SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wbp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_1
(ESTROGEN RECEPTOR)		 2wbp L-ARGININE
BETA-HYDROXYLASE
(Streptomyces
vinaceus) 		5 / 12 ALA A 125
LEU A 127
LEU A  57
ARG A 353
LEU A  71
 None
 1.24A 1errB-2wbpA:
undetectable		 1errB-2wbpA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JC9_A_ADNA1497_1
(CYTOSOLIC PURINE
5'-NUCLEOTIDASE)		 2wbp L-ARGININE
BETA-HYDROXYLASE
(Streptomyces
vinaceus) 		4 / 7 ASP A 268
THR A 169
ASN A 336
GLN A 137
 ZZU  A1359 (-3.0A)
None
None
ZZU  A1359 (-3.8A)
 1.23A 2jc9A-2wbpA:
undetectable		 2jc9A-2wbpA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2wbp L-ARGININE
BETA-HYDROXYLASE
(Streptomyces
vinaceus) 		4 / 5 PRO A 263
PRO A 200
ILE A 292
GLY A 198
 None
 1.05A 2jkjD-2wbpA:
undetectable		 2jkjD-2wbpA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2wbp L-ARGININE
BETA-HYDROXYLASE
(Streptomyces
vinaceus) 		4 / 5 PRO A 263
PRO A 200
ILE A 292
GLY A 198
 None
 1.05A 2jkjF-2wbpA:
undetectable		 2jkjF-2wbpA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_1
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 2wbp L-ARGININE
BETA-HYDROXYLASE
(Streptomyces
vinaceus) 		3 / 3 SER A 161
ASP A 190
ASP A 329
 None
 0.79A 2plwA-2wbpA:
undetectable		 2plwA-2wbpA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 2wbp L-ARGININE
BETA-HYDROXYLASE
(Streptomyces
vinaceus) 		4 / 8 HIS A 225
SER A 224
ASP A 171
ARG A 334
 None
ZZU  A1359 (-3.2A)
ZZU  A1359 ( 4.9A)
ZZU  A1359 ( 2.9A)
 1.31A 2rk8A-2wbpA:
undetectable		 2rk8A-2wbpA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_B_PPFB3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 2wbp L-ARGININE
BETA-HYDROXYLASE
(Streptomyces
vinaceus) 		4 / 7 HIS A 225
SER A 224
ASP A 171
ARG A 334
 None
ZZU  A1359 (-3.2A)
ZZU  A1359 ( 4.9A)
ZZU  A1359 ( 2.9A)
 1.30A 2rk8B-2wbpA:
undetectable		 2rk8B-2wbpA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		 2wbp L-ARGININE
BETA-HYDROXYLASE
(Streptomyces
vinaceus) 		5 / 11 ILE A 309
PHE A 308
ALA A 307
ARG A 110
LEU A 121
 None
 1.05A 2v0mD-2wbpA:
undetectable		 2v0mD-2wbpA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		 2wbp L-ARGININE
BETA-HYDROXYLASE
(Streptomyces
vinaceus) 		5 / 11 LEU A 128
PHE A 308
ALA A 307
ARG A 110
LEU A 121
 None
 1.14A 2v0mD-2wbpA:
undetectable		 2v0mD-2wbpA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		 2wbp L-ARGININE
BETA-HYDROXYLASE
(Streptomyces
vinaceus) 		4 / 5 PRO A 221
SER A 174
LEU A 226
SER A 224
 None
None
None
ZZU  A1359 (-3.2A)
 1.36A 3iluH-2wbpA:
undetectable		 3iluH-2wbpA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTR_A_LQZA90_1
(LACTOTRANSFERRIN)		 2wbp L-ARGININE
BETA-HYDROXYLASE
(Streptomyces
vinaceus) 		3 / 3 PRO A 112
THR A 111
LEU A  99
 None
 0.63A 3ttrA-2wbpA:
undetectable		 3ttrA-2wbpA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD392_1
(TETX2 PROTEIN)		 2wbp L-ARGININE
BETA-HYDROXYLASE
(Streptomyces
vinaceus) 		4 / 5 SER A 158
GLN A 138
SER A 224
VAL A 157
 ZZU  A1359 (-2.9A)
None
ZZU  A1359 (-3.2A)
ZZU  A1359 (-3.1A)
 1.39A 4a99D-2wbpA:
undetectable		 4a99D-2wbpA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_2
(HIV-1 PROTEASE)		 2wbp L-ARGININE
BETA-HYDROXYLASE
(Streptomyces
vinaceus) 		4 / 8 GLY A 191
ASP A 302
ASP A 305
THR A 195
 None
 0.83A 4eyrB-2wbpA:
undetectable		 4eyrB-2wbpA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRQ_C_AVLC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 2wbp L-ARGININE
BETA-HYDROXYLASE
(Streptomyces
vinaceus) 		4 / 7 PHE A 132
PRO A 175
TYR A 176
TRP A 134
 None
 1.45A 4grqA-2wbpA:
0.5
4grqC-2wbpA:
undetectable		 4grqA-2wbpA:
16.62
4grqC-2wbpA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_ACTA303_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 2wbp L-ARGININE
BETA-HYDROXYLASE
(Streptomyces
vinaceus) 		3 / 3 TYR A 180
HIS A 264
ARG A 312
 None
 1.13A 4htfA-2wbpA:
undetectable		 4htfA-2wbpA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTR_A_IBPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2wbp L-ARGININE
BETA-HYDROXYLASE
(Streptomyces
vinaceus) 		4 / 8 VAL A 315
TRP A 167
LEU A 212
LEU A 288
 None
 0.92A 4jtrA-2wbpA:
undetectable		 4jtrA-2wbpA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_A_ACTA603_0
(CHOLINE OXIDASE)		 2wbp L-ARGININE
BETA-HYDROXYLASE
(Streptomyces
vinaceus) 		3 / 3 ARG A 162
HIS A 154
SER A 161
 None
 0.73A 4mjwA-2wbpA:
undetectable
4mjwB-2wbpA:
undetectable		 4mjwA-2wbpA:
23.98
4mjwB-2wbpA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_B_ACTB603_0
(CHOLINE OXIDASE)		 2wbp L-ARGININE
BETA-HYDROXYLASE
(Streptomyces
vinaceus) 		3 / 3 SER A 161
ARG A 162
HIS A 154
 None
 0.72A 4mjwA-2wbpA:
undetectable
4mjwB-2wbpA:
undetectable		 4mjwA-2wbpA:
23.98
4mjwB-2wbpA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA206_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 2wbp L-ARGININE
BETA-HYDROXYLASE
(Streptomyces
vinaceus) 		4 / 4 ALA A  32
ALA A  35
ALA A  36
ALA A  39
 None
 0.10A 4oadA-2wbpA:
undetectable		 4oadA-2wbpA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA208_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 2wbp L-ARGININE
BETA-HYDROXYLASE
(Streptomyces
vinaceus) 		4 / 4 ALA A  32
ALA A  35
ALA A  36
ALA A  39
 None
 0.10A 4oaeA-2wbpA:
undetectable		 4oaeA-2wbpA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		 2wbp L-ARGININE
BETA-HYDROXYLASE
(Streptomyces
vinaceus) 		3 / 3 ASP A 268
LEU A 165
GLY A 166
 ZZU  A1359 (-3.0A)
SIN  A1360 ( 4.7A)
ZZU  A1359 (-4.7A)
 0.54A 4xmfA-2wbpA:
undetectable		 4xmfA-2wbpA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 2wbp L-ARGININE
BETA-HYDROXYLASE
(Streptomyces
vinaceus) 		4 / 8 ARG A 289
ARG A 220
PHE A 271
ASP A 270
 None
None
ZZU  A1359 (-4.8A)
ZZU  A1359 (-3.9A)
 0.99A 4xqgA-2wbpA:
undetectable		 4xqgA-2wbpA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 2wbp L-ARGININE
BETA-HYDROXYLASE
(Streptomyces
vinaceus) 		4 / 8 ARG A 289
ARG A 220
PHE A 271
ASP A 270
 None
None
ZZU  A1359 (-4.8A)
ZZU  A1359 (-3.9A)
 0.98A 4xqgB-2wbpA:
undetectable		 4xqgB-2wbpA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 2wbp L-ARGININE
BETA-HYDROXYLASE
(Streptomyces
vinaceus) 		5 / 12 GLY A 126
GLY A 129
LEU A 128
ALA A  37
LEU A  71
 None
 0.99A 5c0oF-2wbpA:
undetectable		 5c0oF-2wbpA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_A_ACTA1231_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT)		 2wbp L-ARGININE
BETA-HYDROXYLASE
(Streptomyces
vinaceus) 		3 / 3 ARG A 343
THR A 338
ASP A 179
 None
 0.85A 5g5gA-2wbpA:
undetectable
5g5gB-2wbpA:
undetectable		 5g5gA-2wbpA:
22.01
5g5gB-2wbpA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HV1_A_RFPA902_1
(PHOSPHOENOLPYRUVATE
SYNTHASE)		 2wbp L-ARGININE
BETA-HYDROXYLASE
(Streptomyces
vinaceus) 		5 / 12 VAL A 131
PRO A  54
VAL A 142
LEU A 355
SER A 344
 None
 1.16A 5hv1A-2wbpA:
undetectable		 5hv1A-2wbpA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA504_1
(-)		 2wbp L-ARGININE
BETA-HYDROXYLASE
(Streptomyces
vinaceus) 		4 / 8 ILE A 309
VAL A  88
ALA A 193
LEU A 301
 None
 0.65A 5og9A-2wbpA:
undetectable		 5og9A-2wbpA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA605_0
(ALPHA-AMYLASE)		 2wbp L-ARGININE
BETA-HYDROXYLASE
(Streptomyces
vinaceus) 		4 / 8 TYR A 180
GLY A 182
ILE A 335
ASP A 171
 None
None
None
ZZU  A1359 ( 4.9A)
 0.92A 6ag0A-2wbpA:
undetectable		 6ag0A-2wbpA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0I_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2wbp L-ARGININE
BETA-HYDROXYLASE
(Streptomyces
vinaceus) 		5 / 12 LEU A 184
ASP A 305
ALA A  34
PRO A  68
LEU A  67
 None
 1.10A 6b0iB-2wbpA:
undetectable		 6b0iB-2wbpA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CB4_A_BEZA501_0
(CANAVALIN)		 2wbp L-ARGININE
BETA-HYDROXYLASE
(Streptomyces
vinaceus) 		4 / 8 ASN A 311
VAL A 181
LEU A 183
ILE A 309
 None
 0.91A 6cb4A-2wbpA:
3.6		 6cb4A-2wbpA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA825_0
(GEPHYRIN)		 2wbp L-ARGININE
BETA-HYDROXYLASE
(Streptomyces
vinaceus) 		3 / 3 LYS A 333
VAL A 143
ASP A 145
 None
 0.49A 6fgdA-2wbpA:
undetectable		 6fgdA-2wbpA:
23.33