SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2we5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_A_RBFA301_1
(PROTEIN (FLAVODOXIN))		 2we5 CARBAMATE KINASE 1
(Enterococcus
faecalis) 		4 / 7 THR A  82
ASN A  51
THR A 112
GLY A 192
 None
 1.04A 1bu5A-2we5A:
undetectable		 1bu5A-2we5A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_1
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 2we5 CARBAMATE KINASE 1
(Enterococcus
faecalis) 		4 / 7 LEU A  45
ILE A  14
TRP A  89
GLN A  54
 None
 1.00A 1kglA-2we5A:
undetectable		 1kglA-2we5A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2we5 CARBAMATE KINASE 1
(Enterococcus
faecalis) 		4 / 5 GLY A 190
GLN A  83
VAL A 114
SER A 187
 None
 1.46A 1rs6B-2we5A:
undetectable		 1rs6B-2we5A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2we5 CARBAMATE KINASE 1
(Enterococcus
faecalis) 		5 / 12 ILE A 184
ILE A  46
VAL A   7
ALA A   8
LEU A 292
 None
 1.11A 1uduB-2we5A:
undetectable		 1uduB-2we5A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC8_0
(ACTINOMYCIN D)		 2we5 CARBAMATE KINASE 1
(Enterococcus
faecalis) 		3 / 3 PRO A 129
THR A 127
PRO A 162
 None
 0.77A 2d55C-2we5A:
undetectable		 2d55C-2we5A:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCD_A_RAPA138_1
(OUTER MEMBRANE
PROTEIN MIP)		 2we5 CARBAMATE KINASE 1
(Enterococcus
faecalis) 		5 / 11 ASP A 120
GLN A 113
VAL A 114
ILE A 207
VAL A 161
 None
 1.40A 2vcdA-2we5A:
undetectable		 2vcdA-2we5A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_0
(CYTOCHROME P450 2R1)		 2we5 CARBAMATE KINASE 1
(Enterococcus
faecalis) 		5 / 12 VAL A 308
ALA A 287
GLU A 255
VAL A 234
THR A 306
 None
None
None
ADP  A1311 ( 3.9A)
None
 1.10A 3dl9A-2we5A:
undetectable		 3dl9A-2we5A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE)		 2we5 CARBAMATE KINASE 1
(Enterococcus
faecalis) 		4 / 8 SER A 291
ASN A  12
GLN A  30
ASN A 294
 None
 1.33A 3n62A-2we5A:
undetectable		 3n62A-2we5A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_B_RITB401_2
(SECRETED ASPARTIC
PROTEASE)		 2we5 CARBAMATE KINASE 1
(Enterococcus
faecalis) 		4 / 7 VAL A 234
ILE A 272
THR A 250
THR A 309
 ADP  A1311 ( 3.9A)
None
None
None
 1.07A 3tneB-2we5A:
undetectable		 3tneB-2we5A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_B_ECNB403_1
(FLAVOHEMOGLOBIN)		 2we5 CARBAMATE KINASE 1
(Enterococcus
faecalis) 		5 / 11 ILE A 272
ALA A 252
LEU A 254
THR A 250
VAL A 249
 None
 1.12A 4g1bB-2we5A:
undetectable		 4g1bB-2we5A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_A_SAMA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 2we5 CARBAMATE KINASE 1
(Enterococcus
faecalis) 		5 / 12 VAL A   6
ILE A 207
GLY A 189
GLY A 192
ILE A 186
 None
 0.91A 4iv0A-2we5A:
3.2		 4iv0A-2we5A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 2we5 CARBAMATE KINASE 1
(Enterococcus
faecalis) 		5 / 12 VAL A   6
ILE A 207
GLY A 189
GLY A 192
ILE A 186
 None
 0.93A 4mwzB-2we5A:
undetectable		 4mwzB-2we5A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F5U_A_CQNA610_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 2we5 CARBAMATE KINASE 1
(Enterococcus
faecalis) 		5 / 10 VAL A  47
LEU A   9
LEU A  94
THR A 109
LEU A  35
 None
 0.79A 6f5uA-2we5A:
undetectable
6f5uB-2we5A:
undetectable		 6f5uA-2we5A:
15.25
6f5uB-2we5A:
14.71