SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2w9z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B302_2
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 2w9z G1/S-SPECIFIC
CYCLIN-D1
(Homo
sapiens) 		3 / 3 CYH A 106
PRO A  79
ASP A  86
 None
 0.88A 3hlwB-2w9zA:
undetectable		 3hlwB-2w9zA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB323_0
(INVASIN IPAD)		 2w9z G1/S-SPECIFIC
CYCLIN-D1
(Homo
sapiens) 		4 / 7 ILE A 177
ILE A 178
VAL A 212
LEU A 215
 None
 0.62A 3r9vA-2w9zA:
undetectable
3r9vB-2w9zA:
undetectable		 3r9vA-2w9zA:
19.53
3r9vB-2w9zA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2w9z G1/S-SPECIFIC
CYCLIN-D1
(Homo
sapiens) 		5 / 10 SER A  90
PHE A  45
LEU A  99
VAL A  60
VAL A  52
 None
 1.45A 3u9fI-2w9zA:
undetectable		 3u9fI-2w9zA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_A_IMNA701_1
(CYCLOOXYGENASE-2)		 2w9z G1/S-SPECIFIC
CYCLIN-D1
(Homo
sapiens) 		5 / 12 SER A 111
LEU A  85
GLY A 103
ALA A 104
LEU A 137
 None
 1.16A 4coxA-2w9zA:
undetectable		 4coxA-2w9zA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_B_IMNB701_1
(CYCLOOXYGENASE-2)		 2w9z G1/S-SPECIFIC
CYCLIN-D1
(Homo
sapiens) 		5 / 12 SER A 111
LEU A  85
GLY A 103
ALA A 104
LEU A 137
 None
 1.16A 4coxB-2w9zA:
2.3		 4coxB-2w9zA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_D_IMND701_1
(CYCLOOXYGENASE-2)		 2w9z G1/S-SPECIFIC
CYCLIN-D1
(Homo
sapiens) 		5 / 12 SER A 111
LEU A  85
GLY A 103
ALA A 104
LEU A 137
 None
 1.16A 4coxD-2w9zA:
1.7		 4coxD-2w9zA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A602_1
(SERUM ALBUMIN)		 2w9z G1/S-SPECIFIC
CYCLIN-D1
(Homo
sapiens) 		4 / 7 PRO A 157
VAL A 186
ALA A 190
TYR A  84
 None
 1.07A 4lb2A-2w9zA:
3.9		 4lb2A-2w9zA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM5_A_CE3A301_2
(BETA-LACTAMASE
CTX-M-14)		 2w9z G1/S-SPECIFIC
CYCLIN-D1
(Homo
sapiens) 		3 / 3 CYH A 106
PRO A  79
ASP A  86
 None
 0.82A 4pm5A-2w9zA:
undetectable		 4pm5A-2w9zA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2w9z G1/S-SPECIFIC
CYCLIN-D1
(Homo
sapiens) 		3 / 3 ASP A  86
LYS A 194
LEU A 254
 None
 1.00A 4ptjA-2w9zA:
undetectable		 4ptjA-2w9zA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 2w9z G1/S-SPECIFIC
CYCLIN-D1
(Homo
sapiens) 		3 / 3 VAL A  77
GLN A  71
CYH A  68
 None
 0.84A 5icxA-2w9zA:
undetectable
5icxE-2w9zA:
undetectable		 5icxA-2w9zA:
23.95
5icxE-2w9zA:
4.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2w9z G1/S-SPECIFIC
CYCLIN-D1
(Homo
sapiens) 		5 / 12 VAL A  67
LEU A  85
GLY A 103
ALA A 104
LEU A 124
 None
 1.35A 5iktB-2w9zA:
undetectable		 5iktB-2w9zA:
19.96