SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2waw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2waw MOBA RELATE PROTEIN
(Mycobacterium
sp.
DSM
3803) 		5 / 12 LEU A  49
GLY A 104
ASP A 155
SER A  82
ALA A  13
 None
None
None
CSO  A  81 ( 4.5A)
None
 1.12A 2br4C-2wawA:
undetectable		 2br4C-2wawA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A163_1
(BETA-LACTOGLOBULIN)		 2waw MOBA RELATE PROTEIN
(Mycobacterium
sp.
DSM
3803) 		5 / 12 LEU A 101
VAL A 114
ILE A 118
LEU A 117
PHE A  46
 None
 0.82A 2gj5A-2wawA:
undetectable		 2gj5A-2wawA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QJ7_A_SPMA264_1
(THYMIDYLATE SYNTHASE)		 2waw MOBA RELATE PROTEIN
(Mycobacterium
sp.
DSM
3803) 		4 / 8 ARG A  43
ALA A  36
LEU A  28
ASP A  30
 None
PGE  A1200 ( 4.0A)
PGE  A1200 (-4.9A)
PGE  A1200 (-3.6A)
 0.94A 3qj7A-2wawA:
undetectable
3qj7D-2wawA:
undetectable		 3qj7A-2wawA:
21.64
3qj7D-2wawA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2waw MOBA RELATE PROTEIN
(Mycobacterium
sp.
DSM
3803) 		5 / 9 ILE A 109
GLY A 108
VAL A  10
THR A  37
GLY A 104
 None
PGE  A1200 ( 3.7A)
None
None
None
 1.40A 4acaB-2wawA:
undetectable
4acaC-2wawA:
undetectable		 4acaB-2wawA:
19.00
4acaC-2wawA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A202_2
(PROTEASE)		 2waw MOBA RELATE PROTEIN
(Mycobacterium
sp.
DSM
3803) 		5 / 9 ARG A 171
VAL A 141
GLY A 157
VAL A 128
ILE A 126
 None
 0.94A 4ll3B-2wawA:
undetectable		 4ll3B-2wawA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA603_1
(SERUM ALBUMIN)		 2waw MOBA RELATE PROTEIN
(Mycobacterium
sp.
DSM
3803) 		5 / 10 LEU A  34
VAL A   9
LEU A 101
LEU A  85
VAL A 158
 None
 1.21A 4po0A-2wawA:
undetectable		 4po0A-2wawA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA601_1
(SERUM ALBUMIN)		 2waw MOBA RELATE PROTEIN
(Mycobacterium
sp.
DSM
3803) 		5 / 11 LEU A 161
PHE A 146
LEU A  89
GLY A  98
LEU A 101
 None
 1.33A 4zbqA-2wawA:
undetectable		 4zbqA-2wawA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_B_BEZB601_0
(BENZOATE-COENZYME A
LIGASE)		 2waw MOBA RELATE PROTEIN
(Mycobacterium
sp.
DSM
3803) 		5 / 8 ALA A  56
PRO A  22
GLY A  54
ALA A  13
GLY A  14
 CL  A1201 (-3.6A)
None
CL  A1201 (-3.6A)
None
CL  A1201 (-3.8A)
 1.35A 4zjzB-2wawA:
undetectable		 4zjzB-2wawA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2waw MOBA RELATE PROTEIN
(Mycobacterium
sp.
DSM
3803) 		5 / 7 ILE A 172
CYH A 129
LEU A 117
GLY A 121
GLY A 120
 None
 1.43A 5a06A-2wawA:
undetectable		 5a06A-2wawA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2waw MOBA RELATE PROTEIN
(Mycobacterium
sp.
DSM
3803) 		5 / 7 ILE A 172
CYH A 129
LEU A 117
GLY A 121
GLY A 120
 None
 1.43A 5a06E-2wawA:
undetectable		 5a06E-2wawA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_A_GLYA403_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)		 2waw MOBA RELATE PROTEIN
(Mycobacterium
sp.
DSM
3803) 		4 / 4 LEU A 161
LEU A 149
GLY A 147
GLU A 151
 None
 1.23A 5hhjA-2wawA:
undetectable		 5hhjA-2wawA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2waw MOBA RELATE PROTEIN
(Mycobacterium
sp.
DSM
3803) 		4 / 5 TYR A  15
GLY A  80
GLY A 165
LEU A 152
 CSO  A  81 (-4.2A)
CSO  A  81 (-2.4A)
None
None
 0.68A 5jlcA-2wawA:
undetectable		 5jlcA-2wawA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MFX_A_ACTA701_0
(GENOME POLYPROTEIN)		 2waw MOBA RELATE PROTEIN
(Mycobacterium
sp.
DSM
3803) 		4 / 5 ARG A   3
THR A   7
ALA A  96
ASP A  93
 None
 1.06A 5mfxA-2wawA:
undetectable		 5mfxA-2wawA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC902_0
(MRNA CAPPING ENZYME
P5)		 2waw MOBA RELATE PROTEIN
(Mycobacterium
sp.
DSM
3803) 		5 / 12 LEU A  53
GLY A 104
ALA A  13
ASP A 105
THR A  37
 None
 1.36A 5x6yC-2wawA:
undetectable		 5x6yC-2wawA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NCS_A_ACTA303_0
(N-ACETYLNEURAMINIC
ACID (SIALIC ACID)
SYNTHETASE)		 2waw MOBA RELATE PROTEIN
(Mycobacterium
sp.
DSM
3803) 		3 / 3 ILE A 109
THR A 110
PRO A 138
 None
 0.60A 6ncsA-2wawA:
undetectable		 6ncsA-2wawA:
19.66