SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2w8i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_A_IPHA802_0
(PHENOL HYDROXYLASE)		 2w8i PUTATIVE OUTER
MEMBRANE LIPOPROTEIN
WZA
(Escherichia
coli) 		5 / 10 ASP A  91
GLY A  90
VAL A 120
ILE A  87
TYR A  85
 None
 1.19A 1fohA-2w8iA:
undetectable		 1fohA-2w8iA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_B_IPHB802_0
(PHENOL HYDROXYLASE)		 2w8i PUTATIVE OUTER
MEMBRANE LIPOPROTEIN
WZA
(Escherichia
coli) 		5 / 10 ASP A  91
GLY A  90
VAL A 120
ILE A  87
TYR A  85
 None
 1.24A 1fohB-2w8iA:
undetectable		 1fohB-2w8iA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_C_IPHC802_0
(PHENOL HYDROXYLASE)		 2w8i PUTATIVE OUTER
MEMBRANE LIPOPROTEIN
WZA
(Escherichia
coli) 		5 / 10 ASP A  91
GLY A  90
VAL A 120
ILE A  87
TYR A  85
 None
 1.27A 1fohC-2w8iA:
undetectable		 1fohC-2w8iA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_D_IPHD802_0
(PHENOL HYDROXYLASE)		 2w8i PUTATIVE OUTER
MEMBRANE LIPOPROTEIN
WZA
(Escherichia
coli) 		5 / 10 ASP A  91
GLY A  90
VAL A 120
ILE A  87
TYR A  85
 None
 1.24A 1fohD-2w8iA:
undetectable		 1fohD-2w8iA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		 2w8i PUTATIVE OUTER
MEMBRANE LIPOPROTEIN
WZA
(Escherichia
coli) 		5 / 10 GLY A  90
VAL A 120
LEU A  93
TYR A  85
ALA A 137
 None
 1.22A 1pbcA-2w8iA:
undetectable		 1pbcA-2w8iA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_A_IPHA6012_0
(PHENOL
2-MONOOXYGENASE)		 2w8i PUTATIVE OUTER
MEMBRANE LIPOPROTEIN
WZA
(Escherichia
coli) 		5 / 10 ASP A  91
GLY A  90
VAL A 120
ILE A  87
TYR A  85
 None
 1.23A 1pn0A-2w8iA:
undetectable		 1pn0A-2w8iA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_B_IPHB6022_0
(PHENOL
2-MONOOXYGENASE)		 2w8i PUTATIVE OUTER
MEMBRANE LIPOPROTEIN
WZA
(Escherichia
coli) 		5 / 10 ASP A  91
GLY A  90
VAL A 120
ILE A  87
TYR A  85
 None
 1.23A 1pn0B-2w8iA:
undetectable		 1pn0B-2w8iA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_C_IPHC6032_0
(PHENOL
2-MONOOXYGENASE)		 2w8i PUTATIVE OUTER
MEMBRANE LIPOPROTEIN
WZA
(Escherichia
coli) 		5 / 10 ASP A  91
GLY A  90
VAL A 120
ILE A  87
TYR A  85
 None
 1.28A 1pn0C-2w8iA:
undetectable		 1pn0C-2w8iA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_D_IPHD6042_0
(PHENOL
2-MONOOXYGENASE)		 2w8i PUTATIVE OUTER
MEMBRANE LIPOPROTEIN
WZA
(Escherichia
coli) 		5 / 10 ASP A  91
GLY A  90
VAL A 120
ILE A  87
TYR A  85
 None
 1.27A 1pn0D-2w8iA:
undetectable		 1pn0D-2w8iA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PNL_B_PACB559_0
(PENICILLIN
AMIDOHYDROLASE)		 2w8i PUTATIVE OUTER
MEMBRANE LIPOPROTEIN
WZA
(Escherichia
coli) 		4 / 8 MET A 326
SER A 293
ALA A 295
ILE A 298
 None
 1.11A 1pnlA-2w8iA:
undetectable
1pnlB-2w8iA:
undetectable		 1pnlA-2w8iA:
22.02
1pnlB-2w8iA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ1_A_HLTA2001_1
(FERRITIN LIGHT CHAIN)		 2w8i PUTATIVE OUTER
MEMBRANE LIPOPROTEIN
WZA
(Escherichia
coli) 		4 / 4 LEU A  79
SER A  82
TYR A  83
LEU A 240
 None
 1.05A 1xz1A-2w8iA:
undetectable		 1xz1A-2w8iA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		 2w8i PUTATIVE OUTER
MEMBRANE LIPOPROTEIN
WZA
(Escherichia
coli) 		4 / 4 LEU A  79
SER A  82
TYR A  83
LEU A 240
 None
 1.06A 1xz3A-2w8iA:
undetectable		 1xz3A-2w8iA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 2w8i PUTATIVE OUTER
MEMBRANE LIPOPROTEIN
WZA
(Escherichia
coli) 		4 / 8 THR A 330
ARG A  64
LEU A 318
ASP A 322
 None
 0.99A 2zw9A-2w8iA:
undetectable		 2zw9A-2w8iA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F33_A_PFLA2001_1
(FERRITIN LIGHT CHAIN)		 2w8i PUTATIVE OUTER
MEMBRANE LIPOPROTEIN
WZA
(Escherichia
coli) 		4 / 6 LEU A  79
SER A  82
TYR A  83
LEU A 240
 None
 1.04A 3f33A-2w8iA:
undetectable		 3f33A-2w8iA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHX_B_PXLB313_1
(PYRIDOXAL KINASE)		 2w8i PUTATIVE OUTER
MEMBRANE LIPOPROTEIN
WZA
(Escherichia
coli) 		4 / 8 VAL A 144
VAL A 161
TYR A 128
VAL A 136
 None
 1.11A 3fhxB-2w8iA:
undetectable		 3fhxB-2w8iA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_2
(HIV-1 PROTEASE)		 2w8i PUTATIVE OUTER
MEMBRANE LIPOPROTEIN
WZA
(Escherichia
coli) 		5 / 10 VAL A 136
ILE A 126
GLY A 117
VAL A 141
ILE A  87
 None
 1.06A 3oxvB-2w8iA:
undetectable		 3oxvB-2w8iA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_2
(HIV-1 PROTEASE)		 2w8i PUTATIVE OUTER
MEMBRANE LIPOPROTEIN
WZA
(Escherichia
coli) 		5 / 11 VAL A 136
ILE A 126
GLY A 117
VAL A 141
ILE A  87
 None
 1.03A 3oxvD-2w8iA:
undetectable		 3oxvD-2w8iA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB501_1
(HEMOLYTIC LECTIN
CEL-III)		 2w8i PUTATIVE OUTER
MEMBRANE LIPOPROTEIN
WZA
(Escherichia
coli) 		4 / 5 SER A 274
GLY A 275
TRP A 210
ASP A 209
 None
 1.22A 3w9tB-2w8iA:
undetectable		 3w9tB-2w8iA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1003_1
(HEMOLYTIC LECTIN
CEL-III)		 2w8i PUTATIVE OUTER
MEMBRANE LIPOPROTEIN
WZA
(Escherichia
coli) 		4 / 5 SER A 274
GLY A 275
TRP A 210
ASP A 209
 None
 1.22A 3w9tC-2w8iA:
undetectable		 3w9tC-2w8iA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD501_1
(HEMOLYTIC LECTIN
CEL-III)		 2w8i PUTATIVE OUTER
MEMBRANE LIPOPROTEIN
WZA
(Escherichia
coli) 		4 / 5 SER A 274
GLY A 275
TRP A 210
ASP A 209
 None
 1.22A 3w9tD-2w8iA:
undetectable		 3w9tD-2w8iA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2w8i PUTATIVE OUTER
MEMBRANE LIPOPROTEIN
WZA
(Escherichia
coli) 		4 / 7 GLU A  84
TYR A  85
GLY A 138
ARG A  86
 None
 1.02A 4fgzA-2w8iA:
undetectable		 4fgzA-2w8iA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2w8i PUTATIVE OUTER
MEMBRANE LIPOPROTEIN
WZA
(Escherichia
coli) 		4 / 7 ASP A 245
LEU A 192
ASN A 238
LEU A  76
 None
 0.93A 4ib4A-2w8iA:
undetectable		 4ib4A-2w8iA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_C_URFC302_1
(URIDINE
PHOSPHORYLASE)		 2w8i PUTATIVE OUTER
MEMBRANE LIPOPROTEIN
WZA
(Escherichia
coli) 		4 / 7 GLY A 297
MET A  55
ALA A 295
ILE A 288
 None
 0.89A 4txnC-2w8iA:
undetectable		 4txnC-2w8iA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA610_0
(SERUM ALBUMIN)		 2w8i PUTATIVE OUTER
MEMBRANE LIPOPROTEIN
WZA
(Escherichia
coli) 		3 / 3 TYR A 174
LYS A 172
LYS A 184
 None
 1.34A 5dbyA-2w8iA:
undetectable		 5dbyA-2w8iA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HV1_A_RFPA902_1
(PHOSPHOENOLPYRUVATE
SYNTHASE)		 2w8i PUTATIVE OUTER
MEMBRANE LIPOPROTEIN
WZA
(Escherichia
coli) 		5 / 12 GLN A 335
ALA A 281
VAL A 257
LEU A 318
ILE A  60
 None
 1.23A 5hv1A-2w8iA:
undetectable		 5hv1A-2w8iA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA609_0
(NADH DEHYDROGENASE,
PUTATIVE)		 2w8i PUTATIVE OUTER
MEMBRANE LIPOPROTEIN
WZA
(Escherichia
coli) 		3 / 3 VAL A  92
SER A 114
TRP A 119
 None
 0.81A 5jwaA-2w8iA:
undetectable		 5jwaA-2w8iA:
21.37