SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wbm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_B_ID2B2_0
(THYMIDINE KINASE)		 2wbm RIBOSOME MATURATION
PROTEIN SDO1 HOMOLOG
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 ILE A 126
ILE A 108
MET A 130
ALA A 153
ARG A 125
 None
 1.42A 1ki7B-2wbmA:
undetectable		 1ki7B-2wbmA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRG_A_ADNA300_1
(ALPHA-MOMORCHARIN)		 2wbm RIBOSOME MATURATION
PROTEIN SDO1 HOMOLOG
(Methanothermobac
ter
thermautotrophic
us) 		5 / 9 TYR A 180
ILE A 183
ILE A 189
ALA A 202
GLU A 192
 None
None
None
None
GOL  A1235 (-3.5A)
 1.21A 1mrgA-2wbmA:
undetectable		 1mrgA-2wbmA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRJ_A_ADNA300_1
(ALPHA-TRICHOSANTHIN)		 2wbm RIBOSOME MATURATION
PROTEIN SDO1 HOMOLOG
(Methanothermobac
ter
thermautotrophic
us) 		4 / 8 TYR A 180
ILE A 183
ILE A 189
GLU A 192
 None
None
None
GOL  A1235 (-3.5A)
 0.81A 1mrjA-2wbmA:
undetectable		 1mrjA-2wbmA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2wbm RIBOSOME MATURATION
PROTEIN SDO1 HOMOLOG
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 GLU A  34
GLU A  30
LEU A  81
 None
 0.59A 1v8bA-2wbmA:
undetectable		 1v8bA-2wbmA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_2
(PROTEASE)		 2wbm RIBOSOME MATURATION
PROTEIN SDO1 HOMOLOG
(Methanothermobac
ter
thermautotrophic
us) 		5 / 10 LEU A  44
ALA A  28
VAL A   8
VAL A  21
VAL A  23
 None
 1.11A 3nu9B-2wbmA:
undetectable		 3nu9B-2wbmA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 2wbm RIBOSOME MATURATION
PROTEIN SDO1 HOMOLOG
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 ASP A  24
VAL A   8
VAL A 143
ILE A 104
LEU A  88
 None
 1.24A 4a84A-2wbmA:
undetectable		 4a84A-2wbmA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 2wbm RIBOSOME MATURATION
PROTEIN SDO1 HOMOLOG
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 LEU A 218
LEU A 221
ILE A 171
GLY A 181
VAL A 182
 None
 0.76A 4an2A-2wbmA:
undetectable		 4an2A-2wbmA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 2wbm RIBOSOME MATURATION
PROTEIN SDO1 HOMOLOG
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 TYR A 180
ILE A 171
ILE A 169
ALA A 202
 None
 0.90A 4lv9B-2wbmA:
undetectable		 4lv9B-2wbmA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_0
(PROTEASE)		 2wbm RIBOSOME MATURATION
PROTEIN SDO1 HOMOLOG
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 LEU A 230
VAL A 204
ILE A 183
VAL A 165
VAL A 167
 GOL  A1233 ( 4.4A)
None
None
None
GOL  A1233 (-4.5A)
 0.94A 6dh0A-2wbmA:
undetectable		 6dh0A-2wbmA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2wbm RIBOSOME MATURATION
PROTEIN SDO1 HOMOLOG
(Methanothermobac
ter
thermautotrophic
us) 		4 / 8 ASP A  99
HIS A   0
ASP A   6
GLU A   5
 None
 1.30A 6mn4C-2wbmA:
undetectable		 6mn4C-2wbmA:
22.98