SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2w68'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_ACTA421_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 2w68 SIALIDASE
(Vibrio
cholerae) 		5 / 8 GLY A  70
GLY A 202
GLY A 106
MET A 107
SER A 197
 None
None
None
SIA  A1217 ( 4.7A)
SIA  A1217 (-3.7A)
 1.15A 1qzzA-2w68A:
undetectable		 1qzzA-2w68A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)		 2w68 SIALIDASE
(Vibrio
cholerae) 		4 / 8 PHE A 170
TYR A 206
LEU A 131
LEU A 144
 None
 0.90A 2w98B-2w68A:
undetectable		 2w98B-2w68A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_2
(BETA-1 ADRENERGIC
RECEPTOR)		 2w68 SIALIDASE
(Vibrio
cholerae) 		3 / 3 VAL A 102
ASN A 110
TRP A 193
 None
 1.10A 2y00B-2w68A:
undetectable		 2y00B-2w68A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_A_LURA201_1
(TRANSTHYRETIN)		 2w68 SIALIDASE
(Vibrio
cholerae) 		3 / 3 LYS A 101
LEU A 103
ALA A 205
 None
 0.68A 4iizA-2w68A:
undetectable		 4iizA-2w68A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 2w68 SIALIDASE
(Vibrio
cholerae) 		5 / 12 ALA A 204
GLY A 202
LEU A 103
LEU A 125
GLY A 106
 None
 0.92A 4o33A-2w68A:
undetectable		 4o33A-2w68A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 2w68 SIALIDASE
(Vibrio
cholerae) 		5 / 12 ALA A  75
GLY A 202
GLY A  70
GLY A  72
ALA A 204
 None
 0.95A 5c0oG-2w68A:
undetectable		 5c0oG-2w68A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_2
(CYTOCHROME P450 3A5)		 2w68 SIALIDASE
(Vibrio
cholerae) 		3 / 3 ARG A 207
PHE A  37
LEU A  57
 None
 0.55A 5veuA-2w68A:
undetectable		 5veuA-2w68A:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w68 SIALIDASE
(Vibrio
cholerae) 		3 / 3 GLN A  47
TRP A  77
VAL A  68
 None
 0.98A 6auuA-2w68A:
undetectable		 6auuA-2w68A:
18.36