SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2w6r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 2w6r IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
SUBUNIT HISF
(Thermotoga
maritima) 		4 / 8 ASP A   9
SER A 206
ASP A 181
THR A 176
 None
 0.83A 1m4iA-2w6rA:
undetectable		 1m4iA-2w6rA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		 2w6r IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
SUBUNIT HISF
(Thermotoga
maritima) 		4 / 8 SER A 177
LEU A 175
ASP A 188
ASP A 179
 None
 1.10A 2j2pA-2w6rA:
undetectable
2j2pB-2w6rA:
undetectable		 2j2pA-2w6rA:
20.15
2j2pB-2w6rA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2L8M_A_CAMA415_0
(CAMPHOR
5-MONOOXYGENASE)		 2w6r IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
SUBUNIT HISF
(Thermotoga
maritima) 		5 / 9 VAL A 195
THR A 199
VAL A 165
ILE A 134
VAL A 162
 None
 1.42A 2l8mA-2w6rA:
undetectable		 2l8mA-2w6rA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAT_A_CLMA301_0
(XENOBIOTIC
ACETYLTRANSFERASE)		 2w6r IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
SUBUNIT HISF
(Thermotoga
maritima) 		3 / 3 GLY A  81
TYR A  61
SER A  80
 None
 0.74A 2xatA-2w6rA:
undetectable		 2xatA-2w6rA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAT_A_CLMA301_0
(XENOBIOTIC
ACETYLTRANSFERASE)		 2w6r IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
SUBUNIT HISF
(Thermotoga
maritima) 		3 / 3 GLY A 207
TYR A 187
SER A 206
 None
 0.63A 2xatA-2w6rA:
undetectable		 2xatA-2w6rA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S79_A_ASDA601_1
(CYTOCHROME P450 19A1)		 2w6r IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
SUBUNIT HISF
(Thermotoga
maritima) 		5 / 12 ILE A  66
ALA A  92
VAL A 131
LEU A 174
LEU A  48
 None
 1.28A 3s79A-2w6rA:
undetectable		 3s79A-2w6rA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S79_A_ASDA601_1
(CYTOCHROME P450 19A1)		 2w6r IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
SUBUNIT HISF
(Thermotoga
maritima) 		5 / 12 ILE A 192
ALA A 218
VAL A   5
LEU A  48
LEU A 174
 None
 1.27A 3s79A-2w6rA:
undetectable		 3s79A-2w6rA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_A_QPSA951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 2w6r IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
SUBUNIT HISF
(Thermotoga
maritima) 		4 / 6 GLY A 127
ARG A  70
GLU A  46
ARG A   3
 None
 1.27A 4bqfA-2w6rA:
undetectable		 4bqfA-2w6rA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2w6r IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
SUBUNIT HISF
(Thermotoga
maritima) 		4 / 5 SER A  80
ALA A  79
MET A  65
LEU A  48
 None
 1.22A 5dzkb-2w6rA:
2.2
5dzkp-2w6rA:
undetectable		 5dzkb-2w6rA:
20.79
5dzkp-2w6rA:
1.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Q_BEZQ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2w6r IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
SUBUNIT HISF
(Thermotoga
maritima) 		4 / 5 SER A  80
ALA A  79
MET A  65
LEU A  48
 None
 1.28A 5dzkc-2w6rA:
undetectable
5dzkq-2w6rA:
undetectable		 5dzkc-2w6rA:
20.79
5dzkq-2w6rA:
1.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKV_A_ASDA602_1
(AROMATASE)		 2w6r IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
SUBUNIT HISF
(Thermotoga
maritima) 		5 / 12 ILE A 192
ALA A 218
VAL A   5
LEU A  48
LEU A 174
 None
 1.25A 5jkvA-2w6rA:
undetectable		 5jkvA-2w6rA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2w6r IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
SUBUNIT HISF
(Thermotoga
maritima) 		3 / 3 LEU A  49
THR A  28
ASN A  27
 None
 0.70A 6baaE-2w6rA:
undetectable		 6baaE-2w6rA:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2w6r IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
SUBUNIT HISF
(Thermotoga
maritima) 		3 / 3 LEU A 175
THR A 154
ASN A 153
 None
 0.61A 6baaE-2w6rA:
undetectable		 6baaE-2w6rA:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_F_GBMF2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2w6r IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
SUBUNIT HISF
(Thermotoga
maritima) 		3 / 3 LEU A  49
THR A  28
ASN A  27
 None
 0.70A 6baaF-2w6rA:
undetectable		 6baaF-2w6rA:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_F_GBMF2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2w6r IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
SUBUNIT HISF
(Thermotoga
maritima) 		3 / 3 LEU A 175
THR A 154
ASN A 153
 None
 0.61A 6baaF-2w6rA:
undetectable		 6baaF-2w6rA:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_G_GBMG2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2w6r IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
SUBUNIT HISF
(Thermotoga
maritima) 		3 / 3 LEU A  49
THR A  28
ASN A  27
 None
 0.70A 6baaG-2w6rA:
undetectable		 6baaG-2w6rA:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_G_GBMG2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2w6r IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
SUBUNIT HISF
(Thermotoga
maritima) 		3 / 3 LEU A 175
THR A 154
ASN A 153
 None
 0.62A 6baaG-2w6rA:
undetectable		 6baaG-2w6rA:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_H_GBMH2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2w6r IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
SUBUNIT HISF
(Thermotoga
maritima) 		3 / 3 LEU A  49
THR A  28
ASN A  27
 None
 0.71A 6baaH-2w6rA:
undetectable		 6baaH-2w6rA:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_H_GBMH2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2w6r IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
SUBUNIT HISF
(Thermotoga
maritima) 		3 / 3 LEU A 175
THR A 154
ASN A 153
 None
 0.62A 6baaH-2w6rA:
undetectable		 6baaH-2w6rA:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_D_READ601_1
(RETINOIC ACID
RECEPTOR)		 2w6r IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
SUBUNIT HISF
(Thermotoga
maritima) 		4 / 7 VAL A  13
LEU A  31
GLY A  29
GLY A  24
 None
 0.71A 6eu9D-2w6rA:
undetectable		 6eu9D-2w6rA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_D_READ601_1
(RETINOIC ACID
RECEPTOR)		 2w6r IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
SUBUNIT HISF
(Thermotoga
maritima) 		4 / 7 VAL A 139
LEU A 157
GLY A 155
GLY A 150
 None
 0.76A 6eu9D-2w6rA:
undetectable		 6eu9D-2w6rA:
14.74