SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wb7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_B_ESTB354_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 2wb7 PT26-6P
(Thermococcus
sp.
26-2) 		4 / 8 SER A 390
LEU A 383
TYR A 661
MET A 379
 None
 1.08A 1fduB-2wb7A:
undetectable		 1fduB-2wb7A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q13_A_TESA501_1
(PROSTAGLANDIN-E2
9-REDUCTASE)		 2wb7 PT26-6P
(Thermococcus
sp.
26-2) 		4 / 6 TYR A 297
GLU A 523
PRO A 524
VAL A 454
 None
 1.22A 1q13A-2wb7A:
undetectable		 1q13A-2wb7A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 2wb7 PT26-6P
(Thermococcus
sp.
26-2) 		5 / 9 ALA A 521
LEU A 520
PHE A 209
GLY A 208
TYR A 207
 None
 1.49A 1ru9H-2wb7A:
4.7
1ru9L-2wb7A:
3.5		 1ru9H-2wb7A:
17.48
1ru9L-2wb7A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUA_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 2wb7 PT26-6P
(Thermococcus
sp.
26-2) 		5 / 10 ALA A 521
LEU A 520
PHE A 209
GLY A 208
TYR A 207
 None
 1.48A 1ruaH-2wb7A:
4.5
1ruaL-2wb7A:
3.6		 1ruaH-2wb7A:
17.48
1ruaL-2wb7A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_2
(MINERALOCORTICOID
RECEPTOR)		 2wb7 PT26-6P
(Thermococcus
sp.
26-2) 		4 / 4 LEU A 388
LEU A 393
SER A 394
LEU A 391
 None
 1.16A 1ya3A-2wb7A:
undetectable		 1ya3A-2wb7A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE507_0
(NAD-DEPENDENT
DEACETYLASE 2)		 2wb7 PT26-6P
(Thermococcus
sp.
26-2) 		4 / 7 PHE A 387
LEU A 383
ASN A 151
ASP A 153
 None
 0.87A 1yc2E-2wb7A:
undetectable		 1yc2E-2wb7A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		 2wb7 PT26-6P
(Thermococcus
sp.
26-2) 		4 / 6 ARG A 641
ILE A 653
GLU A 649
TYR A 297
 None
 1.17A 2ya7C-2wb7A:
undetectable		 2ya7C-2wb7A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2wb7 PT26-6P
(Thermococcus
sp.
26-2) 		4 / 8 LEU A 218
ARG A 258
ILE A 232
PHE A 257
 None
 0.86A 3ln1A-2wb7A:
undetectable		 3ln1A-2wb7A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2wb7 PT26-6P
(Thermococcus
sp.
26-2) 		4 / 7 LEU A 218
ARG A 258
ILE A 232
PHE A 257
 None
 0.87A 3ln1B-2wb7A:
undetectable		 3ln1B-2wb7A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_B_CVIB301_0
(PUTATIVE REGULATORY
PROTEIN)		 2wb7 PT26-6P
(Thermococcus
sp.
26-2) 		5 / 12 THR A 415
ILE A 283
ALA A 286
PHE A 453
LEU A 485
 None
 1.32A 3vw1B-2wb7A:
2.1		 3vw1B-2wb7A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_J_ACHJ301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2wb7 PT26-6P
(Thermococcus
sp.
26-2) 		4 / 8 LEU A 485
THR A 426
TYR A 498
TYR A 489
 None
 1.19A 3wipF-2wb7A:
undetectable
3wipJ-2wb7A:
undetectable		 3wipF-2wb7A:
17.84
3wipJ-2wb7A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2wb7 PT26-6P
(Thermococcus
sp.
26-2) 		4 / 7 GLY A 475
PHE A 483
ILE A 433
PHE A 453
 None
 0.84A 4fglC-2wb7A:
undetectable		 4fglC-2wb7A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRK_A_KTRA713_1
(LACTOTRANSFERRIN)		 2wb7 PT26-6P
(Thermococcus
sp.
26-2) 		4 / 5 GLY A 204
VAL A 185
PRO A 203
TYR A 439
 None
 1.03A 4grkA-2wb7A:
undetectable		 4grkA-2wb7A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2wb7 PT26-6P
(Thermococcus
sp.
26-2) 		5 / 12 PHE A 411
ILE A 287
ILE A 283
GLY A 502
ALA A 522
 None
 0.80A 4nkvC-2wb7A:
undetectable		 4nkvC-2wb7A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2wb7 PT26-6P
(Thermococcus
sp.
26-2) 		5 / 12 PHE A 411
ILE A 287
ILE A 283
GLY A 502
ALA A 522
 None
 0.80A 4nkvD-2wb7A:
undetectable		 4nkvD-2wb7A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 2wb7 PT26-6P
(Thermococcus
sp.
26-2) 		3 / 3 LYS A 146
ASN A 621
ASP A 153
 None
 0.90A 4o1eA-2wb7A:
undetectable		 4o1eA-2wb7A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA602_1
(SERUM ALBUMIN)		 2wb7 PT26-6P
(Thermococcus
sp.
26-2) 		4 / 8 LEU A 607
LEU A 623
LYS A 627
GLU A 630
 None
 0.62A 4po0A-2wb7A:
3.8		 4po0A-2wb7A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_B_ML1B302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2wb7 PT26-6P
(Thermococcus
sp.
26-2) 		4 / 6 GLY A 475
PHE A 483
ILE A 433
PHE A 453
 None
 0.99A 4qogA-2wb7A:
undetectable
4qogB-2wb7A:
undetectable		 4qogA-2wb7A:
17.84
4qogB-2wb7A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W9N_C_CCSC1548_0
(ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE)		 2wb7 PT26-6P
(Thermococcus
sp.
26-2) 		3 / 3 ALA A 416
TRP A 397
VAL A 398
 None
 0.36A 4w9nC-2wb7A:
undetectable		 4w9nC-2wb7A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_H_SAMH301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2wb7 PT26-6P
(Thermococcus
sp.
26-2) 		5 / 12 ALA A 625
GLY A 633
THR A 532
SER A 662
TYR A 636
 None
 1.37A 5hfjH-2wb7A:
undetectable		 5hfjH-2wb7A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2wb7 PT26-6P
(Thermococcus
sp.
26-2) 		3 / 3 ARG A 258
ILE A 232
PHE A 257
 None
 0.57A 5kirA-2wb7A:
undetectable		 5kirA-2wb7A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_A_ASCA1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 2wb7 PT26-6P
(Thermococcus
sp.
26-2) 		4 / 6 HIS A 499
TYR A 400
GLN A 650
HIS A 421
 None
 1.12A 5kkzA-2wb7A:
0.5
5kkzG-2wb7A:
undetectable		 5kkzA-2wb7A:
21.63
5kkzG-2wb7A:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_E_ASCE1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 2wb7 PT26-6P
(Thermococcus
sp.
26-2) 		4 / 7 HIS A 421
HIS A 499
TYR A 400
GLN A 650
 None
 1.15A 5kkzC-2wb7A:
0.3
5kkzE-2wb7A:
0.0		 5kkzC-2wb7A:
15.66
5kkzE-2wb7A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_K_ASCK1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 2wb7 PT26-6P
(Thermococcus
sp.
26-2) 		4 / 7 HIS A 499
TYR A 400
GLN A 650
HIS A 421
 None
 1.15A 5kkzK-2wb7A:
2.5
5kkzQ-2wb7A:
undetectable		 5kkzK-2wb7A:
21.63
5kkzQ-2wb7A:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_O_ASCO1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 2wb7 PT26-6P
(Thermococcus
sp.
26-2) 		4 / 7 HIS A 421
HIS A 499
TYR A 400
GLN A 650
 None
 1.10A 5kkzM-2wb7A:
0.3
5kkzO-2wb7A:
3.1		 5kkzM-2wb7A:
15.66
5kkzO-2wb7A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2wb7 PT26-6P
(Thermococcus
sp.
26-2) 		4 / 4 LEU A 520
GLY A 406
SER A 210
SER A 409
 None
 1.24A 5uunA-2wb7A:
2.0		 5uunA-2wb7A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB306_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2wb7 PT26-6P
(Thermococcus
sp.
26-2) 		4 / 4 LEU A 520
GLY A 406
SER A 210
SER A 409
 None
 1.22A 5uunB-2wb7A:
undetectable		 5uunB-2wb7A:
19.77