SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2w8q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_A_DVAA6_0
(GRAMICIDIN A)		 2w8q SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ALA A 117
VAL A 115
TRP A 112
 None
 0.93A 1nrmA-2w8qA:
undetectable		 1nrmA-2w8qA:
2.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_B_DVAB6_0
(GRAMICIDIN A)		 2w8q SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ALA A 117
VAL A 115
TRP A 112
 None
 0.93A 1nrmB-2w8qA:
undetectable		 1nrmB-2w8qA:
2.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_A_DVAA6_0
(GRAMICIDIN A)		 2w8q SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ALA A 117
VAL A 115
TRP A 112
 None
 0.87A 1nt5A-2w8qA:
undetectable		 1nt5A-2w8qA:
3.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_B_DVAB6_0
(GRAMICIDIN A)		 2w8q SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ALA A 117
VAL A 115
TRP A 112
 None
 0.86A 1nt5B-2w8qA:
undetectable		 1nt5B-2w8qA:
3.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_A_DVAA6_0
(GRAMICIDIN C)		 2w8q SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ALA A 117
VAL A 115
TRP A 112
 None
 0.82A 1nt6A-2w8qA:
undetectable		 1nt6A-2w8qA:
3.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_B_DVAB6_0
(GRAMICIDIN C)		 2w8q SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ALA A 117
VAL A 115
TRP A 112
 None
 0.83A 1nt6B-2w8qA:
undetectable		 1nt6B-2w8qA:
3.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		 2w8q SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 ARG A 125
ILE A 132
ALA A 161
THR A 212
 None
 0.98A 1w0gA-2w8qA:
undetectable		 1w0gA-2w8qA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_C_DVAC6_0
(GRAMICIDIN D)		 2w8q SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ALA A 117
VAL A 115
TRP A 112
 None
 0.87A 1w5uC-2w8qA:
undetectable
1w5uD-2w8qA:
undetectable		 1w5uC-2w8qA:
2.88
1w5uD-2w8qA:
2.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_C_BEZC5013_0
(CES1 PROTEIN)		 2w8q SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 8 GLY A 252
GLY A  66
ALA A 104
LEU A  70
ILE A 257
 None
 1.08A 1yajC-2w8qA:
undetectable		 1yajC-2w8qA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HZQ_A_STRA300_1
(APOLIPOPROTEIN D)		 2w8q SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 THR A 283
ALA A 467
TYR A 469
PHE A 504
 None
 1.19A 2hzqA-2w8qA:
undetectable		 2hzqA-2w8qA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_B_DVAB6_0
(GRAMICIDIN D)		 2w8q SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 TRP A 112
ALA A 117
VAL A 115
 None
 0.83A 2izqA-2w8qA:
undetectable
2izqB-2w8qA:
undetectable		 2izqA-2w8qA:
2.88
2izqB-2w8qA:
2.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_ACTA148_0
(UPF0066 PROTEIN
AF_0241)		 2w8q SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 VAL A  95
GLU A 269
GLU A 266
 None
 0.60A 2nv4A-2w8qA:
undetectable		 2nv4A-2w8qA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		 2w8q SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 PHE A  76
SER A 208
LEU A  58
ILE A 157
ALA A 139
 None
 1.44A 2v0mA-2w8qA:
undetectable		 2v0mA-2w8qA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YY8_B_SAMB500_0
(UPF0106 PROTEIN
PH0461)		 2w8q SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 LEU A 485
GLY A 465
LYS A 508
VAL A 507
ALA A 459
 None
 1.14A 2yy8A-2w8qA:
3.3
2yy8B-2w8qA:
4.1		 2yy8A-2w8qA:
16.90
2yy8B-2w8qA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZSE_A_PAUA600_0
(PANTOTHENATE KINASE)		 2w8q SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 TYR A 128
PHE A 162
ILE A 132
ASN A 129
 None
 1.09A 2zseA-2w8qA:
undetectable		 2zseA-2w8qA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_A_MIYA2001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2w8q SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 SER A 304
GLY A 216
ILE A 521
ALA A 171
 None
 0.97A 3aodA-2w8qA:
1.5		 3aodA-2w8qA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWS_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 2w8q SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ALA A  98
ALA A 199
LEU A 292
ILE A 280
HIS A 295
 None
 1.07A 3gwsX-2w8qA:
undetectable		 3gwsX-2w8qA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)		 2w8q SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 VAL A 225
GLY A 222
ARG A 111
ALA A 108
ALA A 105
 None
 1.10A 3keeB-2w8qA:
undetectable		 3keeB-2w8qA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_A_DVAA6_0
(GRAMICIDIN D)		 2w8q SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ALA A 117
VAL A 115
TRP A 112
 None
 0.82A 3l8lA-2w8qA:
undetectable
3l8lB-2w8qA:
undetectable		 3l8lA-2w8qA:
2.88
3l8lB-2w8qA:
3.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_C_DVAC6_0
(GRAMICIDIN D)		 2w8q SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ALA A 117
VAL A 115
TRP A 112
 None
 0.80A 3l8lC-2w8qA:
undetectable
3l8lD-2w8qA:
undetectable		 3l8lC-2w8qA:
2.88
3l8lD-2w8qA:
3.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_B_BEZB264_0
(ECHA1_1)		 2w8q SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ILE A 447
LEU A 433
ALA A 461
ALA A 462
 None
 0.81A 3r9tB-2w8qA:
undetectable		 3r9tB-2w8qA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_1
(HIV-1 PROTEASE)		 2w8q SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 GLY A 468
ALA A 467
GLY A 309
THR A 339
 None
 0.67A 3so9A-2w8qA:
undetectable		 3so9A-2w8qA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 2w8q SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 MET A 489
GLU A 515
LYS A 214
ARG A 213
 None
None
None
SIN  A3001 (-3.5A)
 1.06A 4bqfB-2w8qA:
undetectable		 4bqfB-2w8qA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_D_ACTD504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2w8q SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 GLY A 147
SER A 146
TRP A 204
 None
 0.96A 4e7cD-2w8qA:
undetectable		 4e7cD-2w8qA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4II8_A_010A210_0
(LYSOZYME C)		 2w8q SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 GLU A 452
ASP A 474
GLN A 477
TRP A 479
 None
 1.22A 4ii8A-2w8qA:
undetectable		 4ii8A-2w8qA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 2w8q SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ALA A  98
ALA A 199
LEU A 292
ILE A 280
HIS A 295
 None
 1.02A 4lnwA-2w8qA:
undetectable		 4lnwA-2w8qA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 2w8q SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ALA A  98
ALA A 199
LEU A 292
ILE A 280
HIS A 295
 None
 1.04A 4lnxA-2w8qA:
undetectable		 4lnxA-2w8qA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2w8q SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		6 / 12 ILE A 211
GLY A 216
ALA A 218
ALA A 199
VAL A 227
VAL A 200
 None
 1.27A 4nkxB-2w8qA:
undetectable		 4nkxB-2w8qA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB301_1
(CHITOSANASE)		 2w8q SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 GLY A 381
PRO A 382
GLN A 338
 None
 0.46A 4oltB-2w8qA:
undetectable		 4oltB-2w8qA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_2
(PROTEASE)		 2w8q SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ALA A 270
GLY A  94
ASP A  92
VAL A 226
ILE A 257
 None
 0.93A 4q5mA-2w8qA:
undetectable		 4q5mA-2w8qA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB305_1
(CHITOSANASE)		 2w8q SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 GLY A 381
PRO A 382
GLN A 338
 None
 0.28A 4qwpB-2w8qA:
undetectable		 4qwpB-2w8qA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_B_AG2B501_1
(ARGININE/AGMATINE
ANTIPORTER)		 2w8q SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 ILE A 141
GLY A 373
ASN A 372
ILE A 142
 None
 0.95A 5j4nB-2w8qA:
undetectable		 5j4nB-2w8qA:
24.25