SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2w9f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		 2w9f CELL DIVISION
PROTEIN KINASE 4
(Homo
sapiens) 		3 / 3 PHE B  93
TYR B 165
TYR B  17
 None
 0.93A 1x70B-2w9fB:
undetectable		 1x70B-2w9fB:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_1
(RETINOIC ACID
RECEPTOR, BETA)		 2w9f CELL DIVISION
PROTEIN KINASE 4
(Homo
sapiens) 		5 / 12 CYH B 202
LEU B 273
LEU B 276
ILE B 230
ILE B 226
 None
 1.14A 1xdkB-2w9fB:
undetectable		 1xdkB-2w9fB:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_B_NCAB508_0
(NAD-DEPENDENT
DEACETYLASE 2)		 2w9f CELL DIVISION
PROTEIN KINASE 4
(Homo
sapiens) 		4 / 5 GLN B 123
LEU B 120
TYR B 103
GLN B  98
 None
 1.34A 1yc2B-2w9fB:
undetectable
1yc2C-2w9fB:
undetectable		 1yc2B-2w9fB:
22.46
1yc2C-2w9fB:
22.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 2w9f CELL DIVISION
PROTEIN KINASE 4
(Homo
sapiens) 		8 / 12 ILE B  12
VAL B  20
VAL B  72
PHE B  93
VAL B  96
THR B 102
LEU B 147
ALA B 157
 None
 0.92A 2eufB-2w9fB:
27.7		 2eufB-2w9fB:
69.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 2w9f CELL DIVISION
PROTEIN KINASE 4
(Homo
sapiens) 		9 / 12 VAL B  20
VAL B  72
PHE B  93
VAL B  96
ASP B  99
THR B 102
ASN B 145
LEU B 147
ALA B 157
 None
 0.80A 2eufB-2w9fB:
27.7		 2eufB-2w9fB:
69.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 2w9f CELL DIVISION
PROTEIN KINASE 4
(Homo
sapiens) 		4 / 4 PRO B 143
ASP B  99
ASP B  97
ASP B 105
 None
 1.23A 2nyuA-2w9fB:
undetectable		 2nyuA-2w9fB:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 2w9f CELL DIVISION
PROTEIN KINASE 4
(Homo
sapiens) 		4 / 8 ARG B 163
ILE B 136
LEU B 128
GLY B 127
 None
 0.81A 2tsrB-2w9fB:
undetectable		 2tsrB-2w9fB:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2w9f CELL DIVISION
PROTEIN KINASE 4
(Homo
sapiens) 		3 / 3 TYR B 191
ASP B 196
ASP B 129
 None
 0.90A 3ou6B-2w9fB:
undetectable		 3ou6B-2w9fB:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_2
(HIV-1 PROTEASE)		 2w9f CELL DIVISION
PROTEIN KINASE 4
(Homo
sapiens) 		5 / 10 VAL B  37
ILE B 164
ILE B  51
PRO B  40
VAL B  89
 None
 1.05A 3t3cB-2w9fB:
undetectable		 3t3cB-2w9fB:
18.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)		 2w9f CELL DIVISION
PROTEIN KINASE 4
(Homo
sapiens) 		5 / 9 ALA B  33
VAL B  72
PHE B  93
ASP B  99
LEU B 147
 None
 0.52A 3ti1A-2w9fB:
28.5		 3ti1A-2w9fB:
44.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 2w9f CELL DIVISION
PROTEIN KINASE 4
(Homo
sapiens) 		6 / 12 LYS B  35
ASP B 140
LYS B 142
ASN B 145
ASP B 158
GLY B 160
 None
 1.17A 4an2A-2w9fB:
23.6		 4an2A-2w9fB:
29.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 2w9f CELL DIVISION
PROTEIN KINASE 4
(Homo
sapiens) 		6 / 12 LYS B  35
LEU B  60
ASP B 140
LYS B 142
ASN B 145
ASP B 158
 None
 1.29A 4an2A-2w9fB:
23.6		 4an2A-2w9fB:
29.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 2w9f CELL DIVISION
PROTEIN KINASE 4
(Homo
sapiens) 		7 / 12 GLY B  13
VAL B  20
LYS B  35
LEU B  74
LEU B  91
LEU B 147
LEU B 161
 None
 0.95A 4ifgA-2w9fB:
24.3		 4ifgA-2w9fB:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_B_8PRB601_1
(RHODOPSIN KINASE)		 2w9f CELL DIVISION
PROTEIN KINASE 4
(Homo
sapiens) 		5 / 8 GLY B  15
VAL B  20
ALA B  33
ASP B  99
LEU B 147
 None
 1.05A 4l9iB-2w9fB:
18.4		 4l9iB-2w9fB:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2w9f CELL DIVISION
PROTEIN KINASE 4
(Homo
sapiens) 		5 / 12 LEU B 161
ALA B 157
LEU B 156
LEU B 131
LEU B 128
 None
 0.94A 4o1zA-2w9fB:
undetectable		 4o1zA-2w9fB:
19.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 2w9f CELL DIVISION
PROTEIN KINASE 4
(Homo
sapiens) 		6 / 8 GLY B  15
VAL B  20
ALA B  33
ASP B  99
ASN B 145
LEU B 147
 None
 1.05A 4ogrA-2w9fB:
24.5		 4ogrA-2w9fB:
36.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 2w9f CELL DIVISION
PROTEIN KINASE 4
(Homo
sapiens) 		9 / 12 GLY B  13
VAL B  20
ALA B  33
VAL B  72
PHE B  93
ASP B  99
THR B 102
LEU B 147
ALA B 157
 None
 0.63A 5l2iA-2w9fB:
12.1		 5l2iA-2w9fB:
69.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 2w9f CELL DIVISION
PROTEIN KINASE 4
(Homo
sapiens) 		9 / 12 ILE B  12
GLY B  13
VAL B  20
ALA B  33
VAL B  72
PHE B  93
THR B 102
LEU B 147
ALA B 157
 None
 0.77A 5l2iA-2w9fB:
12.1		 5l2iA-2w9fB:
69.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 2w9f CELL DIVISION
PROTEIN KINASE 4
(Homo
sapiens) 		9 / 12 GLY B  13
ALA B  33
VAL B  72
PHE B  93
HIS B  95
ASP B  99
THR B 102
LEU B 147
ALA B 157
 None
 0.72A 5l2tA-2w9fB:
12.0		 5l2tA-2w9fB:
69.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 2w9f CELL DIVISION
PROTEIN KINASE 4
(Homo
sapiens) 		7 / 12 GLY B  13
HIS B  95
ASP B  99
THR B 102
LEU B 147
ALA B 157
ASP B 158
 None
 1.07A 5l2tA-2w9fB:
12.0		 5l2tA-2w9fB:
69.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 2w9f CELL DIVISION
PROTEIN KINASE 4
(Homo
sapiens) 		7 / 12 GLY B  15
ALA B  33
VAL B  72
PHE B  93
ASP B  99
LEU B 147
ALA B 157
 None
 1.45A 5l2tA-2w9fB:
12.0		 5l2tA-2w9fB:
69.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 2w9f CELL DIVISION
PROTEIN KINASE 4
(Homo
sapiens) 		10 / 12 ILE B  12
GLY B  13
VAL B  20
ALA B  33
VAL B  72
PHE B  93
HIS B  95
THR B 102
LEU B 147
ALA B 157
 None
 0.93A 5l2tA-2w9fB:
12.0		 5l2tA-2w9fB:
69.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 2w9f CELL DIVISION
PROTEIN KINASE 4
(Homo
sapiens) 		8 / 12 ILE B  12
GLY B  13
VAL B  20
HIS B  95
THR B 102
LEU B 147
ALA B 157
ASP B 158
 None
 1.29A 5l2tA-2w9fB:
12.0		 5l2tA-2w9fB:
69.11