SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wb1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2wb1 DNA-DIRECTED RNA
POLYMERASE RPO4
SUBUNIT
(Sulfolobus
shibatae) 		5 / 12 ILE F  86
VAL F  68
ASP F  67
ALA F  17
SER F  15
 None
 1.33A 1nbhC-2wb1F:
undetectable		 1nbhC-2wb1F:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1436_1
(CHITINASE)		 2wb1 DNA-DIRECTED RNA
POLYMERASERPO3
SUBUNIT
(Sulfolobus
shibatae) 		3 / 3 ASP D  42
PHE D 156
ARG D 146
 None
 0.89A 2a3aA-2wb1D:
undetectable		 2a3aA-2wb1D:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA270_0
(PROTEIN SSM1)		 2wb1 DNA-DIRECTED RNA
POLYMERASERPO3
SUBUNIT
(Sulfolobus
shibatae) 		4 / 5 LEU D  73
SER D  69
LEU D 147
PRO D  37
 None
 1.29A 3onnA-2wb1D:
undetectable		 3onnA-2wb1D:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		 2wb1 DNA-DIRECTED RNA
POLYMERASERPO3
SUBUNIT
(Sulfolobus
shibatae) 		3 / 3 LEU D 145
MET D  39
ASP D 113
 None
 0.79A 4j7xB-2wb1D:
undetectable		 4j7xB-2wb1D:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_1
(ANDROGEN RECEPTOR)		 2wb1 DNA-DIRECTED RNA
POLYMERASERPO3
SUBUNIT
(Sulfolobus
shibatae) 		5 / 12 LEU D 173
GLY D 215
LEU D 210
VAL D 170
VAL D 182
 None
 1.45A 4okxA-2wb1D:
undetectable		 4okxA-2wb1D:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2wb1 DNA-DIRECTED RNA
POLYMERASE RPO4
SUBUNIT
(Sulfolobus
shibatae) 		5 / 9 ALA F  52
SER F  15
ALA F  73
SER F  74
ALA F  70
 None
 1.26A 4twdA-2wb1F:
undetectable
4twdB-2wb1F:
undetectable
4twdC-2wb1F:
undetectable
4twdD-2wb1F:
undetectable
4twdE-2wb1F:
undetectable		 4twdA-2wb1F:
18.81
4twdB-2wb1F:
18.81
4twdC-2wb1F:
18.81
4twdD-2wb1F:
18.81
4twdE-2wb1F:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_B_CHDB102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2wb1 DNA-DIRECTED RNA
POLYMERASERPO3
SUBUNIT
(Sulfolobus
shibatae) 		5 / 11 LEU D  15
LEU D 228
GLU D 239
LEU D 242
LEU D 230
 None
 0.90A 4wg0B-2wb1D:
undetectable
4wg0C-2wb1D:
undetectable
4wg0D-2wb1D:
undetectable		 4wg0B-2wb1D:
3.85
4wg0C-2wb1D:
3.85
4wg0D-2wb1D:
3.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_D_CHDD102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2wb1 DNA-DIRECTED RNA
POLYMERASERPO3
SUBUNIT
(Sulfolobus
shibatae) 		5 / 11 LEU D  15
LEU D 228
GLU D 239
LEU D 242
LEU D 230
 None
 0.90A 4wg0D-2wb1D:
undetectable
4wg0E-2wb1D:
undetectable
4wg0F-2wb1D:
undetectable		 4wg0D-2wb1D:
3.85
4wg0E-2wb1D:
3.85
4wg0F-2wb1D:
3.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_E_CHDE104_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2wb1 DNA-DIRECTED RNA
POLYMERASERPO3
SUBUNIT
(Sulfolobus
shibatae) 		5 / 11 LEU D 230
GLU D 239
LEU D 242
LEU D  15
LEU D 228
 None
 0.95A 4wg0C-2wb1D:
undetectable
4wg0D-2wb1D:
undetectable
4wg0E-2wb1D:
undetectable		 4wg0C-2wb1D:
3.85
4wg0D-2wb1D:
3.85
4wg0E-2wb1D:
3.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_G_CHDG103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2wb1 DNA-DIRECTED RNA
POLYMERASERPO3
SUBUNIT
(Sulfolobus
shibatae) 		5 / 11 LEU D 230
GLU D 239
LEU D 242
LEU D  15
LEU D 228
 None
 0.93A 4wg0E-2wb1D:
undetectable
4wg0F-2wb1D:
undetectable
4wg0G-2wb1D:
undetectable		 4wg0E-2wb1D:
3.85
4wg0F-2wb1D:
3.85
4wg0G-2wb1D:
3.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA511_1
(PROTON-GATED ION
CHANNEL)		 2wb1 DNA-DIRECTED RNA
POLYMERASERPO3
SUBUNIT
(Sulfolobus
shibatae) 		4 / 8 ILE D  65
ILE D  98
ALA D 143
ILE D  96
 None
 0.74A 5mvmA-2wb1D:
undetectable
5mvmB-2wb1D:
undetectable		 5mvmA-2wb1D:
17.18
5mvmB-2wb1D:
17.18