SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wek'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1501_0
(FERROCHELATASE)		 2wek ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		5 / 12 LEU A 154
LEU A 151
ILE A 139
LEU A 369
VAL A  67
 None
None
DIF  A1374 (-4.7A)
None
None
 1.00A 1hrkA-2wekA:
2.8		 1hrkA-2wekA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2wek ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		5 / 12 GLY A 270
ALA A  76
SER A  77
GLY A 250
SER A 273
 NAP  A1372 (-3.3A)
NAP  A1372 (-3.6A)
DIF  A1373 (-3.0A)
None
NAP  A1372 (-4.8A)
 1.16A 1nbiB-2wekA:
7.9		 1nbiB-2wekA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2wek ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		5 / 12 GLY A 270
ALA A  76
SER A  77
GLY A 250
SER A 273
 NAP  A1372 (-3.3A)
NAP  A1372 (-3.6A)
DIF  A1373 (-3.0A)
None
NAP  A1372 (-4.8A)
 1.20A 1nbiC-2wekA:
7.9		 1nbiC-2wekA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2wek ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		5 / 12 GLY A 270
ALA A  76
SER A  77
GLY A 250
SER A 273
 NAP  A1372 (-3.3A)
NAP  A1372 (-3.6A)
DIF  A1373 (-3.0A)
None
NAP  A1372 (-4.8A)
 1.20A 1nbiD-2wekA:
7.9		 1nbiD-2wekA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_B_BEZB12_0
(CES1 PROTEIN)		 2wek ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		4 / 4 GLY A 100
SER A 128
VAL A 135
LEU A 154
 None
 1.35A 1yajB-2wekA:
undetectable		 1yajB-2wekA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA701_0
(FERROCHELATASE)		 2wek ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		5 / 12 LEU A 154
LEU A 151
ILE A 139
LEU A 369
VAL A  67
 None
None
DIF  A1374 (-4.7A)
None
None
 0.95A 2hrcA-2wekA:
undetectable		 2hrcA-2wekA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1605_0
(FERROCHELATASE)		 2wek ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		5 / 12 LEU A 154
LEU A 151
ILE A 139
LEU A 369
VAL A  67
 None
None
DIF  A1374 (-4.7A)
None
None
 0.97A 2hrcB-2wekA:
2.3		 2hrcB-2wekA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2wek ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		5 / 12 LEU A 154
LEU A 151
ILE A 139
LEU A 369
VAL A  67
 None
None
DIF  A1374 (-4.7A)
None
None
 0.99A 2po5A-2wekA:
3.3		 2po5A-2wekA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2wek ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		5 / 12 LEU A 154
LEU A 151
ILE A 139
LEU A 369
VAL A  67
 None
None
DIF  A1374 (-4.7A)
None
None
 0.96A 2po7A-2wekA:
2.3		 2po7A-2wekA:
23.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X7H_A_PFNA1372_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2wek ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		6 / 11 TYR A 161
LEU A 164
LEU A 170
LEU A 192
LYS A 195
MET A 322
 DIF  A1376 (-4.3A)
DIF  A1376 ( 4.5A)
DIF  A1376 ( 4.5A)
DIF  A1376 (-4.4A)
None
DIF  A1376 (-3.6A)
 0.15A 2x7hA-2wekA:
59.3
2x7hB-2wekA:
59.2		 2x7hA-2wekA:
97.71
2x7hB-2wekA:
97.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X7H_A_PFNA1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2wek ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		6 / 6 PRO A 144
SER A 145
LYS A 147
GLU A 149
TYR A 150
CYH A 323
 None
 0.21A 2x7hA-2wekA:
59.3		 2x7hA-2wekA:
97.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X7H_A_PFNA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2wek ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		4 / 5 SER A  77
PHE A  98
VAL A 155
TYR A 275
 DIF  A1373 (-3.0A)
DIF  A1374 ( 3.9A)
DIF  A1373 (-4.4A)
GOL  A1380 (-3.4A)
 0.22A 2x7hA-2wekA:
59.3		 2x7hA-2wekA:
97.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X7H_B_PFNB1372_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2wek ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		4 / 5 SER A  77
PHE A  98
VAL A 155
TYR A 275
 DIF  A1373 (-3.0A)
DIF  A1374 ( 3.9A)
DIF  A1373 (-4.4A)
GOL  A1380 (-3.4A)
 0.26A 2x7hB-2wekA:
59.2		 2x7hB-2wekA:
97.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFL_A_5CHA693_1
(LACTOTRANSFERRIN)		 2wek ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		4 / 4 THR A 179
VAL A 241
GLY A 230
THR A 231
 None
 0.90A 3cflA-2wekA:
undetectable		 3cflA-2wekA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 2wek ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		5 / 12 GLY A  73
VAL A  72
GLY A 100
ASN A  75
VAL A 155
 None
None
None
DIF  A1373 (-4.1A)
DIF  A1373 (-4.4A)
 1.19A 3f8wA-2wekA:
undetectable		 3f8wA-2wekA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 2wek ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		5 / 12 GLY A  73
VAL A  72
GLY A 100
ASN A  75
VAL A 155
 None
None
None
DIF  A1373 (-4.1A)
DIF  A1373 (-4.4A)
 1.20A 3f8wB-2wekA:
undetectable		 3f8wB-2wekA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 2wek ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		5 / 12 GLY A  73
VAL A  72
GLY A 100
ASN A  75
VAL A 155
 None
None
None
DIF  A1373 (-4.1A)
DIF  A1373 (-4.4A)
 1.19A 3f8wC-2wekA:
undetectable		 3f8wC-2wekA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IW1_A_ASDA1223_1
(CYTOCHROME P450
CYP125)		 2wek ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		5 / 12 ILE A 272
VAL A 353
PRO A  43
SER A  82
ILE A  96
 NAP  A1372 (-4.2A)
None
None
None
None
 1.22A 3iw1A-2wekA:
undetectable		 3iw1A-2wekA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_F_9PLF1_1
(CYTOCHROME P450 2A13)		 2wek ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		5 / 8 PHE A 350
ASN A  44
PHE A  45
ALA A  48
THR A  39
 None
PO4  A1377 (-4.1A)
None
None
None
 1.33A 3t3sF-2wekA:
undetectable		 3t3sF-2wekA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_A_SAMA801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 2wek ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		5 / 12 ILE A 269
GLY A 249
ASP A 254
VAL A 229
LEU A 233
 NAP  A1372 (-4.5A)
None
None
None
None
 1.12A 3v8vA-2wekA:
9.0		 3v8vA-2wekA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD507_1
(HEMOLYTIC LECTIN
CEL-III)		 2wek ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		4 / 5 GLU A 340
GLY A 341
TYR A 355
ASP A 333
 None
 1.04A 3w9tD-2wekA:
undetectable		 3w9tD-2wekA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2wek ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		3 / 3 LEU A 369
PRO A 370
ARG A  53
 None
 0.55A 4klrB-2wekA:
2.9		 4klrB-2wekA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2wek ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		4 / 6 LEU A 260
GLU A 246
VAL A 284
ALA A 286
 None
 0.97A 4nkxA-2wekA:
undetectable		 4nkxA-2wekA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_A_AERA602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 2wek ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		4 / 8 ALA A 160
ASN A 361
GLY A 183
VAL A 329
 None
NAP  A1372 (-3.0A)
NAP  A1372 (-3.5A)
None
 0.76A 4r20A-2wekA:
undetectable		 4r20A-2wekA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_A_SAMA301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 2wek ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		5 / 12 GLY A  63
GLY A  61
ASP A  64
PRO A 136
LEU A 109
 None
 1.03A 5bw4A-2wekA:
4.9		 5bw4A-2wekA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 2wek ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		5 / 12 GLY A 270
PHE A 303
GLY A 274
SER A 273
SER A  77
 NAP  A1372 (-3.3A)
NAP  A1372 (-4.9A)
None
NAP  A1372 (-4.8A)
DIF  A1373 (-3.0A)
 1.05A 5gwxA-2wekA:
7.6		 5gwxA-2wekA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 2wek ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		5 / 12 VAL A 176
ALA A 189
THR A 362
GLY A 217
LEU A 216
 None
 1.10A 5m54E-2wekA:
3.6		 5m54E-2wekA:
22.60