SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2weu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_0
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 2weu TRYPTOPHAN
5-HALOGENASE
(Streptomyces
rugosporus) 		5 / 12 TRP A 336
GLY A  11
THR A  17
ALA A  18
VAL A  31
 None
 1.12A 1jg4A-2weuA:
undetectable		 1jg4A-2weuA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		 2weu TRYPTOPHAN
5-HALOGENASE
(Streptomyces
rugosporus) 		4 / 4 SER A 355
VAL A  52
PHE A 451
VAL A 396
 TRP  A1512 ( 4.8A)
None
TRP  A1512 ( 4.7A)
None
 1.37A 1o86A-2weuA:
undetectable		 1o86A-2weuA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 2weu TRYPTOPHAN
5-HALOGENASE
(Streptomyces
rugosporus) 		5 / 12 GLY A 344
VAL A 341
ALA A 364
ALA A 347
ARG A 328
 None
 1.41A 2avdB-2weuA:
undetectable		 2avdB-2weuA:
18.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OA1_A_TRPA2002_0
(TRYPTOPHAN
HALOGENASE)		 2weu TRYPTOPHAN
5-HALOGENASE
(Streptomyces
rugosporus) 		5 / 12 LYS A  75
ILE A  78
HIS A  92
PHE A  94
GLU A 354
 TRP  A1512 ( 3.7A)
TRP  A1512 ( 4.6A)
TRP  A1512 (-3.2A)
TRP  A1512 (-3.9A)
TRP  A1512 (-4.4A)
 0.20A 2oa1A-2weuA:
47.1		 2oa1A-2weuA:
37.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_B_SAMB500_0
(HYPOTHETICAL PROTEIN)		 2weu TRYPTOPHAN
5-HALOGENASE
(Streptomyces
rugosporus) 		4 / 6 VAL A  44
PHE A 170
THR A 270
TRP A 281
 None
 1.15A 2q6oB-2weuA:
undetectable		 2q6oB-2weuA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_A_LDPA501_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 2weu TRYPTOPHAN
5-HALOGENASE
(Streptomyces
rugosporus) 		4 / 7 GLY A  14
PHE A  55
ILE A 358
PHE A  56
 None
 0.99A 2qmzA-2weuA:
2.3
2qmzB-2weuA:
2.3		 2qmzA-2weuA:
18.59
2qmzB-2weuA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2weu TRYPTOPHAN
5-HALOGENASE
(Streptomyces
rugosporus) 		4 / 8 SER A 455
PHE A 399
TYR A 454
PHE A  49
 TRP  A1512 ( 4.2A)
None
None
TRP  A1512 (-3.5A)
 1.15A 2wekA-2weuA:
undetectable		 2wekA-2weuA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2weu TRYPTOPHAN
5-HALOGENASE
(Streptomyces
rugosporus) 		4 / 8 SER A 455
PHE A 399
TYR A 454
PHE A  49
 TRP  A1512 ( 4.2A)
None
None
TRP  A1512 (-3.5A)
 1.13A 2wekB-2weuA:
undetectable		 2wekB-2weuA:
20.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WET_B_TRPB650_0
(TRYPTOPHAN
5-HALOGENASE)		 2weu TRYPTOPHAN
5-HALOGENASE
(Streptomyces
rugosporus) 		10 / 10 PHE A  49
SER A  50
THR A  51
ILE A  78
HIS A  92
PHE A  94
GLN A 160
GLN A 163
GLU A 354
TYR A 454
 TRP  A1512 (-3.5A)
TRP  A1512 (-2.5A)
TRP  A1512 (-3.8A)
TRP  A1512 ( 4.6A)
TRP  A1512 (-3.2A)
TRP  A1512 (-3.9A)
TRP  A1512 (-3.7A)
TRP  A1512 (-2.9A)
TRP  A1512 (-4.4A)
None
 0.16A 2wetB-2weuA:
62.0		 2wetB-2weuA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WM3_A_NFLA1301_1
(NMRA-LIKE FAMILY
DOMAIN CONTAINING
PROTEIN 1)		 2weu TRYPTOPHAN
5-HALOGENASE
(Streptomyces
rugosporus) 		4 / 6 LEU A  21
THR A  17
LEU A  33
ASP A  30
 None
 0.99A 2wm3A-2weuA:
4.1		 2wm3A-2weuA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 2weu TRYPTOPHAN
5-HALOGENASE
(Streptomyces
rugosporus) 		5 / 12 HIS A  54
GLU A 366
LYS A 370
LEU A 152
GLY A 153
 None
 1.46A 2zj0A-2weuA:
undetectable		 2zj0A-2weuA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_1
(ADENOSYLHOMOCYSTEINA
SE)		 2weu TRYPTOPHAN
5-HALOGENASE
(Streptomyces
rugosporus) 		5 / 12 HIS A  54
GLU A 366
LYS A 370
LEU A 152
GLY A 153
 None
 1.41A 2zj0B-2weuA:
undetectable		 2zj0B-2weuA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_A_ADNA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 2weu TRYPTOPHAN
5-HALOGENASE
(Streptomyces
rugosporus) 		5 / 12 HIS A  54
GLU A 366
LYS A 370
LEU A 152
GLY A 153
 None
 1.43A 3ce6A-2weuA:
2.2		 3ce6A-2weuA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_B_ADNB500_1
(ADENOSYLHOMOCYSTEINA
SE)		 2weu TRYPTOPHAN
5-HALOGENASE
(Streptomyces
rugosporus) 		5 / 12 HIS A  54
GLU A 366
LYS A 370
LEU A 152
GLY A 153
 None
 1.43A 3ce6B-2weuA:
undetectable		 3ce6B-2weuA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_C_ADNC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 2weu TRYPTOPHAN
5-HALOGENASE
(Streptomyces
rugosporus) 		5 / 12 HIS A  54
GLU A 366
LYS A 370
LEU A 152
GLY A 153
 None
 1.44A 3ce6C-2weuA:
undetectable		 3ce6C-2weuA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 2weu TRYPTOPHAN
5-HALOGENASE
(Streptomyces
rugosporus) 		5 / 12 HIS A  54
GLU A 366
LYS A 370
LEU A 152
GLY A 153
 None
 1.42A 3ce6D-2weuA:
undetectable		 3ce6D-2weuA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LK0_D_Z80D92_1
(PROTEIN S100-B)		 2weu TRYPTOPHAN
5-HALOGENASE
(Streptomyces
rugosporus) 		3 / 3 HIS A 391
PHE A 360
PHE A 359
 None
 0.72A 3lk0D-2weuA:
0.0		 3lk0D-2weuA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2weu TRYPTOPHAN
5-HALOGENASE
(Streptomyces
rugosporus) 		5 / 12 LEU A 285
GLY A 292
GLY A  45
ASP A 171
ALA A 322
 None
 1.05A 3ou6A-2weuA:
undetectable		 3ou6A-2weuA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_1
(PUTATIVE REGULATORY
PROTEIN)		 2weu TRYPTOPHAN
5-HALOGENASE
(Streptomyces
rugosporus) 		3 / 3 TYR A 454
MET A 392
LEU A 157
 None
 1.00A 3vw1D-2weuA:
undetectable		 3vw1D-2weuA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 2weu TRYPTOPHAN
5-HALOGENASE
(Streptomyces
rugosporus) 		4 / 8 ARG A 488
ARG A  98
GLU A 485
ARG A 490
 None
 1.11A 4bqfB-2weuA:
undetectable		 4bqfB-2weuA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K17_B_OHBB701_0
(LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A)		 2weu TRYPTOPHAN
5-HALOGENASE
(Streptomyces
rugosporus) 		4 / 5 GLU A 131
SER A 120
ARG A  79
SER A 118
 None
 1.41A 4k17B-2weuA:
undetectable		 4k17B-2weuA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_B_ACTB404_0
(D-ALANINE--D-ALANINE
LIGASE)		 2weu TRYPTOPHAN
5-HALOGENASE
(Streptomyces
rugosporus) 		4 / 7 TYR A 166
TYR A 506
GLY A 141
LEU A 143
 None
 1.18A 5bphB-2weuA:
undetectable		 5bphB-2weuA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB202_0
(HYDROXYNITRILE LYASE)		 2weu TRYPTOPHAN
5-HALOGENASE
(Streptomyces
rugosporus) 		4 / 7 VAL A 195
THR A 211
LEU A 232
VAL A   6
 None
 1.05A 5e4dA-2weuA:
0.6
5e4dB-2weuA:
0.6		 5e4dA-2weuA:
16.96
5e4dB-2weuA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2weu TRYPTOPHAN
5-HALOGENASE
(Streptomyces
rugosporus) 		5 / 12 ILE A   2
LEU A  33
LEU A 232
VAL A 198
ILE A 206
 None
 1.04A 5mugA-2weuA:
undetectable		 5mugA-2weuA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGL_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2weu TRYPTOPHAN
5-HALOGENASE
(Streptomyces
rugosporus) 		3 / 3 VAL A  34
VAL A 191
GLN A 213
 None
 0.70A 5qglA-2weuA:
undetectable		 5qglA-2weuA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGV_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2weu TRYPTOPHAN
5-HALOGENASE
(Streptomyces
rugosporus) 		3 / 3 VAL A  34
VAL A 191
GLN A 213
 None
 0.72A 5qgvA-2weuA:
undetectable		 5qgvA-2weuA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGW_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2weu TRYPTOPHAN
5-HALOGENASE
(Streptomyces
rugosporus) 		3 / 3 VAL A  34
VAL A 191
GLN A 213
 None
 0.72A 5qgwA-2weuA:
undetectable		 5qgwA-2weuA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGX_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2weu TRYPTOPHAN
5-HALOGENASE
(Streptomyces
rugosporus) 		3 / 3 VAL A  34
VAL A 191
GLN A 213
 None
 0.72A 5qgxA-2weuA:
undetectable		 5qgxA-2weuA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH1_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2weu TRYPTOPHAN
5-HALOGENASE
(Streptomyces
rugosporus) 		3 / 3 VAL A  34
VAL A 191
GLN A 213
 None
 0.71A 5qh1A-2weuA:
undetectable		 5qh1A-2weuA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA406_0
(THIOREDOXIN
REDUCTASE)		 2weu TRYPTOPHAN
5-HALOGENASE
(Streptomyces
rugosporus) 		3 / 3 HIS A 437
SER A 434
ARG A 429
 None
 0.65A 5u63A-2weuA:
3.3		 5u63A-2weuA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA303_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2weu TRYPTOPHAN
5-HALOGENASE
(Streptomyces
rugosporus) 		3 / 3 GLU A 181
TYR A 182
ARG A 186
 None
 0.59A 5uunA-2weuA:
undetectable		 5uunA-2weuA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2weu TRYPTOPHAN
5-HALOGENASE
(Streptomyces
rugosporus) 		3 / 3 GLU A 181
TYR A 182
ARG A 186
 None
 0.48A 5uunB-2weuA:
undetectable		 5uunB-2weuA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_0
(REGULATORY PROTEIN
TETR)		 2weu TRYPTOPHAN
5-HALOGENASE
(Streptomyces
rugosporus) 		5 / 12 ALA A 274
SER A  84
GLU A  85
LEU A 463
TYR A 269
 None
 1.26A 5vlmH-2weuA:
0.5		 5vlmH-2weuA:
17.81