SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2w9m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
5 / 9 ALA A 348
THR A 333
HIS A 334
THR A 361
ILE A 396
None
None
ZN  A1566 (-3.5A)
None
None
1.22A 1c9sA-2w9mA:
undetectable
1c9sB-2w9mA:
undetectable
1c9sA-2w9mA:
8.00
1c9sB-2w9mA:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVT_A_FLPA125_1
(TRANSTHYRETIN)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
4 / 8 LEU A 321
ALA A 533
LEU A 547
SER A 546
None
0.86A 1dvtA-2w9mA:
undetectable
1dvtB-2w9mA:
undetectable
1dvtA-2w9mA:
12.45
1dvtB-2w9mA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9Y_B_HAEB800_1
(UREASE SUBUNIT BETA)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
4 / 5 HIS A 332
HIS A 428
HIS A 456
ASP A 516
ZN  A1566 (-3.4A)
ZN  A1567 (-3.4A)
ZN  A1567 (-3.6A)
ZN  A1566 (-2.5A)
0.90A 1e9yB-2w9mA:
7.4
1e9yB-2w9mA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_A_RTLA401_0
(RETINOL DEHYDRATASE)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
5 / 12 LEU A 100
LEU A  99
HIS A 456
HIS A 364
ILE A  26
None
None
ZN  A1567 (-3.6A)
ZN  A1565 (-3.2A)
None
1.36A 1fmlA-2w9mA:
undetectable
1fmlA-2w9mA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FWE_C_HAEC989_1
(UREASE)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
5 / 6 HIS A 332
HIS A 334
HIS A 428
HIS A 456
ASP A 516
ZN  A1566 (-3.4A)
ZN  A1566 (-3.5A)
ZN  A1567 (-3.4A)
ZN  A1567 (-3.6A)
ZN  A1566 (-2.5A)
0.94A 1fweC-2w9mA:
8.0
1fweC-2w9mA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FWE_C_HAEC989_1
(UREASE)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
5 / 6 HIS A 332
HIS A 364
HIS A 428
HIS A 456
ASP A 516
ZN  A1566 (-3.4A)
ZN  A1565 (-3.2A)
ZN  A1567 (-3.4A)
ZN  A1567 (-3.6A)
ZN  A1566 (-2.5A)
1.14A 1fweC-2w9mA:
8.0
1fweC-2w9mA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_R_TRPR81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
5 / 9 ALA A 348
THR A 333
HIS A 334
THR A 361
ILE A 396
None
None
ZN  A1566 (-3.5A)
None
None
1.26A 1gtnR-2w9mA:
undetectable
1gtnS-2w9mA:
undetectable
1gtnR-2w9mA:
8.00
1gtnS-2w9mA:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_A_CILA451_1
(RENAL DIPEPTIDASE)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
5 / 12 ASP A 516
GLU A 401
HIS A 364
HIS A 428
HIS A 456
ZN  A1566 (-2.5A)
ZN  A1567 ( 2.4A)
ZN  A1565 (-3.2A)
ZN  A1567 (-3.4A)
ZN  A1567 (-3.6A)
0.91A 1ituA-2w9mA:
2.9
1ituA-2w9mA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_B_CILB452_1
(RENAL DIPEPTIDASE)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
5 / 12 ASP A 516
GLU A 401
HIS A 364
HIS A 428
HIS A 456
ZN  A1566 (-2.5A)
ZN  A1567 ( 2.4A)
ZN  A1565 (-3.2A)
ZN  A1567 (-3.4A)
ZN  A1567 (-3.6A)
0.96A 1ituB-2w9mA:
3.6
1ituB-2w9mA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE3_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
3 / 3 ASP A 339
HIS A 334
HIS A 364
ZN  A1565 (-2.1A)
ZN  A1566 (-3.5A)
ZN  A1565 (-3.2A)
0.69A 1oe3A-2w9mA:
undetectable
1oe3A-2w9mA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
4 / 4 HIS A 364
GLU A 401
HIS A 334
HIS A 518
ZN  A1565 (-3.2A)
ZN  A1567 ( 2.4A)
ZN  A1566 (-3.5A)
ZN  A1565 (-3.3A)
1.15A 1os2D-2w9mA:
undetectable
1os2D-2w9mA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_B_PODB700_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
5 / 12 LEU A 177
ALA A 174
LEU A 173
ALA A 198
ALA A 185
None
1.06A 1sa1A-2w9mA:
undetectable
1sa1B-2w9mA:
undetectable
1sa1A-2w9mA:
20.00
1sa1B-2w9mA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_D_TRPD81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
5 / 9 ALA A 348
THR A 333
HIS A 334
THR A 361
ILE A 396
None
None
ZN  A1566 (-3.5A)
None
None
1.19A 1utdD-2w9mA:
undetectable
1utdE-2w9mA:
undetectable
1utdD-2w9mA:
8.00
1utdE-2w9mA:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_G_TRPG81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
5 / 9 ALA A 348
THR A 333
HIS A 334
THR A 361
ILE A 396
None
None
ZN  A1566 (-3.5A)
None
None
1.20A 1utdG-2w9mA:
undetectable
1utdH-2w9mA:
undetectable
1utdG-2w9mA:
8.00
1utdH-2w9mA:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_J_TRPJ81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
5 / 8 ALA A 348
THR A 333
HIS A 334
THR A 361
ILE A 396
None
None
ZN  A1566 (-3.5A)
None
None
1.20A 1utdJ-2w9mA:
undetectable
1utdK-2w9mA:
undetectable
1utdJ-2w9mA:
8.00
1utdK-2w9mA:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_K_TRPK81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
5 / 9 ALA A 348
THR A 333
HIS A 334
THR A 361
ILE A 396
None
None
ZN  A1566 (-3.5A)
None
None
1.18A 1utdA-2w9mA:
undetectable
1utdK-2w9mA:
undetectable
1utdA-2w9mA:
8.00
1utdK-2w9mA:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_M_TRPM81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
5 / 11 ALA A 348
THR A 333
HIS A 334
THR A 361
ILE A 396
None
None
ZN  A1566 (-3.5A)
None
None
1.24A 1utdM-2w9mA:
undetectable
1utdN-2w9mA:
undetectable
1utdM-2w9mA:
8.00
1utdN-2w9mA:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
4 / 4 HIS A 364
GLU A 401
HIS A 334
HIS A 518
ZN  A1565 (-3.2A)
ZN  A1567 ( 2.4A)
ZN  A1566 (-3.5A)
ZN  A1565 (-3.3A)
1.10A 1utzA-2w9mA:
undetectable
1utzA-2w9mA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
4 / 4 HIS A 364
GLU A 401
HIS A 334
HIS A 518
ZN  A1565 (-3.2A)
ZN  A1567 ( 2.4A)
ZN  A1566 (-3.5A)
ZN  A1565 (-3.3A)
1.10A 1utzB-2w9mA:
undetectable
1utzB-2w9mA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
4 / 6 ARG A 494
GLY A  90
ALA A  88
HIS A 428
ZN  A1567 ( 4.8A)
None
None
ZN  A1567 (-3.4A)
0.92A 1wmqA-2w9mA:
undetectable
1wmqA-2w9mA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
4 / 6 ARG A 494
GLY A  90
ALA A  88
HIS A 428
ZN  A1567 ( 4.8A)
None
None
ZN  A1567 (-3.4A)
0.92A 1wmqB-2w9mA:
undetectable
1wmqB-2w9mA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
4 / 6 ARG A 494
GLY A  90
ALA A  88
HIS A 428
ZN  A1567 ( 4.8A)
None
None
ZN  A1567 (-3.4A)
0.92A 1wpuA-2w9mA:
undetectable
1wpuA-2w9mA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
4 / 6 ARG A 494
GLY A  90
ALA A  88
HIS A 428
ZN  A1567 ( 4.8A)
None
None
ZN  A1567 (-3.4A)
0.92A 1wpuB-2w9mA:
undetectable
1wpuB-2w9mA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
4 / 6 ARG A 494
GLY A  90
ALA A  88
HIS A 428
ZN  A1567 ( 4.8A)
None
None
ZN  A1567 (-3.4A)
0.93A 1wrqA-2w9mA:
undetectable
1wrqA-2w9mA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
4 / 6 ARG A 494
GLY A  90
ALA A  88
HIS A 428
ZN  A1567 ( 4.8A)
None
None
ZN  A1567 (-3.4A)
0.91A 1wrqB-2w9mA:
undetectable
1wrqB-2w9mA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZEA_A_DHIA6_0
(MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
H CHAIN
MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
L CHAIN
SHORT SYNTHETIC
D-AMINO ACID PEPTIDE
D2)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
3 / 3 TRP A 312
ARG A 304
PHE A 255
None
1.33A 1zeaH-2w9mA:
undetectable
1zeaL-2w9mA:
undetectable
1zeaH-2w9mA:
17.56
1zeaL-2w9mA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_A_RBFA300_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
5 / 11 TYR A 422
GLY A 399
SER A 400
HIS A 334
ILE A 344
None
None
None
ZN  A1566 (-3.5A)
None
1.43A 2a58A-2w9mA:
undetectable
2a58E-2w9mA:
undetectable
2a58A-2w9mA:
16.33
2a58E-2w9mA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_D_RBFD303_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
5 / 11 ILE A 344
TYR A 422
GLY A 399
SER A 400
HIS A 334
None
None
None
None
ZN  A1566 (-3.5A)
1.43A 2a58C-2w9mA:
undetectable
2a58D-2w9mA:
undetectable
2a58C-2w9mA:
16.33
2a58D-2w9mA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2002_1
(SERUM ALBUMIN)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
5 / 11 ALA A 457
LEU A 442
ALA A 445
LEU A 472
VAL A 475
None
1.09A 2bxeB-2w9mA:
undetectable
2bxeB-2w9mA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_B_IBPB2002_1
(SERUM ALBUMIN)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
5 / 10 ALA A 457
LEU A 442
ALA A 445
LEU A 472
VAL A 475
None
1.05A 2bxgB-2w9mA:
undetectable
2bxgB-2w9mA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F80_B_017B301_1
(POL POLYPROTEIN)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
5 / 12 LEU A 410
ASN A 430
VAL A 427
VAL A 425
ILE A 404
None
1.00A 2f80A-2w9mA:
undetectable
2f80A-2w9mA:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_2
(PROTEASE)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
5 / 9 LEU A 410
VAL A 427
ILE A 443
VAL A 425
ILE A 404
None
0.98A 2o4pB-2w9mA:
undetectable
2o4pB-2w9mA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_B_HAEB502_1
(COLLAGENASE 3)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
4 / 4 HIS A 364
GLU A 401
HIS A 334
HIS A 518
ZN  A1565 (-3.2A)
ZN  A1567 ( 2.4A)
ZN  A1566 (-3.5A)
ZN  A1565 (-3.3A)
1.06A 2ow9B-2w9mA:
undetectable
2ow9B-2w9mA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
4 / 4 HIS A 364
GLU A 401
HIS A 334
HIS A 518
ZN  A1565 (-3.2A)
ZN  A1567 ( 2.4A)
ZN  A1566 (-3.5A)
ZN  A1565 (-3.3A)
1.10A 2ozrC-2w9mA:
undetectable
2ozrC-2w9mA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_D_HAED3002_1
(COLLAGENASE 3)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
4 / 4 HIS A 364
GLU A 401
HIS A 334
HIS A 518
ZN  A1565 (-3.2A)
ZN  A1567 ( 2.4A)
ZN  A1566 (-3.5A)
ZN  A1565 (-3.3A)
1.09A 2ozrD-2w9mA:
undetectable
2ozrD-2w9mA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_3
(PROTEASE RETROPEPSIN)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
3 / 3 ASP A 295
THR A 284
PRO A 285
None
0.70A 2pynB-2w9mA:
undetectable
2pynB-2w9mA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_4
(PROTEASE RETROPEPSIN)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
3 / 3 ASP A 295
THR A 284
PRO A 285
None
0.67A 2q64B-2w9mA:
undetectable
2q64B-2w9mA:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA803_0
(FERROCHELATASE)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
4 / 5 LEU A  92
PRO A  93
ILE A  26
ARG A 111
None
ZN  A1565 ( 4.2A)
None
None
0.84A 2qd4A-2w9mA:
2.8
2qd4A-2w9mA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB927_0
(FERROCHELATASE)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
3 / 3 LEU A  92
PRO A  93
ARG A 111
None
ZN  A1565 ( 4.2A)
None
0.50A 2qd4B-2w9mA:
undetectable
2qd4B-2w9mA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOY_A_HISA1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
5 / 10 ARG A 494
GLY A  90
ALA A  88
HIS A 428
HIS A 364
ZN  A1567 ( 4.8A)
None
None
ZN  A1567 (-3.4A)
ZN  A1565 (-3.2A)
1.02A 3boyA-2w9mA:
undetectable
3boyC-2w9mA:
undetectable
3boyA-2w9mA:
14.56
3boyC-2w9mA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOY_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
5 / 10 HIS A 364
ARG A 494
GLY A  90
ALA A  88
HIS A 428
ZN  A1565 (-3.2A)
ZN  A1567 ( 4.8A)
None
None
ZN  A1567 (-3.4A)
1.02A 3boyA-2w9mA:
undetectable
3boyB-2w9mA:
undetectable
3boyA-2w9mA:
14.56
3boyB-2w9mA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOY_A_HISA3001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
5 / 10 HIS A 364
ARG A 494
GLY A  90
ALA A  88
HIS A 428
ZN  A1565 (-3.2A)
ZN  A1567 ( 4.8A)
None
None
ZN  A1567 (-3.4A)
1.02A 3boyB-2w9mA:
undetectable
3boyC-2w9mA:
undetectable
3boyB-2w9mA:
14.56
3boyC-2w9mA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_C_SHHC301_1
(HISTONE DEACETYLASE
7A)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
4 / 6 ASP A 403
HIS A 332
ASP A 516
HIS A 456
None
ZN  A1566 (-3.4A)
ZN  A1566 (-2.5A)
ZN  A1567 (-3.6A)
0.92A 3c0zC-2w9mA:
undetectable
3c0zC-2w9mA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
4 / 6 GLU A  86
THR A  20
ALA A  89
ALA A  88
None
1.26A 3ns1C-2w9mA:
undetectable
3ns1C-2w9mA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
5 / 12 LEU A 420
GLU A 487
GLY A 399
SER A 400
ASP A 421
None
1.31A 3ou6C-2w9mA:
undetectable
3ou6C-2w9mA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
5 / 12 LEU A 154
GLY A 104
GLY A 101
ASP A  98
LEU A  99
None
1.22A 3ou7A-2w9mA:
undetectable
3ou7A-2w9mA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
5 / 12 LEU A 154
GLY A 104
GLY A 101
ASP A  98
LEU A  99
None
1.23A 3ou7D-2w9mA:
undetectable
3ou7D-2w9mA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
4 / 7 ASN A 491
ASP A 339
HIS A 364
HIS A 334
None
ZN  A1565 (-2.1A)
ZN  A1565 (-3.2A)
ZN  A1566 (-3.5A)
1.06A 3t01A-2w9mA:
undetectable
3t01A-2w9mA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_3
(PROTEASE)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
3 / 3 ASP A 295
THR A 284
PRO A 285
None
0.62A 3tkgD-2w9mA:
undetectable
3tkgD-2w9mA:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
4 / 5 LEU A 200
LEU A 177
LEU A 224
SER A 225
None
0.95A 3vhuA-2w9mA:
undetectable
3vhuA-2w9mA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1504_0
(FERROCHELATASE,
MITOCHONDRIAL)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
4 / 4 PRO A  93
LEU A  96
ILE A  26
ARG A 111
ZN  A1565 ( 4.2A)
None
None
None
1.24A 3w1wA-2w9mA:
undetectable
3w1wA-2w9mA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_B_ADNB301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
5 / 10 ALA A 238
GLY A 204
LEU A 224
LEU A 180
ILE A 235
None
1.08A 3wdmB-2w9mA:
undetectable
3wdmB-2w9mA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_C_ADNC301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
5 / 9 ALA A 238
GLY A 204
LEU A 224
LEU A 180
ILE A 235
None
1.07A 3wdmC-2w9mA:
undetectable
3wdmC-2w9mA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_D_ADND301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
5 / 10 ALA A 238
GLY A 204
LEU A 224
LEU A 180
ILE A 235
None
1.09A 3wdmD-2w9mA:
undetectable
3wdmD-2w9mA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_A_NCAA1536_0
(DIPHTHERIA TOXIN)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
4 / 6 GLY A 166
TYR A 228
ALA A 165
GLU A 229
None
0.94A 4ae1A-2w9mA:
undetectable
4ae1A-2w9mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_A_CAMA1419_0
(CYTOCHROME P450)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
4 / 8 LEU A  99
LEU A  96
GLY A  95
VAL A 519
None
0.77A 4c9nA-2w9mA:
undetectable
4c9nA-2w9mA:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EXS_B_X8ZB301_1
(BETA-LACTAMASE NDM-1)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
4 / 8 HIS A 456
ASP A 516
HIS A 428
HIS A 334
ZN  A1567 (-3.6A)
ZN  A1566 (-2.5A)
ZN  A1567 (-3.4A)
ZN  A1566 (-3.5A)
0.90A 4exsB-2w9mA:
undetectable
4exsB-2w9mA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H9M_A_HAEA929_1
(UREASE)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
4 / 5 HIS A 332
HIS A 428
HIS A 456
ASP A 516
ZN  A1566 (-3.4A)
ZN  A1567 (-3.4A)
ZN  A1567 (-3.6A)
ZN  A1566 (-2.5A)
0.95A 4h9mA-2w9mA:
7.2
4h9mA-2w9mA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
3 / 3 HIS A 428
VAL A 475
LEU A 454
ZN  A1567 (-3.4A)
None
None
0.64A 4m2vA-2w9mA:
undetectable
4m2vA-2w9mA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
5 / 12 ILE A  62
ILE A  69
ARG A  35
SER A  39
LEU A  17
None
1.05A 4mwzA-2w9mA:
undetectable
4mwzA-2w9mA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
4 / 5 LEU A 173
ASP A 227
GLU A 199
VAL A 223
None
1.25A 4nkvA-2w9mA:
undetectable
4nkvA-2w9mA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
3 / 3 SER A 400
ALA A 398
VAL A 397
None
0.52A 4o2bA-2w9mA:
undetectable
4o2bA-2w9mA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
3 / 3 SER A 400
ALA A 398
VAL A 397
None
0.57A 4o2bC-2w9mA:
undetectable
4o2bC-2w9mA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA305_1
(TYROSINASE)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
4 / 7 HIS A 334
HIS A 332
HIS A 456
HIS A 428
ZN  A1566 (-3.5A)
ZN  A1566 (-3.4A)
ZN  A1567 (-3.6A)
ZN  A1567 (-3.4A)
0.92A 4p6sA-2w9mA:
undetectable
4p6sA-2w9mA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
4 / 7 HIS A 334
HIS A 332
HIS A 456
HIS A 428
ZN  A1566 (-3.5A)
ZN  A1566 (-3.4A)
ZN  A1567 (-3.6A)
ZN  A1567 (-3.4A)
0.96A 4p6sB-2w9mA:
undetectable
4p6sB-2w9mA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
4 / 7 HIS A 428
HIS A 456
HIS A 332
HIS A 334
ZN  A1567 (-3.4A)
ZN  A1567 (-3.6A)
ZN  A1566 (-3.4A)
ZN  A1566 (-3.5A)
0.72A 4p6sB-2w9mA:
undetectable
4p6sB-2w9mA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_1
(PROLINE--TRNA LIGASE)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
3 / 3 GLU A 507
THR A 539
HIS A 542
None
0.86A 4q15A-2w9mA:
undetectable
4q15A-2w9mA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
5 / 12 ALA A 517
HIS A 428
HIS A 456
GLU A 401
LEU A 359
None
ZN  A1567 (-3.4A)
ZN  A1567 (-3.6A)
ZN  A1567 ( 2.4A)
None
1.18A 4r7lA-2w9mA:
undetectable
4r7lA-2w9mA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBP_C_HAEC800_1
(PROTEIN (UREASE
(CHAIN C)))
2w9m POLYMERASE X
(Deinococcus
radiodurans)
5 / 6 HIS A 332
HIS A 334
HIS A 428
HIS A 456
ASP A 516
ZN  A1566 (-3.4A)
ZN  A1566 (-3.5A)
ZN  A1567 (-3.4A)
ZN  A1567 (-3.6A)
ZN  A1566 (-2.5A)
0.95A 4ubpC-2w9mA:
5.8
4ubpC-2w9mA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_1
(PROLINE--TRNA LIGASE)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
3 / 3 GLU A 507
THR A 539
HIS A 542
None
0.75A 4ydqB-2w9mA:
undetectable
4ydqB-2w9mA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_F_TR6F101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
4 / 5 GLY A 267
ARG A 277
GLY A 278
GLU A 280
None
1.17A 4z2eB-2w9mA:
undetectable
4z2eC-2w9mA:
undetectable
4z2eB-2w9mA:
25.36
4z2eC-2w9mA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_A_WJZA304_0
(BETA-LACTAMASE NDM-1)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
4 / 8 HIS A 456
ASP A 516
HIS A 428
HIS A 334
ZN  A1567 (-3.6A)
ZN  A1566 (-2.5A)
ZN  A1567 (-3.4A)
ZN  A1566 (-3.5A)
0.91A 5a5zA-2w9mA:
undetectable
5a5zA-2w9mA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
5 / 7 ALA A 183
ASP A 187
ARG A 196
GLY A 252
GLU A 253
None
1.13A 5btgA-2w9mA:
undetectable
5btgC-2w9mA:
undetectable
5btgD-2w9mA:
undetectable
5btgA-2w9mA:
24.64
5btgC-2w9mA:
24.64
5btgD-2w9mA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DWK_C_ACTC207_0
(DIACYLGLYCEROL
KINASE)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
4 / 5 GLU A 172
ALA A 168
GLU A 126
GLU A 229
None
1.31A 5dwkC-2w9mA:
undetectable
5dwkC-2w9mA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DWK_C_ACTC207_0
(DIACYLGLYCEROL
KINASE)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
4 / 5 GLU A 172
ALA A 168
GLU A 171
GLU A 129
None
1.43A 5dwkC-2w9mA:
undetectable
5dwkC-2w9mA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_B_010B607_0
(HNL ISOENZYME 5)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
5 / 10 ALA A 512
VAL A 453
HIS A 332
VAL A 424
TYR A 422
None
None
ZN  A1566 (-3.4A)
None
None
1.48A 5eb5B-2w9mA:
undetectable
5eb5B-2w9mA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
4 / 7 HIS A 428
HIS A 456
HIS A 332
HIS A 334
ZN  A1567 (-3.4A)
ZN  A1567 (-3.6A)
ZN  A1566 (-3.4A)
ZN  A1566 (-3.5A)
0.73A 5i3aA-2w9mA:
undetectable
5i3aA-2w9mA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
4 / 7 HIS A 428
HIS A 456
HIS A 332
HIS A 334
ZN  A1567 (-3.4A)
ZN  A1567 (-3.6A)
ZN  A1566 (-3.4A)
ZN  A1566 (-3.5A)
0.72A 5i3aB-2w9mA:
undetectable
5i3aB-2w9mA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MFX_A_ACTA701_0
(GENOME POLYPROTEIN)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
4 / 5 ARG A 189
THR A 201
ALA A 183
ASP A 247
None
1.27A 5mfxA-2w9mA:
undetectable
5mfxA-2w9mA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
5 / 12 ILE A 404
VAL A 424
VAL A 423
SER A 426
ILE A 443
None
None
None
ZN  A1567 ( 4.3A)
None
1.16A 5n0sB-2w9mA:
undetectable
5n0sB-2w9mA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_A_ACTA301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
4 / 6 ASP A 339
HIS A 518
HIS A 334
HIS A 428
ZN  A1565 (-2.1A)
ZN  A1565 (-3.3A)
ZN  A1566 (-3.5A)
ZN  A1567 (-3.4A)
0.76A 5ncdA-2w9mA:
2.9
5ncdD-2w9mA:
2.4
5ncdA-2w9mA:
17.62
5ncdD-2w9mA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_C_ACTC301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
4 / 6 HIS A 428
ASP A 339
HIS A 518
HIS A 334
ZN  A1567 (-3.4A)
ZN  A1565 (-2.1A)
ZN  A1565 (-3.3A)
ZN  A1566 (-3.5A)
0.81A 5ncdB-2w9mA:
2.9
5ncdC-2w9mA:
2.7
5ncdB-2w9mA:
17.62
5ncdC-2w9mA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_A_ACTA302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
4 / 6 ASP A 339
HIS A 518
HIS A 334
HIS A 428
ZN  A1565 (-2.1A)
ZN  A1565 (-3.3A)
ZN  A1566 (-3.5A)
ZN  A1567 (-3.4A)
0.85A 5nelA-2w9mA:
2.3
5nelD-2w9mA:
3.7
5nelA-2w9mA:
17.62
5nelD-2w9mA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA601_0
(THIOCYANATE
DEHYDROGENASE)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
3 / 3 HIS A 518
ASP A 339
HIS A 364
ZN  A1565 (-3.3A)
ZN  A1565 (-2.1A)
ZN  A1565 (-3.2A)
0.45A 5oexA-2w9mA:
undetectable
5oexA-2w9mA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB601_0
(THIOCYANATE
DEHYDROGENASE)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
3 / 3 HIS A 518
ASP A 339
HIS A 364
ZN  A1565 (-3.3A)
ZN  A1565 (-2.1A)
ZN  A1565 (-3.2A)
0.41A 5oexB-2w9mA:
undetectable
5oexB-2w9mA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC601_0
(THIOCYANATE
DEHYDROGENASE)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
3 / 3 HIS A 518
ASP A 339
HIS A 364
ZN  A1565 (-3.3A)
ZN  A1565 (-2.1A)
ZN  A1565 (-3.2A)
0.37A 5oexC-2w9mA:
undetectable
5oexC-2w9mA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD601_0
(THIOCYANATE
DEHYDROGENASE)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
3 / 3 HIS A 518
ASP A 339
HIS A 364
ZN  A1565 (-3.3A)
ZN  A1565 (-2.1A)
ZN  A1565 (-3.2A)
0.37A 5oexD-2w9mA:
undetectable
5oexD-2w9mA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_1
(ENDO-1,4-BETA-XYLANA
SE A)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
5 / 12 LEU A 294
PHE A 291
VAL A 290
ALA A 242
GLY A 244
None
1.16A 5tzoB-2w9mA:
undetectable
5tzoB-2w9mA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_1
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
4 / 5 GLY A 230
ARG A 125
ASP A 227
GLN A 219
None
1.42A 5ubbA-2w9mA:
undetectable
5ubbA-2w9mA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_0
(MRNA CAPPING ENZYME
P5)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
5 / 12 GLY A 244
PRO A 239
ALA A 238
PHE A 291
THR A 286
None
1.30A 5x6yA-2w9mA:
undetectable
5x6yA-2w9mA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC902_0
(MRNA CAPPING ENZYME
P5)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
5 / 12 GLY A 244
PRO A 239
ALA A 238
PHE A 291
THR A 286
None
1.32A 5x6yC-2w9mA:
undetectable
5x6yC-2w9mA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA CHAIN)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
3 / 3 SER A 400
ALA A 398
VAL A 397
None
0.49A 5xiwC-2w9mA:
undetectable
5xiwC-2w9mA:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
3 / 3 ARG A 189
PHE A 298
ARG A 304
None
1.08A 5y9yA-2w9mA:
undetectable
5y9yA-2w9mA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJ8_A_9DCA303_0
(METALLO-BETA-LACTAMA
SE TYPE 2)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
4 / 8 HIS A 456
ASP A 516
HIS A 428
HIS A 334
ZN  A1567 (-3.6A)
ZN  A1566 (-2.5A)
ZN  A1567 (-3.4A)
ZN  A1566 (-3.5A)
0.94A 5zj8A-2w9mA:
undetectable
5zj8A-2w9mA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CCV_C_RFPC1205_1
(-)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
5 / 12 ASP A 516
LEU A 442
ARG A 441
ARG A 494
HIS A 334
ZN  A1566 (-2.5A)
None
None
ZN  A1567 ( 4.8A)
ZN  A1566 (-3.5A)
1.15A 6ccvC-2w9mA:
0.0
6ccvC-2w9mA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_0
(ADENOSYLHOMOCYSTEINA
SE)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
5 / 12 THR A 361
ASP A 516
HIS A 428
GLY A 340
HIS A 518
None
ZN  A1566 (-2.5A)
ZN  A1567 (-3.4A)
None
ZN  A1565 (-3.3A)
1.11A 6exiD-2w9mA:
2.7
6exiD-2w9mA:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)
2w9m POLYMERASE X
(Deinococcus
radiodurans)
4 / 6 THR A 351
LEU A 354
THR A 333
LEU A 327
None
1.10A 6mvxA-2w9mA:
undetectable
6mvxB-2w9mA:
undetectable
6mvxC-2w9mA:
undetectable
6mvxA-2w9mA:
17.87
6mvxB-2w9mA:
17.87
6mvxC-2w9mA:
17.87