SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2w9d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSD_C_DVAC2_0
(ACTINOMYCIN D)		 2w9d ICSM 18-ANTI-PRP
THERAPEUTIC FAB
HEAVY CHAIN
(Mus
musculus) 		4 / 4 THR H 120
PRO H 149
THR H 119
PRO H 121
 None
 1.31A 1dsdC-2w9dH:
undetectable		 1dsdC-2w9dH:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSD_C_DVAC8_0
(ACTINOMYCIN D)		 2w9d ICSM 18-ANTI-PRP
THERAPEUTIC FAB
HEAVY CHAIN
(Mus
musculus) 		4 / 4 THR H 120
PRO H 149
THR H 119
PRO H 121
 None
 1.31A 1dsdC-2w9dH:
undetectable		 1dsdC-2w9dH:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDT_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 2w9d ICSM 18-ANTI-PRP
THERAPEUTIC FAB
HEAVY CHAIN
(Mus
musculus) 		5 / 11 VAL H 112
LEU H  86
HIS H  84
PHE H  64
GLU H  82
 None
 1.34A 1fdtA-2w9dH:
undetectable		 1fdtA-2w9dH:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_A_5FWA601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 2w9d ICSM 18-ANTI-PRP
THERAPEUTIC FAB
HEAVY CHAIN
(Mus
musculus) 		5 / 12 VAL H 165
VAL H 183
SER H 181
ASN H 198
ASN H 157
 None
 1.44A 2y03A-2w9dH:
undetectable		 2y03A-2w9dH:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_B_5FWB601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 2w9d ICSM 18-ANTI-PRP
THERAPEUTIC FAB
HEAVY CHAIN
(Mus
musculus) 		5 / 12 VAL H 165
VAL H 183
SER H 181
ASN H 198
ASN H 157
 None
 1.47A 2y03B-2w9dH:
undetectable		 2y03B-2w9dH:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NYA_A_JTZA1203_1
(BETA-2 ADRENERGIC
RECEPTOR, LYSOZYME)		 2w9d ICSM 18-ANTI-PRP
THERAPEUTIC FAB
HEAVY CHAIN
(Mus
musculus) 		5 / 12 VAL H 165
VAL H 183
SER H 181
ASN H 198
ASN H 157
 None
 1.42A 3nyaA-2w9dH:
undetectable		 3nyaA-2w9dH:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LDO_A_ALEA1402_1
(LYSOZYME, BETA-2
ADRENERGIC RECEPTOR)		 2w9d ICSM 18-ANTI-PRP
THERAPEUTIC FAB
HEAVY CHAIN
(Mus
musculus) 		5 / 10 VAL H 165
VAL H 183
SER H 181
ASN H 198
ASN H 157
 None
 1.48A 4ldoA-2w9dH:
undetectable		 4ldoA-2w9dH:
17.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MTH_A_ACTA302_0
(ANTIBODY FAB HEAVY
CHAIN)		 2w9d ICSM 18-ANTI-PRP
THERAPEUTIC FAB
HEAVY CHAIN
(Mus
musculus) 		5 / 5 SER H 115
ALA H 117
PHE H 148
LEU H 172
ASP H 175
 None
 0.33A 5mthA-2w9dH:
28.1		 5mthA-2w9dH:
81.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7M_B_68HB405_0
(BETA-1 ADRENERGIC
RECEPTOR)		 2w9d ICSM 18-ANTI-PRP
THERAPEUTIC FAB
HEAVY CHAIN
(Mus
musculus) 		5 / 12 VAL H 165
VAL H 183
SER H 181
ASN H 198
ASN H 157
 None
 1.46A 6h7mB-2w9dH:
undetectable		 6h7mB-2w9dH:
19.80