SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2w87'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLB_A_NVPA999_1
(HIV-1 RT A-CHAIN)		 2w87 ESTERASE D
(Cellvibrio
japonicus) 		4 / 8 VAL A  91
TYR A  89
GLY A  77
LEU A  63
 None
 0.87A 1jlbA-2w87A:
undetectable		 1jlbA-2w87A:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		 2w87 ESTERASE D
(Cellvibrio
japonicus) 		3 / 3 LEU A  63
ARG A  61
ILE A 107
 None
 0.62A 2xn5B-2w87A:
undetectable		 2xn5B-2w87A:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 2w87 ESTERASE D
(Cellvibrio
japonicus) 		5 / 12 GLU A 126
ASN A  43
GLY A 127
GLY A  71
ASN A  69
 None
GCU  A1150 ( 2.9A)
None
None
None
 1.19A 3k13A-2w87A:
undetectable		 3k13A-2w87A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 2w87 ESTERASE D
(Cellvibrio
japonicus) 		5 / 12 GLU A 126
ASN A  43
GLY A 127
GLY A  71
ASN A  69
 None
GCU  A1150 ( 2.9A)
None
None
None
 1.18A 3k13B-2w87A:
undetectable		 3k13B-2w87A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 2w87 ESTERASE D
(Cellvibrio
japonicus) 		5 / 12 GLU A 126
ASN A  43
GLY A 127
GLY A  71
ASN A  69
 None
GCU  A1150 ( 2.9A)
None
None
None
 1.20A 3k13C-2w87A:
undetectable		 3k13C-2w87A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_C_ZPCC1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2w87 ESTERASE D
(Cellvibrio
japonicus) 		5 / 12 VAL A 118
ILE A  53
ILE A  26
GLU A  14
VAL A 136
 None
None
None
CA  A1149 (-2.2A)
None
 1.04A 4a97B-2w87A:
undetectable
4a97C-2w87A:
undetectable		 4a97B-2w87A:
18.03
4a97C-2w87A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_1
(CDL2.2)		 2w87 ESTERASE D
(Cellvibrio
japonicus) 		5 / 12 ILE A  65
GLU A 126
THR A 124
ALA A 122
LEU A 120
 None
 1.10A 5ienA-2w87A:
undetectable		 5ienA-2w87A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_2
(CDL2.2)		 2w87 ESTERASE D
(Cellvibrio
japonicus) 		5 / 12 ILE A  65
GLU A 126
THR A 124
ALA A 122
LEU A 120
 None
 1.20A 5ienB-2w87A:
undetectable		 5ienB-2w87A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 2w87 ESTERASE D
(Cellvibrio
japonicus) 		4 / 7 ASN A  29
HIS A  30
TRP A  99
ASN A 130
 GCU  A1150 ( 4.7A)
GCU  A1150 (-4.0A)
GCU  A1150 (-3.9A)
GCU  A1150 (-3.1A)
 0.21A 5x7pA-2w87A:
6.7		 5x7pA-2w87A:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_D_READ601_1
(RETINOIC ACID
RECEPTOR)		 2w87 ESTERASE D
(Cellvibrio
japonicus) 		4 / 7 VAL A 118
LEU A 128
GLY A  87
GLY A  77
 None
 0.76A 6eu9D-2w87A:
undetectable		 6eu9D-2w87A:
18.71