SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2w92'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 2w92 ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE D
(Streptococcus
pneumoniae) 		5 / 12 GLY A 696
TYR A 609
PHE A 594
MET A 635
VAL A 678
 None
 1.24A 1fduC-2w92A:
undetectable		 1fduC-2w92A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HMY_A_SAMA328_0
(HAEIII
METHYLTRANSFERASE)		 2w92 ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE D
(Streptococcus
pneumoniae) 		4 / 8 PHE A 493
ILE A 514
PRO A 473
LEU A 470
 None
 0.94A 1hmyA-2w92A:
undetectable		 1hmyA-2w92A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_C_URFC999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 2w92 ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE D
(Streptococcus
pneumoniae) 		4 / 5 ALA A 515
TYR A 254
ILE A 514
ASP A 491
 None
 1.16A 1upfC-2w92A:
undetectable		 1upfC-2w92A:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)		 2w92 ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE D
(Streptococcus
pneumoniae) 		3 / 3 ARG A 210
VAL A 273
GLY A 286
 None
 0.60A 2avvE-2w92A:
undetectable		 2avvE-2w92A:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O5Y_H_STRH249_1
(CHIMERIC ANTIBODY
FAB 1E9-DB3)		 2w92 ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE D
(Streptococcus
pneumoniae) 		4 / 7 ASN A 735
GLY A 734
THR A 711
SER A 792
 None
 1.19A 2o5yH-2w92A:
5.0
2o5yL-2w92A:
4.0		 2o5yH-2w92A:
17.75
2o5yL-2w92A:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_B_ACTB141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 2w92 ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE D
(Streptococcus
pneumoniae) 		3 / 3 PRO A 707
ASN A 788
ARG A 622
 None
 1.02A 2qeuB-2w92A:
undetectable		 2qeuB-2w92A:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_B_PAUB248_0
(TYPE III
PANTOTHENATE KINASE)		 2w92 ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE D
(Streptococcus
pneumoniae) 		5 / 12 THR A 619
VAL A 525
GLY A 526
THR A 674
ILE A 675
 None
 0.95A 3bf1A-2w92A:
undetectable
3bf1B-2w92A:
undetectable		 3bf1A-2w92A:
17.38
3bf1B-2w92A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_1
(PHOSPHOLIPASE A2)		 2w92 ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE D
(Streptococcus
pneumoniae) 		4 / 5 VAL A 782
VAL A 783
THR A 760
THR A 796
 None
 1.13A 3bjwA-2w92A:
undetectable		 3bjwA-2w92A:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB1_A_IMNA701_1
(LACTOTRANSFERRIN)		 2w92 ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE D
(Streptococcus
pneumoniae) 		4 / 4 PRO A 269
THR A 270
GLY A 536
THR A 535
 None
 1.19A 3ib1A-2w92A:
undetectable		 3ib1A-2w92A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KL3_A_DHIA403_0
(GLUCURONOXYLANASE
XYNC)		 2w92 ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE D
(Streptococcus
pneumoniae) 		4 / 4 GLY A 286
TYR A 285
GLY A 331
ASP A 330
 None
 1.06A 3kl3A-2w92A:
4.8		 3kl3A-2w92A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SU9_A_ACTA426_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2w92 ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE D
(Streptococcus
pneumoniae) 		3 / 3 GLN A 692
GLU A 579
LYS A 593
 None
 1.14A 3su9A-2w92A:
undetectable		 3su9A-2w92A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_E_9PLE1_1
(CYTOCHROME P450 2A13)		 2w92 ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE D
(Streptococcus
pneumoniae) 		4 / 8 PHE A 409
ALA A 375
PHE A 471
PHE A 412
 NGT  A1809 ( 4.6A)
None
NGT  A1809 (-4.1A)
NGT  A1809 (-4.4A)
 1.13A 3t3sE-2w92A:
undetectable		 3t3sE-2w92A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_C_UEGC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2w92 ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE D
(Streptococcus
pneumoniae) 		5 / 10 GLY A 277
ALA A 208
GLY A 281
VAL A 205
VAL A 561
 None
 1.06A 4c5lC-2w92A:
3.1		 4c5lC-2w92A:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2w92 ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE D
(Streptococcus
pneumoniae) 		5 / 10 GLY A 277
ALA A 208
GLY A 281
VAL A 205
VAL A 561
 None
 1.08A 4c5lD-2w92A:
3.2		 4c5lD-2w92A:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2w92 ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE D
(Streptococcus
pneumoniae) 		5 / 10 GLY A 277
ALA A 208
GLY A 281
VAL A 205
VAL A 561
 None
 1.02A 4c5nB-2w92A:
3.4		 4c5nB-2w92A:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYS_A_ACTA402_0
(MCCC FAMILY PROTEIN)		 2w92 ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE D
(Streptococcus
pneumoniae) 		4 / 6 SER A 548
ASP A 544
ARG A 791
GLU A 742
 None
 1.22A 4eysA-2w92A:
undetectable		 4eysA-2w92A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2w92 ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE D
(Streptococcus
pneumoniae) 		4 / 8 ASN A 280
GLY A 560
VAL A 561
PHE A 582
 None
 0.93A 4fglD-2w92A:
undetectable		 4fglD-2w92A:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 2w92 ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE D
(Streptococcus
pneumoniae) 		3 / 3 TYR A 643
ARG A 211
SER A 610
 None
 1.12A 4khpI-2w92A:
undetectable
4khpJ-2w92A:
undetectable		 4khpI-2w92A:
12.34
4khpJ-2w92A:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_B_TOPB202_1
(DIHYDROFOLATE
REDUCTASE)		 2w92 ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE D
(Streptococcus
pneumoniae) 		5 / 12 ALA A 585
PHE A 533
LEU A 680
VAL A 606
LEU A 608
 None
 0.83A 4km2B-2w92A:
undetectable		 4km2B-2w92A:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 2w92 ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE D
(Streptococcus
pneumoniae) 		5 / 9 SER A 478
ALA A 472
LEU A 442
GLY A 446
ALA A 224
 None
 1.29A 4l6va-2w92A:
undetectable
4l6vf-2w92A:
undetectable		 4l6va-2w92A:
21.15
4l6vf-2w92A:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 2w92 ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE D
(Streptococcus
pneumoniae) 		4 / 7 SER A 758
ALA A 276
SER A 559
ARG A 556
 None
 1.27A 4lv9A-2w92A:
3.3
4lv9B-2w92A:
4.4		 4lv9A-2w92A:
20.91
4lv9B-2w92A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_2
(NUPC FAMILY PROTEIN)		 2w92 ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE D
(Streptococcus
pneumoniae) 		3 / 3 THR A 377
ASN A 413
PHE A 412
 None
None
NGT  A1809 (-4.4A)
 0.71A 4pd9A-2w92A:
undetectable		 4pd9A-2w92A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 2w92 ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE D
(Streptococcus
pneumoniae) 		5 / 12 TRP A 751
THR A 797
THR A 796
ALA A 795
ALA A 794
 None
 1.03A 4u15A-2w92A:
undetectable		 4u15A-2w92A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_A_RTZA602_1
(CYTOCHROME P450 2D6)		 2w92 ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE D
(Streptococcus
pneumoniae) 		5 / 12 PHE A 594
LEU A 576
LEU A 654
VAL A 623
VAL A 606
 None
 1.22A 4wnwA-2w92A:
undetectable		 4wnwA-2w92A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_B_GBMB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 2w92 ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE D
(Streptococcus
pneumoniae) 		5 / 12 LEU A 464
VAL A 518
ILE A 514
TRP A 454
LEU A 440
 None
 1.30A 4yvpB-2w92A:
4.8		 4yvpB-2w92A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2w92 ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE D
(Streptococcus
pneumoniae) 		3 / 3 THR A 564
HIS A 625
LEU A 680
 None
 0.88A 5axdC-2w92A:
undetectable		 5axdC-2w92A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)		 2w92 ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE D
(Streptococcus
pneumoniae) 		5 / 11 ASN A 590
VAL A 561
ASP A 253
THR A 535
TYR A 609
 None
 1.30A 5jh7D-2w92A:
2.8		 5jh7D-2w92A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_B_SALB301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 2w92 ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE D
(Streptococcus
pneumoniae) 		4 / 5 ALA A 228
VAL A 226
PHE A 252
ILE A 514
 None
 0.85A 5of1B-2w92A:
3.6		 5of1B-2w92A:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2w92 ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE D
(Streptococcus
pneumoniae) 		4 / 6 GLN A 731
PHE A 732
PHE A 713
LEU A 780
 None
 1.13A 5zcoP-2w92A:
undetectable
5zcoW-2w92A:
undetectable		 5zcoP-2w92A:
16.90
5zcoW-2w92A:
7.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0L_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2w92 ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE D
(Streptococcus
pneumoniae) 		5 / 12 VAL A 623
LEU A 562
LEU A 592
ARG A 279
GLY A 789
 None
 1.08A 6b0lB-2w92A:
undetectable		 6b0lB-2w92A:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_A_BEZA502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 2w92 ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE D
(Streptococcus
pneumoniae) 		4 / 6 PHE A 693
LEU A 698
LEU A 695
HIS A 625
 None
 1.02A 6e43A-2w92A:
undetectable		 6e43A-2w92A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EUQ_A_DXCA502_0
(MULTIDRUG
TRANSPORTER MDFA)		 2w92 ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE D
(Streptococcus
pneumoniae) 		5 / 11 MET A 635
LEU A 680
GLY A 596
LEU A 608
GLN A 569
 None
 1.47A 6euqA-2w92A:
undetectable		 6euqA-2w92A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_1
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 2w92 ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE D
(Streptococcus
pneumoniae) 		3 / 3 ASP A 749
SER A 772
SER A 770
 None
 0.79A 6mxtA-2w92A:
undetectable		 6mxtA-2w92A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_E_BEZE701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 2w92 ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE D
(Streptococcus
pneumoniae) 		5 / 11 GLY A 439
LEU A 442
ALA A 472
PHE A 409
ALA A 228
 None
None
None
NGT  A1809 ( 4.6A)
None
 1.49A 6qgbE-2w92A:
2.2		 6qgbE-2w92A:
23.08