SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wbi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4002_1
(SERUM ALBUMIN)		 2wbi ACYL-COA
DEHYDROGENASE FAMILY
MEMBER 11
(Homo
sapiens) 		4 / 4 ARG A 326
ALA A 328
ALA A 291
GLU A 292
 None
 1.09A 1e7bA-2wbiA:
undetectable		 1e7bA-2wbiA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4002_1
(SERUM ALBUMIN)		 2wbi ACYL-COA
DEHYDROGENASE FAMILY
MEMBER 11
(Homo
sapiens) 		4 / 4 ARG A 326
ALA A 328
ALA A 291
GLU A 292
 None
 1.08A 1e7bB-2wbiA:
undetectable		 1e7bB-2wbiA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2wbi ACYL-COA
DEHYDROGENASE FAMILY
MEMBER 11
(Homo
sapiens) 		4 / 5 LEU A 233
CYH A 153
ALA A 198
CYH A 151
 None
 1.18A 1mz9D-2wbiA:
undetectable		 1mz9D-2wbiA:
8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2wbi ACYL-COA
DEHYDROGENASE FAMILY
MEMBER 11
(Homo
sapiens) 		6 / 9 LEU A 127
VAL A 126
CYH A 153
LEU A 201
LEU A 219
LEU A 276
 None
 1.23A 1xkkA-2wbiA:
undetectable		 1xkkA-2wbiA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 2wbi ACYL-COA
DEHYDROGENASE FAMILY
MEMBER 11
(Homo
sapiens) 		4 / 4 ASP A 112
ASP A  70
ASP A 120
GLY A  64
 None
 1.23A 2igtC-2wbiA:
undetectable		 2igtC-2wbiA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		 2wbi ACYL-COA
DEHYDROGENASE FAMILY
MEMBER 11
(Homo
sapiens) 		4 / 7 SER A 325
VAL A 376
ILE A 322
TRP A 321
 None
 1.21A 2x45B-2wbiA:
undetectable		 2x45B-2wbiA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		 2wbi ACYL-COA
DEHYDROGENASE FAMILY
MEMBER 11
(Homo
sapiens) 		4 / 7 SER A 325
VAL A 376
ILE A 322
TRP A 321
 None
 1.19A 2x45C-2wbiA:
undetectable		 2x45C-2wbiA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2wbi ACYL-COA
DEHYDROGENASE FAMILY
MEMBER 11
(Homo
sapiens) 		5 / 12 ILE A 271
SER A 187
ALA A 190
ILE A 199
MET A 217
 None
 1.22A 2xkwB-2wbiA:
undetectable		 2xkwB-2wbiA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC505_1
(PHOSPHOLIPASE A2)		 2wbi ACYL-COA
DEHYDROGENASE FAMILY
MEMBER 11
(Homo
sapiens) 		5 / 10 GLU A 102
GLY A 105
LYS A 106
THR A 395
ARG A 333
 None
 1.49A 3bjwD-2wbiA:
0.0		 3bjwD-2wbiA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		 2wbi ACYL-COA
DEHYDROGENASE FAMILY
MEMBER 11
(Homo
sapiens) 		4 / 7 SER A 325
VAL A 376
ILE A 322
TRP A 321
 None
 1.17A 3bu1A-2wbiA:
undetectable		 3bu1A-2wbiA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B2000_1
(P38A)		 2wbi ACYL-COA
DEHYDROGENASE FAMILY
MEMBER 11
(Homo
sapiens) 		5 / 10 ILE A 218
ILE A 249
ILE A 229
MET A 222
VAL A 256
 None
 1.36A 3ohtA-2wbiA:
undetectable
3ohtB-2wbiA:
undetectable		 3ohtA-2wbiA:
21.29
3ohtB-2wbiA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 2wbi ACYL-COA
DEHYDROGENASE FAMILY
MEMBER 11
(Homo
sapiens) 		3 / 3 HIS A 283
VAL A 370
LEU A 290
 UNX  A1428 (-4.6A)
None
None
 0.76A 4m2vA-2wbiA:
undetectable		 4m2vA-2wbiA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2wbi ACYL-COA
DEHYDROGENASE FAMILY
MEMBER 11
(Homo
sapiens) 		6 / 10 THR A 336
ALA A 362
ALA A 328
ALA A 365
GLY A 289
THR A 287
 None
 1.34A 4qvyK-2wbiA:
undetectable
4qvyL-2wbiA:
undetectable		 4qvyK-2wbiA:
20.81
4qvyL-2wbiA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2wbi ACYL-COA
DEHYDROGENASE FAMILY
MEMBER 11
(Homo
sapiens) 		6 / 10 THR A 336
ALA A 362
ALA A 328
ALA A 365
GLY A 289
THR A 287
 None
 1.33A 4qvyY-2wbiA:
undetectable
4qvyZ-2wbiA:
undetectable		 4qvyY-2wbiA:
20.81
4qvyZ-2wbiA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2wbi ACYL-COA
DEHYDROGENASE FAMILY
MEMBER 11
(Homo
sapiens) 		4 / 5 GLU A 103
THR A 104
HIS A 341
LEU A 337
 None
 1.27A 5axaA-2wbiA:
undetectable		 5axaA-2wbiA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2wbi ACYL-COA
DEHYDROGENASE FAMILY
MEMBER 11
(Homo
sapiens) 		5 / 9 GLY A 264
LEU A 263
ILE A 271
GLY A 268
ILE A 197
 None
 0.99A 5vkqC-2wbiA:
2.4
5vkqD-2wbiA:
2.4		 5vkqC-2wbiA:
12.86
5vkqD-2wbiA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DHB_A_BEZA202_0
(HEPATITIS A VIRUS
CELLULAR RECEPTOR 2)		 2wbi ACYL-COA
DEHYDROGENASE FAMILY
MEMBER 11
(Homo
sapiens) 		4 / 6 PHE A 269
ILE A 167
ASN A 166
ASP A 163
 None
 1.47A 6dhbA-2wbiA:
undetectable		 6dhbA-2wbiA:
13.62