SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wdu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE)		 2wdu GLUTATHIONE
TRANSFERASE SIGMA
CLASS
(Fasciola
hepatica) 		4 / 7 TYR A  10
PHE A  11
GLY A  15
ARG A  16
 DMS  A1214 ( 4.3A)
GSH  A 301 (-4.4A)
DMS  A1214 (-3.0A)
GDS  A 300 ( 4.1A)
 0.80A 11gsB-2wduA:
24.4		 11gsB-2wduA:
29.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_1
(VITAMIN D NUCLEAR
RECEPTOR)		 2wdu GLUTATHIONE
TRANSFERASE SIGMA
CLASS
(Fasciola
hepatica) 		5 / 12 TYR A  93
LEU A 135
LEU A 138
VAL A 139
SER A 142
 DMS  A1212 ( 4.7A)
None
None
None
None
 1.04A 1db1A-2wduA:
undetectable		 1db1A-2wduA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2wdu GLUTATHIONE
TRANSFERASE SIGMA
CLASS
(Fasciola
hepatica) 		3 / 3 GLU A 103
TYR A 106
PHE A 162
 None
 0.94A 1eqbB-2wduA:
undetectable		 1eqbB-2wduA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2wdu GLUTATHIONE
TRANSFERASE SIGMA
CLASS
(Fasciola
hepatica) 		3 / 3 GLU A 103
TYR A 106
PHE A 162
 None
 0.94A 1eqbA-2wduA:
undetectable		 1eqbA-2wduA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2wdu GLUTATHIONE
TRANSFERASE SIGMA
CLASS
(Fasciola
hepatica) 		3 / 3 GLU A 103
TYR A 106
PHE A 162
 None
 0.94A 1eqbD-2wduA:
undetectable		 1eqbD-2wduA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2wdu GLUTATHIONE
TRANSFERASE SIGMA
CLASS
(Fasciola
hepatica) 		3 / 3 GLU A 103
TYR A 106
PHE A 162
 None
 0.95A 1eqbC-2wduA:
undetectable		 1eqbC-2wduA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE9_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 2wdu GLUTATHIONE
TRANSFERASE SIGMA
CLASS
(Fasciola
hepatica) 		5 / 12 TYR A  93
LEU A 135
LEU A 138
VAL A 139
SER A 142
 DMS  A1212 ( 4.7A)
None
None
None
None
 1.09A 1ie9A-2wduA:
undetectable		 1ie9A-2wduA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		 2wdu GLUTATHIONE
TRANSFERASE SIGMA
CLASS
(Fasciola
hepatica) 		4 / 5 GLU A 141
LEU A 135
LEU A 138
LEU A 136
 None
 1.17A 1np1A-2wduA:
undetectable		 1np1A-2wduA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I2Z_A_SALA1100_1
(SERUM ALBUMIN)		 2wdu GLUTATHIONE
TRANSFERASE SIGMA
CLASS
(Fasciola
hepatica) 		4 / 5 LEU A 158
ILE A  20
ILE A  74
ALA A  73
 None
 0.73A 2i2zA-2wduA:
2.8		 2i2zA-2wduA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1200_1
(SERUM ALBUMIN)		 2wdu GLUTATHIONE
TRANSFERASE SIGMA
CLASS
(Fasciola
hepatica) 		4 / 4 LEU A 158
ILE A  20
ILE A  74
ALA A  73
 None
 0.80A 2i30A-2wduA:
3.5		 2i30A-2wduA:
17.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WB9_A_CYSA301_0
(GLUTATHIONE
TRANSFERASE SIGMA
CLASS)		 2wdu GLUTATHIONE
TRANSFERASE SIGMA
CLASS
(Fasciola
hepatica) 		5 / 5 TYR A  10
GLY A  15
ARG A  16
TYR A 106
TYR A 110
 DMS  A1214 ( 4.3A)
DMS  A1214 (-3.0A)
GDS  A 300 ( 4.1A)
None
GDS  A 300 (-4.6A)
 0.17A 2wb9A-2wduA:
36.4		 2wb9A-2wduA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2wdu GLUTATHIONE
TRANSFERASE SIGMA
CLASS
(Fasciola
hepatica) 		4 / 7 LEU A  78
ILE A  20
GLN A  35
ILE A  44
 None
 0.81A 2xkwA-2wduA:
undetectable		 2xkwA-2wduA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M7R_A_VDXA425_1
(VITAMIN D3 RECEPTOR)		 2wdu GLUTATHIONE
TRANSFERASE SIGMA
CLASS
(Fasciola
hepatica) 		5 / 12 TYR A  93
LEU A 135
LEU A 138
VAL A 139
SER A 142
 DMS  A1212 ( 4.7A)
None
None
None
None
 1.31A 3m7rA-2wduA:
undetectable		 3m7rA-2wduA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2wdu GLUTATHIONE
TRANSFERASE SIGMA
CLASS
(Fasciola
hepatica) 		4 / 6 GLU A 101
ILE A  98
HIS A 169
VAL A 174
 None
None
BR  A1218 (-3.7A)
None
 1.21A 4a97I-2wduA:
4.6		 4a97I-2wduA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M7T_A_SAMA503_0
(BTRN)		 2wdu GLUTATHIONE
TRANSFERASE SIGMA
CLASS
(Fasciola
hepatica) 		5 / 11 GLU A 179
THR A 168
HIS A 189
LEU A 199
SER A 200
 None
BR  A1215 ( 3.3A)
None
None
None
 0.97A 4m7tA-2wduA:
undetectable		 4m7tA-2wduA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT7_A_TOPA302_1
(RV2671)		 2wdu GLUTATHIONE
TRANSFERASE SIGMA
CLASS
(Fasciola
hepatica) 		5 / 11 ILE A 156
THR A 194
SER A 195
ASP A 160
THR A 157
 None
 1.42A 4xt7A-2wduA:
undetectable		 4xt7A-2wduA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_B_DIFB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2wdu GLUTATHIONE
TRANSFERASE SIGMA
CLASS
(Fasciola
hepatica) 		4 / 8 SER A 195
LEU A 161
LEU A  22
MET A  84
 None
 0.90A 4xtaB-2wduA:
undetectable		 4xtaB-2wduA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2wdu GLUTATHIONE
TRANSFERASE SIGMA
CLASS
(Fasciola
hepatica) 		5 / 12 LEU A  78
ILE A  20
GLN A  35
ILE A  44
LEU A  48
 None
 0.96A 5y2tB-2wduA:
undetectable		 5y2tB-2wduA:
undetectable