SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2w8z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_C_ADNC1503_1
(CLASS B ACID
PHOSPHATASE)		 2w8z 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Geobacillus
stearothermophil
us) 		4 / 8 PHE A 156
LEU A  71
GLY A 124
ASP A  99
 None
 0.99A 1rmtC-2w8zA:
4.3		 1rmtC-2w8zA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2w8z 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Geobacillus
stearothermophil
us) 		5 / 12 ALA A 358
ILE A 357
ILE A 375
ALA A 335
LEU A 277
 None
 1.05A 1uduB-2w8zA:
undetectable		 1uduB-2w8zA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 2w8z 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Geobacillus
stearothermophil
us) 		5 / 12 ILE A 280
GLY A 421
ALA A 423
GLU A 189
ALA A 286
 None
None
None
6PG  A1470 (-3.7A)
None
 1.33A 1vq1A-2w8zA:
6.9		 1vq1A-2w8zA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2w8z 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Geobacillus
stearothermophil
us) 		4 / 4 GLY A 176
GLY A 143
GLY A 173
GLY A 178
 None
 0.62A 3bogC-2w8zA:
undetectable		 3bogC-2w8zA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2w8z 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Geobacillus
stearothermophil
us) 		4 / 4 GLY A 176
GLY A 143
GLY A 173
GLY A 178
 None
 0.59A 3bogD-2w8zA:
undetectable		 3bogD-2w8zA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_B_SVRB516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 2w8z 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Geobacillus
stearothermophil
us) 		4 / 7 PRO A 174
GLY A 176
ALA A 177
ALA A 344
 None
 0.64A 3ur0B-2w8zA:
0.9		 3ur0B-2w8zA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 2w8z 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 372
LEU A 388
LEU A 195
TYR A 327
ALA A 425
 None
 0.97A 3vw7A-2w8zA:
undetectable		 3vw7A-2w8zA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_1
(PROTEASE)		 2w8z 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A 178
ASN A 102
ILE A  98
THR A  80
ILE A  96
 None
6PG  A1470 (-3.1A)
None
None
None
 1.01A 4q5mA-2w8zA:
undetectable		 4q5mA-2w8zA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		 2w8z 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Geobacillus
stearothermophil
us) 		4 / 8 GLY A 101
TYR A 180
ALA A 177
GLY A 124
 None
 0.90A 5albL-2w8zA:
undetectable		 5albL-2w8zA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_1
(CYP51 VARIANT1)		 2w8z 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A 129
PHE A 394
TYR A 379
PHE A 371
HIS A 185
 6PG  A1470 (-3.7A)
None
None
None
6PG  A1470 (-4.5A)
 1.10A 5fsaB-2w8zA:
undetectable		 5fsaB-2w8zA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_0
(METHYLTRANSFERASE)		 2w8z 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 426
ALA A 425
GLU A 198
ILE A 417
GLU A 407
 None
 1.02A 5n5dB-2w8zA:
6.8		 5n5dB-2w8zA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NKN_A_LOCA201_2
(NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN)		 2w8z 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Geobacillus
stearothermophil
us) 		3 / 3 VAL A 419
LYS A 204
MET A 209
 None
 1.09A 5nknA-2w8zA:
undetectable		 5nknA-2w8zA:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUK_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 2w8z 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Geobacillus
stearothermophil
us) 		5 / 10 ILE A 397
ILE A 331
PHE A 371
ALA A 369
GLN A 370
 None
 1.12A 5nukA-2w8zA:
undetectable		 5nukA-2w8zA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_1
(CYTOCHROME P450 3A5)		 2w8z 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 388
PHE A 361
PHE A 371
ALA A 425
GLY A 187
 None
 1.11A 5veuA-2w8zA:
undetectable		 5veuA-2w8zA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA606_0
(ALPHA-AMYLASE)		 2w8z 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Geobacillus
stearothermophil
us) 		5 / 7 GLY A 101
GLY A 100
GLY A 124
GLY A 176
GLY A 178
 None
 1.04A 6ag0A-2w8zA:
undetectable		 6ag0A-2w8zA:
12.04