SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wc7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2wc7 ALPHA AMYLASE,
CATALYTIC REGION
(Nostoc
punctiforme) 		5 / 12 GLY A 481
CYH A 482
LEU A 474
LEU A 401
LEU A 391
 None
 1.23A 1fm6D-2wc7A:
undetectable		 1fm6D-2wc7A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHY_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2wc7 ALPHA AMYLASE,
CATALYTIC REGION
(Nostoc
punctiforme) 		5 / 9 THR A 387
GLY A 481
SER A 480
GLU A 339
GLY A 457
 None
 1.34A 1jhyA-2wc7A:
undetectable		 1jhyA-2wc7A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		 2wc7 ALPHA AMYLASE,
CATALYTIC REGION
(Nostoc
punctiforme) 		5 / 12 ASP A 205
ILE A 237
LYS A  10
ARG A 225
THR A 228
 None
 1.31A 1kijA-2wc7A:
undetectable		 1kijA-2wc7A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L4N_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2wc7 ALPHA AMYLASE,
CATALYTIC REGION
(Nostoc
punctiforme) 		5 / 9 THR A 387
GLY A 481
SER A 480
GLU A 339
GLY A 457
 None
 1.34A 1l4nA-2wc7A:
undetectable		 1l4nA-2wc7A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2wc7 ALPHA AMYLASE,
CATALYTIC REGION
(Nostoc
punctiforme) 		5 / 12 TYR A  15
GLY A 357
GLY A 361
ILE A  17
PHE A  22
 None
 1.44A 2akeA-2wc7A:
undetectable		 2akeA-2wc7A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BU8_A_TF4A1379_1
(PYRUVATE
DEHYDROGENASE KINASE
ISOENZYME 2)		 2wc7 ALPHA AMYLASE,
CATALYTIC REGION
(Nostoc
punctiforme) 		5 / 8 LEU A 346
ILE A 354
HIS A 388
ILE A 392
ILE A  70
 None
 1.08A 2bu8A-2wc7A:
undetectable		 2bu8A-2wc7A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DR2_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2wc7 ALPHA AMYLASE,
CATALYTIC REGION
(Nostoc
punctiforme) 		5 / 11 TYR A  15
GLY A 357
GLY A 361
ILE A  17
PHE A  22
 None
 1.44A 2dr2A-2wc7A:
undetectable		 2dr2A-2wc7A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J5M_A_ACTA1321_0
(CHLOROPEROXIDASE)		 2wc7 ALPHA AMYLASE,
CATALYTIC REGION
(Nostoc
punctiforme) 		4 / 6 LEU A 200
PHE A 224
ILE A 237
ALA A 235
 None
 0.94A 2j5mA-2wc7A:
undetectable		 2j5mA-2wc7A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1002_0
(ALDEHYDE
DEHYDROGENASE A)		 2wc7 ALPHA AMYLASE,
CATALYTIC REGION
(Nostoc
punctiforme) 		3 / 3 GLY A 373
ARG A 372
TYR A 356
 None
 0.65A 2opxA-2wc7A:
undetectable		 2opxA-2wc7A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		 2wc7 ALPHA AMYLASE,
CATALYTIC REGION
(Nostoc
punctiforme) 		4 / 7 SER A 436
TYR A 410
ASN A 432
LEU A 415
 None
 1.26A 3lslA-2wc7A:
undetectable
3lslD-2wc7A:
undetectable		 3lslA-2wc7A:
19.17
3lslD-2wc7A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		 2wc7 ALPHA AMYLASE,
CATALYTIC REGION
(Nostoc
punctiforme) 		4 / 7 SER A 437
TYR A 410
ASN A 432
LEU A 415
 None
 1.39A 3lslA-2wc7A:
undetectable
3lslD-2wc7A:
undetectable		 3lslA-2wc7A:
19.17
3lslD-2wc7A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_A_SAMA6734_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 2wc7 ALPHA AMYLASE,
CATALYTIC REGION
(Nostoc
punctiforme) 		6 / 12 ALA A 411
TYR A 410
ASN A 432
LEU A 340
TYR A 416
PHE A 269
 None
 1.41A 3qxyA-2wc7A:
undetectable		 3qxyA-2wc7A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_B_SAMB6735_0
(N-LYSINE
METHYLTRANSFERASE
SETD6
TRANSCRIPTION FACTOR
P65)		 2wc7 ALPHA AMYLASE,
CATALYTIC REGION
(Nostoc
punctiforme) 		5 / 11 ALA A 411
TYR A 410
ASN A 432
TYR A 416
PHE A 269
 None
 1.38A 3qxyB-2wc7A:
undetectable
3qxyQ-2wc7A:
undetectable		 3qxyB-2wc7A:
21.86
3qxyQ-2wc7A:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_B_SAMB480_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 2wc7 ALPHA AMYLASE,
CATALYTIC REGION
(Nostoc
punctiforme) 		6 / 12 ALA A 411
TYR A 410
ASN A 432
LEU A 340
TYR A 416
PHE A 269
 None
 1.40A 3rc0B-2wc7A:
undetectable		 3rc0B-2wc7A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UZZ_B_ASDB501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 2wc7 ALPHA AMYLASE,
CATALYTIC REGION
(Nostoc
punctiforme) 		4 / 8 TYR A  74
HIS A 322
TYR A 260
TRP A 242
 None
 1.43A 3uzzB-2wc7A:
8.8		 3uzzB-2wc7A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQ7_A_LEUA902_0
(LEUCINE--TRNA LIGASE)		 2wc7 ALPHA AMYLASE,
CATALYTIC REGION
(Nostoc
punctiforme) 		4 / 7 MET A  59
ASP A  54
SER A  25
GLU A 107
 None
 1.24A 4aq7A-2wc7A:
undetectable		 4aq7A-2wc7A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_A_BEZA1000_0
(BENZOATE-COENZYME A
LIGASE)		 2wc7 ALPHA AMYLASE,
CATALYTIC REGION
(Nostoc
punctiforme) 		4 / 7 ALA A 400
GLY A 485
ILE A 428
ILE A 429
 None
 0.65A 4eatA-2wc7A:
undetectable		 4eatA-2wc7A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_A_VK3A202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 2wc7 ALPHA AMYLASE,
CATALYTIC REGION
(Nostoc
punctiforme) 		4 / 5 TYR A  64
TYR A  15
LEU A  68
TRP A 380
 None
 0.95A 4f8yA-2wc7A:
0.1
4f8yB-2wc7A:
0.7		 4f8yA-2wc7A:
16.53
4f8yB-2wc7A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 2wc7 ALPHA AMYLASE,
CATALYTIC REGION
(Nostoc
punctiforme) 		4 / 7 TYR A  64
TYR A  15
LEU A  68
TRP A 380
 None
 1.11A 4f8yC-2wc7A:
undetectable
4f8yD-2wc7A:
undetectable		 4f8yC-2wc7A:
16.53
4f8yD-2wc7A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_D_VK3D202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 2wc7 ALPHA AMYLASE,
CATALYTIC REGION
(Nostoc
punctiforme) 		4 / 5 TRP A 380
TYR A  64
TYR A  15
LEU A  68
 None
 0.92A 4f8yC-2wc7A:
0.1
4f8yD-2wc7A:
0.0		 4f8yC-2wc7A:
16.53
4f8yD-2wc7A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_2
(MDR769 HIV-1
PROTEASE)		 2wc7 ALPHA AMYLASE,
CATALYTIC REGION
(Nostoc
punctiforme) 		4 / 6 ASN A 317
GLY A 243
PRO A 265
THR A 266
 None
 0.67A 4l1aB-2wc7A:
undetectable		 4l1aB-2wc7A:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 2wc7 ALPHA AMYLASE,
CATALYTIC REGION
(Nostoc
punctiforme) 		4 / 8 SER A 337
ASP A 334
THR A 435
ARG A 479
 None
 1.16A 4lnwA-2wc7A:
undetectable		 4lnwA-2wc7A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2wc7 ALPHA AMYLASE,
CATALYTIC REGION
(Nostoc
punctiforme) 		4 / 7 PRO A 146
SER A 128
PHE A 151
ASP A 137
 None
 1.33A 4ndnC-2wc7A:
undetectable		 4ndnC-2wc7A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_1
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 2wc7 ALPHA AMYLASE,
CATALYTIC REGION
(Nostoc
punctiforme) 		3 / 3 SER A 321
TYR A 260
ASP A 122
 None
 0.90A 4rp8C-2wc7A:
undetectable		 4rp8C-2wc7A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA503_1
(PENTALENIC ACID
SYNTHASE)		 2wc7 ALPHA AMYLASE,
CATALYTIC REGION
(Nostoc
punctiforme) 		4 / 7 LEU A 454
ALA A 430
LEU A 474
ILE A 429
 None
 0.86A 4ubsA-2wc7A:
undetectable		 4ubsA-2wc7A:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_A_BEZA301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 2wc7 ALPHA AMYLASE,
CATALYTIC REGION
(Nostoc
punctiforme) 		5 / 10 GLY A 256
GLY A 239
LEU A 318
GLU A 240
TYR A 260
 None
 1.36A 5hwkA-2wc7A:
undetectable		 5hwkA-2wc7A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_B_BEZB301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 2wc7 ALPHA AMYLASE,
CATALYTIC REGION
(Nostoc
punctiforme) 		5 / 10 GLY A 256
GLY A 239
LEU A 318
GLU A 240
TYR A 260
 None
 1.36A 5hwkB-2wc7A:
undetectable		 5hwkB-2wc7A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_A_FUAA1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2wc7 ALPHA AMYLASE,
CATALYTIC REGION
(Nostoc
punctiforme) 		4 / 5 ILE A  58
ILE A 117
HIS A 113
VAL A 119
 None
 0.77A 5jmnA-2wc7A:
undetectable		 5jmnA-2wc7A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 2wc7 ALPHA AMYLASE,
CATALYTIC REGION
(Nostoc
punctiforme) 		3 / 3 THR A 324
SER A 321
ASP A 210
 None
 0.68A 5kvaA-2wc7A:
undetectable		 5kvaA-2wc7A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 2wc7 ALPHA AMYLASE,
CATALYTIC REGION
(Nostoc
punctiforme) 		3 / 3 THR A 324
SER A 321
ASP A 210
 None
 0.66A 5kvaB-2wc7A:
undetectable		 5kvaB-2wc7A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_2
(RIBOFLAVIN LYASE)		 2wc7 ALPHA AMYLASE,
CATALYTIC REGION
(Nostoc
punctiforme) 		4 / 5 GLN A  94
ASP A  96
SER A  81
ARG A  86
 None
 1.44A 5w4zA-2wc7A:
9.3		 5w4zA-2wc7A:
8.81