SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wbj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_A_BEZA524_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2wbj OB TCR
(Homo
sapiens) 		4 / 6 SER D 123
THR D 122
PHE D  50
GLU D 128
 None
 0.99A 1kqbA-2wbjD:
undetectable
1kqbB-2wbjD:
undetectable		 1kqbA-2wbjD:
21.92
1kqbB-2wbjD:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_B_BEZB525_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2wbj OB TCR
(Homo
sapiens) 		4 / 5 GLU D 128
SER D 123
THR D 122
PHE D  50
 None
 0.99A 1kqbA-2wbjD:
undetectable
1kqbB-2wbjD:
undetectable		 1kqbA-2wbjD:
21.92
1kqbB-2wbjD:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_C_BEZC522_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2wbj OB TCR
(Homo
sapiens) 		4 / 6 SER D 123
THR D 122
PHE D  50
GLU D 128
 None
 1.05A 1kqbC-2wbjD:
undetectable
1kqbD-2wbjD:
undetectable		 1kqbC-2wbjD:
21.92
1kqbD-2wbjD:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_2
(CYCLIN-DEPENDENT
KINASE 8)		 2wbj OB TCR
(Homo
sapiens) 		4 / 7 LEU D 137
VAL D  33
VAL D 103
LEU D 243
 None
 0.92A 3rgfA-2wbjD:
undetectable		 3rgfA-2wbjD:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOA_A_ACRA1587_2
(TREHALOSE
SYNTHASE/AMYLASE
TRES)		 2wbj OB TCR
(Homo
sapiens) 		3 / 3 ARG D  59
PHE D  61
PRO D  62
 None
 0.74A 3zoaB-2wbjD:
undetectable		 3zoaB-2wbjD:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW9_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 2wbj OB TCR
(Homo
sapiens) 		4 / 8 THR D  39
GLY D  38
ALA D 106
GLU D 141
 None
 0.69A 5vw9A-2wbjD:
undetectable		 5vw9A-2wbjD:
19.94