SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wae'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GHM_A_CEDA1_1
(BETA-LACTAMASE)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		6 / 12 SER A 386
LYS A 389
SER A 443
ASN A 445
LYS A 615
GLY A 617
 None
 0.40A 1ghmA-2waeA:
14.3		 1ghmA-2waeA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_2
(HIV-1 PROTEASE)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		3 / 3 ARG A 223
THR A 265
VAL A 237
 None
 1.01A 1hxbA-2waeA:
undetectable		 1hxbA-2waeA:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		7 / 12 SER A 386
LYS A 389
SER A 443
ASN A 445
THR A 600
LYS A 615
GLY A 617
 None
 0.46A 1i2wA-2waeA:
14.7		 1i2wA-2waeA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		6 / 12 SER A 386
LYS A 389
SER A 443
ASN A 445
THR A 600
GLY A 617
 None
 0.40A 1i2wB-2waeA:
14.8		 1i2wB-2waeA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_A_SAMA401_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		5 / 12 THR A 524
GLY A 501
ASP A 521
VAL A 503
ASN A 633
 None
 1.27A 1n2xA-2waeA:
undetectable		 1n2xA-2waeA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_I_TRPI81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		4 / 8 GLY A 396
ALA A 436
THR A 451
ILE A 393
 None
 0.81A 1utdI-2waeA:
undetectable
1utdJ-2waeA:
undetectable		 1utdI-2waeA:
6.98
1utdJ-2waeA:
6.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		3 / 3 ASP A 580
GLU A 484
TYR A 531
 None
 0.85A 1wsvA-2waeA:
undetectable		 1wsvA-2waeA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOS_A_VIAA1_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		5 / 12 ASP A 288
LEU A 287
MET A  88
PHE A 187
ILE A 285
 None
 1.32A 1xosA-2waeA:
undetectable		 1xosA-2waeA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		7 / 12 SER A 386
LYS A 389
SER A 443
ASN A 445
THR A 600
LYS A 615
GLY A 617
 None
 0.53A 1ymxA-2waeA:
15.9		 1ymxA-2waeA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		6 / 12 SER A 386
LYS A 389
SER A 443
ASN A 445
LYS A 615
GLY A 617
 None
 0.44A 1ymxB-2waeA:
15.9		 1ymxB-2waeA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2L8M_A_CAMA415_0
(CAMPHOR
5-MONOOXYGENASE)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		5 / 9 TYR A 176
VAL A 104
VAL A  79
ILE A 192
VAL A  80
 None
 1.12A 2l8mA-2waeA:
undetectable		 2l8mA-2waeA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		5 / 12 ALA A 648
LEU A 348
SER A 374
THR A 491
ILE A 493
 None
 1.02A 2oipA-2waeA:
undetectable		 2oipA-2waeA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_D_MTXD617_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		5 / 12 ALA A 648
LEU A 348
SER A 374
THR A 491
ILE A 493
 None
 0.95A 2oipD-2waeA:
undetectable		 2oipD-2waeA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_E_MTXE621_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		5 / 12 ALA A 648
LEU A 348
SER A 374
THR A 491
ILE A 493
 None
 0.95A 2oipE-2waeA:
undetectable		 2oipE-2waeA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_A_SAMA500_0
(HYPOTHETICAL PROTEIN)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		4 / 7 VAL A 346
ALA A 529
PHE A 316
THR A 311
 None
 0.94A 2q6oA-2waeA:
undetectable		 2q6oA-2waeA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		4 / 7 PHE A 604
ILE A 612
THR A 600
ILE A 645
 None
 0.79A 2v0mB-2waeA:
undetectable		 2v0mB-2waeA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_2
(BETA-1 ADRENERGIC
RECEPTOR)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		3 / 3 VAL A 237
ASN A  74
TRP A 221
 None
 1.03A 2y00B-2waeA:
undetectable		 2y00B-2waeA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		3 / 3 THR A 392
SER A 386
LYS A 615
 None
 1.14A 3aocC-2waeA:
3.0		 3aocC-2waeA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_1
(PROTEASE)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		5 / 10 ALA A 636
GLY A 662
ILE A 665
ALA A 608
ILE A 612
 None
 0.96A 3ekwA-2waeA:
undetectable		 3ekwA-2waeA:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		5 / 12 ALA A 648
LEU A 348
SER A 374
THR A 491
ILE A 493
 None
 0.96A 3hj3A-2waeA:
undetectable		 3hj3A-2waeA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		5 / 12 ALA A 648
LEU A 348
SER A 374
THR A 491
ILE A 493
 None
 0.99A 3hj3B-2waeA:
undetectable		 3hj3B-2waeA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_A_CE3A301_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		6 / 12 LYS A 389
SER A 443
ASN A 445
THR A 600
LYS A 615
GLY A 617
 None
 0.46A 3hlwA-2waeA:
16.0		 3hlwA-2waeA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B302_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		6 / 12 SER A 443
ASN A 445
THR A 600
LYS A 615
THR A 616
GLY A 617
 None
 0.40A 3hlwB-2waeA:
15.8		 3hlwB-2waeA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA300_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		5 / 12 LYS A 389
ASN A 445
LYS A 615
THR A 616
GLY A 617
 None
 0.40A 3huoA-2waeA:
16.0		 3huoA-2waeA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_1
(UNCHARACTERIZED
PROTEIN)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		3 / 3 THR A 168
LYS A 129
GLU A 174
 None
 1.00A 3ijdB-2waeA:
undetectable		 3ijdB-2waeA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		4 / 6 SER A 232
LEU A 276
ILE A 225
LEU A 495
 None
 0.96A 3kk6A-2waeA:
undetectable		 3kk6A-2waeA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KL3_A_DHIA403_0
(GLUCURONOXYLANASE
XYNC)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		4 / 4 GLY A 342
TYR A 344
GLY A 360
ASP A 373
 None
 1.05A 3kl3A-2waeA:
undetectable		 3kl3A-2waeA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL201_1
(PROTEIN S100-A4)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		4 / 7 GLY A 476
PHE A 415
PHE A 512
PHE A 509
 None
 1.15A 3ko0L-2waeA:
undetectable
3ko0N-2waeA:
undetectable		 3ko0L-2waeA:
9.10
3ko0N-2waeA:
9.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		4 / 8 ILE A 493
PRO A 544
SER A 489
GLY A 492
 None
 0.96A 3lslA-2waeA:
undetectable
3lslD-2waeA:
undetectable		 3lslA-2waeA:
19.10
3lslD-2waeA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		4 / 8 ILE A 493
PRO A 544
SER A 489
GLY A 492
 None
 0.93A 3lslA-2waeA:
undetectable
3lslD-2waeA:
undetectable		 3lslA-2waeA:
19.10
3lslD-2waeA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA308_1
(BETA-LACTAMASE)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		6 / 12 SER A 386
SER A 443
THR A 600
LYS A 615
THR A 616
GLY A 617
 None
 0.58A 3ny4A-2waeA:
15.4		 3ny4A-2waeA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q07_A_WPPA300_1
(BETA-LACTAMASE)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		5 / 12 LYS A 389
SER A 443
ASN A 445
LYS A 615
GLY A 617
 None
 0.48A 3q07A-2waeA:
16.0		 3q07A-2waeA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q07_B_WPPB400_1
(BETA-LACTAMASE)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		5 / 12 LYS A 389
SER A 443
ASN A 445
LYS A 615
GLY A 617
 None
 0.47A 3q07B-2waeA:
15.9		 3q07B-2waeA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SH8_A_CEDA1_1
(BETA-LACTAMASE)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		6 / 12 SER A 386
SER A 443
ASN A 445
LYS A 615
THR A 616
GLY A 617
 None
 0.45A 3sh8A-2waeA:
15.1		 3sh8A-2waeA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SH8_B_CEDB1_1
(BETA-LACTAMASE)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		6 / 12 SER A 386
LYS A 389
SER A 443
ASN A 445
LYS A 615
GLY A 617
 None
 0.55A 3sh8B-2waeA:
15.2		 3sh8B-2waeA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AT2_A_ASDA1490_1
(3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		5 / 10 ALA A 439
THR A 451
PHE A 432
TYR A 425
SER A 423
 None
 1.42A 4at2A-2waeA:
0.0		 4at2A-2waeA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EUZ_A_MEMA401_1
(CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		7 / 12 LYS A 389
SER A 443
ASN A 445
THR A 600
LYS A 615
THR A 616
GLY A 617
 None
 0.45A 4euzA-2waeA:
15.7		 4euzA-2waeA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FH2_A_0RNA303_1
(BETA-LACTAMASE SHV-1)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		5 / 10 SER A 443
ASN A 445
LYS A 615
THR A 616
GLY A 617
 None
 0.56A 4fh2A-2waeA:
16.7		 4fh2A-2waeA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_B_HFGB1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		5 / 12 LEU A 197
VAL A 104
GLU A 240
SER A 239
GLY A 243
 None
 1.35A 4hvcB-2waeA:
undetectable		 4hvcB-2waeA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		4 / 8 ALA A 347
ASP A  65
ILE A 312
ILE A 233
 None
 0.88A 4kttB-2waeA:
undetectable		 4kttB-2waeA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_A_CEDA301_1
(BETA-LACTAMASE)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		6 / 12 SER A 386
SER A 443
ASN A 445
LYS A 615
THR A 616
GLY A 617
 None
 0.45A 4n9kA-2waeA:
14.8		 4n9kA-2waeA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_B_CEDB301_1
(BETA-LACTAMASE)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		6 / 12 SER A 386
SER A 443
ASN A 445
LYS A 615
THR A 616
GLY A 617
 None
 0.45A 4n9kB-2waeA:
14.9		 4n9kB-2waeA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA602_1
(SERUM ALBUMIN)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		5 / 9 PHE A 316
ALA A  66
LEU A  71
LEU A 356
VAL A 355
 None
 1.34A 4or0A-2waeA:
undetectable		 4or0A-2waeA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM5_A_CE3A301_1
(BETA-LACTAMASE
CTX-M-14)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		6 / 12 SER A 443
ASN A 445
THR A 600
LYS A 615
THR A 616
GLY A 617
 None
 0.66A 4pm5A-2waeA:
16.0		 4pm5A-2waeA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM7_A_CE3A301_1
(BETA-LACTAMASE
CTX-M-14)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		6 / 12 LYS A 389
SER A 443
ASN A 445
THR A 600
LYS A 615
GLY A 617
 None
 0.70A 4pm7A-2waeA:
16.0		 4pm7A-2waeA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM9_A_CE3A301_1
(BETA-LACTAMASE
CTX-M-14)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		6 / 12 SER A 443
ASN A 445
THR A 600
LYS A 615
THR A 616
GLY A 617
 None
 0.65A 4pm9A-2waeA:
16.1		 4pm9A-2waeA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		5 / 12 LEU A 197
VAL A 104
GLU A 240
SER A 239
GLY A 243
 None
 1.30A 4q15B-2waeA:
undetectable		 4q15B-2waeA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHZ_A_CEDA301_1
(BETA-LACTAMASE)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		6 / 11 SER A 386
SER A 443
ASN A 445
LYS A 615
THR A 616
GLY A 617
 None
 0.46A 5ghzA-2waeA:
14.9		 5ghzA-2waeA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHZ_B_CEDB301_1
(BETA-LACTAMASE)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		6 / 10 SER A 386
SER A 443
ASN A 445
LYS A 615
THR A 616
GLY A 617
 None
 0.46A 5ghzB-2waeA:
14.8		 5ghzB-2waeA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_A_FUAA1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		4 / 5 ILE A 233
ILE A 493
HIS A 545
VAL A 355
 None
 0.93A 5jmnA-2waeA:
2.9		 5jmnA-2waeA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		5 / 12 GLY A 486
ASN A 572
VAL A 574
VAL A 532
ALA A 533
 None
 1.07A 5kocA-2waeA:
undetectable		 5kocA-2waeA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_1
(PROTEASE PR5-DRV)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		5 / 10 ARG A  60
ASP A  65
GLY A 549
ILE A 550
ILE A  63
 None
 1.04A 5kr1A-2waeA:
undetectable		 5kr1A-2waeA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_C_SAMC501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		5 / 7 GLY A 396
GLY A 400
LEU A 453
THR A 451
ALA A 452
 None
 1.30A 5o96C-2waeA:
undetectable		 5o96C-2waeA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OJ0_A_9WTA801_0
(PENICILLIN-BINDING
PROTEIN 2X)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		6 / 12 TRP A 424
SER A 443
ASN A 445
GLN A 519
THR A 600
GLY A 617
 None
 1.17A 5oj0A-2waeA:
29.9		 5oj0A-2waeA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIH_A_8CVA201_1
(DIHYDROFOLATE
REDUCTASE)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		4 / 8 ILE A 308
ASP A 494
LEU A 495
ILE A  63
 None
 0.90A 5uihA-2waeA:
undetectable		 5uihA-2waeA:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		4 / 5 LEU A  93
LYS A  94
ALA A  97
LEU A 100
 None
 0.67A 5vkqA-2waeA:
2.1
5vkqD-2waeA:
2.1		 5vkqA-2waeA:
17.60
5vkqD-2waeA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		4 / 5 LEU A  93
LYS A  94
ALA A  97
LEU A 100
 None
 0.66A 5vkqA-2waeA:
2.1
5vkqB-2waeA:
2.1		 5vkqA-2waeA:
17.60
5vkqB-2waeA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		4 / 5 LEU A  93
LYS A  94
ALA A  97
LEU A 100
 None
 0.65A 5vkqB-2waeA:
2.1
5vkqC-2waeA:
2.1		 5vkqB-2waeA:
17.60
5vkqC-2waeA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		4 / 5 LEU A  93
LYS A  94
ALA A  97
LEU A 100
 None
 0.66A 5vkqC-2waeA:
2.1
5vkqD-2waeA:
2.1		 5vkqC-2waeA:
17.60
5vkqD-2waeA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA503_1
(CYTOCHROME P450 2C9)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		4 / 5 GLY A 617
THR A 618
ASN A 633
LYS A 630
 None
 1.11A 5x23A-2waeA:
undetectable		 5x23A-2waeA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		4 / 6 TYR A  64
GLU A 548
TYR A 551
GLY A 558
 None
 0.97A 5x7pB-2waeA:
undetectable		 5x7pB-2waeA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_A_HFGA1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		5 / 12 LEU A 197
VAL A 104
GLU A 240
SER A 239
GLY A 243
 None
 1.33A 5xiqA-2waeA:
undetectable		 5xiqA-2waeA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5Y_B_9F2B400_1
(BETA-LACTAMASE)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		6 / 12 SER A 386
SER A 443
THR A 600
LYS A 615
THR A 616
GLY A 617
 None
 0.48A 6b5yB-2waeA:
15.7		 6b5yB-2waeA:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5Y_D_9F2D400_1
(BETA-LACTAMASE)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		6 / 12 SER A 386
SER A 443
THR A 600
LYS A 615
THR A 616
GLY A 617
 None
 0.54A 6b5yD-2waeA:
15.6		 6b5yD-2waeA:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B68_B_9F2B301_1
(BETA-LACTAMASE)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		6 / 12 SER A 386
SER A 443
THR A 600
LYS A 615
THR A 616
GLY A 617
 None
 0.37A 6b68B-2waeA:
16.0		 6b68B-2waeA:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B68_D_9F2D400_1
(BETA-LACTAMASE)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		5 / 12 SER A 386
SER A 443
THR A 600
LYS A 615
GLY A 617
 None
 0.50A 6b68D-2waeA:
15.6		 6b68D-2waeA:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B69_B_9F2B301_1
(BETA-LACTAMASE)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		6 / 12 SER A 386
SER A 443
THR A 600
LYS A 615
THR A 616
GLY A 617
 None
 0.37A 6b69A-2waeA:
15.8
6b69B-2waeA:
15.5		 6b69A-2waeA:
8.60
6b69B-2waeA:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B69_D_9F2D301_1
(BETA-LACTAMASE)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		6 / 12 SER A 386
SER A 443
THR A 600
LYS A 615
THR A 616
GLY A 617
 None
 0.36A 6b69D-2waeA:
16.1		 6b69D-2waeA:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6A_B_9F2B301_1
(BETA-LACTAMASE)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		6 / 12 SER A 386
SER A 443
THR A 600
LYS A 615
THR A 616
GLY A 617
 None
 0.37A 6b6aB-2waeA:
16.1		 6b6aB-2waeA:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6A_D_9F2D301_1
(BETA-LACTAMASE)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		5 / 12 SER A 386
SER A 443
LYS A 615
THR A 616
GLY A 617
 None
 0.33A 6b6aD-2waeA:
16.3		 6b6aD-2waeA:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6D_A_9F2A302_1
(BETA-LACTAMASE)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		6 / 12 SER A 386
SER A 443
THR A 600
LYS A 615
THR A 616
GLY A 617
 None
 0.63A 6b6dA-2waeA:
15.4		 6b6dA-2waeA:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6E_A_9F2A302_1
(BETA-LACTAMASE)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		6 / 12 SER A 386
SER A 443
THR A 600
LYS A 615
THR A 616
GLY A 617
 None
 0.40A 6b6eA-2waeA:
15.5		 6b6eA-2waeA:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6F_A_9F2A301_1
(BETA-LACTAMASE)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		5 / 12 SER A 386
SER A 443
LYS A 615
THR A 616
GLY A 617
 None
 0.60A 6b6fA-2waeA:
16.0		 6b6fA-2waeA:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C79_A_CE3A301_1
(BETA-LACTAMASE
TOHO-1)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		5 / 12 SER A 443
ASN A 445
THR A 600
LYS A 615
GLY A 617
 None
 0.34A 6c79A-2waeA:
16.0		 6c79A-2waeA:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBO_A_ADNA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2wae PENICILLIN-BINDING
PROTEIN 2B
(Streptococcus
pneumoniae) 		4 / 8 LYS A  87
SER A  85
PHE A 187
ASP A 288
 None
 1.02A 6fboA-2waeA:
undetectable		 6fboA-2waeA:
9.01