SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2w8d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_B_T44B328_1
(TRANSTHYRETIN)		 2w8d PROCESSED GLYCEROL
PHOSPHATE
LIPOTEICHOIC ACID
SYNTHASE 2
(Bacillus
subtilis) 		4 / 8 LEU A 395
LYS A 363
ALA A 340
THR A 404
 None
PG4  A1637 (-2.8A)
None
None
 0.94A 1ie4B-2w8dA:
undetectable
1ie4D-2w8dA:
undetectable		 1ie4B-2w8dA:
13.53
1ie4D-2w8dA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VID_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 2w8d PROCESSED GLYCEROL
PHOSPHATE
LIPOTEICHOIC ACID
SYNTHASE 2
(Bacillus
subtilis) 		4 / 5 SER A 315
GLU A 359
TYR A 356
ASP A 299
 None
 1.49A 1vidA-2w8dA:
undetectable		 1vidA-2w8dA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2888_0
(AMINOMETHYLTRANSFERA
SE)		 2w8d PROCESSED GLYCEROL
PHOSPHATE
LIPOTEICHOIC ACID
SYNTHASE 2
(Bacillus
subtilis) 		5 / 10 LEU A 533
LEU A 534
ILE A 465
GLU A 305
LEU A 332
 None
 1.25A 1wopA-2w8dA:
undetectable		 1wopA-2w8dA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA702_0
(FERROCHELATASE)		 2w8d PROCESSED GLYCEROL
PHOSPHATE
LIPOTEICHOIC ACID
SYNTHASE 2
(Bacillus
subtilis) 		4 / 7 MET A 227
LEU A 602
PRO A 528
VAL A 524
 None
 1.25A 2hrcA-2w8dA:
undetectable		 2hrcA-2w8dA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PCP_C_1PCC212_1
(IMMUNOGLOBULIN)		 2w8d PROCESSED GLYCEROL
PHOSPHATE
LIPOTEICHOIC ACID
SYNTHASE 2
(Bacillus
subtilis) 		5 / 10 HIS A 290
TYR A 473
PHE A 415
GLY A 474
HIS A 412
 None
None
None
None
TPO  A 297 ( 4.0A)
 1.39A 2pcpC-2w8dA:
undetectable
2pcpD-2w8dA:
undetectable		 2pcpC-2w8dA:
18.81
2pcpD-2w8dA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA801_1
(PROSTAGLANDIN
REDUCTASE 1)		 2w8d PROCESSED GLYCEROL
PHOSPHATE
LIPOTEICHOIC ACID
SYNTHASE 2
(Bacillus
subtilis) 		4 / 8 VAL A 536
VAL A 247
TYR A 249
VAL A 328
 None
 1.10A 2y05A-2w8dA:
undetectable
2y05B-2w8dA:
undetectable		 2y05A-2w8dA:
20.70
2y05B-2w8dA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CB8_A_SAMA501_0
(PYRUVATE
FORMATE-LYASE
1-ACTIVATING ENZYME)		 2w8d PROCESSED GLYCEROL
PHOSPHATE
LIPOTEICHOIC ACID
SYNTHASE 2
(Bacillus
subtilis) 		5 / 12 TYR A 380
HIS A 343
SER A 251
ASP A 471
ASN A 411
 None
None
TPO  A 297 ( 4.3A)
MG  A1636 (-2.6A)
None
 1.50A 3cb8A-2w8dA:
0.1		 3cb8A-2w8dA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHX_B_PXLB313_1
(PYRIDOXAL KINASE)		 2w8d PROCESSED GLYCEROL
PHOSPHATE
LIPOTEICHOIC ACID
SYNTHASE 2
(Bacillus
subtilis) 		4 / 8 VAL A 503
VAL A 526
HIS A 290
TYR A 469
 None
 0.98A 3fhxB-2w8dA:
undetectable		 3fhxB-2w8dA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_F_TFPF201_1
(PROTEIN S100-A4)		 2w8d PROCESSED GLYCEROL
PHOSPHATE
LIPOTEICHOIC ACID
SYNTHASE 2
(Bacillus
subtilis) 		4 / 5 MET A 392
PHE A 365
PHE A 342
PHE A 402
 None
 1.45A 3ko0F-2w8dA:
undetectable
3ko0G-2w8dA:
undetectable		 3ko0F-2w8dA:
13.30
3ko0G-2w8dA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2w8d PROCESSED GLYCEROL
PHOSPHATE
LIPOTEICHOIC ACID
SYNTHASE 2
(Bacillus
subtilis) 		4 / 8 GLU A 268
HIS A 278
ASN A 274
ILE A 259
 None
 1.11A 3kp6A-2w8dA:
undetectable
3kp6B-2w8dA:
undetectable		 3kp6A-2w8dA:
15.97
3kp6B-2w8dA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_2
(CARBONIC ANHYDRASE)		 2w8d PROCESSED GLYCEROL
PHOSPHATE
LIPOTEICHOIC ACID
SYNTHASE 2
(Bacillus
subtilis) 		3 / 3 GLN A 256
PHE A 258
TYR A 437
 None
 0.97A 3ucjB-2w8dA:
2.1		 3ucjB-2w8dA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_1
(CARBONIC ANHYDRASE)		 2w8d PROCESSED GLYCEROL
PHOSPHATE
LIPOTEICHOIC ACID
SYNTHASE 2
(Bacillus
subtilis) 		3 / 3 GLN A 256
PHE A 258
TYR A 437
 None
 0.98A 3ucjA-2w8dA:
2.1		 3ucjA-2w8dA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4APJ_A_ACTA1635_0
(ANGIOTENSIN-CONVERTI
NG ENZYME
BRADYKININ-POTENTIAT
ING PEPTIDE B)		 2w8d PROCESSED GLYCEROL
PHOSPHATE
LIPOTEICHOIC ACID
SYNTHASE 2
(Bacillus
subtilis) 		4 / 6 HIS A 472
GLU A 301
ASP A 471
SER A 251
 MG  A1636 (-3.4A)
TPO  A 297 ( 4.7A)
MG  A1636 (-2.6A)
TPO  A 297 ( 4.3A)
 1.29A 4apjA-2w8dA:
undetectable
4apjP-2w8dA:
undetectable		 4apjA-2w8dA:
22.59
4apjP-2w8dA:
2.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		 2w8d PROCESSED GLYCEROL
PHOSPHATE
LIPOTEICHOIC ACID
SYNTHASE 2
(Bacillus
subtilis) 		4 / 7 LYS A 363
THR A 338
ALA A 340
THR A 404
 PG4  A1637 (-2.8A)
None
None
None
 0.94A 4d7bA-2w8dA:
undetectable		 4d7bA-2w8dA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F5Z_A_BEZA302_0
(HALOALKANE
DEHALOGENASE)		 2w8d PROCESSED GLYCEROL
PHOSPHATE
LIPOTEICHOIC ACID
SYNTHASE 2
(Bacillus
subtilis) 		4 / 8 ASP A 547
PHE A 285
VAL A 517
LEU A 533
 None
 1.03A 4f5zA-2w8dA:
undetectable		 4f5zA-2w8dA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_H_D16H301_1
(THYMIDYLATE SYNTHASE)		 2w8d PROCESSED GLYCEROL
PHOSPHATE
LIPOTEICHOIC ACID
SYNTHASE 2
(Bacillus
subtilis) 		5 / 11 HIS A 412
GLU A 301
ILE A 407
ASP A 366
TYR A 369
 TPO  A 297 ( 4.0A)
TPO  A 297 ( 4.7A)
TPO  A 297 ( 4.8A)
None
None
 1.48A 4foxH-2w8dA:
undetectable		 4foxH-2w8dA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)		 2w8d PROCESSED GLYCEROL
PHOSPHATE
LIPOTEICHOIC ACID
SYNTHASE 2
(Bacillus
subtilis) 		3 / 3 LYS A 245
ILE A 465
ILE A 507
 None
 0.54A 4y0qA-2w8dA:
undetectable		 4y0qA-2w8dA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_E_ACTE403_0
(PROTON-GATED ION
CHANNEL)		 2w8d PROCESSED GLYCEROL
PHOSPHATE
LIPOTEICHOIC ACID
SYNTHASE 2
(Bacillus
subtilis) 		3 / 3 ARG A 554
TYR A 309
GLU A 601
 None
 0.58A 4zzbE-2w8dA:
undetectable		 4zzbE-2w8dA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_C_WJZC304_0
(BETA-LACTAMASE NDM-1)		 2w8d PROCESSED GLYCEROL
PHOSPHATE
LIPOTEICHOIC ACID
SYNTHASE 2
(Bacillus
subtilis) 		4 / 7 HIS A 343
GLY A 381
ASN A 345
HIS A 412
 None
None
None
TPO  A 297 ( 4.0A)
 1.08A 5a5zC-2w8dA:
undetectable		 5a5zC-2w8dA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 2w8d PROCESSED GLYCEROL
PHOSPHATE
LIPOTEICHOIC ACID
SYNTHASE 2
(Bacillus
subtilis) 		4 / 5 SER A 315
GLU A 359
TYR A 356
ASP A 299
 None
 1.49A 5fhrA-2w8dA:
undetectable		 5fhrA-2w8dA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_C_FUAC1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2w8d PROCESSED GLYCEROL
PHOSPHATE
LIPOTEICHOIC ACID
SYNTHASE 2
(Bacillus
subtilis) 		3 / 3 VAL A 247
HIS A 532
VAL A 536
 None
 0.70A 5jmnC-2w8dA:
undetectable		 5jmnC-2w8dA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		 2w8d PROCESSED GLYCEROL
PHOSPHATE
LIPOTEICHOIC ACID
SYNTHASE 2
(Bacillus
subtilis) 		4 / 8 PRO A 504
PHE A 258
SER A 440
ASN A 411
 None
 1.00A 5l1fA-2w8dA:
undetectable
5l1fB-2w8dA:
undetectable		 5l1fA-2w8dA:
19.57
5l1fB-2w8dA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYI_A_NIZA805_1
(CATALASE-PEROXIDASE)		 2w8d PROCESSED GLYCEROL
PHOSPHATE
LIPOTEICHOIC ACID
SYNTHASE 2
(Bacillus
subtilis) 		4 / 5 ARG A 554
HIS A 553
ALA A 521
PRO A 567
 None
 1.39A 5syiA-2w8dA:
undetectable		 5syiA-2w8dA:
20.03