SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wa0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT4_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2wa0 MELANOMA-ASSOCIATED
ANTIGEN 4
(Homo
sapiens) 		5 / 12 LEU A 202
LEU A 207
ALA A 278
VAL A 206
TYR A 187
 None
 1.35A 1kt4A-2wa0A:
undetectable		 1kt4A-2wa0A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT4_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2wa0 MELANOMA-ASSOCIATED
ANTIGEN 4
(Homo
sapiens) 		5 / 12 LEU A 202
LEU A 207
ALA A 280
ALA A 278
VAL A 206
 None
 1.31A 1kt4A-2wa0A:
undetectable		 1kt4A-2wa0A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECLB600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2wa0 MELANOMA-ASSOCIATED
ANTIGEN 4
(Homo
sapiens) 		4 / 8 TYR A 240
LEU A 246
THR A 209
ILE A 205
 None
 0.82A 3jusB-2wa0A:
undetectable		 3jusB-2wa0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IP7_D_ADND604_1
(PYRUVATE KINASE
ISOZYMES L)		 2wa0 MELANOMA-ASSOCIATED
ANTIGEN 4
(Homo
sapiens) 		3 / 3 ARG A 277
GLU A 254
ASN A 255
 None
 0.90A 4ip7D-2wa0A:
undetectable		 4ip7D-2wa0A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTP_A_ASCA802_0
(RRNA N-GLYCOSIDASE)		 2wa0 MELANOMA-ASSOCIATED
ANTIGEN 4
(Homo
sapiens) 		4 / 5 TYR A 144
ILE A 141
ASN A 112
ILE A 151
 None
 1.00A 4jtpA-2wa0A:
undetectable		 4jtpA-2wa0A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2wa0 MELANOMA-ASSOCIATED
ANTIGEN 4
(Homo
sapiens) 		4 / 6 GLU A 221
GLU A 219
TYR A 270
GLU A 271
 None
 0.99A 4mi4A-2wa0A:
undetectable		 4mi4A-2wa0A:
27.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2wa0 MELANOMA-ASSOCIATED
ANTIGEN 4
(Homo
sapiens) 		4 / 7 GLU A 221
GLU A 219
TYR A 270
GLU A 271
 None
 1.00A 4mi4B-2wa0A:
undetectable
4mi4C-2wa0A:
undetectable		 4mi4B-2wa0A:
27.56
4mi4C-2wa0A:
27.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2wa0 MELANOMA-ASSOCIATED
ANTIGEN 4
(Homo
sapiens) 		4 / 7 GLU A 221
GLU A 219
TYR A 270
GLU A 271
 None
 0.99A 4mi4A-2wa0A:
undetectable
4mi4C-2wa0A:
undetectable		 4mi4A-2wa0A:
27.56
4mi4C-2wa0A:
27.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2wa0 MELANOMA-ASSOCIATED
ANTIGEN 4
(Homo
sapiens) 		4 / 8 GLU A 221
GLU A 219
TYR A 270
GLU A 271
 None
 1.04A 4mj8A-2wa0A:
undetectable
4mj8C-2wa0A:
undetectable		 4mj8A-2wa0A:
19.37
4mj8C-2wa0A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2wa0 MELANOMA-ASSOCIATED
ANTIGEN 4
(Homo
sapiens) 		4 / 8 GLU A 221
GLU A 219
TYR A 270
GLU A 271
 None
 1.00A 4mj8B-2wa0A:
undetectable
4mj8C-2wa0A:
undetectable		 4mj8B-2wa0A:
19.37
4mj8C-2wa0A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2wa0 MELANOMA-ASSOCIATED
ANTIGEN 4
(Homo
sapiens) 		4 / 7 GLU A 221
GLU A 219
TYR A 270
GLU A 271
 None
 1.13A 4mj8C-2wa0A:
undetectable		 4mj8C-2wa0A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_B_LOCB502_1
(TUBULIN BETA CHAIN)		 2wa0 MELANOMA-ASSOCIATED
ANTIGEN 4
(Homo
sapiens) 		5 / 12 LEU A 203
ALA A 278
LEU A 257
ALA A 211
ILE A 222
 None
 1.02A 4x20B-2wa0A:
undetectable		 4x20B-2wa0A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2wa0 MELANOMA-ASSOCIATED
ANTIGEN 4
(Homo
sapiens) 		3 / 3 GLY A 153
VAL A 140
MET A 136
 None
 0.59A 5ycpA-2wa0A:
undetectable		 5ycpA-2wa0A:
17.96