SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wbe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_0
(ALCOHOL
DEHYDROGENASE)		 2wbe BIPOLAR KINESIN
KRP-130
(Drosophila
melanogaster) 		5 / 11 MET C 101
LEU C 247
CYH C  85
VAL C  71
ILE C  76
 None
 1.32A 1ee2A-2wbeC:
undetectable		 1ee2A-2wbeC:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_1
(ALCOHOL
DEHYDROGENASE)		 2wbe BIPOLAR KINESIN
KRP-130
(Drosophila
melanogaster) 		5 / 11 MET C 101
LEU C 247
CYH C  85
VAL C  71
ILE C  76
 None
 1.35A 1ee2B-2wbeC:
undetectable		 1ee2B-2wbeC:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 2wbe BIPOLAR KINESIN
KRP-130
(Drosophila
melanogaster) 		3 / 3 ASP C 170
LYS C 175
ARG C 312
 None
 0.80A 1ra8A-2wbeC:
undetectable		 1ra8A-2wbeC:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_A_SAMA1501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 2wbe BIPOLAR KINESIN
KRP-130
(Drosophila
melanogaster) 		4 / 7 TYR C 296
THR C  86
THR C 315
VAL C 283
 None
 1.06A 1tv8A-2wbeC:
undetectable		 1tv8A-2wbeC:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_2
(DIHYDROFOLATE
REDUCTASE)		 2wbe BIPOLAR KINESIN
KRP-130
(Drosophila
melanogaster) 		4 / 4 SER C 145
ILE C 144
VAL C 227
THR C 313
 None
 1.15A 1u70A-2wbeC:
undetectable		 1u70A-2wbeC:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_A_NCAA506_0
(NAD-DEPENDENT
DEACETYLASE 2)		 2wbe BIPOLAR KINESIN
KRP-130
(Drosophila
melanogaster) 		4 / 6 SER C 112
ASN C 104
ILE C 119
ASP C 115
 None
 1.02A 1yc2A-2wbeC:
undetectable		 1yc2A-2wbeC:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EFJ_A_37TA502_1
(3,7-DIMETHYLXANTHINE
METHYLTRANSFERASE)		 2wbe BIPOLAR KINESIN
KRP-130
(Drosophila
melanogaster) 		5 / 12 LEU C 277
ILE C 317
ILE C   8
ILE C 284
TYR C  90
 None
 1.29A 2efjA-2wbeC:
undetectable		 2efjA-2wbeC:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_A_SAMA501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 2wbe BIPOLAR KINESIN
KRP-130
(Drosophila
melanogaster) 		4 / 8 TYR C 296
THR C  86
THR C 315
VAL C 283
 None
 1.06A 2fb2A-2wbeC:
undetectable		 2fb2A-2wbeC:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_B_SAMB501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 2wbe BIPOLAR KINESIN
KRP-130
(Drosophila
melanogaster) 		4 / 7 TYR C 296
THR C  86
THR C 315
VAL C 283
 None
 1.10A 2fb2B-2wbeC:
undetectable		 2fb2B-2wbeC:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 2wbe BIPOLAR KINESIN
KRP-130
(Drosophila
melanogaster) 		5 / 12 LEU C 147
GLN C 306
ILE C 284
LEU C 250
VAL C 248
 None
 1.09A 3gwxB-2wbeC:
undetectable		 3gwxB-2wbeC:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2wbe BIPOLAR KINESIN
KRP-130
(Drosophila
melanogaster) 		3 / 3 GLY C  94
GLY C  96
THR C  98
 ANP  C1358 (-3.5A)
ANP  C1358 (-3.0A)
MG  C1359 ( 3.2A)
 0.41A 3si7B-2wbeC:
undetectable		 3si7B-2wbeC:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKA_A_SAMA400_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H)		 2wbe BIPOLAR KINESIN
KRP-130
(Drosophila
melanogaster) 		5 / 12 THR C  98
GLY C  96
ARG C  15
GLY C  91
GLU C 108
 MG  C1359 ( 3.2A)
ANP  C1358 (-3.0A)
None
None
None
 1.37A 3tkaA-2wbeC:
undetectable		 3tkaA-2wbeC:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_A_CAMA1419_0
(CYTOCHROME P450)		 2wbe BIPOLAR KINESIN
KRP-130
(Drosophila
melanogaster) 		4 / 8 THR C 221
LEU C 158
LEU C 157
GLY C 201
 None
 0.72A 4c9nA-2wbeC:
undetectable		 4c9nA-2wbeC:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 2wbe BIPOLAR KINESIN
KRP-130
(Drosophila
melanogaster) 		5 / 12 LEU C 247
LEU C  75
ILE C 317
ILE C   8
LEU C 305
 None
 1.00A 4j24A-2wbeC:
undetectable		 4j24A-2wbeC:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_C_ESTC600_1
(ESTROGEN RECEPTOR
BETA)		 2wbe BIPOLAR KINESIN
KRP-130
(Drosophila
melanogaster) 		5 / 12 LEU C 247
LEU C  75
ILE C 317
ILE C   8
LEU C 305
 None
 1.01A 4j24C-2wbeC:
undetectable		 4j24C-2wbeC:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 2wbe BIPOLAR KINESIN
KRP-130
(Drosophila
melanogaster) 		5 / 12 LEU C 247
LEU C  75
ILE C 317
ILE C   8
LEU C 305
 None
 0.94A 4j26B-2wbeC:
undetectable		 4j26B-2wbeC:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ENT_C_MIYC901_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB)		 2wbe BIPOLAR KINESIN
KRP-130
(Drosophila
melanogaster) 		5 / 9 GLN C   6
SER C 308
GLU C 307
ILE C 344
ALA C 341
 None
 1.36A 5entC-2wbeC:
undetectable		 5entC-2wbeC:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 2wbe BIPOLAR KINESIN
KRP-130
(Drosophila
melanogaster) 		4 / 4 GLU C 105
PRO C 123
ILE C 122
LEU C 198
 None
 1.28A 5m45D-2wbeC:
undetectable		 5m45D-2wbeC:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 2wbe BIPOLAR KINESIN
KRP-130
(Drosophila
melanogaster) 		4 / 4 GLU C 105
PRO C 123
ILE C 122
LEU C 198
 None
 1.28A 5m45J-2wbeC:
undetectable		 5m45J-2wbeC:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_A_SAMA501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2wbe BIPOLAR KINESIN
KRP-130
(Drosophila
melanogaster) 		5 / 11 LEU C 147
GLY C 201
LEU C 154
THR C 221
GLN C 215
 None
 1.12A 5o96A-2wbeC:
2.1
5o96B-2wbeC:
undetectable		 5o96A-2wbeC:
22.19
5o96B-2wbeC:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YVN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 2wbe BIPOLAR KINESIN
KRP-130
(Drosophila
melanogaster) 		4 / 6 GLU C 152
LYS C 165
LEU C 154
LEU C 149
 None
 1.01A 5yvnA-2wbeC:
undetectable		 5yvnA-2wbeC:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2wbe BIPOLAR KINESIN
KRP-130
(Drosophila
melanogaster) 		4 / 7 ALA C 319
THR C 320
GLN C   9
VAL C  10
 None
 0.92A 6cduA-2wbeC:
undetectable
6cduE-2wbeC:
undetectable		 6cduA-2wbeC:
21.66
6cduE-2wbeC:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_B_EY4B500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2wbe BIPOLAR KINESIN
KRP-130
(Drosophila
melanogaster) 		4 / 6 GLN C   9
VAL C  10
ALA C 319
THR C 320
 None
 0.92A 6cduB-2wbeC:
undetectable
6cduC-2wbeC:
undetectable		 6cduB-2wbeC:
21.66
6cduC-2wbeC:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_D_EY4D500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2wbe BIPOLAR KINESIN
KRP-130
(Drosophila
melanogaster) 		4 / 7 GLN C   9
VAL C  10
ALA C 319
THR C 320
 None
 0.95A 6cduC-2wbeC:
undetectable
6cduD-2wbeC:
undetectable		 6cduC-2wbeC:
21.66
6cduD-2wbeC:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_D_BEZD502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 2wbe BIPOLAR KINESIN
KRP-130
(Drosophila
melanogaster) 		4 / 6 PHE C  54
LEU C 332
LEU C 335
HIS C 339
 None
 1.03A 6e43D-2wbeC:
undetectable		 6e43D-2wbeC:
22.76