SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wc1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_A_RBFA301_1
(PROTEIN (FLAVODOXIN))		 2wc1 FLAVODOXIN
(Rhodobacter
capsulatus) 		5 / 7 THR A  12
THR A  57
GLY A  98
ASP A  99
TYR A 103
 FMN  A 183 (-3.6A)
FMN  A 183 (-3.7A)
FMN  A 183 (-3.2A)
None
FMN  A 183 (-3.4A)
 0.64A 1bu5A-2wc1A:
17.9		 1bu5A-2wc1A:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_A_RBFA301_1
(PROTEIN (FLAVODOXIN))		 2wc1 FLAVODOXIN
(Rhodobacter
capsulatus) 		5 / 7 THR A  14
THR A  57
GLY A  98
ASP A  99
TYR A 103
 FMN  A 183 (-3.3A)
FMN  A 183 (-3.7A)
FMN  A 183 (-3.2A)
None
FMN  A 183 (-3.4A)
 0.86A 1bu5A-2wc1A:
17.9		 1bu5A-2wc1A:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_B_RBFB302_1
(PROTEIN (FLAVODOXIN))		 2wc1 FLAVODOXIN
(Rhodobacter
capsulatus) 		4 / 8 THR A  12
ASP A  60
ASP A  99
TYR A 103
 FMN  A 183 (-3.6A)
None
None
FMN  A 183 (-3.4A)
 0.93A 1bu5B-2wc1A:
17.8		 1bu5B-2wc1A:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_B_RBFB302_1
(PROTEIN (FLAVODOXIN))		 2wc1 FLAVODOXIN
(Rhodobacter
capsulatus) 		4 / 8 THR A  12
THR A  57
ASP A  99
TYR A 103
 FMN  A 183 (-3.6A)
FMN  A 183 (-3.7A)
None
FMN  A 183 (-3.4A)
 0.48A 1bu5B-2wc1A:
17.8		 1bu5B-2wc1A:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_B_RBFB302_1
(PROTEIN (FLAVODOXIN))		 2wc1 FLAVODOXIN
(Rhodobacter
capsulatus) 		4 / 8 THR A  14
THR A  57
ASP A  99
TYR A 103
 FMN  A 183 (-3.3A)
FMN  A 183 (-3.7A)
None
FMN  A 183 (-3.4A)
 0.81A 1bu5B-2wc1A:
17.8		 1bu5B-2wc1A:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_B_RBFB302_1
(PROTEIN (FLAVODOXIN))		 2wc1 FLAVODOXIN
(Rhodobacter
capsulatus) 		4 / 8 THR A  57
GLY A  98
ASP A  99
TYR A 103
 FMN  A 183 (-3.7A)
FMN  A 183 (-3.2A)
None
FMN  A 183 (-3.4A)
 0.41A 1bu5B-2wc1A:
17.8		 1bu5B-2wc1A:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4001_1
(SERUM ALBUMIN)		 2wc1 FLAVODOXIN
(Rhodobacter
capsulatus) 		5 / 9 LEU A 169
ILE A 172
LEU A 152
GLY A 149
ALA A  93
 None
 0.78A 1e7aA-2wc1A:
undetectable		 1e7aA-2wc1A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_2
(LIVER
CARBOXYLESTERASE I)		 2wc1 FLAVODOXIN
(Rhodobacter
capsulatus) 		3 / 3 PHE A  45
LEU A  51
MET A  31
 None
 0.83A 1mx1D-2wc1A:
2.0		 1mx1D-2wc1A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 2wc1 FLAVODOXIN
(Rhodobacter
capsulatus) 		3 / 3 ALA A 110
GLY A  54
SER A  74
 None
 0.59A 2ivuA-2wc1A:
undetectable		 2ivuA-2wc1A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_B_VDYB6178_1
(VITAMIN D
HYDROXYLASE)		 2wc1 FLAVODOXIN
(Rhodobacter
capsulatus) 		5 / 12 PRO A  64
LEU A  63
ASN A  36
VAL A 125
LEU A  94
 None
 1.35A 3a51B-2wc1A:
undetectable		 3a51B-2wc1A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 2wc1 FLAVODOXIN
(Rhodobacter
capsulatus) 		5 / 12 LEU A  94
GLY A 149
PHE A  95
VAL A 143
ALA A 110
 None
 1.07A 3dh0B-2wc1A:
undetectable		 3dh0B-2wc1A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_H_DHIH3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 2wc1 FLAVODOXIN
(Rhodobacter
capsulatus) 		3 / 3 LEU A 165
TRP A 168
GLY A 149
 None
 0.79A 3l35A-2wc1A:
undetectable
3l35H-2wc1A:
undetectable		 3l35A-2wc1A:
13.41
3l35H-2wc1A:
6.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_K_DHIK3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 2wc1 FLAVODOXIN
(Rhodobacter
capsulatus) 		3 / 3 LEU A 165
TRP A 168
GLY A 149
 None
 0.79A 3l35B-2wc1A:
undetectable
3l35K-2wc1A:
undetectable		 3l35B-2wc1A:
13.41
3l35K-2wc1A:
6.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEC_A_65BA561_0
(P66 REVERSE
TRANSCRIPTASE)		 2wc1 FLAVODOXIN
(Rhodobacter
capsulatus) 		5 / 12 LEU A  63
VAL A  37
GLY A   9
PHE A  78
LEU A  79
 None
 1.19A 3mecA-2wc1A:
undetectable		 3mecA-2wc1A:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MED_A_65BA561_0
(P51 REVERSE
TRANSCRIPTASE
P66 REVERSE
TRANSCRIPTASE)		 2wc1 FLAVODOXIN
(Rhodobacter
capsulatus) 		5 / 12 LEU A  63
VAL A  37
GLY A   9
PHE A  78
LEU A  79
 None
 1.19A 3medA-2wc1A:
undetectable
3medB-2wc1A:
undetectable		 3medA-2wc1A:
15.65
3medB-2wc1A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TPX_E_ACTE204_0
(E3 UBIQUITIN-PROTEIN
LIGASE MDM2)		 2wc1 FLAVODOXIN
(Rhodobacter
capsulatus) 		3 / 3 LYS A  33
PRO A  34
LEU A  35
 None
 0.75A 3tpxE-2wc1A:
undetectable		 3tpxE-2wc1A:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DXU_A_ACAA711_1
(LACTOTRANSFERRIN)		 2wc1 FLAVODOXIN
(Rhodobacter
capsulatus) 		4 / 6 GLY A  98
VAL A 108
PRO A  56
GLY A  54
 FMN  A 183 (-3.2A)
FMN  A 183 (-4.1A)
FMN  A 183 (-4.2A)
None
 0.84A 4dxuA-2wc1A:
2.1		 4dxuA-2wc1A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOR_A_FLPA711_1
(LACTOTRANSFERRIN)		 2wc1 FLAVODOXIN
(Rhodobacter
capsulatus) 		4 / 7 GLY A  98
VAL A 108
PRO A  56
GLY A  54
 FMN  A 183 (-3.2A)
FMN  A 183 (-4.1A)
FMN  A 183 (-4.2A)
None
 0.85A 4forA-2wc1A:
undetectable		 4forA-2wc1A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 2wc1 FLAVODOXIN
(Rhodobacter
capsulatus) 		3 / 3 VAL A 179
ALA A 173
PHE A  26
 None
 0.92A 4olbA-2wc1A:
3.3		 4olbA-2wc1A:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 2wc1 FLAVODOXIN
(Rhodobacter
capsulatus) 		5 / 12 PHE A 118
ILE A  82
THR A  57
THR A  55
LEU A  79
 None
None
FMN  A 183 (-3.7A)
None
None
 1.19A 4qzuC-2wc1A:
undetectable		 4qzuC-2wc1A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_B_URFB302_1
(URIDINE
PHOSPHORYLASE)		 2wc1 FLAVODOXIN
(Rhodobacter
capsulatus) 		4 / 7 GLY A 133
GLN A 157
ARG A 164
ALA A 131
 None
 0.94A 4txnB-2wc1A:
undetectable		 4txnB-2wc1A:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_C_URFC302_1
(URIDINE
PHOSPHORYLASE)		 2wc1 FLAVODOXIN
(Rhodobacter
capsulatus) 		4 / 7 GLY A 133
GLN A 157
ARG A 164
ALA A 131
 None
 0.95A 4txnC-2wc1A:
2.1		 4txnC-2wc1A:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_D_URFD302_1
(URIDINE
PHOSPHORYLASE)		 2wc1 FLAVODOXIN
(Rhodobacter
capsulatus) 		4 / 7 GLY A 133
GLN A 157
ARG A 164
ALA A 131
 None
 0.95A 4txnD-2wc1A:
2.7		 4txnD-2wc1A:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y4D_A_CFFA411_1
(ENDOTHIAPEPSIN)		 2wc1 FLAVODOXIN
(Rhodobacter
capsulatus) 		4 / 6 LEU A 111
LEU A  97
ILE A  52
PHE A  95
 None
FMN  A 183 (-4.3A)
None
None
 1.25A 4y4dA-2wc1A:
undetectable		 4y4dA-2wc1A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 2wc1 FLAVODOXIN
(Rhodobacter
capsulatus) 		3 / 3 VAL A 179
ALA A 173
PHE A  26
 None
 0.92A 4z4iA-2wc1A:
3.5		 4z4iA-2wc1A:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 2wc1 FLAVODOXIN
(Rhodobacter
capsulatus) 		4 / 5 PHE A 176
LEU A  94
GLY A  54
ILE A   4
 None
 0.98A 5ik1A-2wc1A:
undetectable		 5ik1A-2wc1A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 2wc1 FLAVODOXIN
(Rhodobacter
capsulatus) 		3 / 3 VAL A 179
ALA A 173
PHE A  26
 None
 0.91A 5js1A-2wc1A:
undetectable		 5js1A-2wc1A:
13.48