SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wcu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_A_T3A1_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 2wcu PROTEIN FUCU HOMOLOG
(Mus
musculus) 		5 / 12 ILE A  55
ILE A 141
ARG A  97
ALA A  61
LEU A  58
 None
 1.15A 1bsxA-2wcuA:
undetectable		 1bsxA-2wcuA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_B_T3B2_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 2wcu PROTEIN FUCU HOMOLOG
(Mus
musculus) 		5 / 12 ILE A  55
ILE A 141
ARG A  97
ALA A  61
LEU A  58
 None
 1.15A 1bsxB-2wcuA:
undetectable		 1bsxB-2wcuA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_H_FUAH709_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2wcu PROTEIN FUCU HOMOLOG
(Mus
musculus) 		5 / 12 LEU A  30
VAL A 130
VAL A  62
VAL A  46
ALA A 128
 None
 1.02A 1q23H-2wcuA:
undetectable
1q23I-2wcuA:
undetectable		 1q23H-2wcuA:
20.26
1q23I-2wcuA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FBX_A_ACTA608_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2)		 2wcu PROTEIN FUCU HOMOLOG
(Mus
musculus) 		3 / 3 GLU A  47
VAL A  46
CYH A  41
 None
 1.04A 3fbxA-2wcuA:
undetectable		 3fbxA-2wcuA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_B_LOCB502_1
(TUBULIN BETA CHAIN)		 2wcu PROTEIN FUCU HOMOLOG
(Mus
musculus) 		5 / 12 LEU A  11
LEU A  19
MET A  22
ILE A  48
ILE A  28
 None
 1.18A 3ut5B-2wcuA:
undetectable		 3ut5B-2wcuA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_B_CHDB102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2wcu PROTEIN FUCU HOMOLOG
(Mus
musculus) 		5 / 11 LEU A  30
LEU A  59
GLU A  27
LEU A 143
TYR A  98
 None
 1.13A 4wg0B-2wcuA:
undetectable
4wg0C-2wcuA:
undetectable
4wg0D-2wcuA:
undetectable		 4wg0B-2wcuA:
8.41
4wg0C-2wcuA:
8.41
4wg0D-2wcuA:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_D_CHDD102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2wcu PROTEIN FUCU HOMOLOG
(Mus
musculus) 		5 / 11 LEU A  30
LEU A  59
GLU A  27
LEU A 143
TYR A  98
 None
 1.14A 4wg0D-2wcuA:
undetectable
4wg0E-2wcuA:
undetectable
4wg0F-2wcuA:
undetectable		 4wg0D-2wcuA:
8.41
4wg0E-2wcuA:
8.41
4wg0F-2wcuA:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2wcu PROTEIN FUCU HOMOLOG
(Mus
musculus) 		5 / 11 LEU A  30
LEU A  59
GLU A  27
LEU A 143
TYR A  98
 None
 1.12A 4wg0F-2wcuA:
undetectable
4wg0G-2wcuA:
undetectable
4wg0H-2wcuA:
undetectable		 4wg0F-2wcuA:
8.41
4wg0G-2wcuA:
8.41
4wg0H-2wcuA:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_I_CHDI103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2wcu PROTEIN FUCU HOMOLOG
(Mus
musculus) 		5 / 11 TYR A  98
GLU A  27
LEU A 143
LEU A  30
LEU A  59
 None
 1.11A 4wg0G-2wcuA:
undetectable
4wg0H-2wcuA:
undetectable
4wg0I-2wcuA:
undetectable		 4wg0G-2wcuA:
8.41
4wg0H-2wcuA:
8.41
4wg0I-2wcuA:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_J_CHDJ103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2wcu PROTEIN FUCU HOMOLOG
(Mus
musculus) 		5 / 11 LEU A  30
LEU A  59
GLU A  27
LEU A 143
TYR A  98
 None
 1.16A 4wg0J-2wcuA:
undetectable
4wg0K-2wcuA:
undetectable
4wg0L-2wcuA:
undetectable		 4wg0J-2wcuA:
8.41
4wg0K-2wcuA:
8.41
4wg0L-2wcuA:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_K_CHDK103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2wcu PROTEIN FUCU HOMOLOG
(Mus
musculus) 		5 / 11 TYR A  98
GLU A  27
LEU A 143
LEU A  30
LEU A  59
 None
 1.16A 4wg0I-2wcuA:
undetectable
4wg0J-2wcuA:
undetectable
4wg0K-2wcuA:
undetectable		 4wg0I-2wcuA:
8.41
4wg0J-2wcuA:
8.41
4wg0K-2wcuA:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_2
(TUBULIN BETA CHAIN)		 2wcu PROTEIN FUCU HOMOLOG
(Mus
musculus) 		5 / 11 LEU A  11
LEU A  19
MET A  22
VAL A 130
ILE A  28
 None
 1.09A 4x20D-2wcuA:
undetectable		 4x20D-2wcuA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB203_0
(HYDROXYNITRILE LYASE)		 2wcu PROTEIN FUCU HOMOLOG
(Mus
musculus) 		4 / 4 VAL A  29
ALA A 131
ILE A  40
THR A  37
 None
 0.99A 5e4dB-2wcuA:
undetectable		 5e4dB-2wcuA:
18.66