SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wd5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2wd5 STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
3
(Mus
musculus) 		3 / 3 GLN B 525
ILE B 511
HIS B 560
 None
 0.75A 1fm9A-2wd5B:
undetectable		 1fm9A-2wd5B:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_A_EAAA223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 2wd5 STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
1A
(Mus
musculus) 		4 / 8 GLY A 654
LEU A 659
VAL A 537
PHE A 646
 None
 1.13A 1gsfA-2wd5A:
undetectable		 1gsfA-2wd5A:
26.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_B_EAAB223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 2wd5 STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
1A
(Mus
musculus) 		4 / 8 GLY A 654
LEU A 659
VAL A 537
PHE A 646
 None
 1.13A 1gsfB-2wd5A:
undetectable		 1gsfB-2wd5A:
26.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_D_EAAD223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 2wd5 STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
1A
(Mus
musculus) 		4 / 8 GLY A 654
LEU A 659
VAL A 537
PHE A 646
 None
 1.13A 1gsfD-2wd5A:
undetectable		 1gsfD-2wd5A:
26.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2wd5 STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
3
(Mus
musculus) 		3 / 3 GLN B 525
ILE B 511
HIS B 560
 None
 0.71A 1k74A-2wd5B:
undetectable		 1k74A-2wd5B:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_1
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 2wd5 STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
3
(Mus
musculus) 		4 / 7 LEU B 495
ILE B 504
THR B 500
MET B 536
 None
 1.05A 1kglA-2wd5B:
undetectable		 1kglA-2wd5B:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA502_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2wd5 STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
1A
STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
3
(Mus
musculus;
Mus
musculus) 		4 / 6 ASN B 590
ARG A 635
ILE A 652
GLY A 650
 None
 1.06A 1oniA-2wd5B:
undetectable
1oniB-2wd5B:
undetectable		 1oniA-2wd5B:
20.37
1oniB-2wd5B:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD508_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2wd5 STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
1A
STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
3
(Mus
musculus;
Mus
musculus) 		4 / 6 ASN B 590
ARG A 635
ILE A 652
GLY A 650
 None
 1.06A 1oniD-2wd5B:
undetectable
1oniF-2wd5B:
undetectable		 1oniD-2wd5B:
20.37
1oniF-2wd5B:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCU_A_TYLA3001_1
(LACTOTRANSFERRIN)		 2wd5 STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
1A
(Mus
musculus) 		3 / 3 LEU A 576
TYR A 611
GLY A 614
 None
 0.63A 2ocuA-2wd5A:
undetectable		 2ocuA-2wd5A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS4_A_AZMA702_1
(CARBONIC ANHYDRASE 2)		 2wd5 STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
1A
STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
3
(Mus
musculus) 		4 / 7 VAL B 551
TYR B 668
GLU A 568
PRO A 567
 None
 1.24A 3hs4A-2wd5B:
undetectable		 3hs4A-2wd5B:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZS3_A_ACTA1224_0
(THAUMATIN-LIKE
PROTEIN)		 2wd5 STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
1A
STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
3
(Mus
musculus;
Mus
musculus) 		4 / 5 SER A 653
GLU B 583
THR B 585
TYR B 559
 None
 1.15A 3zs3A-2wd5A:
0.0		 3zs3A-2wd5A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_A_IMNA201_1
(TRANSTHYRETIN)		 2wd5 STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
1A
(Mus
musculus) 		3 / 3 LYS A 662
LEU A 659
ALA A 661
 None
 0.60A 4ikiA-2wd5A:
undetectable		 4ikiA-2wd5A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_A_ASCA303_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 2wd5 STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
3
(Mus
musculus) 		4 / 7 PHE B 586
HIS B 560
PHE B 575
ASN B 576
 None
 1.24A 4o7gA-2wd5B:
undetectable
4o7gB-2wd5B:
undetectable		 4o7gA-2wd5B:
21.29
4o7gB-2wd5B:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_B_ASCB304_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 2wd5 STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
3
(Mus
musculus) 		4 / 6 PHE B 586
HIS B 560
PHE B 575
ASN B 576
 None
 1.37A 4o7gB-2wd5B:
undetectable		 4o7gB-2wd5B:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_B_RTLB201_0
(RETINOL-BINDING
PROTEIN 2)		 2wd5 STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
3
(Mus
musculus) 		5 / 12 PHE B 626
ALA B 553
ARG B 674
TYR B 546
LEU B 675
 None
 1.48A 4qzuB-2wd5B:
undetectable		 4qzuB-2wd5B:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YBN_A_ACTA303_0
(FLAVIN-NUCLEOTIDE-BI
NDING PROTEIN)		 2wd5 STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
1A
(Mus
musculus) 		3 / 3 VAL A 618
TYR A 530
ALA A 533
 None
 0.47A 4ybnA-2wd5A:
undetectable		 4ybnA-2wd5A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_B_REAB602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 2wd5 STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
1A
(Mus
musculus) 		5 / 9 GLY A 517
LEU A 522
ASN A 541
LEU A 571
LEU A 573
 None
 1.23A 5fhzB-2wd5A:
undetectable		 5fhzB-2wd5A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_A_IPHA101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 2wd5 STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
1A
(Mus
musculus) 		4 / 4 CYH A 523
LEU A 519
LEU A 609
ALA A 608
 None
 1.03A 5hpuA-2wd5A:
undetectable
5hpuB-2wd5A:
undetectable		 5hpuA-2wd5A:
8.39
5hpuB-2wd5A:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_A_IPHA101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 2wd5 STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
1A
(Mus
musculus) 		4 / 4 CYH A 523
LEU A 538
LEU A 609
ALA A 612
 None
 1.08A 5hpuA-2wd5A:
undetectable
5hpuB-2wd5A:
undetectable		 5hpuA-2wd5A:
8.39
5hpuB-2wd5A:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMF_A_6U9A1301_1
(ION TRANSPORT
PROTEIN)		 2wd5 STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
1A
(Mus
musculus) 		4 / 6 GLY A 553
GLU A 550
PHE A 570
ILE A 546
 None
 0.92A 5kmfA-2wd5A:
undetectable
5kmfC-2wd5A:
undetectable		 5kmfA-2wd5A:
19.74
5kmfC-2wd5A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 2wd5 STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
3
(Mus
musculus) 		4 / 5 TYR B 668
TYR B 667
GLY B 666
GLY B 665
 None
 0.75A 5x7pA-2wd5B:
undetectable		 5x7pA-2wd5B:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 2wd5 STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
3
(Mus
musculus) 		4 / 6 TYR B 668
TYR B 667
GLY B 666
GLY B 665
 None
 0.75A 5x7pB-2wd5B:
undetectable		 5x7pB-2wd5B:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)		 2wd5 STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
3
(Mus
musculus) 		4 / 5 TYR B 531
GLN B 528
GLY B 582
ILE B 508
 None
 1.47A 6debB-2wd5B:
undetectable		 6debB-2wd5B:
14.95