SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wda'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_1
(NEURAMINIDASE)		 2wda PUTATIVE SECRETED
LYASE
(Streptomyces
violaceoruber) 		5 / 12 ARG A 149
GLU A 434
ARG A 307
ASN A 432
TYR A 253
 PEG  A1775 ( 2.9A)
L42  A1784 (-3.5A)
L42  A1784 (-3.4A)
GOL  A1773 (-3.7A)
L42  A1784 ( 3.4A)
 1.45A 1a4gB-2wdaA:
undetectable		 1a4gB-2wdaA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BRP_A_RTLA183_0
(RETINOL BINDING
PROTEIN)		 2wda PUTATIVE SECRETED
LYASE
(Streptomyces
violaceoruber) 		5 / 12 LEU A 294
PHE A 529
LEU A 299
HIS A 398
PHE A 401
 None
 1.40A 1brpA-2wdaA:
undetectable		 1brpA-2wdaA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD8_0
(GRAMICIDIN A)		 2wda PUTATIVE SECRETED
LYASE
(Streptomyces
violaceoruber) 		3 / 3 TRP A 461
VAL A 321
TRP A 599
 None
 0.82A 1c4dC-2wdaA:
undetectable
1c4dD-2wdaA:
undetectable		 1c4dC-2wdaA:
2.06
1c4dD-2wdaA:
2.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2wda PUTATIVE SECRETED
LYASE
(Streptomyces
violaceoruber) 		4 / 7 GLY A 232
HIS A 244
THR A 245
THR A 191
 PEG  A1779 (-4.4A)
FMT  A1766 (-3.9A)
None
None
 0.85A 1c9sT-2wdaA:
undetectable
1c9sU-2wdaA:
undetectable		 1c9sT-2wdaA:
6.68
1c9sU-2wdaA:
6.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 2wda PUTATIVE SECRETED
LYASE
(Streptomyces
violaceoruber) 		4 / 8 ASP A 483
TRP A 439
TYR A 469
ARG A 480
 None
None
None
PEG  A1777 (-3.0A)
 1.39A 1ceaA-2wdaA:
undetectable
1ceaB-2wdaA:
undetectable		 1ceaA-2wdaA:
7.49
1ceaB-2wdaA:
7.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEB_A_AMHA90_1
(PLASMINOGEN)		 2wda PUTATIVE SECRETED
LYASE
(Streptomyces
violaceoruber) 		4 / 7 ASP A 483
TRP A 439
TYR A 469
ARG A 480
 None
None
None
PEG  A1777 (-3.0A)
 1.45A 1cebA-2wdaA:
undetectable		 1cebA-2wdaA:
7.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEB_B_AMHB90_1
(PLASMINOGEN)		 2wda PUTATIVE SECRETED
LYASE
(Streptomyces
violaceoruber) 		4 / 7 ASP A 483
TRP A 439
TYR A 469
ARG A 480
 None
None
None
PEG  A1777 (-3.0A)
 1.50A 1cebB-2wdaA:
undetectable		 1cebB-2wdaA:
7.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)		 2wda PUTATIVE SECRETED
LYASE
(Streptomyces
violaceoruber) 		5 / 10 LEU A 530
HIS A 398
ALA A 508
PHE A 528
GLY A 501
 None
 1.27A 1cmcA-2wdaA:
undetectable
1cmcB-2wdaA:
undetectable		 1cmcA-2wdaA:
7.04
1cmcB-2wdaA:
7.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_2
(DIHYDROFOLATE
REDUCTASE)		 2wda PUTATIVE SECRETED
LYASE
(Streptomyces
violaceoruber) 		3 / 3 TRP A 599
ARG A  60
THR A 607
 None
 1.01A 1df7A-2wdaA:
undetectable		 1df7A-2wdaA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F9G_A_ASCA950_0
(HYALURONATE LYASE)		 2wda PUTATIVE SECRETED
LYASE
(Streptomyces
violaceoruber) 		5 / 7 ARG A 149
ASN A 139
ARG A 307
ARG A 311
ASN A 432
 PEG  A1775 ( 2.9A)
GOL  A1773 (-2.8A)
L42  A1784 (-3.4A)
L42  A1784 (-2.8A)
GOL  A1773 (-3.7A)
 1.34A 1f9gA-2wdaA:
43.4		 1f9gA-2wdaA:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F9G_A_ASCA950_0
(HYALURONATE LYASE)		 2wda PUTATIVE SECRETED
LYASE
(Streptomyces
violaceoruber) 		4 / 7 ARG A 149
TYR A 249
ARG A 307
ARG A 311
 PEG  A1775 ( 2.9A)
None
L42  A1784 (-3.4A)
L42  A1784 (-2.8A)
 1.17A 1f9gA-2wdaA:
43.4		 1f9gA-2wdaA:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F9G_A_ASCA950_0
(HYALURONATE LYASE)		 2wda PUTATIVE SECRETED
LYASE
(Streptomyces
violaceoruber) 		6 / 7 ASN A 139
TRP A 141
TYR A 253
ARG A 307
ARG A 311
ASN A 432
 GOL  A1773 (-2.8A)
L42  A1784 (-3.8A)
L42  A1784 ( 3.4A)
L42  A1784 (-3.4A)
L42  A1784 (-2.8A)
GOL  A1773 (-3.7A)
 0.51A 1f9gA-2wdaA:
43.4		 1f9gA-2wdaA:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC8_0
(GRAMICIDIN A)		 2wda PUTATIVE SECRETED
LYASE
(Streptomyces
violaceoruber) 		3 / 4 VAL A 466
TRP A 461
TRP A 468
 PEG  A1782 ( 3.7A)
None
None
 1.07A 1gmkC-2wdaA:
undetectable
1gmkD-2wdaA:
undetectable		 1gmkC-2wdaA:
2.06
1gmkD-2wdaA:
2.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 2wda PUTATIVE SECRETED
LYASE
(Streptomyces
violaceoruber) 		4 / 7 GLY A 232
HIS A 244
THR A 245
THR A 191
 PEG  A1779 (-4.4A)
FMT  A1766 (-3.9A)
None
None
 0.86A 1gtfL-2wdaA:
undetectable
1gtfM-2wdaA:
undetectable		 1gtfL-2wdaA:
6.68
1gtfM-2wdaA:
6.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 2wda PUTATIVE SECRETED
LYASE
(Streptomyces
violaceoruber) 		4 / 8 GLY A 232
HIS A 244
THR A 245
THR A 191
 PEG  A1779 (-4.4A)
FMT  A1766 (-3.9A)
None
None
 0.85A 1gtfN-2wdaA:
undetectable
1gtfO-2wdaA:
undetectable		 1gtfN-2wdaA:
6.68
1gtfO-2wdaA:
6.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J8U_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 2wda PUTATIVE SECRETED
LYASE
(Streptomyces
violaceoruber) 		4 / 7 VAL A 196
LEU A 258
PHE A 265
ALA A 343
 None
 0.75A 1j8uA-2wdaA:
undetectable		 1j8uA-2wdaA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT6_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2wda PUTATIVE SECRETED
LYASE
(Streptomyces
violaceoruber) 		5 / 11 LEU A  30
LEU A  35
TYR A 159
LEU A 204
HIS A 161
 None
 1.39A 1kt6A-2wdaA:
undetectable		 1kt6A-2wdaA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_1
(ALPHA-AMYLASE)		 2wda PUTATIVE SECRETED
LYASE
(Streptomyces
violaceoruber) 		5 / 12 GLN A 243
VAL A 256
GLY A 254
ALA A 308
GLU A 434
 None
PEG  A1775 (-3.8A)
None
L42  A1784 ( 4.9A)
L42  A1784 (-3.5A)
 1.20A 1kxhA-2wdaA:
3.9		 1kxhA-2wdaA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2200_0
(PROTEIN (METHIONINE
REPRESSOR))		 2wda PUTATIVE SECRETED
LYASE
(Streptomyces
violaceoruber) 		5 / 12 ALA A 508
PHE A 528
GLY A 501
LEU A 530
HIS A 398
 None
 1.26A 1mj2A-2wdaA:
undetectable
1mj2B-2wdaA:
undetectable		 1mj2A-2wdaA:
6.90
1mj2B-2wdaA:
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XP0_A_VDNA201_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2wda PUTATIVE SECRETED
LYASE
(Streptomyces
violaceoruber) 		5 / 10 ALA A 221
VAL A 196
ALA A 193
LEU A 258
PHE A 226
 None
 1.19A 1xp0A-2wdaA:
undetectable		 1xp0A-2wdaA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z35_A_2FAA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2wda PUTATIVE SECRETED
LYASE
(Streptomyces
violaceoruber) 		5 / 10 ARG A 470
GLY A 623
THR A 475
VAL A 549
GLU A 550
 PEG  A1782 ( 3.3A)
None
None
None
PEG  A1777 (-3.2A)
 1.45A 1z35A-2wdaA:
undetectable		 1z35A-2wdaA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_B_CQAB401_0
(HISTAMINE
N-METHYLTRANSFERASE)		 2wda PUTATIVE SECRETED
LYASE
(Streptomyces
violaceoruber) 		4 / 7 GLY A 397
PRO A 412
ASP A 531
TYR A 507
 None
 0.88A 2aouB-2wdaA:
undetectable		 2aouB-2wdaA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 2wda PUTATIVE SECRETED
LYASE
(Streptomyces
violaceoruber) 		5 / 12 ALA A 693
SER A 694
ALA A 502
PRO A 751
GLY A 692
 None
 1.19A 2igtC-2wdaA:
undetectable		 2igtC-2wdaA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 2wda PUTATIVE SECRETED
LYASE
(Streptomyces
violaceoruber) 		5 / 12 THR A  38
VAL A 338
GLY A 262
ALA A 335
GLN A 255
 FMT  A1767 ( 4.3A)
None
None
None
PEG  A1775 (-3.5A)
 1.29A 2x2iC-2wdaA:
4.1		 2x2iC-2wdaA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2wda PUTATIVE SECRETED
LYASE
(Streptomyces
violaceoruber) 		6 / 12 ALA A 157
LEU A  94
ILE A 118
THR A  98
LEU A 119
ASP A 123
 None
 1.35A 3gcsA-2wdaA:
undetectable		 3gcsA-2wdaA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_B_FLPB701_1
(CYCLOOXYGENASE-2)		 2wda PUTATIVE SECRETED
LYASE
(Streptomyces
violaceoruber) 		5 / 11 VAL A 583
LEU A 620
MET A 636
VAL A 635
GLY A 580
 None
 1.16A 3pghB-2wdaA:
undetectable		 3pghB-2wdaA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SM2_A_478A126_2
(GAG-PRO-POL
POLYPROTEIN)		 2wda PUTATIVE SECRETED
LYASE
(Streptomyces
violaceoruber) 		5 / 11 ALA A 675
VAL A 668
VAL A 535
LEU A 654
LEU A 673
 None
MG  A1783 (-4.2A)
None
None
None
 0.99A 3sm2B-2wdaA:
undetectable		 3sm2B-2wdaA:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1002_1
(HEMOLYTIC LECTIN
CEL-III)		 2wda PUTATIVE SECRETED
LYASE
(Streptomyces
violaceoruber) 		3 / 3 ASP A 594
GLU A 560
GLY A 561
 None
 0.56A 3w9tA-2wdaA:
undetectable		 3w9tA-2wdaA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1002_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 2wda PUTATIVE SECRETED
LYASE
(Streptomyces
violaceoruber) 		3 / 3 ASN A 557
TRP A 615
ASP A 456
 FMT  A1769 (-4.5A)
PEG  A1782 (-3.2A)
FMT  A1769 (-3.5A)
 0.99A 4a7tA-2wdaA:
undetectable
4a7tF-2wdaA:
1.2		 4a7tA-2wdaA:
12.35
4a7tF-2wdaA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_B_LURB201_1
(TRANSTHYRETIN)		 2wda PUTATIVE SECRETED
LYASE
(Streptomyces
violaceoruber) 		4 / 8 LEU A 566
ALA A 573
LEU A 575
VAL A 583
 PEG  A1781 (-4.7A)
None
None
None
 0.65A 4iizB-2wdaA:
undetectable		 4iizB-2wdaA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 2wda PUTATIVE SECRETED
LYASE
(Streptomyces
violaceoruber) 		3 / 3 PRO A  84
VAL A 129
HIS A 131
 None
 0.69A 4pevC-2wdaA:
undetectable		 4pevC-2wdaA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 2wda PUTATIVE SECRETED
LYASE
(Streptomyces
violaceoruber) 		5 / 11 THR A 703
CYH A 760
ALA A 728
GLY A 727
THR A 741
 None
 0.95A 4qvvH-2wdaA:
undetectable		 4qvvH-2wdaA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 2wda PUTATIVE SECRETED
LYASE
(Streptomyces
violaceoruber) 		5 / 11 THR A 703
CYH A 760
ALA A 728
GLY A 727
THR A 741
 None
 0.95A 4qvvV-2wdaA:
undetectable		 4qvvV-2wdaA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 2wda PUTATIVE SECRETED
LYASE
(Streptomyces
violaceoruber) 		5 / 11 THR A 703
CYH A 760
ALA A 728
GLY A 727
THR A 741
 None
 0.94A 4qvyH-2wdaA:
undetectable		 4qvyH-2wdaA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2wda PUTATIVE SECRETED
LYASE
(Streptomyces
violaceoruber) 		4 / 6 ASN A 139
GLU A 434
GLU A 429
TYR A 253
 GOL  A1773 (-2.8A)
L42  A1784 (-3.5A)
None
L42  A1784 ( 3.4A)
 1.47A 4twdG-2wdaA:
undetectable
4twdH-2wdaA:
undetectable		 4twdG-2wdaA:
16.36
4twdH-2wdaA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_B_0HKB1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 2wda PUTATIVE SECRETED
LYASE
(Streptomyces
violaceoruber) 		5 / 12 ASP A 545
SER A 519
THR A 551
THR A 474
ALA A 443
 None
 1.31A 4u15B-2wdaA:
undetectable		 4u15B-2wdaA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIL_H_QI9H1223_0
(FAB 314.1)		 2wda PUTATIVE SECRETED
LYASE
(Streptomyces
violaceoruber) 		5 / 12 SER A 286
GLY A 260
GLN A 243
GLY A 192
LEU A 235
 None
 1.25A 4uilH-2wdaA:
undetectable
4uilL-2wdaA:
undetectable		 4uilH-2wdaA:
14.50
4uilL-2wdaA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_C_QDNC602_1
(CYTOCHROME P450 2D6)		 2wda PUTATIVE SECRETED
LYASE
(Streptomyces
violaceoruber) 		5 / 11 PHE A 401
GLY A 234
LEU A 235
ALA A 248
SER A 250
 None
 1.36A 4wnuC-2wdaA:
undetectable		 4wnuC-2wdaA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_1
(CYTOCHROME P450 2D6)		 2wda PUTATIVE SECRETED
LYASE
(Streptomyces
violaceoruber) 		5 / 12 PHE A 401
GLY A 234
LEU A 235
ALA A 248
SER A 250
 None
 1.11A 4wnwB-2wdaA:
undetectable		 4wnwB-2wdaA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YSH_B_GLYB402_0
(GLYCINE OXIDASE)		 2wda PUTATIVE SECRETED
LYASE
(Streptomyces
violaceoruber) 		4 / 5 GLU A 429
TYR A 253
ARG A 311
ARG A 307
 None
L42  A1784 ( 3.4A)
L42  A1784 (-2.8A)
L42  A1784 (-3.4A)
 1.29A 4yshB-2wdaA:
0.0		 4yshB-2wdaA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2wda PUTATIVE SECRETED
LYASE
(Streptomyces
violaceoruber) 		5 / 12 GLY A 516
PHE A 529
GLY A 417
THR A 303
HIS A 427
 GOL  A1771 (-4.3A)
None
None
None
GOL  A1771 ( 4.3A)
 1.18A 4zdyA-2wdaA:
undetectable		 4zdyA-2wdaA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2wda PUTATIVE SECRETED
LYASE
(Streptomyces
violaceoruber) 		4 / 7 PHE A 529
GLY A 417
THR A 303
MET A 420
 None
 0.86A 4zdzA-2wdaA:
undetectable		 4zdzA-2wdaA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 2wda PUTATIVE SECRETED
LYASE
(Streptomyces
violaceoruber) 		5 / 11 THR A 703
CYH A 760
ALA A 728
GLY A 727
THR A 741
 None
 0.94A 5d0xV-2wdaA:
undetectable		 5d0xV-2wdaA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2wda PUTATIVE SECRETED
LYASE
(Streptomyces
violaceoruber) 		4 / 8 THR A 191
GLY A 232
HIS A 244
THR A 245
 None
PEG  A1779 (-4.4A)
FMT  A1766 (-3.9A)
None
 0.86A 5eezL-2wdaA:
0.0
5eezV-2wdaA:
undetectable		 5eezL-2wdaA:
6.68
5eezV-2wdaA:
6.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2wda PUTATIVE SECRETED
LYASE
(Streptomyces
violaceoruber) 		4 / 8 THR A 191
GLY A 232
HIS A 244
THR A 245
 None
PEG  A1779 (-4.4A)
FMT  A1766 (-3.9A)
None
 0.86A 5ef1L-2wdaA:
undetectable
5ef1V-2wdaA:
0.0		 5ef1L-2wdaA:
6.68
5ef1V-2wdaA:
6.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2wda PUTATIVE SECRETED
LYASE
(Streptomyces
violaceoruber) 		4 / 8 THR A 191
GLY A 232
HIS A 244
THR A 245
 None
PEG  A1779 (-4.4A)
FMT  A1766 (-3.9A)
None
 0.87A 5ef2L-2wdaA:
undetectable
5ef2V-2wdaA:
undetectable		 5ef2L-2wdaA:
6.68
5ef2V-2wdaA:
6.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESJ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2wda PUTATIVE SECRETED
LYASE
(Streptomyces
violaceoruber) 		4 / 8 PHE A 529
GLY A 417
THR A 303
MET A 420
 None
 0.82A 5esjA-2wdaA:
undetectable		 5esjA-2wdaA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 2wda PUTATIVE SECRETED
LYASE
(Streptomyces
violaceoruber) 		4 / 6 PRO A 494
ALA A 407
LEU A 400
TYR A 236
 GOL  A1771 (-4.3A)
None
GOL  A1772 (-4.3A)
PEG  A1779 (-4.4A)
 1.10A 5igiA-2wdaA:
undetectable		 5igiA-2wdaA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2wda PUTATIVE SECRETED
LYASE
(Streptomyces
violaceoruber) 		5 / 12 THR A 703
CYH A 760
ALA A 728
GLY A 727
THR A 741
 None
 0.90A 5l5zH-2wdaA:
undetectable
5l5zI-2wdaA:
undetectable		 5l5zH-2wdaA:
16.06
5l5zI-2wdaA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2wda PUTATIVE SECRETED
LYASE
(Streptomyces
violaceoruber) 		5 / 12 THR A 703
CYH A 760
ALA A 728
GLY A 727
THR A 741
 None
 0.90A 5l5zV-2wdaA:
undetectable
5l5zW-2wdaA:
undetectable		 5l5zV-2wdaA:
16.06
5l5zW-2wdaA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2wda PUTATIVE SECRETED
LYASE
(Streptomyces
violaceoruber) 		5 / 9 VAL A 553
GLY A 623
VAL A 549
GLU A 550
PRO A 626
 None
None
None
PEG  A1777 (-3.2A)
None
 1.20A 5zniA-2wdaA:
undetectable		 5zniA-2wdaA:
7.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_A_9KLA402_0
(EST-Y29)		 2wda PUTATIVE SECRETED
LYASE
(Streptomyces
violaceoruber) 		5 / 12 ILE A 720
LEU A 706
GLY A 501
ALA A 502
LEU A 696
 None
 1.16A 5zwrA-2wdaA:
undetectable		 5zwrA-2wdaA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AY6_A_VORA501_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 2wda PUTATIVE SECRETED
LYASE
(Streptomyces
violaceoruber) 		5 / 9 TYR A  91
ALA A 173
ALA A 169
LEU A 162
LEU A 208
 None
 1.27A 6ay6A-2wdaA:
undetectable		 6ay6A-2wdaA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_0
(NS3 PROTEASE)		 2wda PUTATIVE SECRETED
LYASE
(Streptomyces
violaceoruber) 		5 / 12 GLY A 262
VAL A 287
ILE A 145
LEU A 198
ALA A 193
 None
 1.10A 6c2mA-2wdaA:
undetectable		 6c2mA-2wdaA:
7.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_2
(PROTEASE)		 2wda PUTATIVE SECRETED
LYASE
(Streptomyces
violaceoruber) 		3 / 3 LEU A 368
ASP A 297
ILE A 295
 None
 0.59A 6dh0B-2wdaA:
undetectable		 6dh0B-2wdaA:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DYO_A_LDPA901_0
(EBONY)		 2wda PUTATIVE SECRETED
LYASE
(Streptomyces
violaceoruber) 		4 / 5 VAL A 668
LEU A 530
HIS A 409
THR A 634
 MG  A1783 (-4.2A)
None
None
None
 1.42A 6dyoA-2wdaA:
undetectable		 6dyoA-2wdaA:
7.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FZB_B_SRYB301_1
(STREPTOMYCIN
3''-ADENYLYLTRANSFER
ASE)		 2wda PUTATIVE SECRETED
LYASE
(Streptomyces
violaceoruber) 		5 / 12 ASP A 197
TRP A 140
ASP A  82
ILE A  87
THR A  88
 PEG  A1775 (-3.3A)
GOL  A1773 ( 4.2A)
None
None
None
 1.37A 6fzbB-2wdaA:
undetectable		 6fzbB-2wdaA:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_1
(BETA-1 ADRENERGIC
RECEPTOR)		 2wda PUTATIVE SECRETED
LYASE
(Streptomyces
violaceoruber) 		4 / 6 GLY A 672
LEU A 671
PHE A 528
PHE A 678
 None
 1.05A 6h7lA-2wdaA:
undetectable		 6h7lA-2wdaA:
8.33