SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wfd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_B_9CRB130_1
(TRANSTHYRETIN)		 2wfd LEUCYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Homo
sapiens) 		4 / 7 LEU A 269
THR A 293
ALA A 291
LEU A 289
 None
 0.89A 1tyrB-2wfdA:
undetectable		 1tyrB-2wfdA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_1
(POL POLYPROTEIN)		 2wfd LEUCYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Homo
sapiens) 		5 / 9 ILE A 287
GLY A 315
ILE A 314
VAL A 307
ILE A 357
 None
 1.00A 2avoA-2wfdA:
undetectable		 2avoA-2wfdA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_B_VD3B700_1
(CYTOCHROME P450 2R1)		 2wfd LEUCYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Homo
sapiens) 		5 / 12 ALA A 360
VAL A 374
GLY A 354
GLU A 356
VAL A 348
 None
 1.09A 3c6gB-2wfdA:
undetectable		 3c6gB-2wfdA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_2
(HIV-1 PROTEASE)		 2wfd LEUCYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Homo
sapiens) 		5 / 9 ILE A 287
GLY A 315
ILE A 314
VAL A 307
ILE A 357
 None
 1.08A 3d1yB-2wfdA:
undetectable		 3d1yB-2wfdA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_A_BEZA302_0
(DISULFIDE
INTERCHANGE PROTEIN)		 2wfd LEUCYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Homo
sapiens) 		4 / 6 PRO A 296
LEU A 366
LYS A 497
ALA A 504
 None
 1.33A 3gv1A-2wfdA:
undetectable
3gv1C-2wfdA:
undetectable		 3gv1A-2wfdA:
20.85
3gv1C-2wfdA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDW_A_RITA100_2
(PROTEASE)		 2wfd LEUCYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Homo
sapiens) 		5 / 9 ILE A 287
GLY A 315
ILE A 314
VAL A 307
ILE A 357
 None
 1.04A 3ndwB-2wfdA:
undetectable		 3ndwB-2wfdA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_A_T44A128_1
(TRANSTHYRETIN)		 2wfd LEUCYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Homo
sapiens) 		5 / 9 LEU A 269
THR A 293
ALA A 291
LEU A 289
THR A 386
 None
 1.43A 3ozkA-2wfdA:
undetectable		 3ozkA-2wfdA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		 2wfd LEUCYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Homo
sapiens) 		5 / 7 LEU A 269
THR A 293
ALA A 291
LEU A 289
THR A 386
 None
 1.37A 4d7bA-2wfdA:
undetectable		 4d7bA-2wfdA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		 2wfd LEUCYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Homo
sapiens) 		4 / 6 LEU A 269
THR A 293
ALA A 291
LEU A 289
 None
 0.95A 4pwjA-2wfdA:
undetectable		 4pwjA-2wfdA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		 2wfd LEUCYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Homo
sapiens) 		4 / 7 LEU A 269
THR A 293
ALA A 291
LEU A 289
 None
 0.89A 4pwjB-2wfdA:
undetectable		 4pwjB-2wfdA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_A_29SA601_1
(ESTROGEN RECEPTOR)		 2wfd LEUCYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Homo
sapiens) 		5 / 12 ALA A 442
ASP A 395
LEU A 440
LEU A 449
PRO A 428
 None
 1.33A 4xi3A-2wfdA:
undetectable		 4xi3A-2wfdA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 2wfd LEUCYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Homo
sapiens) 		5 / 12 LEU A 449
ALA A 463
GLU A 462
ILE A 434
GLY A 471
 None
 1.14A 5gtrA-2wfdA:
undetectable		 5gtrA-2wfdA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_C_FK5C201_1
(FK506-BINDING
PROTEIN 1)		 2wfd LEUCYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Homo
sapiens) 		5 / 10 ASP A 480
VAL A 490
ILE A 494
LEU A 366
PHE A 300
 None
 1.31A 5hw8C-2wfdA:
undetectable
5hw8H-2wfdA:
undetectable		 5hw8C-2wfdA:
23.68
5hw8H-2wfdA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC605_0
(ALPHA-AMYLASE)		 2wfd LEUCYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Homo
sapiens) 		4 / 8 GLY A 475
ILE A 476
ASP A 395
PRO A 430
 None
 0.99A 6ag0C-2wfdA:
undetectable		 6ag0C-2wfdA:
13.94