SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2w7z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_1
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN))		 2w7z PENTAPEPTIDE REPEAT
FAMILY PROTEIN
(Enterococcus
faecalis) 		4 / 6 LEU A 182
TRP A 164
PHE A 174
VAL A 194
 None
None
None
LP6  A 193 ( 2.7A)
 1.30A 1ibgH-2w7zA:
undetectable		 1ibgH-2w7zA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_B_4CHB192_0
(DEHALOPEROXIDASE A)		 2w7z PENTAPEPTIDE REPEAT
FAMILY PROTEIN
(Enterococcus
faecalis) 		4 / 6 PHE A 104
PHE A  94
THR A 102
VAL A  82
 None
 1.21A 3lb3B-2w7zA:
undetectable		 3lb3B-2w7zA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LK0_D_Z80D92_1
(PROTEIN S100-B)		 2w7z PENTAPEPTIDE REPEAT
FAMILY PROTEIN
(Enterococcus
faecalis) 		3 / 3 HIS A  90
PHE A  74
PHE A  94
 LP6  A 110 ( 4.1A)
None
None
 0.78A 3lk0D-2w7zA:
undetectable		 3lk0D-2w7zA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC610_0
(GBAA_1210 PROTEIN)		 2w7z PENTAPEPTIDE REPEAT
FAMILY PROTEIN
(Enterococcus
faecalis) 		3 / 3 ASN A 103
ALA A 105
ARG A 125
 None
 0.62A 3tj7C-2w7zA:
undetectable
3tj7D-2w7zA:
undetectable		 3tj7C-2w7zA:
18.47
3tj7D-2w7zA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LA0_A_198A601_1
(SERUM ALBUMIN)		 2w7z PENTAPEPTIDE REPEAT
FAMILY PROTEIN
(Enterococcus
faecalis) 		5 / 10 LEU A 113
ALA A 122
PHE A 124
PHE A 144
LEU A 154
 LP6  A   2 ( 4.7A)
None
None
None
CL  A1213 (-4.9A)
 1.46A 4la0A-2w7zA:
undetectable		 4la0A-2w7zA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA301_0
(THAUMATIN-1)		 2w7z PENTAPEPTIDE REPEAT
FAMILY PROTEIN
(Enterococcus
faecalis) 		3 / 3 THR A 183
ASN A 163
SER A 162
 None
 0.75A 4tvtA-2w7zA:
undetectable		 4tvtA-2w7zA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2w7z PENTAPEPTIDE REPEAT
FAMILY PROTEIN
(Enterococcus
faecalis) 		3 / 3 GLY A 207
THR A 167
PRO A 186
 None
None
CL  A1212 ( 4.1A)
 0.65A 5v5zA-2w7zA:
undetectable		 5v5zA-2w7zA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2w7z PENTAPEPTIDE REPEAT
FAMILY PROTEIN
(Enterococcus
faecalis) 		4 / 5 PHE A 144
PHE A 129
LEU A 109
PHE A  89
 None
None
LP6  A 110 ( 4.5A)
None
 1.31A 5xdqP-2w7zA:
undetectable
5xdqW-2w7zA:
undetectable		 5xdqP-2w7zA:
23.33
5xdqW-2w7zA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_B_CHDB401_0
(BILE SALT HYDROLASE)		 2w7z PENTAPEPTIDE REPEAT
FAMILY PROTEIN
(Enterococcus
faecalis) 		5 / 10 TYR A  34
ILE A  37
LEU A  39
ALA A  27
LEU A  47
 None
 1.10A 5y7pB-2w7zA:
undetectable		 5y7pB-2w7zA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_D_CHDD401_0
(BILE SALT HYDROLASE)		 2w7z PENTAPEPTIDE REPEAT
FAMILY PROTEIN
(Enterococcus
faecalis) 		5 / 10 TYR A  34
ILE A  37
LEU A  39
ALA A  27
LEU A  47
 None
 1.17A 5y7pD-2w7zA:
undetectable		 5y7pD-2w7zA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_H_CHDH401_0
(BILE SALT HYDROLASE)		 2w7z PENTAPEPTIDE REPEAT
FAMILY PROTEIN
(Enterococcus
faecalis) 		5 / 10 TYR A  34
ILE A  37
LEU A  39
ALA A  27
LEU A  47
 None
 1.15A 5y7pH-2w7zA:
undetectable		 5y7pH-2w7zA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCO_A_FY5A1003_0
(ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2)		 2w7z PENTAPEPTIDE REPEAT
FAMILY PROTEIN
(Enterococcus
faecalis) 		5 / 11 THR A 102
ASN A 103
PHE A 104
THR A 137
PHE A 134
 None
 1.47A 6hcoA-2w7zA:
undetectable
6hcoB-2w7zA:
undetectable		 6hcoA-2w7zA:
15.34
6hcoB-2w7zA:
15.34