SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2w7y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDN_A_LEUA487_0
(L-AMINO ACID OXIDASE)		 2w7y PROBABLE SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		4 / 7 ARG A 207
ASN A 106
PHE A 155
TRP A 280
 A2G  A1428 (-3.3A)
A2G  A1428 (-3.8A)
GAL  A1429 ( 4.5A)
GAL  A1429 ( 3.6A)
 1.09A 1tdnA-2w7yA:
undetectable		 1tdnA-2w7yA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_B_CHDB2_0
(LIVER
CARBOXYLESTERASE 1)		 2w7y PROBABLE SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 TRP A  53
LYS A 287
PRO A  54
 None
 1.37A 2dqyB-2w7yA:
undetectable		 2dqyB-2w7yA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		 2w7y PROBABLE SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		4 / 6 ARG A 207
PHE A 209
ILE A 398
PHE A 237
 A2G  A1428 (-3.3A)
None
None
None
 1.21A 2qeiA-2w7yA:
undetectable		 2qeiA-2w7yA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO4_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 2w7y PROBABLE SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 LEU A 121
ILE A 125
VAL A 100
THR A 331
MET A 330
 None
 1.30A 2qo4A-2w7yA:
undetectable		 2qo4A-2w7yA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_A_X2NA1480_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 2w7y PROBABLE SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 PHE A 166
PRO A 297
ALA A 298
ALA A 273
ALA A 198
 None
 1.24A 2x2nA-2w7yA:
undetectable		 2x2nA-2w7yA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLO_A_TESA1920_1
(ANDROGEN RECEPTOR)		 2w7y PROBABLE SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 LEU A 327
LEU A 324
GLN A 320
VAL A 118
PHE A  75
 None
 1.15A 2yloA-2w7yA:
undetectable		 2yloA-2w7yA:
18.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JZJ_A_ACRA405_1
(ACARBOSE/MALTOSE
BINDING PROTEIN GACH)		 2w7y PROBABLE SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 GLY A 105
GLU A 203
ALA A 260
GLY A 202
ASN A 277
 A2G  A1428 (-3.8A)
A2G  A1428 (-2.7A)
A2G  A1428 (-3.4A)
None
A2G  A1428 ( 2.9A)
 1.30A 3jzjA-2w7yA:
29.0		 3jzjA-2w7yA:
30.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_G_TFPG201_1
(PROTEIN S100-A4)		 2w7y PROBABLE SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		5 / 9 GLY A 200
PHE A 199
GLY A 257
ILE A 206
PHE A 183
 None
 1.30A 3ko0F-2w7yA:
undetectable
3ko0G-2w7yA:
0.0		 3ko0F-2w7yA:
13.38
3ko0G-2w7yA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1478_0
(MJ0495-LIKE PROTEIN)		 2w7y PROBABLE SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		4 / 7 SER A 305
GLY A 308
SER A 304
THR A 385
 None
 0.95A 4ac9C-2w7yA:
undetectable		 4ac9C-2w7yA:
24.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CCQ_A_ACTA1317_0
(THIOREDOXIN
REDUCTASE)		 2w7y PROBABLE SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 LEU A 357
GLU A 359
SER A 361
 None
 0.74A 4ccqA-2w7yA:
undetectable		 4ccqA-2w7yA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2w7y PROBABLE SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		4 / 6 GLY A 370
ILE A 368
GLN A 371
SER A 282
 None
 0.90A 4d39B-2w7yA:
undetectable		 4d39B-2w7yA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_ACTA803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2w7y PROBABLE SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		4 / 6 GLY A 370
ILE A 368
GLN A 371
SER A 282
 None
 1.10A 4kcnA-2w7yA:
undetectable		 4kcnA-2w7yA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZ8_A_GCSA208_1
(GLUCANASE/CHITOSANAS
E)		 2w7y PROBABLE SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		4 / 7 GLU A 203
ASP A 259
ALA A 260
TYR A 263
 A2G  A1428 (-2.7A)
None
A2G  A1428 (-3.4A)
None
 1.20A 4zz8A-2w7yA:
undetectable		 4zz8A-2w7yA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2w7y PROBABLE SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 VAL A 354
LEU A  62
MET A 330
 None
 0.86A 5ikrA-2w7yA:
undetectable		 5ikrA-2w7yA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2w7y PROBABLE SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 HIS A 395
THR A 149
SER A 303
ILE A 302
PHE A 155
 None
None
None
None
GAL  A1429 ( 4.5A)
 1.43A 5iwuA-2w7yA:
undetectable		 5iwuA-2w7yA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_F_SAMF501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2w7y PROBABLE SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		5 / 10 PRO A 384
GLY A 214
GLU A 217
GLY A 219
ALA A 381
 None
 1.13A 5o96E-2w7yA:
undetectable
5o96F-2w7yA:
undetectable		 5o96E-2w7yA:
19.48
5o96F-2w7yA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA304_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2w7y PROBABLE SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		4 / 4 ARG A 207
THR A 385
GLY A 105
PHE A 155
 A2G  A1428 (-3.3A)
None
A2G  A1428 (-3.8A)
GAL  A1429 ( 4.5A)
 1.05A 5uunA-2w7yA:
0.2		 5uunA-2w7yA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2w7y PROBABLE SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 TYR A 197
ALA A 262
TYR A 263
 None
 0.88A 5uunB-2w7yA:
undetectable		 5uunB-2w7yA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA826_0
(GEPHYRIN)		 2w7y PROBABLE SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 HIS A 395
ARG A 207
ILE A 206
 None
A2G  A1428 (-3.3A)
None
 0.78A 6fgdA-2w7yA:
undetectable		 6fgdA-2w7yA:
22.49