TYR A3944
PHE A3946
CYH A3957
 SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
None
ZN  A4970 ( 2.3A)
 0.81A 5ttfB-2w5zA:
12.1		 5ttfB-2w5zA:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 ( 2.3A)
 0.14A 5ttfB-2w5zA:
12.1		 5ttfB-2w5zA:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3959
 SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 (-2.3A)
 1.24A 5ttfB-2w5zA:
12.1		 5ttfB-2w5zA:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_C_SAMC1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		6 / 12 GLY A3840
ASN A3906
HIS A3907
TYR A3944
PHE A3946
CYH A3957
 SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
None
ZN  A4970 ( 2.3A)
 0.83A 5ttfC-2w5zA:
11.9		 5ttfC-2w5zA:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_D_SAMD1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 11 ASN A3906
HIS A3907
TYR A3944
PHE A3946
CYH A3957
 SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
None
ZN  A4970 ( 2.3A)
 0.82A 5ttfD-2w5zA:
12.0		 5ttfD-2w5zA:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_D_SAMD1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 11 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 ( 2.3A)
 0.25A 5ttfD-2w5zA:
12.0		 5ttfD-2w5zA:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_D_SAMD1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 11 GLY A3840
TYR A3883
ASN A3906
HIS A3907
CYH A3957
 SAH  A4971 ( 3.7A)
None
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
ZN  A4970 ( 2.3A)
 0.76A 5ttfD-2w5zA:
12.0		 5ttfD-2w5zA:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTG_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 ASN A3906
HIS A3907
TYR A3944
PHE A3946
CYH A3957
 SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
None
ZN  A4970 ( 2.3A)
 0.87A 5ttgA-2w5zA:
12.2		 5ttgA-2w5zA:
27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTG_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 ( 2.3A)
 0.20A 5ttgA-2w5zA:
12.2		 5ttgA-2w5zA:
27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTG_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3840
TYR A3883
ASN A3906
HIS A3907
CYH A3957
 SAH  A4971 ( 3.7A)
None
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
ZN  A4970 ( 2.3A)
 0.69A 5ttgA-2w5zA:
12.2		 5ttgA-2w5zA:
27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTG_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 11 ASN A3906
HIS A3907
TYR A3944
PHE A3946
CYH A3957
 SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
None
ZN  A4970 ( 2.3A)
 0.86A 5ttgB-2w5zA:
12.2		 5ttgB-2w5zA:
27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTG_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 11 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 ( 2.3A)
 0.21A 5ttgB-2w5zA:
12.2		 5ttgB-2w5zA:
27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUY_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 ASN A3906
HIS A3907
TYR A3944
PHE A3946
CYH A3957
 SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
None
ZN  A4970 ( 2.3A)
 0.87A 5tuyA-2w5zA:
12.1		 5tuyA-2w5zA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUY_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		6 / 12 GLY A3840
TYR A3883
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4971 ( 3.7A)
None
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 ( 2.3A)
 0.64A 5tuyA-2w5zA:
12.1		 5tuyA-2w5zA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUY_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3842
TYR A3883
HIS A3907
TYR A3944
CYH A3957
 None
None
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 ( 2.3A)
 1.37A 5tuyA-2w5zA:
12.1		 5tuyA-2w5zA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUY_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 ASN A3906
HIS A3907
TYR A3944
PHE A3946
CYH A3957
 SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
None
ZN  A4970 ( 2.3A)
 0.81A 5tuyB-2w5zA:
12.1		 5tuyB-2w5zA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUY_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 ( 2.3A)
 0.23A 5tuyB-2w5zA:
12.1		 5tuyB-2w5zA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUY_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3840
TYR A3883
ASN A3906
HIS A3907
TYR A3944
 SAH  A4971 ( 3.7A)
None
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
 0.59A 5tuyB-2w5zA:
12.1		 5tuyB-2w5zA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUZ_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		6 / 12 ASN A3906
HIS A3907
TYR A3944
PHE A3946
CYH A3957
CYH A3959
 SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
None
ZN  A4970 ( 2.3A)
ZN  A4970 (-2.3A)
 0.80A 5tuzA-2w5zA:
12.2		 5tuzA-2w5zA:
29.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUZ_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		6 / 12 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3957
CYH A3959
 SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 ( 2.3A)
ZN  A4970 (-2.3A)
 0.21A 5tuzA-2w5zA:
12.2		 5tuzA-2w5zA:
29.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUZ_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3842
HIS A3907
TYR A3944
CYH A3957
CYH A3959
 None
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 ( 2.3A)
ZN  A4970 (-2.3A)
 1.08A 5tuzA-2w5zA:
12.2		 5tuzA-2w5zA:
29.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUZ_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 ASN A3906
HIS A3907
TYR A3944
PHE A3946
CYH A3957
 SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
None
ZN  A4970 ( 2.3A)
 0.86A 5tuzB-2w5zA:
12.2		 5tuzB-2w5zA:
29.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUZ_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 ( 2.3A)
 0.20A 5tuzB-2w5zA:
12.2		 5tuzB-2w5zA:
29.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUZ_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3840
TYR A3883
ASN A3906
HIS A3907
CYH A3957
 SAH  A4971 ( 3.7A)
None
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
ZN  A4970 ( 2.3A)
 0.67A 5tuzB-2w5zA:
12.2		 5tuzB-2w5zA:
29.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UPD_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		7 / 11 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3957
CYH A3959
LEU A3968
 SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 ( 2.3A)
ZN  A4970 (-2.3A)
SAH  A4971 ( 4.9A)
 0.53A 5updA-2w5zA:
14.4		 5updA-2w5zA:
26.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UPD_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 11 GLY A3840
TYR A3883
ASN A3906
HIS A3907
CYH A3959
 SAH  A4971 ( 3.7A)
None
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
ZN  A4970 (-2.3A)
 0.67A 5updA-2w5zA:
14.4		 5updA-2w5zA:
26.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V21_A_SAMA1804_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		6 / 12 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3957
LEU A3968
 SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 ( 2.3A)
SAH  A4971 ( 4.9A)
 0.41A 5v21A-2w5zA:
14.4		 5v21A-2w5zA:
27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V21_A_SAMA1804_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3959
 SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 (-2.3A)
 1.19A 5v21A-2w5zA:
14.4		 5v21A-2w5zA:
27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V21_A_SAMA1804_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		6 / 12 GLY A3840
TYR A3883
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4971 ( 3.7A)
None
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 ( 2.3A)
 0.64A 5v21A-2w5zA:
14.4		 5v21A-2w5zA:
27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 ( 2.3A)
 0.13A 5v9iA-2w5zA:
11.9		 5v9iA-2w5zA:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3959
 SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 (-2.3A)
 1.22A 5v9iA-2w5zA:
11.9		 5v9iA-2w5zA:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 11 ASN A3906
HIS A3907
TYR A3944
PHE A3946
CYH A3957
 SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
None
ZN  A4970 ( 2.3A)
 0.83A 5v9iB-2w5zA:
12.0		 5v9iB-2w5zA:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 11 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 ( 2.3A)
 0.11A 5v9iB-2w5zA:
12.0		 5v9iB-2w5zA:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_C_SAMC1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 11 ASN A3906
HIS A3907
TYR A3944
PHE A3946
CYH A3957
 SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
None
ZN  A4970 ( 2.3A)
 0.85A 5v9iC-2w5zA:
11.9		 5v9iC-2w5zA:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_C_SAMC1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 11 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 ( 2.3A)
 0.22A 5v9iC-2w5zA:
11.9		 5v9iC-2w5zA:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_C_SAMC1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 11 GLY A3840
TYR A3883
ASN A3906
HIS A3907
CYH A3957
 SAH  A4971 ( 3.7A)
None
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
ZN  A4970 ( 2.3A)
 0.72A 5v9iC-2w5zA:
11.9		 5v9iC-2w5zA:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9J_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 ( 2.3A)
 0.19A 5v9jA-2w5zA:
12.2		 5v9jA-2w5zA:
27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9J_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3840
TYR A3883
ASN A3906
HIS A3907
CYH A3957
 SAH  A4971 ( 3.7A)
None
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
ZN  A4970 ( 2.3A)
 0.67A 5v9jA-2w5zA:
12.2		 5v9jA-2w5zA:
27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9J_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 ( 2.3A)
 0.22A 5v9jB-2w5zA:
12.2		 5v9jB-2w5zA:
27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSC_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 ( 2.3A)
 0.23A 5vscA-2w5zA:
12.2		 5vscA-2w5zA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSC_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3959
 SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 (-2.3A)
 1.23A 5vscA-2w5zA:
12.2		 5vscA-2w5zA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSC_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 ( 2.3A)
 0.22A 5vscB-2w5zA:
12.0		 5vscB-2w5zA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSC_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3959
 SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 (-2.3A)
 1.21A 5vscB-2w5zA:
12.0		 5vscB-2w5zA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSD_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 ASN A3906
HIS A3907
TYR A3944
PHE A3946
CYH A3957
 SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
None
ZN  A4970 ( 2.3A)
 0.89A 5vsdA-2w5zA:
12.2		 5vsdA-2w5zA:
29.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSD_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 ( 2.3A)
 0.18A 5vsdA-2w5zA:
12.2		 5vsdA-2w5zA:
29.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSD_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 ( 2.3A)
 0.20A 5vsdB-2w5zA:
12.2		 5vsdB-2w5zA:
29.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSD_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3840
TYR A3883
ASN A3906
HIS A3907
CYH A3957
 SAH  A4971 ( 3.7A)
None
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
ZN  A4970 ( 2.3A)
 0.73A 5vsdB-2w5zA:
12.2		 5vsdB-2w5zA:
29.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSE_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 ( 2.3A)
 0.23A 5vseA-2w5zA:
12.2		 5vseA-2w5zA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSE_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3959
 SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 (-2.3A)
 1.23A 5vseA-2w5zA:
12.2		 5vseA-2w5zA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSE_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 ( 2.3A)
 0.24A 5vseB-2w5zA:
12.0		 5vseB-2w5zA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSE_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3959
 SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 (-2.3A)
 1.23A 5vseB-2w5zA:
12.0		 5vseB-2w5zA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSF_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 ( 2.3A)
 0.19A 5vsfA-2w5zA:
12.2		 5vsfA-2w5zA:
29.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSF_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3957
 SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 ( 2.3A)
 0.17A 5vsfB-2w5zA:
12.2		 5vsfB-2w5zA:
29.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSF_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3840
TYR A3883
ASN A3906
HIS A3907
CYH A3957
 SAH  A4971 ( 3.7A)
None
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
ZN  A4970 ( 2.3A)
 0.66A 5vsfB-2w5zA:
12.2		 5vsfB-2w5zA:
29.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5K_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		7 / 12 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3957
CYH A3959
LEU A3968
 SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 ( 2.3A)
ZN  A4970 (-2.3A)
SAH  A4971 ( 4.9A)
 0.48A 6a5kA-2w5zA:
12.3		 6a5kA-2w5zA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5K_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3842
HIS A3907
TYR A3944
CYH A3957
CYH A3959
 None
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 ( 2.3A)
ZN  A4970 (-2.3A)
 1.14A 6a5kA-2w5zA:
12.3		 6a5kA-2w5zA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5M_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		8 / 12 GLY A3840
TYR A3883
ASN A3906
HIS A3907
TYR A3944
CYH A3957
CYH A3959
LEU A3968
 SAH  A4971 ( 3.7A)
None
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 ( 2.3A)
ZN  A4970 (-2.3A)
SAH  A4971 ( 4.9A)
 0.54A 6a5mA-2w5zA:
12.4		 6a5mA-2w5zA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5M_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3840
TYR A3883
HIS A3907
TYR A3944
CYH A3957
 SAH  A4971 ( 3.7A)
None
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 ( 2.3A)
 1.45A 6a5mA-2w5zA:
12.4		 6a5mA-2w5zA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5M_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		6 / 12 GLY A3842
TYR A3883
HIS A3907
TYR A3944
CYH A3957
CYH A3959
 None
None
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 ( 2.3A)
ZN  A4970 (-2.3A)
 1.38A 6a5mA-2w5zA:
12.4		 6a5mA-2w5zA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AGO_A_SAMA2301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		7 / 11 GLY A3840
TYR A3883
ASN A3906
HIS A3907
TYR A3944
CYH A3957
CYH A3959
 SAH  A4971 ( 3.7A)
None
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 ( 2.3A)
ZN  A4970 (-2.3A)
 1.02A 6agoA-2w5zA:
14.2		 6agoA-2w5zA:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AGO_A_SAMA2301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 11 GLY A3842
TYR A3883
HIS A3907
TYR A3944
CYH A3959
 None
None
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 (-2.3A)
 1.36A 6agoA-2w5zA:
14.2		 6agoA-2w5zA:
25.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BP4_A_SAMA505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3840
HIS A3907
TYR A3944
CYH A3959
LEU A3968
 SAH  A4971 ( 3.7A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 (-2.3A)
SAH  A4971 ( 4.9A)
 0.66A 6bp4A-2w5zA:
11.5		 6bp4A-2w5zA:
30.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BP4_A_SAMA505_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		3 / 3 ILE A3838
ASN A3912
CYH A3845
 SAH  A4971 (-4.3A)
None
None
 0.92A 6bp4A-2w5zA:
11.5		 6bp4A-2w5zA:
30.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BP4_B_SAMB505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		6 / 12 GLY A3840
TYR A3883
HIS A3907
TYR A3944
CYH A3957
CYH A3959
 SAH  A4971 ( 3.7A)
None
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 ( 2.3A)
ZN  A4970 (-2.3A)
 0.67A 6bp4B-2w5zA:
12.0		 6bp4B-2w5zA:
30.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BP4_B_SAMB505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 GLY A3842
TYR A3883
HIS A3907
TYR A3944
CYH A3959
 None
None
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 (-2.3A)
 1.35A 6bp4B-2w5zA:
12.0		 6bp4B-2w5zA:
30.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BP4_B_SAMB505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 12 HIS A3907
TYR A3944
CYH A3957
CYH A3959
LEU A3968
 SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 ( 2.3A)
ZN  A4970 (-2.3A)
SAH  A4971 ( 4.9A)
 0.40A 6bp4B-2w5zA:
12.0		 6bp4B-2w5zA:
30.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CEN_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		7 / 11 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3957
CYH A3959
LEU A3968
 SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 ( 2.3A)
ZN  A4970 (-2.3A)
SAH  A4971 ( 4.9A)
 0.53A 6cenA-2w5zA:
14.5		 6cenA-2w5zA:
26.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CEN_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		5 / 11 GLY A3840
TYR A3883
ASN A3906
HIS A3907
CYH A3959
 SAH  A4971 ( 3.7A)
None
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
ZN  A4970 (-2.3A)
 0.69A 6cenA-2w5zA:
14.5		 6cenA-2w5zA:
26.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CHG_C_SAMC1101_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-4 SPECIFIC)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		7 / 12 ILE A3838
HIS A3839
TYR A3883
PHE A3904
ASN A3906
HIS A3907
LEU A3968
 SAH  A4971 (-4.3A)
SAH  A4971 (-3.5A)
None
None
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 ( 4.9A)
 0.91A 6chgC-2w5zA:
13.9		 6chgC-2w5zA:
42.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6INE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX
(Homo
sapiens) 		6 / 12 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3957
CYH A3959
 SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 ( 2.3A)
ZN  A4970 (-2.3A)
 0.25A 6ineA-2w5zA:
13.5		 6ineA-2w5zA:
26.42