SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wfh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_2
(ESTROGEN RECEPTOR)		 2wfh SLIT HOMOLOG 2
PROTEIN C-PRODUCT
(Homo
sapiens) 		4 / 6 LEU A 768
LEU A 784
LEU A 813
LEU A 779
 None
 0.79A 1errA-2wfhA:
undetectable		 1errA-2wfhA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_C_AG2C7004_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2wfh SLIT HOMOLOG 2
PROTEIN C-PRODUCT
(Homo
sapiens) 		4 / 6 LEU A 779
GLU A 772
LEU A 748
LEU A 784
 None
 0.83A 1mt1D-2wfhA:
undetectable
1mt1E-2wfhA:
undetectable		 1mt1D-2wfhA:
18.81
1mt1E-2wfhA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC439_0
(ADP-RIBOSYL CYCLASE)		 2wfh SLIT HOMOLOG 2
PROTEIN C-PRODUCT
(Homo
sapiens) 		3 / 3 TRP A 869
PHE A 845
TRP A 873
 None
 1.04A 1r15C-2wfhA:
undetectable		 1r15C-2wfhA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF469_0
(ADP-RIBOSYL CYCLASE)		 2wfh SLIT HOMOLOG 2
PROTEIN C-PRODUCT
(Homo
sapiens) 		3 / 3 TRP A 869
PHE A 845
TRP A 873
 None
 1.04A 1r15F-2wfhA:
undetectable		 1r15F-2wfhA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_G_NCAG479_0
(ADP-RIBOSYL CYCLASE)		 2wfh SLIT HOMOLOG 2
PROTEIN C-PRODUCT
(Homo
sapiens) 		3 / 3 TRP A 869
PHE A 845
TRP A 873
 None
 1.03A 1r15G-2wfhA:
undetectable		 1r15G-2wfhA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_H_NCAH489_0
(ADP-RIBOSYL CYCLASE)		 2wfh SLIT HOMOLOG 2
PROTEIN C-PRODUCT
(Homo
sapiens) 		3 / 3 TRP A 869
PHE A 845
TRP A 873
 None
 1.04A 1r15H-2wfhA:
undetectable		 1r15H-2wfhA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN)		 2wfh SLIT HOMOLOG 2
PROTEIN C-PRODUCT
(Homo
sapiens) 		5 / 11 LEU A 803
ASN A 835
LEU A 792
VAL A 840
PHE A 821
 None
 1.42A 1tw4A-2wfhA:
undetectable		 1tw4A-2wfhA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_0
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 2wfh SLIT HOMOLOG 2
PROTEIN C-PRODUCT
(Homo
sapiens) 		5 / 12 PHE A 845
ILE A 856
THR A 820
LEU A 832
LEU A 824
 None
 1.24A 2rctA-2wfhA:
undetectable		 2rctA-2wfhA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQ5_B_LDPB1197_1
(S-NORCOCLAURINE
SYNTHASE)		 2wfh SLIT HOMOLOG 2
PROTEIN C-PRODUCT
(Homo
sapiens) 		5 / 7 LEU A 761
LEU A 745
PHE A 766
LEU A 773
GLU A 772
 None
 1.08A 2vq5B-2wfhA:
undetectable		 2vq5B-2wfhA:
26.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 2wfh SLIT HOMOLOG 2
PROTEIN C-PRODUCT
(Homo
sapiens) 		4 / 7 THR A 820
LEU A 830
LEU A 808
LEU A 806
 None
 0.91A 3bgdB-2wfhA:
undetectable		 3bgdB-2wfhA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 2wfh SLIT HOMOLOG 2
PROTEIN C-PRODUCT
(Homo
sapiens) 		5 / 11 ALA A 884
ASN A 835
GLU A 880
LEU A 854
VAL A 874
 None
 1.26A 3jw5A-2wfhA:
undetectable		 3jw5A-2wfhA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV1_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 2wfh SLIT HOMOLOG 2
PROTEIN C-PRODUCT
(Homo
sapiens) 		3 / 3 LYS A 903
LYS A 904
PRO A 901
 None
 0.98A 4dv1L-2wfhA:
undetectable		 4dv1L-2wfhA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7G_B_ACTB902_0
(3-HYDROXYPROLINE
DEHYDRATSE)		 2wfh SLIT HOMOLOG 2
PROTEIN C-PRODUCT
(Homo
sapiens) 		4 / 7 ASP A 872
SER A 871
TRP A 869
SER A 902
 None
 1.20A 4k7gB-2wfhA:
undetectable		 4k7gB-2wfhA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2wfh SLIT HOMOLOG 2
PROTEIN C-PRODUCT
(Homo
sapiens) 		4 / 8 LEU A 803
LEU A 827
LEU A 848
ILE A 782
 None
 0.89A 4klaA-2wfhA:
undetectable		 4klaA-2wfhA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_B_RTLB201_0
(RETINOL-BINDING
PROTEIN 2)		 2wfh SLIT HOMOLOG 2
PROTEIN C-PRODUCT
(Homo
sapiens) 		5 / 12 PHE A 845
ILE A 856
THR A 820
LEU A 832
LEU A 824
 None
 1.24A 4qynB-2wfhA:
undetectable		 4qynB-2wfhA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_2
(CDL2.2)		 2wfh SLIT HOMOLOG 2
PROTEIN C-PRODUCT
(Homo
sapiens) 		5 / 12 LEU A 806
LEU A 830
THR A 820
ALA A 844
LEU A 870
 None
 1.17A 5ienB-2wfhA:
undetectable		 5ienB-2wfhA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6M_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2wfh SLIT HOMOLOG 2
PROTEIN C-PRODUCT
(Homo
sapiens) 		5 / 11 ASP A 847
LEU A 848
PHE A 821
LEU A 832
ILE A 816
 None
 1.08A 5z6mA-2wfhA:
undetectable		 5z6mA-2wfhA:
20.79