SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2we9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T03_P_TFOP822_1
(POL POLYPROTEIN
SYNTHETIC
OLIGONUCLEOTIDE
PRIMER)		 2we9 MOBA-RELATED PROTEIN
(Mycobacterium
tuberculosis) 		4 / 7 ASP A 181
ASP A 183
ASP A 105
HIS A 137
 None
None
GOL  A1196 (-3.4A)
None
 1.41A 1t03A-2we9A:
undetectable		 1t03A-2we9A:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 2we9 MOBA-RELATED PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 191
ASP A 105
VAL A  33
GLY A  20
ASP A 183
 None
GOL  A1196 (-3.4A)
None
None
None
 1.02A 3bwcB-2we9A:
2.6		 3bwcB-2we9A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_2
(HIV-1 PROTEASE)		 2we9 MOBA-RELATED PROTEIN
(Mycobacterium
tuberculosis) 		4 / 4 GLY A  68
ASP A  70
GLY A   8
THR A  37
 None
 1.02A 3k4vC-2we9A:
undetectable		 3k4vC-2we9A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		 2we9 MOBA-RELATED PROTEIN
(Mycobacterium
tuberculosis) 		3 / 3 PRO A 107
TYR A  28
GLY A  35
 None
 0.72A 4g2zA-2we9A:
undetectable		 4g2zA-2we9A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J03_A_FVSA603_1
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 2we9 MOBA-RELATED PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 TYR A 131
ILE A 117
PHE A  46
LEU A  53
LEU A  66
 None
 1.16A 4j03A-2we9A:
undetectable		 4j03A-2we9A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA303_1
(CHITOSANASE)		 2we9 MOBA-RELATED PROTEIN
(Mycobacterium
tuberculosis) 		4 / 6 ILE A 117
GLY A   8
VAL A  10
HIS A 137
 None
 1.04A 4oltA-2we9A:
undetectable		 4oltA-2we9A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_3
(PROTEASE)		 2we9 MOBA-RELATED PROTEIN
(Mycobacterium
tuberculosis) 		3 / 3 ASP A 105
ASP A 183
ASN A  17
 GOL  A1196 (-3.4A)
None
None
 0.84A 4q5mA-2we9A:
undetectable		 4q5mA-2we9A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA601_1
(SERUM ALBUMIN)		 2we9 MOBA-RELATED PROTEIN
(Mycobacterium
tuberculosis) 		5 / 11 LEU A 161
PHE A 146
LEU A  89
GLY A  98
LEU A 101
 None
 1.30A 4zbqA-2we9A:
undetectable		 4zbqA-2we9A:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 2we9 MOBA-RELATED PROTEIN
(Mycobacterium
tuberculosis) 		4 / 5 GLY A  35
PRO A  22
THR A  32
GLN A  24
 None
 1.26A 5h5fA-2we9A:
2.8		 5h5fA-2we9A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 2we9 MOBA-RELATED PROTEIN
(Mycobacterium
tuberculosis) 		3 / 3 THR A  52
SER A  84
ASP A  76
 None
 0.69A 5kvaA-2we9A:
2.4		 5kvaA-2we9A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 2we9 MOBA-RELATED PROTEIN
(Mycobacterium
tuberculosis) 		3 / 3 THR A  52
SER A  84
ASP A  76
 None
 0.68A 5kvaB-2we9A:
2.4		 5kvaB-2we9A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0I_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2we9 MOBA-RELATED PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 VAL A  77
ASP A  76
ASP A 155
ALA A  82
GLY A  14
 None
None
None
None
GOL  A1196 (-4.2A)
 1.09A 6b0iB-2we9A:
undetectable		 6b0iB-2we9A:
19.39