SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wa5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG1_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 2wa5 FILAMIN-B
(Homo
sapiens) 		3 / 3 TRP A 128
VAL A 127
PRO A 126
 None
 0.80A 1rg1A-2wa5A:
undetectable		 1rg1A-2wa5A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH0_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 2wa5 FILAMIN-B
(Homo
sapiens) 		3 / 3 TRP A 128
VAL A 127
PRO A 126
 None
 0.80A 1rh0A-2wa5A:
undetectable		 1rh0A-2wa5A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_2
(RETINOIC ACID
RECEPTOR, BETA)		 2wa5 FILAMIN-B
(Homo
sapiens) 		3 / 3 LEU A 174
PHE A 237
ARG A 199
 None
 0.81A 1xdkB-2wa5A:
undetectable		 1xdkB-2wa5A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		 2wa5 FILAMIN-B
(Homo
sapiens) 		4 / 4 LEU A  53
PRO A 126
ILE A 118
LEU A 117
 None
 0.87A 1ya4B-2wa5A:
undetectable		 1ya4B-2wa5A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		 2wa5 FILAMIN-B
(Homo
sapiens) 		4 / 4 LEU A  53
PRO A 126
ILE A 118
LEU A 117
 None
 0.94A 1ya4C-2wa5A:
undetectable		 1ya4C-2wa5A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WQ5_A_MIYA1120_1
(PHOSPHOLIPASE A2,
ACIDIC)		 2wa5 FILAMIN-B
(Homo
sapiens) 		5 / 7 LEU A 234
TRP A 165
ALA A 170
GLY A 172
PHE A 237
 None
 1.35A 2wq5A-2wa5A:
undetectable		 2wq5A-2wa5A:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2wa5 FILAMIN-B
(Homo
sapiens) 		5 / 12 ILE A  97
ILE A 102
GLY A  47
LEU A  53
LEU A  87
 None
 0.96A 3em0B-2wa5A:
undetectable		 3em0B-2wa5A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_B_DESB800_1
(ESTROGEN RECEPTOR
ALPHA)		 2wa5 FILAMIN-B
(Homo
sapiens) 		5 / 10 ALA A  83
LEU A  94
LEU A  84
HIS A 120
LEU A 117
 None
 1.32A 3erdB-2wa5A:
undetectable		 3erdB-2wa5A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_2
(PROTEASE)		 2wa5 FILAMIN-B
(Homo
sapiens) 		6 / 12 GLY A 172
ALA A 173
ASP A 176
PRO A 157
ILE A 158
ILE A 153
 None
 1.42A 3s54B-2wa5A:
undetectable		 3s54B-2wa5A:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_1
(THYMIDYLATE SYNTHASE)		 2wa5 FILAMIN-B
(Homo
sapiens) 		3 / 3 ASN A 160
ASP A 167
GLY A 168
 None
 0.65A 5fctB-2wa5A:
undetectable		 5fctB-2wa5A:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_1
(ADENOSYLHOMOCYSTEINA
SE)		 2wa5 FILAMIN-B
(Homo
sapiens) 		3 / 3 LEU A 182
GLN A 204
LYS A 241
 None
 0.80A 6exiB-2wa5A:
undetectable		 6exiB-2wa5A:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_0
(ADENOSYLHOMOCYSTEINA
SE)		 2wa5 FILAMIN-B
(Homo
sapiens) 		3 / 3 LEU A 182
GLN A 204
LYS A 241
 None
 0.81A 6exiA-2wa5A:
undetectable		 6exiA-2wa5A:
14.57