SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wex'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MZ9_A_VDYA1002_4 (CARTILAGE OLIGOMERIC MATRIX PROTEIN)	2wex	APOLIPOPROTEIN M (Homo sapiens)	4 / 5	LEU A 175 VAL A 158 CYH A 157 CYH A 128	None	1.14A	1mz9D-2wexA: undetectable	1mz9D-2wexA: 13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3MJR_D_AC2D601_1 (DEOXYCYTIDINE KINASE)	2wex	APOLIPOPROTEIN M (Homo sapiens)	4 / 8	GLU A 136 PHE A 71 ARG A 143 PHE A 63	GYM A1186 (-3.1A) GYM A1186 (-3.8A) None GYM A1186 (-4.6A)	1.07A	3mjrD-2wexA: undetectable	3mjrD-2wexA: 21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IEN_A_VDYA201_1 (CDL2.2)	2wex	APOLIPOPROTEIN M (Homo sapiens)	5 / 12	LEU A 60 PHE A 63 MET A 73 ILE A 132 LEU A 123	None GYM A1186 (-4.6A) GYM A1186 ( 4.9A) GYM A1186 ( 4.6A) None	1.26A	5ienA-2wexA: undetectable	5ienA-2wexA: 23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6GB9_A_ACTA508_0 (MOLYBDOPTERIN BIOSYNTHESIS PROTEIN CNX1)	2wex	APOLIPOPROTEIN M (Homo sapiens)	3 / 3	VAL A 70 ALA A 182 GLN A 46	None	0.69A	6gb9A-2wexA: undetectable	6gb9A-2wexA: 14.47

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1MZ9_A_VDYA1002_4","CARTILAGE OLIGOMERIC MATRIX PROTEIN;CARTILAGE OLIGOMERIC MATRIX PROTEIN","2wex","APOLIPOPROTEIN M","Homo sapiens",4,"LEU A 175;VAL A 158;CYH A 157;CYH A 128","None","1.14A","1mz9D-2wexA:undetectable","1mz9D-2wexA:13.25"],["3MJR_D_AC2D601_1","DEOXYCYTIDINE KINASE","2wex","APOLIPOPROTEIN M","Homo sapiens",4,"GLU A 136;PHE A  71;ARG A 143;PHE A  63","GYM A1186 (-3.1A);GYM A1186 (-3.8A);None;GYM A1186 (-4.6A)","1.07A","3mjrD-2wexA:undetectable","3mjrD-2wexA:21.64"],["5IEN_A_VDYA201_1","CDL2.2","2wex","APOLIPOPROTEIN M","Homo sapiens",5,"LEU A  60;PHE A  63;MET A  73;ILE A 132;LEU A 123","None;GYM A1186 (-4.6A);GYM A1186 ( 4.9A);GYM A1186 ( 4.6A);None","1.26A","5ienA-2wexA:undetectable","5ienA-2wexA:23.63"],["6GB9_A_ACTA508_0","MOLYBDOPTERIN BIOSYNTHESIS PROTEIN CNX1","2wex","APOLIPOPROTEIN M","Homo sapiens",3,"VAL A  70;ALA A 182;GLN A  46","None","0.69A","6gb9A-2wexA:undetectable","6gb9A-2wexA:14.47"]]