SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wam'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_B_CCSB417_0
(ESTROGEN RECEPTOR)		 2wam CONSERVED
HYPOTHETICAL ALANINE
AND LEUCINE RICH
PROTEIN
(Mycobacterium
tuberculosis) 		4 / 6 PRO A 154
PHE A 310
GLU A 308
GLN A 313
 None
 1.37A 1l2iB-2wamA:
undetectable		 1l2iB-2wamA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_2
(MINERALOCORTICOID
RECEPTOR)		 2wam CONSERVED
HYPOTHETICAL ALANINE
AND LEUCINE RICH
PROTEIN
(Mycobacterium
tuberculosis) 		4 / 4 LEU A 108
LEU A 105
SER A 104
LEU A  69
 None
 1.16A 1ya3A-2wamA:
undetectable		 1ya3A-2wamA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2wam CONSERVED
HYPOTHETICAL ALANINE
AND LEUCINE RICH
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 THR A 152
GLY A 151
GLY A 149
GLU A 196
PHE A 307
 None
 1.29A 2akeA-2wamA:
undetectable		 2akeA-2wamA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2wam CONSERVED
HYPOTHETICAL ALANINE
AND LEUCINE RICH
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 THR A 152
GLY A 151
GLY A 149
GLU A 196
PHE A 307
 None
 1.26A 2azxA-2wamA:
undetectable		 2azxA-2wamA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2wam CONSERVED
HYPOTHETICAL ALANINE
AND LEUCINE RICH
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 THR A 152
GLY A 151
GLY A 149
GLU A 196
PHE A 307
 None
 1.27A 2azxB-2wamA:
undetectable		 2azxB-2wamA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 2wam CONSERVED
HYPOTHETICAL ALANINE
AND LEUCINE RICH
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 187
PHE A 307
ILE A 182
THR A 166
HIS A 168
 None
 1.18A 2jn3A-2wamA:
undetectable		 2jn3A-2wamA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCU_A_TYLA3001_1
(LACTOTRANSFERRIN)		 2wam CONSERVED
HYPOTHETICAL ALANINE
AND LEUCINE RICH
PROTEIN
(Mycobacterium
tuberculosis) 		3 / 3 LEU A  23
TYR A  21
GLY A  19
 None
 0.57A 2ocuA-2wamA:
undetectable		 2ocuA-2wamA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_D_C2FD1200_0
(GLYCINE
N-METHYLTRANSFERASE)		 2wam CONSERVED
HYPOTHETICAL ALANINE
AND LEUCINE RICH
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 118
SER A 111
LEU A  61
HIS A  60
THR A  67
 None
 1.43A 3thrA-2wamA:
undetectable
3thrB-2wamA:
undetectable
3thrC-2wamA:
undetectable
3thrD-2wamA:
undetectable		 3thrA-2wamA:
23.24
3thrB-2wamA:
23.24
3thrC-2wamA:
23.24
3thrD-2wamA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2wam CONSERVED
HYPOTHETICAL ALANINE
AND LEUCINE RICH
PROTEIN
(Mycobacterium
tuberculosis) 		4 / 7 TYR A 216
ILE A 257
TYR A 222
PRO A 214
 None
 1.12A 4g5jA-2wamA:
undetectable		 4g5jA-2wamA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_1
(PROLINE--TRNA LIGASE)		 2wam CONSERVED
HYPOTHETICAL ALANINE
AND LEUCINE RICH
PROTEIN
(Mycobacterium
tuberculosis) 		3 / 3 GLU A 306
THR A 164
HIS A 212
 None
 0.82A 4q15A-2wamA:
undetectable		 4q15A-2wamA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_1
(PROLINE--TRNA LIGASE)		 2wam CONSERVED
HYPOTHETICAL ALANINE
AND LEUCINE RICH
PROTEIN
(Mycobacterium
tuberculosis) 		3 / 3 GLU A 306
THR A 164
HIS A 212
 None
 0.83A 4q15B-2wamA:
undetectable		 4q15B-2wamA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2wam CONSERVED
HYPOTHETICAL ALANINE
AND LEUCINE RICH
PROTEIN
(Mycobacterium
tuberculosis) 		4 / 7 GLU A 102
LEU A 138
PHE A  73
TYR A 106
 None
 0.90A 4twdF-2wamA:
undetectable
4twdJ-2wamA:
undetectable		 4twdF-2wamA:
21.23
4twdJ-2wamA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_C_QDNC602_1
(CYTOCHROME P450 2D6)		 2wam CONSERVED
HYPOTHETICAL ALANINE
AND LEUCINE RICH
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 11 LEU A 229
PHE A  47
GLY A 208
ALA A  43
SER A 192
 None
 1.34A 4wnuC-2wamA:
undetectable		 4wnuC-2wamA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_A_DESA601_1
(ESTROGEN RECEPTOR)		 2wam CONSERVED
HYPOTHETICAL ALANINE
AND LEUCINE RICH
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 229
ALA A  57
LEU A 243
LEU A 246
LEU A  61
 None
 1.20A 4zn7A-2wamA:
undetectable		 4zn7A-2wamA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		 2wam CONSERVED
HYPOTHETICAL ALANINE
AND LEUCINE RICH
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 267
GLU A 306
PHE A 310
GLN A 314
ILE A 163
 None
 1.31A 6becA-2wamA:
undetectable
6becB-2wamA:
undetectable
6becC-2wamA:
undetectable		 6becA-2wamA:
18.74
6becB-2wamA:
18.74
6becC-2wamA:
18.74