SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2w6l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		 2w6l COBE
(Pseudomonas
aeruginosa) 		3 / 3 ASP A 125
LEU A  24
LEU A  27
 None
 0.74A 1ikeA-2w6lA:
undetectable		 1ikeA-2w6lA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZQ_A_PCFA954_0
(CATECHOL
1,2-DIOXYGENASE)		 2w6l COBE
(Pseudomonas
aeruginosa) 		5 / 9 THR A  31
LEU A  32
ALA A 104
GLU A 109
LEU A 135
 None
 1.41A 2azqA-2w6lA:
undetectable		 2azqA-2w6lA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_1
(MINERALOCORTICOID
RECEPTOR)		 2w6l COBE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 107
LEU A 132
ALA A 131
LEU A  28
LEU A  57
 None
 1.21A 2oaxD-2w6lA:
undetectable		 2oaxD-2w6lA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_E_SNLE5001_1
(MINERALOCORTICOID
RECEPTOR)		 2w6l COBE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 107
LEU A 132
ALA A 131
LEU A  28
LEU A  57
 None
 1.24A 2oaxE-2w6lA:
undetectable		 2oaxE-2w6lA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 2w6l COBE
(Pseudomonas
aeruginosa) 		3 / 3 LEU A  39
VAL A  68
ARG A  66
 None
 0.81A 3b0wB-2w6lA:
undetectable		 3b0wB-2w6lA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2w6l COBE
(Pseudomonas
aeruginosa) 		5 / 11 LEU A  24
ILE A 130
GLY A  12
ALA A  11
LEU A  42
 None
 1.14A 3n8yA-2w6lA:
undetectable		 3n8yA-2w6lA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		 2w6l COBE
(Pseudomonas
aeruginosa) 		6 / 9 LEU A  84
LEU A 119
GLY A 120
LEU A 118
LEU A 105
ALA A 133
 None
 1.48A 5dqfA-2w6lA:
undetectable		 5dqfA-2w6lA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_A_08JA602_1
(CYTOCHROME P450 3A4)		 2w6l COBE
(Pseudomonas
aeruginosa) 		4 / 7 SER A  98
ALA A 131
THR A  31
LEU A  27
 SO4  A1138 (-2.5A)
None
None
None
 0.84A 5te8A-2w6lA:
undetectable		 5te8A-2w6lA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_B_08JB602_1
(CYTOCHROME P450 3A4)		 2w6l COBE
(Pseudomonas
aeruginosa) 		4 / 8 SER A  98
ALA A 131
THR A  31
LEU A  27
 SO4  A1138 (-2.5A)
None
None
None
 0.79A 5te8B-2w6lA:
undetectable		 5te8B-2w6lA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_C_08JC602_1
(CYTOCHROME P450 3A4)		 2w6l COBE
(Pseudomonas
aeruginosa) 		4 / 7 SER A  98
ALA A 131
THR A  31
LEU A  27
 SO4  A1138 (-2.5A)
None
None
None
 0.82A 5te8C-2w6lA:
undetectable		 5te8C-2w6lA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VYH_A_FOLA409_0
(S PROTEIN)		 2w6l COBE
(Pseudomonas
aeruginosa) 		5 / 10 ARG A  82
PRO A  81
ALA A 116
GLY A 113
ALA A 106
 None
 1.14A 5vyhA-2w6lA:
undetectable		 5vyhA-2w6lA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2w6l COBE
(Pseudomonas
aeruginosa) 		4 / 7 ILE A 130
LEU A  28
ARG A  16
LEU A  57
 None
 0.94A 5xdqN-2w6lA:
undetectable
5xdqW-2w6lA:
undetectable		 5xdqN-2w6lA:
12.79
5xdqW-2w6lA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_H_PCFH604_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 2w6l COBE
(Pseudomonas
aeruginosa) 		4 / 8 GLY A  50
GLY A  14
SER A  47
ALA A  46
 GOL  A1141 (-4.5A)
SO4  A1138 ( 3.7A)
None
None
 0.75A 6hu9H-2w6lA:
undetectable
6hu9e-2w6lA:
undetectable		 6hu9H-2w6lA:
16.90
6hu9e-2w6lA:
20.53